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  1. Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome, and is associated with a number of other diseases. PCV2 is widely distributed in most developed swine indu...

    Authors: Shuai Zhang, Chunxiao Mou, Yanan Cao, En Zhang and Qian Yang

    Citation: Cell Communication and Signaling 2020 18:23

    Content type: Research

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  2. Glioblastoma multiforme is an aggressive primary brain tumor that is characterized by local invasive growth and resistance to therapy. The role of the microenvironment in glioblastoma invasiveness remains uncl...

    Authors: Nicholas W. Colangelo and Edouard I. Azzam

    Citation: Cell Communication and Signaling 2020 18:21

    Content type: Research

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  3. Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex ...

    Authors: Baoyi Zhu, Zhengfu Feng, Yan Guo, Tian Zhang, Ai Mai, Zhanfang Kang, Ting Weijen, Dai Wang, Dazhong Yin, Dongxing Zhu and Jun Gao

    Citation: Cell Communication and Signaling 2020 18:19

    Content type: Research

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  4. Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment. We have ...

    Authors: Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah, Mathew A. Vadas and Jennifer R. Gamble

    Citation: Cell Communication and Signaling 2020 18:18

    Content type: Research

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  5. Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive tumor. The inflammatory environment plays an important role in the tumorigenesis and development of ESCC. Cancer stem cells are a small ...

    Authors: Fengkai Xu, Zhonghe Liu, Ronghua Liu, Chunlai Lu, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Kunpeng Zhang, Yin Li, Yiwei Chu, Jie Gu and Di Ge

    Citation: Cell Communication and Signaling 2020 18:17

    Content type: Research

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  6. The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamid...

    Authors: Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen and Shu Zheng

    Citation: Cell Communication and Signaling 2020 18:16

    Content type: Research

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  7. We have previously shown that the zinc finger transcription repressor SNAI2 (SLUG) represses tumor suppressor BRCA2-expression in non-dividing cells by binding to the E2-box upstream of the transcription start si...

    Authors: Marshall Ellison, Mukul Mittal, Minu Chaudhuri, Gautam Chaudhuri and Smita Misra

    Citation: Cell Communication and Signaling 2020 18:15

    Content type: Research

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  8. CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirecti...

    Authors: Ao-Xiang Guo, Jia-Jia Cui, Lei-Yun Wang and Ji-Ye Yin

    Citation: Cell Communication and Signaling 2020 18:14

    Content type: Review

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  9. Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this study, mass spectrometry (MS)-based tyrosine phosph...

    Authors: Nicole J. Chew, Elizabeth V. Nguyen, Shih-Ping Su, Karel Novy, Howard C. Chan, Lan K. Nguyen, Jennii Luu, Kaylene J. Simpson, Rachel S. Lee and Roger J. Daly

    Citation: Cell Communication and Signaling 2020 18:13

    Content type: Research

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  10. Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. To gain more in...

    Authors: Paula Lindner, Søren Brøgger Christensen, Poul Nissen, Jesper Vuust Møller and Nikolai Engedal

    Citation: Cell Communication and Signaling 2020 18:12

    Content type: Research

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  11. Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clin...

    Authors: Hannes Neuwirt, Jan Bouchal, Gvantsa Kharaishvili, Christian Ploner, Karin Jöhrer, Florian Pitterl, Anja Weber, Helmut Klocker and Iris E. Eder

    Citation: Cell Communication and Signaling 2020 18:11

    Content type: Research

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  12. The establishment of parasitic infection is dependent on the development of efficient strategies to evade the host defense mechanisms. Phosphatidylserine (PS) molecules are pivotal for apoptotic cell recogniti...

    Authors: João Luiz Mendes Wanderley, Renato Augusto DaMatta and Marcello André Barcinski

    Citation: Cell Communication and Signaling 2020 18:10

    Content type: Review

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  13. Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bo...

    Authors: Aihua Xu, Yang Yang, Yang Shao, Meng Wu and Yongxin Sun

    Citation: Cell Communication and Signaling 2020 18:9

    Content type: Research

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  14. NR2F6 has been proposed as an alternative cancer immune checkpoint in the effector T cell compartment. However, a realistic assessment of the in vivo therapeutic potential of NR2F6 requires acute depletion.

    Authors: Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter and Gottfried Baier

    Citation: Cell Communication and Signaling 2020 18:8

    Content type: Research

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  15. Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying...

    Authors: Weixing Dai, Xianke Meng, Shaobo Mo, Wenqiang Xiang, Ye Xu, Long Zhang, Renjie Wang, Qingguo Li and Guoxiang Cai

    Citation: Cell Communication and Signaling 2020 18:7

    Content type: Research

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  16. Following publication of the original article [1], the authors reported that they would like to correct the second last sentence of “Authors’ information” section as PW is an undergraduate, but was incorrectly...

    Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li

    Citation: Cell Communication and Signaling 2020 18:4

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2019 17:16

  17. Ras are small cellular GTPases which regulate diverse cellular processes. It has three isoforms: H-Ras, K-Ras, and N-Ras. Owing to the N-terminus (1–165 residues) sequence homology these isoforms were thought ...

    Authors: Arathi Nair, Sushmita Chakraborty, Late Anirban Banerji, Ankita Srivastava, Charudutta Navare and Bhaskar Saha

    Citation: Cell Communication and Signaling 2020 18:3

    Content type: Research

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  18. Gliomas are the most common and malignant brain tumors. The standard therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive methods. However, the emergence of chemoresistance i...

    Authors: Fan Zeng, Kuanyu Wang, Xiu Liu and Zheng Zhao

    Citation: Cell Communication and Signaling 2020 18:2

    Content type: Research

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  19. The calcium/calcineurin signaling pathway is mediated by the transcription factors NFAT (nuclear factor of activated T cells) in mammals and Crz1 (calcineurin-responsive zinc finger 1) in yeasts and other lowe...

    Authors: Huihui Xu, Tianshu Fang, Raha Parvizi Omran, Malcolm Whiteway and Linghuo Jiang

    Citation: Cell Communication and Signaling 2020 18:1

    Content type: Research

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  20. LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important com...

    Authors: Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Weidong Zhu, Yong Fang and Dan-ni Ren

    Citation: Cell Communication and Signaling 2019 17:174

    Content type: Research

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  21. Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-L1) has been documented in several cancers and contributes to the evasion of the host immune system. However, cancer cell-intrinsic signa...

    Authors: Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang, Xiaomin Bian, Tingting Gu and Lianji Wen

    Citation: Cell Communication and Signaling 2019 17:173

    Content type: Research

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  22. Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metast...

    Authors: Sandra Grund-Gröschke, Georg Stockmaier and Fritz Aberger

    Citation: Cell Communication and Signaling 2019 17:172

    Content type: Review

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  23. Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the de...

    Authors: Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb and Marta Miączyńska

    Citation: Cell Communication and Signaling 2019 17:171

    Content type: Research

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  24. Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose...

    Authors: Kateřina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal and Vítězslav Bryja

    Citation: Cell Communication and Signaling 2019 17:170

    Content type: Research

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  25. Tumor endothelial cells (TECs) perform tumor angiogenesis, which is essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid from glycolysis; however, the mechanism underlyin...

    Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida and Kyoko Hida

    Citation: Cell Communication and Signaling 2019 17:169

    Content type: Research

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  26. Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell. However, th...

    Authors: Hong-Zhong Zhou, Han-Qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Bo Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang and Juan Chen

    Citation: Cell Communication and Signaling 2019 17:168

    Content type: Research

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  27. Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC). Herein, we investigated ...

    Authors: Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia and Dan J. Raz

    Citation: Cell Communication and Signaling 2019 17:167

    Content type: Research

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  28. In vitro chondrogenesis depends on the concerted action of numerous signalling pathways, many of which are sensitive to the changes of intracellular Ca2+ concentration. N-methyl-D-aspartate (NMDA) glutamate recep...

    Authors: Csaba Matta, Tamás Juhász, János Fodor, Tibor Hajdú, Éva Katona, Csilla Szűcs-Somogyi, Roland Takács, Judit Vágó, Tamás Oláh, Ádám Bartók, Zoltan Varga, Gyorgy Panyi, László Csernoch and Róza Zákány

    Citation: Cell Communication and Signaling 2019 17:166

    Content type: Research

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  29. Non-targeting effects of radiotherapy have become as clinical concern due to secondary tumorigenesis in the patients receiving radiotherapy. Radiotherapy also affects non-tumoral cells present in the tumor mic...

    Authors: Nasrollah Jabbari, Muhammad Nawaz and Jafar Rezaie

    Citation: Cell Communication and Signaling 2019 17:165

    Content type: Research

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  30. Carcinoma cells shift between epithelial and mesenchymal phenotypes during cancer progression, as defined by surface presentation of the cell-cell cohesion molecule E-cadherin, affecting dissemination, progres...

    Authors: Bo Ma, Ahmad Khazali, Hanshuang Shao, Yuhan Jiang and Alan Wells

    Citation: Cell Communication and Signaling 2019 17:164

    Content type: Research

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  31. Recent evidence has suggested that the 1,25(OH)2D3/Vitamin D receptor (VDR) acts to suppress the immune response associated with systemic lupus erythematosus (SLE), a serious multisystem autoimmune disease. Hence...

    Authors: Dan Liu, Yu-Xuan Fang, Xia Wu, Wei Tan, Wei Zhou, Yu Zhang, Yan-Qing Liu and Guo-Qing Li

    Citation: Cell Communication and Signaling 2019 17:163

    Content type: Research

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  32. Interleukin-22 (IL-22) belongs to the IL-10 cytokine family and is mainly produced by activated Th1 cells. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression c...

    Authors: Wei Li, Fen Li, Weiwei Lei and Zezhang Tao

    Citation: Cell Communication and Signaling 2019 17:162

    Content type: Research

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  33. Serine protease HtrA exhibits both proteolytic and chaperone activities, which are involved in cellular protein quality control. Moreover, HtrA is an important virulence factor in many pathogens including Helicob...

    Authors: Urszula Zarzecka, Aileen Harrer, Anna Zawilak-Pawlik, Joanna Skorko-Glonek and Steffen Backert

    Citation: Cell Communication and Signaling 2019 17:161

    Content type: Research

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  34. Decondesation of the highly compacted chromatin architecture is essential for efficient DNA repair, but how this is achieved remains largely unknown. Here, we report that microrchidia family CW-type zinc finge...

    Authors: Hong-Yan Xie, Tai-Mei Zhang, Shu-Yuan Hu, Zhi-Ming Shao and Da-Qiang Li

    Citation: Cell Communication and Signaling 2019 17:160

    Content type: Research

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  35. Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of kar...

    Authors: Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn and Stephan Singer

    Citation: Cell Communication and Signaling 2019 17:159

    Content type: Research

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  36. Following publication of the original article [1], the authors reported that Figs. 3 and 6 are incorrect.

    Authors: Jinsoo Song, Dongkyun Kim, Churl-Hong Chun and Eun-Jung Jin

    Citation: Cell Communication and Signaling 2019 17:158

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2013 11:66

  37. Patients with advanced gastric cancer usually have a poor prognosis and limited therapeutic options. Overcoming this challenge requires novel targets and effective drugs. The Hedgehog (Hh) signaling pathway pl...

    Authors: Yan Xu, Shumei Song, Zhenning Wang and Jaffer A. Ajani

    Citation: Cell Communication and Signaling 2019 17:157

    Content type: Review

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  38. The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in this special issue. This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK – compr...

    Authors: Tal Burstyn-Cohen and Avi Maimon

    Citation: Cell Communication and Signaling 2019 17:156

    Content type: Review

    Published on:

  39. E-cadherin has been awarded a key role in the aetiology of both sporadic and hereditary forms of gastric cancer. In this study, we aimed to identify molecular interactors that influence the expression and func...

    Authors: Patrícia Carneiro, Ana Margarida Moreira, Joana Figueiredo, Rita Barros, Patrícia Oliveira, Maria Sofia Fernandes, Anabela Ferro, Raquel Almeida, Carla Oliveira, Fátima Carneiro, Fernando Schmitt, Joana Paredes, Sérgia Velho and Raquel Seruca

    Citation: Cell Communication and Signaling 2019 17:155

    Content type: Research

    Published on:

  40. Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its functi...

    Authors: Nanyang Yang, Sitong Liu, Tian Qin, Xintong Liu, Nobumoto Watanabe, Kevin H. Mayo, Jiang Li and Xiaomeng Li

    Citation: Cell Communication and Signaling 2019 17:153

    Content type: Research

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  41. Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent EPO inducer, is a major stimulating factor in the g...

    Authors: Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum and Qiuyang Zhang

    Citation: Cell Communication and Signaling 2019 17:152

    Content type: Research

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  42. Following publication of the original article [1], it was reported that Fig. 1c was not entirely readable due to overlapping Fig. 1d. The publishers apologise for this error.

    Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray

    Citation: Cell Communication and Signaling 2019 17:151

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2019 17:131

  43. Authors: Rachel NeMoyer, Arindam Mondal, Mehul Vora, Elaine Langenfeld, Danea Glover, Michael Scott, Lauren Lairson, Christopher Rongo, David J. Augeri, Youyi Peng, Salma K. Jabbour and John Langenfeld

    Citation: Cell Communication and Signaling 2019 17:150

    Content type: Research

    Published on:

  44. In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (...

    Authors: Jiangjuan Shao, Mengmeng Li, Zijian Guo, Chun Jin, Feng Zhang, Chunyan Ou, Yaochen Xie, Shanzhong Tan, Zhenyi Wang, Shizhong Zheng and Xiaoyong Wang

    Citation: Cell Communication and Signaling 2019 17:149

    Content type: Research

    Published on:

  45. Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer ...

    Authors: Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi and Päivi J. Koskinen

    Citation: Cell Communication and Signaling 2019 17:148

    Content type: Research

    Published on:

  46. Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of ne...

    Authors: Yang Li, Wei Wang, Fan Yang, Yanan Xu, Chang Feng and Yong Zhao

    Citation: Cell Communication and Signaling 2019 17:147

    Content type: Review

    Published on:

  47. Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we teste...

    Authors: Masoumeh Es-Haghi, Kasun Godakumara, Annika Häling, Freddy Lättekivi, Arina Lavrits, Janeli Viil, Aneta Andronowska, Tamer Nafee, Victoria James, Ülle Jaakma, Andres Salumets and Alireza Fazeli

    Citation: Cell Communication and Signaling 2019 17:146

    Content type: Research

    Published on:

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