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  1. IL-6 classic signaling is linked to anti-inflammatory functions while the trans-signaling is associated with pro-inflammatory responses. Classic signaling is induced via membrane-bound IL-6 receptor (IL-6R) wh...

    Authors: Mulugeta M. Zegeye, Madelene Lindkvist, Knut Fälker, Ashok K. Kumawat, Geena Paramel, Magnus Grenegård, Allan Sirsjö and Liza U. Ljungberg

    Citation: Cell Communication and Signaling 2018 16:55

    Content type: Research

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  2. The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)...

    Authors: Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saito and Mitsuo Shimada

    Citation: Cell Communication and Signaling 2018 16:54

    Content type: Research

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  3. Chemotherapeutic insensitivity remains a big challenge in prostate cancer treatment. Recently, increasing evidence has indicated that KLF4 plays a key role in prostate cancer. However, the potential biological...

    Authors: Lu Zhang, Xiaojie Li, Yulin Chao, Ruiping He, Junqiang Liu, Yi Yuan, Wenzhi Zhao, Chuanchun Han and Xishuang Song

    Citation: Cell Communication and Signaling 2018 16:53

    Content type: Research

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  4. Targeting TopoisomeraseII (TopoII) and generate enzyme mediated DNA damage is an effective strategy for treatment of breast cancer. TopoII is known as a validated target for drug discovery and cancer chemother...

    Authors: Yajie Wang, Hua Sun, Zhiyan Xiao, Gang Zhang, Dan Zhang, Xiuqi Bao, Fangfang Li, Shaoyu Wu, Yuanchao Gao and Ning Wei

    Citation: Cell Communication and Signaling 2018 16:52

    Content type: Research

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  5. The outcome of cancer therapy is greatly defined by the ability of a tumor cell to evade treatment and re-establish its bulk mass after medical interventions. Consequently, there is an urgent need for the char...

    Authors: Balint Csoboz, Imre Gombos, Eniko Tatrai, Jozsef Tovari, Anna L. Kiss, Ibolya Horvath and Laszlo Vigh

    Citation: Cell Communication and Signaling 2018 16:51

    Content type: Research

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  6. Wilms’ tumor 1-associating protein (WTAP) is a nuclear protein, which is ubiquitously expressed in many tissues. Furthermore, in various types of malignancies WTAP is overexpressed and plays a role as an oncog...

    Authors: Yue Kuai, Xin Gong, Liya Ding, Fang Li, Lizhen Lei, Yuqi Gong, Qingmeng Liu, Huajiao Tan, Xinxia Zhang, Dongyu Liu, Guoping Ren, Hongyang Pan, Yaoyao Shi, Friederike Berberich-Siebelt, Zhengrong Mao and Ren Zhou

    Citation: Cell Communication and Signaling 2018 16:50

    Content type: Research

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  7. The relationship between various external agents such as pollen, food, and infectious agents and human sensitivity exists and is variable depending upon individual’s health conditions. For example, we believe ...

    Authors: Ichiro Murakami, Noriko Wada, Junko Nakashima, Mitsuko Iguchi, Makoto Toi, Yumiko Hashida, Tomonori Higuchi, Masanori Daibata, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Yasushi Horie, Keiko Nagata, Kazuhiko Hayashi, Takashi Oka, Tadashi Yoshino…

    Citation: Cell Communication and Signaling 2018 16:49

    Content type: Review

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  8. Dormant estrogen receptor positive (ER+) breast cancer micrometastases in the bone marrow survive adjuvant chemotherapy and recur stochastically for more than 20 years. We hypothesized that inflammatory cytoki...

    Authors: Samir Tivari, Haiyan Lu, Tanya Dasgupta, Mariana S. De Lorenzo and Robert Wieder

    Citation: Cell Communication and Signaling 2018 16:48

    Content type: Research

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  9. 5-Fluorouracil (5-FU) has been widely applied to treat various types of cancers, including hepatocellular carcinoma (HCC). However, primary or acquired 5-FU resistance prevents the clinical application of this...

    Authors: Lili Wu, Chenwei Pan, Xin Wei, Yifen Shi, Jianjian Zheng, Xiangyang Lin and Liang Shi

    Citation: Cell Communication and Signaling 2018 16:47

    Content type: Research

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  10. Proteins of the ubiquitously expressed core proteome are quantitatively correlated across multiple eukaryotic species. In addition, it was found that many protein paralogues exhibit expression anticorrelation,...

    Authors: E. Besray Unal, Christina Kiel, Hannah Benisty, Andrew Campbell, Karen Pickering, Nils Blüthgen, Owen J. Sansom and Luis Serrano

    Citation: Cell Communication and Signaling 2018 16:46

    Content type: Research

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  11. In T cells, the Kv1.3 and the KCa3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during TEM cell activation, the number of Kv1.3 channels on the cell membrane dramatically...

    Authors: José Ignacio Veytia-Bucheli, Juana María Jiménez-Vargas, Erika Isabel Melchy-Pérez, Monserrat Alba Sandoval-Hernández, Lourival Domingos Possani and Yvonne Rosenstein

    Citation: Cell Communication and Signaling 2018 16:45

    Content type: Short report

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  12. The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential appl...

    Authors: Zhihong Li, Rui Fang, Jia Fang, Shasha He and Tang Liu

    Citation: Cell Communication and Signaling 2018 16:44

    Content type: Review

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  13. The highly refractory nature of non-small cell lung cancer (NSCLC) to chemotherapeutic drugs is an important factor resulting in its poor prognosis. Recent studies have revealed that tumour necrosis factor alp...

    Authors: Ying Xing, Yuechao Liu, Tianbo Liu, Qingwei Meng, Hailing Lu, Wei Liu, Jing Hu, Chunhong Li, Mengru Cao, Shi Yan, Jian Huang, Ting Wang and Li Cai

    Citation: Cell Communication and Signaling 2018 16:43

    Content type: Research

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  14. Chronic muscle injury is characteristics of fatty infiltration and fibrosis. Recently, fibro/adipogenic progenitors (FAPs) were found to be indispensable for muscular regeneration while were also responsible f...

    Authors: Xia Kang, Ming-yu Yang, You-xing Shi, Mei-ming Xie, Min Zhu, Xiao-long Zheng, Chen-ke Zhang, Zi-lu Ge, Xu-ting Bian, Jing-tong Lv, Yun-jiao Wang, Bing-hua Zhou and Kang-lai Tang

    Citation: Cell Communication and Signaling 2018 16:42

    Content type: Research

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  15. PPFIA1 is located at the 11q13 region commonly amplified in cancer. The protein liprin-α1 encoded by PPF1A1 contributes to the adhesive and invasive structures of cytoskeletal elements and is located at the invad...

    Authors: Henna Pehkonen, Mira Lento, Pernilla von Nandelstadh, Artemis Filippou, Reidar Grénman, Kaisa Lehti and Outi Monni

    Citation: Cell Communication and Signaling 2018 16:41

    Content type: Research

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  16. The epidermal growth factor receptor (EGFR) is closely implicated in cancer, and sequencing analyses have revealed a high mutation rate of EGFR in lung cancer. Recent advances have provided novel insights into th...

    Authors: Taishu Wang, Jinrui Zhang, Shanshan Wang, Xiuna Sun, Duchuang Wang, Yurou Gao, Yang Zhang, Lu Xu, Yue Wu, Yueguang Wu, Fang Liu, Xiuxiu Liu, Shuyan Liu, Yingqiu Zhang, Yang Wang, Lijuan Zou…

    Citation: Cell Communication and Signaling 2018 16:40

    Content type: Research

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  17. CRM1 enrichment has been shown to be indicative of invasive as well as chemoresistant tumors. On the other hand, TRAIL, a powerful and specific anti-tumoral agent, has yet to be used effectively to treat gynec...

    Authors: François Fabi, Pascal Adam, Keven Vincent, Françis Demontigny, Sophie Parent, France-Hélène Joncas and Eric Asselin

    Citation: Cell Communication and Signaling 2018 16:39

    Content type: Research

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  18. Integrins are essential regulators of angiogenesis. However, the antiangiogenic potential of peptides derived from the integrin cytoplasmic tails (CT) remains mostly undetermined.

    Authors: Zhongyuan Cao, Xinfeng Suo, Yudan Chu, Zhou Xu, Yun Bao, Chunxiao Miao, Wenfeng Deng, Kaijun Mao, Juan Gao, Zhen Xu and Yan-Qing Ma

    Citation: Cell Communication and Signaling 2018 16:38

    Content type: Research

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  19. Fascin is a F-actin bundling protein and its overexpression is correlated with poor prognosis and increases metastatic potential in a number of cancers. But underlying function and mechanism of fascin on tumor...

    Authors: Jiaxin Kang, Jian Wang, Zhuang Yao, Yuanzhao Hu, Shijie Ma, Qin Fan, Feng Gao, Yan Sun and Jianwei Sun

    Citation: Cell Communication and Signaling 2018 16:37

    Content type: Research

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  20. Chemotherapeutic efficacy can be improved by targeting the structure and function of the extracellular matrix (ECM) in the carcinomal stroma. This can be accomplished by e.g. inhibiting TGF-β1 and -β3 or treat...

    Authors: P. Olof Olsson, Renata Gustafsson, Alexei V. Salnikov, Maria Göthe, Kathrin S. Zeller, Tomas Friman, Bo Baldetorp, Louise A. Koopman, Paul H. Weinreb, Shelia M. Violette, Sebastian Kalamajski, Nils-Erik Heldin and Kristofer Rubin

    Citation: Cell Communication and Signaling 2018 16:36

    Content type: Research

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  21. Loss of PTEN is involved in tumor progression of several tumor entities including renal cell carcinoma (RCC). During the translation process PTEN generates a number of splice variants, including PTEN-Δ. We ana...

    Authors: Ines Breuksch, Jonas Welter, Heide-Katharina Bauer, Thorsten Enklaar, Sebastian Frees, Joachim W. Thüroff, Annette Hasenburg, Dirk Prawitt and Walburgis Brenner

    Citation: Cell Communication and Signaling 2018 16:35

    Content type: Research

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  22. The International Conference on Cell Death in Cancer and Toxicology 2018 (February 20–22, 2018) provided an international forum for scientific collaborations across multiple disciplines in cancer, cell death, ...

    Authors: Kausar M. Ansari, Praveen R. Arany, Eli Arama, Sarit Larisch, Raymond B. Birge and Dhyan Chandra

    Citation: Cell Communication and Signaling 2018 16:34

    Content type: Short report

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  23. Saccharomyces cerevisiae ScGdt1 and mammalian TMEM165 are two members of the UPF0016 membrane protein family that is likely to form a new group of Ca2+/H+ antiporter and/or a Mn2+ transporter in the Golgi apparat...

    Authors: Linghuo Jiang, Junjun Wang, Faiza Asghar, Nathan Snyder and Kyle W. Cunningham

    Citation: Cell Communication and Signaling 2018 16:33

    Content type: Research

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  24. To determine whether adipocyte-derived lipids could be transferred into breast cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty acid trafficking in breast cancer cells.

    Authors: Dejuan Yang, Yunhai Li, Lei Xing, Yiqing Tan, Jiazheng Sun, Beilei Zeng, Tingxiu Xiang, Jinxiang Tan, Guosheng Ren and Yuanyuan Wang

    Citation: Cell Communication and Signaling 2018 16:32

    Content type: Research

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  25. The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phos...

    Authors: Min Yang, En Liu, Li Tang, Yuanyuan Lei, Xuemei Sun, Jiaxi Hu, Hui Dong, Shi-Ming Yang, Mingfa Gao and Bo Tang

    Citation: Cell Communication and Signaling 2018 16:31

    Content type: Review

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  26. In this study, we investigated the role of microRNA-644a (miR-644a) in the growth and survival of hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower in HCC tissues than in adjacent peri-cancerous...

    Authors: Wenjin Liang, Yong Liao, Zeming Li, Yan Wang, Siqi Zheng, Xiaochen Xu, Fulin Ran, Bo Tang and Zhenran Wang

    Citation: Cell Communication and Signaling 2018 16:30

    Content type: Research

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  27. TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP va...

    Authors: Sungjin Park, Hyunji Lee, Minhee Kim, Jisoo Park, Seon-Hwan Kim and Jongsun Park

    Citation: Cell Communication and Signaling 2018 16:29

    Content type: Review

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  28. SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the...

    Authors: Shuai Li, Lanyan Fu, Tian Tian, Liwen Deng, Huangbin Li, Weixiong Xia and Qing Gong

    Citation: Cell Communication and Signaling 2018 16:28

    Content type: Research

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  29. Altered expression of Solute Carrier Family 12 Member 7 (SLC12A7) is implicated to promote malignant behavior in multiple cancer types through an incompletely understood mechanism. Recent studies have shown re...

    Authors: Taylor C. Brown, Timothy D. Murtha, Jill C. Rubinstein, Reju Korah and Tobias Carling

    Citation: Cell Communication and Signaling 2018 16:27

    Content type: Research

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  30. Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer. Recent years have witnessed the im...

    Authors: Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai and Xinxiang Li

    Citation: Cell Communication and Signaling 2018 16:26

    Content type: Research

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  31. Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fract...

    Authors: Jiangfeng Du, Yaping Qin, Yahong Wu, Wenshan Zhao, Wenjie Zhai, Yuanming Qi, Chuchu Wang and Yanfeng Gao

    Citation: Cell Communication and Signaling 2018 16:25

    Content type: Research

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  32. The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens. Recently it became clear tha...

    Authors: Omar Elaskalani, Norbaini Binti Abdol Razak and Pat Metharom

    Citation: Cell Communication and Signaling 2018 16:24

    Content type: Research

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  33. Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, c...

    Authors: Shaojie Jiang, Miaofeng Zhang, Jihong Sun and Xiaoming Yang

    Citation: Cell Communication and Signaling 2018 16:23

    Content type: Review

    Published on:

  34. SDF1/CXCR4 and AnnexinA7 play important roles in many physiological and pathological conditions, but the molecular association between them in cancer cells has not been studied thus far.

    Authors: Jingwen Wang, Yuhong Huang, Jun Zhang, Boyi Xing, Wei Xuan, Honghai Wang, He Huang, Jiayu Yang and Jianwu Tang

    Citation: Cell Communication and Signaling 2018 16:22

    Content type: Research

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  35. The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine – receptor interaction between neoplastic cells and their microenvironmen...

    Authors: Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen and Jenny Potratz

    Citation: Cell Communication and Signaling 2018 16:21

    Content type: Research

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  36. Histone deacetylases (HDACs) are involved in epigenetic gene regulation via deacetylation of acetylated lysine residues of both histone and non-histone proteins. Among the 18 HDACs identified in humans, HDAC8,...

    Authors: G. R. Vanaja, Hemalatha Golaconda Ramulu and Arunasree M. Kalle

    Citation: Cell Communication and Signaling 2018 16:20

    Content type: Research

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  37. Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer rem...

    Authors: Rae-Mann Hsu, Cai-Yan Zhong, Chih-Liang Wang, Wei-Chao Liao, Chi Yang, Shih-Yu Lin, Jia-Wei Lin, Hsiao-Yun Cheng, Po-Yu Li and Chia-Jung Yu

    Citation: Cell Communication and Signaling 2018 16:19

    Content type: Research

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  38. Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact ...

    Authors: Zhaoping Qin, Wei Xia, Gary J. Fisher, John J. Voorhees and Taihao Quan

    Citation: Cell Communication and Signaling 2018 16:18

    Content type: Research

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  39. Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influen...

    Authors: Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē and Una Riekstiņa

    Citation: Cell Communication and Signaling 2018 16:17

    Content type: Short report

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  40. Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis.

    Authors: Yu Wang, Jun Li, Dong Kuang, Xiaoyan Wang, Yuanli Zhu, Sanpeng Xu, Yaobing Chen, Henghui Cheng, Qiu Zhao, Yaqi Duan and Guoping Wang

    Citation: Cell Communication and Signaling 2018 16:16

    Content type: Research

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  41. In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonic...

    Authors: Juvenal A. Ríos, Juan A. Godoy and Nibaldo C. Inestrosa

    Citation: Cell Communication and Signaling 2018 16:15

    Content type: Research

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  42. In addition to physiological events such as fertilisation, placentation, osteoclastogenesis, or tissue regeneration/wound healing, cell fusion is involved in pathophysiological conditions such as cancer. Cell ...

    Authors: Julian Weiler, Marieke Mohr, Kurt S. Zänker and Thomas Dittmar

    Citation: Cell Communication and Signaling 2018 16:14

    Content type: Research

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  43. Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly ...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki and Hiroshi Tsumura

    Citation: Cell Communication and Signaling 2018 16:13

    Content type: Research

    Published on:

  44. Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio ...

    Authors: Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes and Tania Cristina Leite de Sampaio e Spohr

    Citation: Cell Communication and Signaling 2018 16:11

    Content type: Review

    Published on:

  45. Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how...

    Authors: Sheng Liu, Josephine Iaria, Richard J. Simpson and Hong-Jian Zhu

    Citation: Cell Communication and Signaling 2018 16:10

    Content type: Research

    Published on:

  46. The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances i...

    Authors: Yuanyuan Tang, Joshua Berlind and Nirmala Mavila

    Citation: Cell Communication and Signaling 2018 16:9

    Content type: Research

    Published on:

  47. High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown.

    Authors: Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan and Chuanli Ren

    Citation: Cell Communication and Signaling 2018 16:8

    Content type: Research

    Published on:

  48. 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal ...

    Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu and John C. Schmitz

    Citation: Cell Communication and Signaling 2018 16:7

    Content type: Research

    Published on:

  49. Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear.

    Authors: Li Wu, Jiayu Zhao, Kexin Cao, Xiao Liu, Hao Cai, Jiaqi Wang, Weidong Li and Zhipeng Chen

    Citation: Cell Communication and Signaling 2018 16:6

    Content type: Research

    Published on:

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