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  1. Inhibitors targeting immune checkpoint were proved effective in cancer immunotherapy, such as PD-1/PD-L1 blockade. The novel immune checkpoint TIGIT/PVR plays critical roles in suppressing the anti-tumor effec...

    Authors: Xiuman Zhou, Jiangfeng Du, Hongfei Wang, Chunxia Chen, Ling Jiao, Xiangrui Cheng, Xiaowen Zhou, Shaomeng Chen, Shanshan Gou, Wenshan Zhao, Wenjie Zhai, Junhui Chen and Yanfeng Gao

    Citation: Cell Communication and Signaling 2020 18:142

    Content type: Research

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  2. Low molecular weight carrageenan (Cg) is a seaweed-derived sulfated polysaccharide widely used as inflammatory stimulus in preclinical studies. However, the molecular mechanisms of Cg-induced inflammation are ...

    Authors: Alexandre H. Lopes, Rangel L. Silva, Miriam D. Fonseca, Francisco I. Gomes, Alexandre G. Maganin, Lucas S. Ribeiro, Lucas Maciel Mauriz Marques, Fernando Q. Cunha, Jose C. Alves-Filho, Dario S. Zamboni, Norberto P. Lopes, Bernardo S. Franklin, Aurélie Gombault, Fernando Silva Ramalho, Valerie F. J. Quesniaux, Isabelle Couillin…

    Citation: Cell Communication and Signaling 2020 18:141

    Content type: Research

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  3. Alpha-1 antitrypsin deficiency (AATD)-mediated liver disease is a toxic “gain-of-function” inflammation in the liver associated with intracellular retention of mutant alpha-1 antitrypsin. The clinical presenta...

    Authors: Nazli Khodayari, Regina Oshins, L. Shannon Holliday, Virginia Clark, Qiang Xiao, George Marek, Borna Mehrad and Mark Brantly

    Citation: Cell Communication and Signaling 2020 18:140

    Content type: Research

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  4. Venous malformations (VMs), most of which associated with activating mutations in the endothelial cells (ECs) tyrosine kinase receptor TIE2, are characterized by dilated and immature veins with scarce smooth m...

    Authors: Yameng Si, Jiadong Huang, Xiang Li, Yu Fu, Rongyao Xu, Yifei Du, Jie Cheng and Hongbing Jiang

    Citation: Cell Communication and Signaling 2020 18:139

    Content type: Research

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  5. Polycystin-2 (TRPP2) is a Ca2+ permeable nonselective cationic channel essential for maintaining physiological function in live cells. Stromal interaction molecule 1 (STIM1) is an important Ca2+ sensor in store-o...

    Authors: Jizheng Guo, Ren Zhao, Muyao Zhou, Jie Li, Xiaoqiang Yao, Juan Du, Jiexia Chen and Bing Shen

    Citation: Cell Communication and Signaling 2020 18:138

    Content type: Research

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  6. The serine/threonine phosphatase calcineurin acts as a crucial connection between calcium signaling the phosphorylation states of numerous important substrates. These substrates include, but are not limited to...

    Authors: Trevor P. Creamer

    Citation: Cell Communication and Signaling 2020 18:137

    Content type: Review

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  7. Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical spec...

    Authors: Ioannis Skalidis, Christian Tüting and Panagiotis L. Kastritis

    Citation: Cell Communication and Signaling 2020 18:136

    Content type: Review

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  8. Glioma stem cells (GSCs) are glioma cells with stemness and are responsible for a variety of malignant behaviors of glioma. Evidence has shown that signals from tumor microenvironment (TME) enhance stemness of...

    Authors: Jian Zang, Min-Hua Zheng, Xiu-Li Cao, Yi-Zhe Zhang, Yu-Fei Zhang, Xiang-Yu Gao, Yuan Cao, Mei Shi, Hua Han and Liang Liang

    Citation: Cell Communication and Signaling 2020 18:135

    Content type: Research

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  9. Chimeric Antigen Receptor (CAR) immunotherapy utilizes genetically-engineered immune cells that express a unique cell surface receptor that combines tumor antigen specificity with immune cell activation. In re...

    Authors: Dongfang Liu, Saiaditya Badeti, Gianpietro Dotti, Jie-gen Jiang, He Wang, James Dermody, Patricia Soteropoulos, Deanna Streck, Raymond B. Birge and Chen Liu

    Citation: Cell Communication and Signaling 2020 18:134

    Content type: Review

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  10. Class 1 cytokine receptors (C1CRs) are single-pass transmembrane proteins responsible for transmitting signals between the outside and the inside of cells. Remarkably, they orchestrate key biological processes...

    Authors: Pernille Seiffert, Katrine Bugge, Mads Nygaard, Gitte W. Haxholm, Jacob H. Martinsen, Martin N. Pedersen, Lise Arleth, Wouter Boomsma and Birthe B. Kragelund

    Citation: Cell Communication and Signaling 2020 18:132

    Content type: Research

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  11. Metabolic reprogramming, in which energetic metabolism changes from oxidative phosphorylation to glycolysis, is well-accepted as a hallmark of cancers including hepatocellular carcinoma (HCC). A growing body o...

    Authors: Chuanzong Zhao, Ben Wang, Enyu Liu and Zongli Zhang

    Citation: Cell Communication and Signaling 2020 18:131

    Content type: Research

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  12. Exosomes are extracellular vesicles containing a variety of biological molecules including microRNAs (miRNAs). We have recently demonstrated that certain miRNA species are selectively and highly enriched in pa...

    Authors: Yi-Fan Xu, Xiaohui Xu, Amy Gin, Jean D. Nshimiyimana, Blaine H. M. Mooers, Massimo Caputi, Bethany N. Hannafon and Wei-Qun Ding

    Citation: Cell Communication and Signaling 2020 18:130

    Content type: Research

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  13. Syndecans regulate cell migration thus having key roles in scarring and wound healing processes. Our previous results have shown that Thy-1/CD90 can engage both αvβ3 integrin and Syndecan-4 expressed on the su...

    Authors: Alejandra Valdivia, Areli Cárdenas, Marianne Brenet, Horacio Maldonado, Milene Kong, Jorge Díaz, Keith Burridge, Pascal Schneider, Alejandra San Martín, Rafael García-Mata, Andrew F. G. Quest and Lisette Leyton

    Citation: Cell Communication and Signaling 2020 18:129

    Content type: Research

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  14. The activation of the NF-κB pathway plays a crucial role in the progression of breast cancer (BCa) and also involved in endocrine therapy resistance. On the contrary to the canonical NF-κB pathway, the effect ...

    Authors: Mei Wang, Yanyan Zhang, Zhi Xu, Peipei Qian, Wenbo Sun, Xiumei Wang, Zhang Jian, Tiansong Xia, Yong Xu and Jinhai Tang

    Citation: Cell Communication and Signaling 2020 18:128

    Content type: Research

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  15. Bladder cancer (BCa) is a frequent urothelial malignancy with a high ratio of morbidity and mortality. Various genetic and environmental factors are involved in BCa progression. Since, majority of BCa cases ar...

    Authors: Amir Sadra Zangouei, Amir Hossein Barjasteh, Hamid Reza Rahimi, Majid Mojarrad and Meysam Moghbeli

    Citation: Cell Communication and Signaling 2020 18:127

    Content type: Review

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  16. Current pharmacological therapies and treatments targeting pancreatic neuroendocrine tumors (PNETs) have proven ineffective, far too often. Therefore, there is an urgent need for alternative therapeutic approa...

    Authors: Dexter L. Puckett, Mohammed Alquraishi, Dina Alani, Samah Chahed, Dallas Donohoe, Brynn Voy, Jay Whelan and Ahmed Bettaieb

    Citation: Cell Communication and Signaling 2020 18:126

    Content type: Research

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  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang and Yong-gang Shi

    Citation: Cell Communication and Signaling 2020 18:125

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2019 17:142

  18. The metabolic syndrome (MetS) is a combination of cardiovascular risk-factors, including obesity, hypertension, hyperglycemia, and insulin resistance. MetS may induce senescence in mesenchymal stem/stromal cel...

    Authors: Yongxin Li, Yu Meng, Xiangyang Zhu, Ishran M. Saadiq, Kyra L. Jordan, Alfonso Eirin and Lilach O. Lerman

    Citation: Cell Communication and Signaling 2020 18:124

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2020 18:171

  19. Neurodegeneration is a representative phenotype of patients with chronic alcoholism. Ethanol-induced calcium overload causes NOD-like receptor protein 3 (NLRP3) inflammasome formation and an imbalance in mitoc...

    Authors: Jae Ryong Lim, Hyun Jik Lee, Young Hyun Jung, Jun Sung Kim, Chang Woo Chae, Seo Yihl Kim and Ho Jae Han

    Citation: Cell Communication and Signaling 2020 18:123

    Content type: Research

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  20. Multivesicular bodies (MVBs) are endosome organelles that are gradually attracting research attention. Initially, MVBs were considered as important components of the endosomal-lysosomal degradation pathway. In...

    Authors: Xueqiang Peng, Liang Yang, Yingbo Ma, Yan Li and Hangyu Li

    Citation: Cell Communication and Signaling 2020 18:122

    Content type: Review

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  21. The PIM family kinases promote cancer cell survival and motility as well as metastatic growth in various types of cancer. We have previously identified several PIM substrates, which support cancer cell migrati...

    Authors: Niina M. Santio, Veera Vainio, Tuuli Hoikkala, Kwan Long Mung, Mirka Lång, Riitta Vahakoski, Justyna Zdrojewska, Eleanor T. Coffey, Elena Kremneva, Eeva-Marja Rainio and Päivi J. Koskinen

    Citation: Cell Communication and Signaling 2020 18:121

    Content type: Research

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  22. Malignant gliomas are the most common and deadly type of central nervous system tumors. Despite some advances in treatment, the mean survival time remains only about 1.25 years. Even after surgery, radiotherap...

    Authors: Amir B. Ghaemmaghami, Maryam Mahjoubin-Tehran, Ahmad Movahedpour, Korosh Morshedi, Amirhossein Sheida, Seyed Pouya Taghavi, Hamed Mirzaei and Michael R. Hamblin

    Citation: Cell Communication and Signaling 2020 18:120

    Content type: Review

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  23. Exosomes have been considered as novel and potent vehicles of intercellular communication, instead of “cell dust”. Exosomes are consistent with anucleate cells, and organelles with lipid bilayer consisting of ...

    Authors: Wei Wang, Neng Zhu, Tao Yan, Ya-Ning Shi, Jing Chen, Chan-Juan Zhang, Xue-Jiao Xie, Duan-Fang Liao and Li Qin

    Citation: Cell Communication and Signaling 2020 18:119

    Content type: Review

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  24. The term mesenchymal stromal cells (MSCs) designates an assorted cell population comprised of stem cells, progenitor cells, fibroblasts, and stromal cells. MSCs contribute to the homeostatic maintenance of man...

    Authors: Serife Ayaz-Guner, Nicola Alessio, Mustafa B. Acar, Domenico Aprile, Servet Özcan, Giovanni Di Bernardo, Gianfranco Peluso and Umberto Galderisi

    Citation: Cell Communication and Signaling 2020 18:118

    Content type: Research

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  25. Estrogen receptor α (ERα) has been suggested to regulate anti-inflammatory signaling in brain microglia, the only resident immune cells in the brain. ERα conserves the phosphorylation motif at Ser216 within th...

    Authors: Sawako Shindo, Shih-Heng Chen, Saki Gotoh, Kosuke Yokobori, Hao Hu, Manas Ray, Rick Moore, Kiyoshi Nagata, Jennifer Martinez, Jau-Shyong Hong and Masahiko Negishi

    Citation: Cell Communication and Signaling 2020 18:117

    Content type: Research

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  26. Aberrant activation of the Hedgehog (Hh) signaling pathway is frequently observed in hepatocellular carcinoma (HCC), nevertheless, the precise molecular mechanism remains unclear. Forkhead box M1 (FOXM1), a ta...

    Authors: Yiting Wang, Hailong Wang, Zhengwei Yan, Guohua Li, Guohui Hu, Hong Zhang, Dengliang Huang, Yao Wang, Xiang Zhang, Yehong Yan, Quqin Lu, Minzhang Cheng and Shiwen Luo

    Citation: Cell Communication and Signaling 2020 18:116

    Content type: Research

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  27. Colorectal cancer (CRC) is associated with resistance to anti-epidermal growth factor receptor (EGFR) antibodies (both acquired and intrinsic), owing to the amplification or mutation of the KRAS oncogene. However...

    Authors: Hua Ye, Yi Liu, Kefeng Wu, Hui Luo and Liao Cui

    Citation: Cell Communication and Signaling 2020 18:115

    Content type: Research

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  28. Progression of Colorectal cancer (CRC) is influenced by single or compounded environmental factors. Accumulating evidence shows that microbiota can influence the outcome of cancer immunotherapy. T cell, one of...

    Authors: Hua Sui, Lu Zhang, Kaijuan Gu, Ni Chai, Qing Ji, Lihong Zhou, Yan Wang, Junze Ren, Limei Yang, Bimeng Zhang, Jing Hu and Qi Li

    Citation: Cell Communication and Signaling 2020 18:113

    Content type: Research

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  29. Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation and thereafter cancer cell death mediated ...

    Authors: Yu Wang, Qingguo Sun, Ning Mu, Xiaoyang Sun, Yingying Wang, Songqing Fan, Ling Su and Xiangguo Liu

    Citation: Cell Communication and Signaling 2020 18:112

    Content type: Research

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  30. Cells taken from mouse embryos before sex differentiation respond to insults according to their chromosomal sex, a difference traceable to differential methylation. We evaluated the mechanism for this differen...

    Authors: Carlos G. Penaloza, Mayra Cruz, Gabrielle Germain, Sidra Jabeen, Mohammad Javdan, Richard A. Lockshin and Zahra Zakeri

    Citation: Cell Communication and Signaling 2020 18:111

    Content type: Research

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  31. Epithelial-to-mesenchymal transition (EMT) and mesenchymal-to-epithelial transition (MET) are both reversible processes, and regulation of phenotypical transition is very important for progression of several c...

    Authors: Hande Topel, Ezgi Bagirsakci, Dehan Comez, Gulsun Bagci, Gulcin Cakan-Akdogan and Nese Atabey

    Citation: Cell Communication and Signaling 2020 18:110

    Content type: Research

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  32. The pre-implantation embryo in a competent status and post-implantation fully differentiation of the inner cell mass (ICM) and trophectoderm (TE) are prerequisites of successful implantation. Type I embryonic ...

    Authors: Qian Li, Juanzi Shi and Weimin Liu

    Citation: Cell Communication and Signaling 2020 18:108

    Content type: Research

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  33. Foxp3+CD4+ regulatory T cells (Treg) constitutes a key event in autoimmune diseases. STAT5b is the critical link between the IL-2/15 and FOXP3, the master regulator of Treg cells.

    Authors: Yuan Xiang, Jun Wang, Jia Peng Li, Wei Guo, Feng Huang, Hui Min Zhang, Han Han Li, Zhou Tong Dai, Zi Jian Zhang, Hui Li, Le Yuan Bao, Chao Jiang Gu, Kun Chen, Tong Cun Zhang and Xing Hua Liao

    Citation: Cell Communication and Signaling 2020 18:107

    Content type: Research

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  34. Although Myeloid-derived suppressor cells (MDSCs) have a prominent ability to suppress the immune responses of T lymphocytes and propel tumor immune escape, a lack of profound systemic immunesuppression in tum...

    Authors: Yingying Gao, Haoyu Xu, Nan Li, Hexi Wang, Lei Ma, Shiyou Chen, Jiayu Liu, Yongbo Zheng and Yao Zhang

    Citation: Cell Communication and Signaling 2020 18:106

    Content type: Research

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  35. In the setting of diabetes mellitus, mitochondrial dysfunction and oxidative stress are important pathogenic mechanisms causing end organ damage, including diabetic kidney disease (DKD), but mechanistic unders...

    Authors: Gabriella A. Casalena, Liping Yu, Roberto Gil, Samuel Rodriguez, Shantel Sosa, William Janssen, Evren U. Azeloglu, Jeremy S. Leventhal and Ilse S. Daehn

    Citation: Cell Communication and Signaling 2020 18:105

    Content type: Research

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  36. Sepsis is an infection-induced aggressive and life-threatening organ dysfunction with high morbidity and mortality worldwide. Infection-associated inflammation and coagulation promote the progression of advers...

    Authors: Shunyao Xu, Xiaojun Pan, Lingjie Mao, Hao Pan, Wenwei Xu, Yufeng Hu, Xueshu Yu, Zhiqiang Chen, Songzan Qian, Yincai Ye, Yueyue Huang and Jingye Pan

    Citation: Cell Communication and Signaling 2020 18:104

    Content type: Research

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  37. We previously demonstrated that ovarian high grade serous carcinomas (OHGSeCa) and ovarian clear cell carcinomas (OCCCa) with an HNF-1β+/p53+/ARID1A+ immunophenotype were associated with the worst unfavorable ...

    Authors: Ako Yokoi, Toshihide Matsumoto, Yasuko Oguri, Yoshinori Hasegawa, Masataka Tochimoto, Mayu Nakagawa and Makoto Saegusa

    Citation: Cell Communication and Signaling 2020 18:103

    Content type: Research

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  38. Wnt signaling drives epithelial self-renewal and disease progression in human colonic epithelium and colorectal cancer (CRC). Characterization of Wnt effector pathways is key for our understanding of these pro...

    Authors: Vanessa Dietinger, Cira R. García de Durango, Svenja Wiechmann, Sophie L. Boos, Marlies Michl, Jens Neumann, Heiko Hermeking, Bernhard Kuster and Peter Jung

    Citation: Cell Communication and Signaling 2020 18:102

    Content type: Research

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  39. Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in ...

    Authors: Akio Tsutaho, Ari Hashimoto, Shigeru Hashimoto, Soichiro Hata, Shion Kachi, Satoshi Hirano and Hisataka Sabe

    Citation: Cell Communication and Signaling 2020 18:101

    Content type: Research

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  40. Heat shot protein 90 (HSP90) AA1 functions as an onco-protein to regulate the assembly, manipulation, folding and degradation of its client proteins, including c-MYC. However, little is known about the mechani...

    Authors: Weidong Shi, Lanyun Feng, Shu Dong, Zhouyu Ning, Yongqiang Hua, Luming Liu, Zhen Chen and Zhiqiang Meng

    Citation: Cell Communication and Signaling 2020 18:100

    Content type: Research

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  41. Aberrant hedgehog (HH) signaling is implicated in the development of various cancer entities such as medulloblastoma. Activation of GLI transcription factors was revealed as the driving force upon pathway acti...

    Authors: Tamara Scheidt, Oliver Alka, Humberto Gonczarowska-Jorge, Wolfgang Gruber, Florian Rathje, Margherita Dell’Aica, Marc Rurik, Oliver Kohlbacher, René P. Zahedi, Fritz Aberger and Christian G. Huber

    Citation: Cell Communication and Signaling 2020 18:99

    Content type: Research

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  42. Targeted therapy and immunotherapy have led to dramatic change in the treatment of lung cancer, however, the overall 5-year survival rate of lung cancer patients is still suboptimal. It is important to exploit...

    Authors: Meiling Gong, Yan Li, Xiaoping Ye, Linlin Zhang, Zhifang Wang, Xiaowen Xu, Yejing Shen and Cuixia Zheng

    Citation: Cell Communication and Signaling 2020 18:98

    Content type: Research

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  43. Cancer cells primarily utilize aerobic glycolysis for energy production, a phenomenon known as the Warburg effect. Increased aerobic glycolysis supports cancer cell survival and rapid proliferation and predict...

    Authors: Chenying Lu, Shiji Fang, Qiaoyou Weng, Xiuling Lv, Miaomiao Meng, Jinyu Zhu, Liyun Zheng, Yumin Hu, Yang Gao, Xulu Wu, Jianting Mao, Bufu Tang, Zhongwei Zhao, Li Huang and Jiansong Ji

    Citation: Cell Communication and Signaling 2020 18:97

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2020 18:165

  44. While inflammation is associated with pancreatic cancer, the underlying mechanisms leading to cancer initiation are still being delineated. Eosinophils may promote or inhibit tumor growth, although the specifi...

    Authors: Sarah B. Gitto, Jordan M. Beardsley, Sai Preethi Nakkina, Jeremiah L. Oyer, Kathryn A. Cline, Sally A. Litherland, Alicja J. Copik, Amr S. Khaled, Na’im Fanaian, J. Pablo Arnoletti and Deborah A. Altomare

    Citation: Cell Communication and Signaling 2020 18:95

    Content type: Research

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  45. Endothelial progenitor cells (EPCs) are non-differentiated endothelial cells (ECs) present in blood circulation that are involved in neo-vascularization and correction of damaged endothelial sites. Since EPCs ...

    Authors: Sina Naserian, Mohamed Essameldin Abdelgawad, Mazdak Afshar Bakshloo, Guillaume Ha, Nassim Arouche, José L. Cohen, Benoît L. Salomon and Georges Uzan

    Citation: Cell Communication and Signaling 2020 18:94

    Content type: Research

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  46. The Wnt/β-catenin signaling pathway is a prolific regulator of cell-to-cell communication and gene expression. Canonical Wnt/β-catenin signaling involves partnering of β-catenin with members of the TCF/LEF fam...

    Authors: KaReisha F. Robinson, Srinivas D. Narasipura, Jennillee Wallace, Ethan M. Ritz and Lena Al-Harthi

    Citation: Cell Communication and Signaling 2020 18:93

    Content type: Research

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