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  1. Alzheimer’s disease (AD) and glioblastoma are the most common and devastating diseases in the neurology and neurosurgery departments, respectively. Our previous research reports that the AD-related protein Pre...

    Authors: Wei Yang, Yan Xiang, Mao-Jun Liao, Peng-Fei Wu, Lin Yang, Guo-Hao Huang, Bao-Zhong Shi, Liang Yi and Sheng-Qing Lv
    Citation: Cell Communication and Signaling 2021 19:112
  2. Despite the considerable efforts in screening and diagnostic protocols, prostate cancer still represents the second leading cause of cancer-related death in men. Many patients with localized disease and low ri...

    Authors: Pia Giovannelli, Marzia Di Donato, Giovanni Galasso, Alessandra Monaco, Fabrizio Licitra, Bruno Perillo, Antimo Migliaccio and Gabriella Castoria
    Citation: Cell Communication and Signaling 2021 19:110
  3. Heart failure, which is characterized by cardiac remodelling, is one of the most common chronic diseases in the aged. Stimulator of interferon genes (STING) acts as an indispensable molecule modulating immune ...

    Authors: Rui Xiong, Ning Li, Lei Chen, Wei Wang, Bo Wang, Wenyang Jiang and Qing Geng
    Citation: Cell Communication and Signaling 2021 19:109
  4. High temperature requirement A (HtrA) is an active serine protease secreted by the group-I carcinogen Helicobacter pylori (H. pylori). The human cell adhesion protein and tumor suppressor E-cadherin (hCdh1) expre...

    Authors: Sabine Bernegger, Robert Vidmar, Marko Fonovic, Gernot Posselt, Boris Turk and Silja Wessler
    Citation: Cell Communication and Signaling 2021 19:108
  5. Myocardial reperfusion injury is often accompanied by cell death and inflammatory reactions. Recently, pyroptosis is gradually recognized as pivotal role in cardiovascular disease. However, little is known abo...

    Authors: Wenjing Sun, Hongquan Lu, Shujuan Dong, Rui Li, Yingjie Chu, Nan Wang, Yu Zhao, Yabin Zhang, Limeiting Wang, Lin Sun and Di Lu
    Citation: Cell Communication and Signaling 2021 19:107
  6. Protein tyrosine phosphatase 1B (PTP1B) and low molecular weight protein tyrosine phosphatase (LMPTP) are implicated in the development of metabolic disorders. Yet, their role in progenitor stem cell adipogeni...

    Authors: Katarzyna Kornicka-Garbowska, Lynda Bourebaba, Michael Röcken and Krzysztof Marycz
    Citation: Cell Communication and Signaling 2021 19:106
  7. Intercellular communication is a critical process that ensures cooperation between distinct cell types and maintains homeostasis. EVs, which were initially described as cellular debris and devoid of biological...

    Authors: Greg Berumen Sánchez, Kaitlyn E. Bunn, Heather H. Pua and Marjan Rafat
    Citation: Cell Communication and Signaling 2021 19:104
  8. Transcription factor CREB is involved in the development of pulmonary hypertension (PH). However, little is known about the role and regulatory signaling of CREB in PH.

    Authors: Genfa Xiao, Guili Lian, Tingjun Wang, Weixiao Chen, Wei Zhuang, Li Luo, Huajun Wang and Liangdi Xie
    Citation: Cell Communication and Signaling 2021 19:103
  9. Glioma is the most common primary brain tumor and its prognosis is poor. Despite surgical removal, glioma is still prone to recurrence because it grows rapidly in the brain, is resistant to chemotherapy, and i...

    Authors: Xiangdong Xu, Lingfei Li, Linting Luo, Lingling Shu, Xiaoli Si, Zhenzhen Chen, Wenqing Xia, Jinyu Huang, Yang Liu, Anwen Shao and Yiquan Ke
    Citation: Cell Communication and Signaling 2021 19:102
  10. During pregnancy, trophoblast cell invasion needs to be finely controlled. Aberrant trophoblast cell invasion is associated with placental diseases. Epidermal growth factor (EGF) and its receptor, EGFR, are ex...

    Authors: Lanlan Fang, Yibo Gao, Zhen Wang, Yuxi Li, Yang Yan, Ze Wu, Jung-Chien Cheng and Ying-Pu Sun
    Citation: Cell Communication and Signaling 2021 19:101
  11. Fetal cell-derived exosomes (extracellular vesicles, 40–160 nm) are communication channels that can signal parturition by inducing inflammatory changes in maternal decidua and myometrium. Little is known about...

    Authors: Megan C. Shepherd, Enkhtuya Radnaa, Ourlad Alzeus Tantengco, Talar Kechichian, Rheanna Urrabaz-Garza, Ananth Kumar Kammala, Samantha Sheller-Miller and Ramkumar Menon
    Citation: Cell Communication and Signaling 2021 19:100
  12. The calcium (Ca2+)/calmodulin (CAM)-activated kinase kinase 2 (CAMKK2)-signaling regulates several physiological processes, for example, glucose metabolism and energy homeostasis, underlying the pathogenesis o...

    Authors: Mohammad Golam Sabbir, Carla G. Taylor and Peter Zahradka
    Citation: Cell Communication and Signaling 2021 19:98
  13. Recent studies have shown that bone morphogenetic protein receptor 2 (BMPR2) regulates cell survival signaling events in cancer cells independent of the BMP type 1 receptor (BMPR1) or the Smad-1/5 transcriptio...

    Authors: Arindam Mondal, Rachel NeMoyer, Mehul Vora, Logan Napoli, Zoya Syed, Elaine Langenfeld, Dongxuan Jia, Youyi Peng, John Gilleran, Jacques Roberge, Christopher Rongo, Salma K. Jabbour and John Langenfeld
    Citation: Cell Communication and Signaling 2021 19:97
  14. Notch signaling drives many aspects of neoplastic phenotype. Here, we report that the Integrator complex (INT) is a new component of the Notch transcriptional supercomplex. Together with Notch Activation Compl...

    Authors: Elena Shersher, Mohini Lahiry, Annamil Alvarez-Trotta, Giulia Diluvio, David J. Robbins, Ramin Shiekhattar and Anthony J. Capobianco
    Citation: Cell Communication and Signaling 2021 19:96
  15. Loss of the Ras GTPase-activating protein neurofibromin promotes nervous system tumor pathogenesis in patients with neurofibromatosis type 1 (NF1). Neurofibromin loss potentially hyperactivates classic Ras (H-...

    Authors: Shannon M. Weber, Nicole M. Brossier, Amanda Prechtl, Stephen Barnes, Landon S. Wilson, Stephanie N. Brosius, Jody Fromm Longo and Steven L. Carroll
    Citation: Cell Communication and Signaling 2021 19:95
  16. Cell-to-cell heterogeneity is an inherent feature of multicellular organisms and is central in all physiological and pathophysiological processes including cellular signal transduction. The cytokine IL-6 is an...

    Authors: Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper and Anna Dittrich
    Citation: Cell Communication and Signaling 2021 19:94
  17. Exosomes mediated crosstalk between tumor cells and other stromal cells including tumor associated macrophages plays an essential role in reprogramming tumor microenvironment (TME) to facilitate tumor progress...

    Authors: Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang and Jinjian Yang
    Citation: Cell Communication and Signaling 2021 19:93
  18. Once thought of primarily as a means to neutralize pathogens or to facilitate feeding, endocytosis is now known to regulate a wide range of eukaryotic cell processes. Among these are regulation of signal trans...

    Authors: John C. Charpentier and Philip D. King
    Citation: Cell Communication and Signaling 2021 19:92
  19. Autophagy is catabolic process by degradation of intracellular components in lysosome including proteins, lipids, and mitochondria in response to nutrient deficiency or stress such as hypoxia or chemotherapy. ...

    Authors: Yalan Duan, Xiaoqing Tian, Qian Liu, Jianhua Jin, Juanjuan Shi and Yongzhong Hou
    Citation: Cell Communication and Signaling 2021 19:91
  20. Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for surv...

    Authors: Jing Li, Shengqi Wang, Neng Wang, Yifeng Zheng, Bowen Yang, Xuan Wang, Juping Zhang, Bo Pan and Zhiyu Wang
    Citation: Cell Communication and Signaling 2021 19:89

    The Correction to this article has been published in Cell Communication and Signaling 2021 19:113

  21. For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured pro...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky
    Citation: Cell Communication and Signaling 2021 19:88
  22. Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defin...

    Authors: Juan A. Godoy, Jasson Espinoza-Caicedo and Nibaldo C. Inestrosa
    Citation: Cell Communication and Signaling 2021 19:87
  23. Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indica...

    Authors: M. T. Longhi, L. E. Silva, M. Pereira, M. Magalhães, J. Reina, F. N. L. Vitorino, B. M. Gumbiner, J. P. C. da Cunha and N. Cella
    Citation: Cell Communication and Signaling 2021 19:86
  24. Vitamin D receptor (VDR) plays a vital protective role in oral and colonic epithelial cells. Albeit we know that VDR expression is reduced in the mucosal epithelial layers of autoimmune diseases, the mechanism...

    Authors: Xiangyu Wang, Xuejun Ge, Wang Liao, Yong Cao, Ran Li, Fang Zhang, Bin Zhao and Jie Du
    Citation: Cell Communication and Signaling 2021 19:85
  25. RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE, for in vitro use. REPAIR was developed by fusing inactivated ...

    Authors: Guo Li, Yihan Wang, Xiangyang Li, Yuzhe Wang, Xingxu Huang, Jianen Gao and Xiaoxiang Hu
    Citation: Cell Communication and Signaling 2021 19:84
  26. The positive transcription elongation factor b (P-TEFb) kinase activity is involved in the process of transcription. Cyclin-dependent kinase 9 (CDK9), a core component of P-TEFb, regulates the process of trans...

    Authors: Yingjie Qing, Xiangyuan Wang, Hongzheng Wang, Po Hu, Hui Li, Xiaoxuan Yu, Mengyuan Zhu, Zhanyu Wang, Yu Zhu, Jingyan Xu, Qinglong Guo and Hui Hui
    Citation: Cell Communication and Signaling 2021 19:83
  27. As a ubiquitous second messenger, calcium (Ca2+) can interact with numerous cellular proteins to regulate multiple physiological processes and participate in a variety of diseases, including hepatitis B virus ...

    Authors: Fanyun Kong, Fulong Zhang, Xiangye Liu, Suping Qin, Xiaoying Yang, Delong Kong, Xiucheng Pan, Hongjuan You, Kuiyang Zheng and Renxian Tang
    Citation: Cell Communication and Signaling 2021 19:82
  28. The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-targ...

    Authors: Yihan Wang, Guo Li, Xiangyang Li, Yuzhe Wang, Xingxu Huang, Xiaoxiang Hu and Jianen Gao
    Citation: Cell Communication and Signaling 2021 19:81
  29. Hhex(human hematopoietically expressed homeobox), also known as PRH, is originally considered as a transcription factor to regulate gene expression due to its homebox domain. Increasing studies show that Hhex ...

    Authors: Xiaopeng Li, Guilin Ma, Wenjie Guo, Ning Mu, Yingying Wang, Xiangguo Liu and Ling Su
    Citation: Cell Communication and Signaling 2021 19:80
  30. The urinary tract is highly innervated by autonomic nerves which are essential in urinary tract development, the production of growth factors, and the control of homeostasis. These neural signals may become dy...

    Authors: M. Archer, N. Dogra, Z. Dovey, T. Ganta, H.-S. Jang, J. A. Khusid, A. Lantz, M. Mihalopoulos, J. A. Stockert, A. Zahalka, L. Björnebo, S. Gaglani, M. R. Noh, S. A. Kaplan, R. Mehrazin, K. K. Badani…
    Citation: Cell Communication and Signaling 2021 19:78
  31. CMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor progression. Rab5 forms complexes with Beclin1 and VPS34, and acts in the ea...

    Authors: Baocai Liu, Yinliang Lu, Tingting Zhang, Xinyue Yu, Qian Wang, Yunbo Chi, Shunzi Jin and Guanghui Cheng
    Citation: Cell Communication and Signaling 2021 19:77
  32. Small extracellular vesicles (sEVs) mediate intercellular communication by transferring RNA, proteins, and lipids to recipient cells. These cargo molecules are selectively loaded into sEVs and mirror the physi...

    Authors: Xuan Luo, Renée Jean-Toussaint, Ahmet Sacan and Seena K. Ajit
    Citation: Cell Communication and Signaling 2021 19:75
  33. Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumo...

    Authors: Xiaoping Chen, Li Qin, Wen Hu and Dickson Adah
    Citation: Cell Communication and Signaling 2021 19:74
  34. The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has become an ongoing pandemic. Understanding the respiratory immune microenvironment whi...

    Authors: Lei He, Quan Zhang, Yue Zhang, Yixian Fan, Fahu Yuan and Songming Li
    Citation: Cell Communication and Signaling 2021 19:73
  35. The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with trans...

    Authors: Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian and Maryam Farzaneh
    Citation: Cell Communication and Signaling 2021 19:72
  36. The fusion oncoprotein Bcr-Abl is mostly located in the cytoplasm, which causes chronic myeloid leukemia (CML). After moving into the nucleus, the fusion protein can induce apoptosis of CML cells. The coiled-c...

    Authors: Yuhang Peng, Zhenglan Huang, Fangzhu Zhou, Teng Wang, Ke Mou and Wenli Feng
    Citation: Cell Communication and Signaling 2021 19:71
  37. Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Amon...

    Authors: Yi-Wei Lin, Jennifer Nhieu, Chin-Wen Wei, Yu-Lung Lin, Hiroyuki Kagechika and Li-Na Wei
    Citation: Cell Communication and Signaling 2021 19:69
  38. The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kina...

    Authors: Kwan Long Mung, William B. Eccleshall, Niina M. Santio, Adolfo Rivero-Müller and Päivi J. Koskinen
    Citation: Cell Communication and Signaling 2021 19:68
  39. Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progre...

    Authors: Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah and Leszek Kotula
    Citation: Cell Communication and Signaling 2021 19:67
  40. Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are needed. Qualities of the tumor microenvironment as...

    Authors: Emma Persson, Pernilla Gregersson, Anna Gustafsson, Paul Fitzpatrick, Sara Rhost, Anders Ståhlberg and Göran Landberg
    Citation: Cell Communication and Signaling 2021 19:66
  41. Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the f...

    Authors: Ryan J. Emenecker, Alex S. Holehouse and Lucia C. Strader
    Citation: Cell Communication and Signaling 2021 19:65
  42. Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia forma...

    Authors: Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti and Daniela Corda
    Citation: Cell Communication and Signaling 2021 19:64

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