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  1. Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of Notch1 in the formation of myofibroblasts and fibrosis ...

    Authors: Weilong Hong, Ge Zhang, Hong Lu, Yangyang Guo, Shizhang Zheng, Hengyue Zhu, Yanyi Xiao, Akuetteh Percy David Papa, Cunzao Wu, Linxiao Sun, Bicheng Chen and Yongheng Bai

    Citation: Cell Communication and Signaling 2019 17:145

    Content type: Research

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  2. Excessive TGF-β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and signific...

    Authors: Fernando de la Cuesta, Ilaria Passalacqua, Julie Rodor, Raghu Bhushan, Laura Denby and Andrew H. Baker

    Citation: Cell Communication and Signaling 2019 17:143

    Content type: Research

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  3. Integrin-mediated platelet-tumor cell contacting plays an important role in promoting epithelial-mesenchymal transition (EMT) transformation of tumor cells and cancer metastasis, but whether it occurs in breas...

    Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang and Yong-gang Shi

    Citation: Cell Communication and Signaling 2019 17:142

    Content type: Research

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  4. Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previ...

    Authors: Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges and Gottfried Baier

    Citation: Cell Communication and Signaling 2019 17:141

    Content type: Research

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  5. In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of...

    Authors: Ulrike Neckmann, Camilla Wolowczyk, Martina Hall, Eivind Almaas, Jiang Ren, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim, Geir Bjørkøy, Peter ten Dijke and Toril Holien

    Citation: Cell Communication and Signaling 2019 17:140

    Content type: Research

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  6. Following publication of the original article [1], it was reported that Figs. 4 and 5 were not updated during the production process.

    Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan

    Citation: Cell Communication and Signaling 2019 17:138

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2019 17:125

  7. p21-activated kinase 1 (PAK1) stimulates growth and metastasis in non-small cell lung cancer (NSCLC). Protein kinase C iota (PKCι) is an enzyme highly expressed in NSCLC, regulating PAK1 signaling. In the pres...

    Authors: Masaoki Ito, Carles Codony-Servat, Jordi Codony-Servat, David Lligé, Imane Chaib, Xiaoyan Sun, Jing Miao, Rongwei Sun, Xueting Cai, Alberto Verlicchi, Morihito Okada, Miguel Angel Molina-Vila, Niki Karachaliou, Peng Cao and Rafael Rosell

    Citation: Cell Communication and Signaling 2019 17:137

    Content type: Research

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  8. Osteoclasts are key determinant cellular components implicated in the development and progression of disorders driven by bone damage. Herein, we studied the upshot of T007, an antagonist of peroxisome prolifer...

    Authors: Xiang Li, Lei Ning, Jianjun Ma, Ziang Xie, Xiangde Zhao, Gangliang Wang, Xinyu Wan, Pengcheng Qiu, Teng Yao, Haoming Wang, Shunwu Fan and Shuanglin Wan

    Citation: Cell Communication and Signaling 2019 17:136

    Content type: Research

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  9. Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signa...

    Authors: Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller and Fred Schaper

    Citation: Cell Communication and Signaling 2019 17:135

    Content type: Research

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  10. Osteoarthritis (OA) is one of the most prevalent joint disease, and there are still no effective therapeutic agents or clinical methods for the cure of this disease to date. The degradation of cartilage extrac...

    Authors: Biao Duan, Yan Liu, He Hu, Fu-Guo Shi, Ya-Long Liu, Hao Xue, Xin-Yu Yun, Ming-Yu Yan, Xi-Rui Han, An-Fu Chen, Yong Wang and Zhe-Hai Li

    Citation: Cell Communication and Signaling 2019 17:134

    Content type: Research

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  11. Notch signalling pathway is central to development of metazoans. The pathway codes a binary fate switch. Upon activation, downstream signals contribute to resolution of fate dichotomies such as proliferation/d...

    Authors: Filip Vujovic, Neil Hunter and Ramin M. Farahani

    Citation: Cell Communication and Signaling 2019 17:133

    Content type: Hypothesis

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  12. Phosphatidylserine (PtdSer) is usually present only in the inner leaf of the lipid bilayers of the cell membrane, but is exposed on the outer leaf when cells are activated and/or die. Exposure of PtdSer has ph...

    Authors: Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ and Kouki Morizono

    Citation: Cell Communication and Signaling 2019 17:132

    Content type: Review

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  13. Metabolic reprogramming is one of the hallmarks of cancer which favours rapid energy production, biosynthetic capabilities and therapy resistance. In our previous study, we showed bitter melon extract (BME) pr...

    Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray

    Citation: Cell Communication and Signaling 2019 17:131

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2019 17:151

  14. Following publication of the original article [1], the authors reported that the given name of Qinhao Wang was incorrectly published as Qinghao Wang. The original article has been corrected.

    Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinhao Wang and Xia Li

    Citation: Cell Communication and Signaling 2019 17:130

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2019 17:44

  15. While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal c...

    Authors: Yi-Heng Hao, M. Carmen Lafita-Navarro, Lauren Zacharias, Nofit Borenstein-Auerbach, Min Kim, Spencer Barnes, Jiwoong Kim, Jerry Shay, Ralph J. DeBerardinis and Maralice Conacci-Sorrell

    Citation: Cell Communication and Signaling 2019 17:129

    Content type: Research

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  16. Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential ...

    Authors: Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Yasushi Ueyanagi, Dongchon Kang, Hisataka Sabe and Shintaro Kinugawa

    Citation: Cell Communication and Signaling 2019 17:128

    Content type: Research

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  17. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phlore...

    Authors: Sarita Saraswati, Abdulqader Alhaider, Abdelgalil Mohamed Abdelgadir, Pooja Tanwer and Hesham M. Korashy

    Citation: Cell Communication and Signaling 2019 17:127

    Content type: Research

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  18. Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 t...

    Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan

    Citation: Cell Communication and Signaling 2019 17:125

    Content type: Research

    Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2019 17:138

  19. Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands of energy and biomass during proliferation and metastasis. Computational modeling of genome-scale metabolic models is an effe...

    Authors: Ziwei Dai, Shiyu Yang, Liyan Xu, Hongrong Hu, Kun Liao, Jianghuang Wang, Qian Wang, Shuaishi Gao, Bo Li and Luhua Lai

    Citation: Cell Communication and Signaling 2019 17:124

    Content type: Research

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  20. The neuropeptide Y system affects various processes, among others food intake, and is frequently discussed in the context of targeting obesity. Studies in model organisms are indispensable to enable molecular ...

    Authors: Miron Mikhailowitsch Gershkovich, Victoria Elisabeth Groß, Anette Kaiser and Simone Prömel

    Citation: Cell Communication and Signaling 2019 17:123

    Content type: Research

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  21. Prostate cancer development involves various mechanisms, which are poorly understood but pointing to epithelial mesenchymal transition (EMT) as the key mechanism in progression to metastatic disease. ABI1, a memb...

    Authors: Disharee Nath, Xiang Li, Claudia Mondragon, Dawn Post, Ming Chen, Julie R. White, Anita Hryniewicz-Jankowska, Tiffany Caza, Vladimir A. Kuznetsov, Heidi Hehnly, Tamara Jamaspishvili, David M. Berman, Fan Zhang, Sonia H. Y. Kung, Ladan Fazli, Martin E. Gleave…

    Citation: Cell Communication and Signaling 2019 17:120

    Content type: Research

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  22. The glycoprotein (GP) Ib-IX-V complex is a unique platelet plasma membrane receptor, which is essential for platelet adhesion and thrombus formation. GPIbα, part of the GPIb-IX-V complex, has several physiolog...

    Authors: Stephanie Makhoul, Katharina Trabold, Stepan Gambaryan, Stefan Tenzer, Daniele Pillitteri, Ulrich Walter and Kerstin Jurk

    Citation: Cell Communication and Signaling 2019 17:122

    Content type: Research

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  23. Pancreatic cancer (PC) is one of the most fatal diseases with a very high rate of metastasis and low rate of survival. Despite the advances in understanding this devastating disease, PC still accounts for 3% o...

    Authors: Jiang-Jiang Qin, Xiang-Dong Cheng, Jia Zhang and Wei-Dong Zhang

    Citation: Cell Communication and Signaling 2019 17:121

    Content type: Review

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  24. Stromal-derived CXCL12 play an important role which influence the proliferation and invasiveness of colon cancer in microenvironment. The present study aimed to analyze the underlying mechanism by which CXCL12...

    Authors: Jiachi Ma, Xiaowen Sun, Yimin Wang, Bangling Chen, Liyu Qian and Yaguo Wang

    Citation: Cell Communication and Signaling 2019 17:119

    Content type: Research

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  25. Mechanisms driving the progression of castration-resistant prostate cancer are believed to relate substantially to the tumor microenvironment. However, the cross-talks between tumor epithelial cell, stromal ce...

    Authors: Yongning Lu, Baijun Dong, Fan Xu, Yunze Xu, Jiahua Pan, Jiajia Song, Jin Zhang, Yiran Huang and Wei Xue

    Citation: Cell Communication and Signaling 2019 17:118

    Content type: Research

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  26. Cryptococcus neoformans (C. neoformans) is an encapsulated budding yeast that causes life-threatening meningoencephalitis in immunocompromised individuals, especially those with acquired immunodeficiency syndrome...

    Authors: Xiaofan Yang, Huijuan Wang, Fan Hu, Xichen Chen and Mingshun Zhang

    Citation: Cell Communication and Signaling 2019 17:117

    Content type: Short report

    Published on:

  27. Ventricular Zone Expressed PH Domain-Containing 1 (VEPH1) is an 833-amino acid protein encoded by an evolutionarily conserved single-copy gene that emerged with pseudocoelomates. This gene has no paralog in an...

    Authors: Theodore J. Brown, Alexandra Kollara, Premalatha Shathasivam and Maurice J. Ringuette

    Citation: Cell Communication and Signaling 2019 17:116

    Content type: Review

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  28. Gastric cancer (GC) has high incidence and mortality worldwide. However, the underlying mechanisms that regulate gastric carcinogenesis are largely undefined. 4.1B is an adaptor protein found at the interface ...

    Authors: Fumin Xue, Chao An, Lixiang Chen, Gang Liu, Feifei Ren, Xinhua Guo, Haibin Sun, Lu Mei, Xiangdong Sun, Jinpeng Li, Youcai Tang, Xiuli An and Pengyuan Zheng

    Citation: Cell Communication and Signaling 2019 17:115

    Content type: Research

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  29. KIT tyrosine kinase is expressed in mast cells, interstitial cells of Cajal, and hematopoietic cells. Permanently active KIT mutations lead these host cells to tumorigenesis, and to such diseases as mast cell leu...

    Authors: Yuuki Obata, Yasushi Hara, Isamu Shiina, Takatsugu Murata, Yasutaka Tasaki, Kyohei Suzuki, Keiichi Ito, Shou Tsugawa, Kouhei Yamawaki, Tsuyoshi Takahashi, Koji Okamoto, Toshirou Nishida and Ryo Abe

    Citation: Cell Communication and Signaling 2019 17:114

    Content type: Research

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  30. C-Type Lectin Domain Family 3 Member B (CLEC3B), is down-regulated in serum and tumor tissues in different cancers including hepatocellular carcinoma (HCC). However, the functions of CLEC3B in HCC remains eluc...

    Authors: Wenjuan Dai, Yilin Wang, Tianxiao Yang, Jing Wang, Weicheng Wu and Jianxin Gu

    Citation: Cell Communication and Signaling 2019 17:113

    Content type: Research

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  31. Following publication of the original article [1], the authors reported that the given name of Liqing Wang was incorrectly published as Liqiang Wang. The original article has been updated.

    Authors: Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan and Shengmei Zhu

    Citation: Cell Communication and Signaling 2019 17:112

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2019 17:103

  32. Overexpression of ATP-binding cassette (ABC) transporters, such as ABCB1 and ABCG2, has been proved to be a major trigger for multidrug resistance (MDR) in certain types of cancer. A promising approach to reve...

    Authors: Zhiqiang Zhang, Chunling Ma, Peng Li, Min Wu, Shengnan Ye, Liwu Fu and Jianhua Xu

    Citation: Cell Communication and Signaling 2019 17:110

    Content type: Research

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  33. Distinctive from their normal counterparts, cancer cells exhibit unique metabolic dependencies on glutamine to fuel anabolic processes. Specifically, pancreatic ductal adenocarcinoma (PDAC) cells rely on an un...

    Authors: Weiguang Sun, Shanshan Luan, Changxing Qi, Qingyi Tong, Shan Yan, Hua Li and Yonghui Zhang

    Citation: Cell Communication and Signaling 2019 17:111

    Content type: Research

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  34. Breast cancer is the leading cause of cancer-related death in women worldwide. Metastatic disease remains the primary cause of death in patients with breast cancer. Basal-like breast cancer (BLBC) is associate...

    Authors: Shaojie Jiang, Miaofeng Zhang, Yanhua Zhang, Weiping Zhou, Tao Zhu, Qing Ruan, Hui Chen, Jie Fang, Fei Zhou, Jihong Sun and Xiaoming Yang

    Citation: Cell Communication and Signaling 2019 17:109

    Content type: Research

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  35. Glioma is the most common and primary brain tumors in adults. Despite the available multimodal therapies, glioma patients appear to have a poor prognosis. The Hedgehog (Hh) signaling is involved in tumorigenes...

    Authors: Giuseppina D’Alessandro, Deborah Quaglio, Lucia Monaco, Clotilde Lauro, Francesca Ghirga, Cinzia Ingallina, Michela De Martino, Sergio Fucile, Alessandra Porzia, Maria Amalia Di Castro, Federica Bellato, Francesca Mastrotto, Mattia Mori, Paola Infante, Paola Turano, Stefano Salmaso…

    Citation: Cell Communication and Signaling 2019 17:108

    Content type: Research

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  36. Ligands of the C-type lectin CLEC10A such as Tn and sialyl-Tn representing early intermediates of O-glycosylation are hallmarks of many human malignancies. A variety of regulatory mechanisms underlying their e...

    Authors: Anna-Katharina Kurze, Sophia Buhs, Dennis Eggert, Leticia Oliveira-Ferrer, Volkmar Müller, Axel Niendorf, Christoph Wagener and Peter Nollau

    Citation: Cell Communication and Signaling 2019 17:107

    Content type: Research

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  37. HER3/ErbB3 receptor deletion or blockade leads to tumor cell apoptosis, whereas its overexpression confers anti-cancer drug resistance through upregulation of protective mechanisms against apoptosis. We produc...

    Authors: Christophe Le Clorennec, Yassamine Lazrek, Olivier Dubreuil, Carla Sampaio, Christel Larbouret, Romain Lanotte, Marie-Alix Poul, Jean-Marc Barret, Jean-François Prost, André Pèlegrin and Thierry Chardès

    Citation: Cell Communication and Signaling 2019 17:106

    Content type: Research

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  38. Breast cancer is a life-threatening disease in females and the leading cause of mortality among the female population, presenting huge challenges for prognosis and treatment. ITM2A is a member of the BRICHOS s...

    Authors: Cefan Zhou, Ming Wang, Jing Yang, Hui Xiong, Yefu Wang and Jingfeng Tang

    Citation: Cell Communication and Signaling 2019 17:105

    Content type: Research

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  39. Alcohol abuse and alcoholism lead to alcohol liver disease such as alcoholic fatty liver. Parkin is a component of the multiprotein E3 ubiquitin ligase complex and is associated with hepatic lipid accumulation...

    Authors: Dong Hun Lee, Mi Hee Park, Chul Ju Hwang, Youngsoo Kim, Dae Yeon Hwang, Sang Bae Han and Jin Tae Hong

    Citation: Cell Communication and Signaling 2019 17:104

    Content type: Research

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  40. The T cell Ig domain and mucin domain (TIM)-1 protein expressed on the surface of Th2 cells regulates the immune response by modulating cytokine production. The present study aimed to investigate the role and ...

    Authors: Yueying Zheng, Liqing Wang, Manli Chen, Lu Liu, Aijie Pei, Rong Zhang, Shuyuan Gan and Shengmei Zhu

    Citation: Cell Communication and Signaling 2019 17:103

    Content type: Research

    Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2019 17:112

  41. How high-salt intake leads to the occurrence of many cardiovascular diseases such as atherosclerosis is a fundamental question in pathology. Here we postulated that high-salt-induced NFAT5 controls the inflamm...

    Authors: Pingping Ma, Shenfang Zha, Xinkun Shen, Yulan Zhao, Li Li, Li Yang, Mingxing Lei and Wanqian Liu

    Citation: Cell Communication and Signaling 2019 17:102

    Content type: Research

    Published on:

  42. Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits.

    Authors: Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu and Yan-Qing Ma

    Citation: Cell Communication and Signaling 2019 17:101

    Content type: Research

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  43. Androgen receptor (AR) plays important role in the development, progression, and metastasis of prostate cancer (PCa). Caffeic acid phenethyl ester (CAPE) is the main component of honey bee propolis. We determi...

    Authors: Ying-Yu Kuo, Chieh Huo, Ching-Yu Lin, Hui-Ping Lin, Jai-Shin Liu, Wen-Ching Wang, Chuang-Rung Chang and Chih-Pin Chuu

    Citation: Cell Communication and Signaling 2019 17:100

    Content type: Research

    Published on:

  44. Excessive estrogen exposure is an important pathogenic factor in uterine endometrial cancer (UEC). Recent studies have reported the metabolic propertie...

    Authors: Wen-Jie Zhou, Jie Zhang, Hui-Li Yang, Ke Wu, Feng Xie, Jiang-Nan Wu, Yan Wang, Li Yao, Yan Zhuang, Jiang-Dong Xiang, Ai-Jun Zhang, Yin-Yan He and Ming-Qing Li

    Citation: Cell Communication and Signaling 2019 17:99

    Content type: Research

    Published on:

  45. Autophagy is a macromolecular degradation process playing a pivotal role in the maintenance of stem-like features and in the morpho-functional remodeling of the tissues undergoing differentiation. In this work...

    Authors: Chiara Vidoni, Alessandra Ferraresi, Eleonora Secomandi, Letizia Vallino, Chiara Gardin, Barbara Zavan, Carmen Mortellaro and Ciro Isidoro

    Citation: Cell Communication and Signaling 2019 17:98

    Content type: Research

    Published on:

  46. Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of disability. Characterized by degradation of articular cartilage, synovial inflammation, and changes in periarticular and su...

    Authors: Yudan Wang, Xinhao Fan, Lei Xing and Faming Tian

    Citation: Cell Communication and Signaling 2019 17:97

    Content type: Review

    Published on:

  47. Neural stem/progenitor cells (NPCs) are known to have potent therapeutic effects in neurological disorders through secreting exosomes. The limited numbers of NPCs in adult brain and the decline of NPC pool in ...

    Authors: Yizhao Ma, Chunhong Li, Yunlong Huang, Yi Wang, Xiaohuan Xia and Jialin C. Zheng

    Citation: Cell Communication and Signaling 2019 17:96

    Content type: Short report

    Published on:

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