Figure 7From: Hepatocyte-specific S100a8 and S100a9 transgene expression in mice causes Cxcl1 induction and systemic neutrophil enrichmentInvolvement of signaling pathways in Cxcl1 upregulation in hepatocytes. (A) Primary hepatocytes were isolated from Control and TgS100a8a9hep mice (n=2). Expression of p65, c-Jun, Stat3, p38, ERK1/2, and the corresponding phosphorylated forms was monitored by Western Blot analysis. (B) Primary hepatocytes were treated either with SB203580 or with (DMSO) for 5 h and relative expression of Cxcl1, Cxcl2, and Csf1 was determined by qRT-PCR; n=5, Mean +SD, students t-test, **p≤0.01.Back to article page