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  1. Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restric...

    Authors: David C. Calianese and Raymond B. Birge

    Citation: Cell Communication and Signaling 2020 18:41

    Content type: Editorial

    Published on:

  2. Diabetic wounds are a disturbing and rapidly growing clinical problem. A novel peptide, parathyroid hormone related peptide (PTHrP-2), is assumed as multifunctional factor in angiogenesis, fibrogenesis and re-...

    Authors: Yi-Fan Shen, Jing-Huan Huang, Kai-Yang Wang, Jin Zheng, Lin Cai, Hong Gao, Xiao-Lin Li and Jing-Feng Li

    Citation: Cell Communication and Signaling 2020 18:40

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2020 18:75

  3. The (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR pathways, that are involved in a wide range of ...

    Authors: Juan Wang, Akira Nishiyama, Makoto Matsuyama, Zhiyu Wang and Ying Yuan

    Citation: Cell Communication and Signaling 2020 18:39

    Content type: Review

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  4. Cancer stem cells (CSCs), the major driver of tumorigenesis, is a sub-population of tumor cells responsible for poor clinical outcomes. However, molecular mechanism to identify targets for controlling CSCs is ...

    Authors: Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Dong-Kyu Kwak, Jaebeom Cho, Dong Woo Kang, Ho-Young Lee and Kang-Yell Choi

    Citation: Cell Communication and Signaling 2020 18:38

    Content type: Research

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  5. This investigation was arranged to elucidate whether single nucleotide polymorphisms (SNPs) of lncRNA UCA1 was implicated in elevating colorectal cancer (CRC) risk by interacting with environmental exposures.

    Authors: Yang Fu, Yizheng Zhang, Jinyuan Cui, Ge Yang, Sanfei Peng, Wunan Mi, Xiangya Yin, Yang Yu, Jianwu Jiang, Qi Liu, Yiyu Qin and Wen Xu

    Citation: Cell Communication and Signaling 2020 18:37

    Content type: Research

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  6. The current successful clinical use of agents promoting robust anti-tumor immunity in cancer patients warrants noting that radiation therapy (RT) induces immunogenic cell death (ICD) of tumor cells, which can ...

    Authors: Ting Sun, Wei Yang, Sneh M. Toprani, Wei Guo, Lile He, Albert B. DeLeo, Soldano Ferrone, Gong Zhang, Enwen Wang, Zunwen Lin, Pan Hu and Xinhui Wang

    Citation: Cell Communication and Signaling 2020 18:36

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2020 18:53

  7. Chitinase 3 like 1 protein (Chi3L1) is expressed in several cancers, and a few evidences suggest that the secreted Chi3L1 contributes to tumor development. However, the molecular mechanisms of intracellular Ch...

    Authors: Kyung-Ran Park, Hyung-Mun Yun, Kyeongwon Yoo, Young Wan Ham, Sang Bae Han and Jin Tae Hong

    Citation: Cell Communication and Signaling 2020 18:5

    Content type: Research

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  8. Inflammation and oxidative stress induced by oxidized low density lipoprotein are the main causes of vascular endothelial injury and atherosclerosis. Endothelial cells are important for the formation and repai...

    Authors: Jianming Guo, Qiuling Xiang, Yaojie Xin, Yongyi Huang, Gang Zou and Te Liu

    Citation: Cell Communication and Signaling 2020 18:35

    Content type: Research

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  9. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy and its mortality continues to rise globally. Because of its high heterogeneity and complex molecular landscapes, published gene signatures...

    Authors: Ping Wang, Chunlong Zhang, Weidong Li, Bo Zhai, Xian Jiang, Shiva Reddy, Hongchi Jiang and Xueying Sun

    Citation: Cell Communication and Signaling 2020 18:34

    Content type: Research

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  10. Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast cancer due to the widespread occurrence of chemoresistance, which...

    Authors: Jia-hui Ma, Li Qin and Xia Li

    Citation: Cell Communication and Signaling 2020 18:33

    Content type: Review

    Published on:

  11. Mimicking ischemia-reperfusion injury, oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) applied to endometrial cells produces significant oxidative stress and programmed necrosis, which can be inhibi...

    Authors: Shu-ping Li, Wei-nan Cheng, Ya Li, Hong-bin Xu, Hui Han, Ping Li and Deng-Xia Zhang

    Citation: Cell Communication and Signaling 2020 18:32

    Content type: Research

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  12. Medium-chain fatty acids and their 3-hydroxy derivatives are metabolites endogenously produced in humans, food-derived or originating from bacteria. They activate G protein-coupled receptors, including GPR84 a...

    Authors: Anna Peters, Philipp Rabe, Petra Krumbholz, Hermann Kalwa, Robert Kraft, Torsten Schöneberg and Claudia Stäubert

    Citation: Cell Communication and Signaling 2020 18:31

    Content type: Research

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  13. Candida albicans is the most common opportunistic human fungal pathogen. The chemokine ligand CXCL1 plays a protective role in fungal infection through the recruitment of neutrophils. TRAF1 (tumor necrosis factor...

    Authors: Wenjuan Bai, Qingqing Wang, Zihou Deng, Tiantian Li, Hui Xiao and Zhiyuan Wu

    Citation: Cell Communication and Signaling 2020 18:30

    Content type: Research

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  14. Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cell...

    Authors: Yi-Ran Pan, Jing-Yao Song, Bin Fan, Ying Wang, Lin Che, Si-Ming Zhang, Yu-Xin Chang, Chang He and Guang-Yu Li

    Citation: Cell Communication and Signaling 2020 18:27

    Content type: Research

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  15. The limited options to treat obesity and its complications result from an incomplete understanding of the underlying molecular mechanisms regulating white adipose tissue development, including adipocyte hypert...

    Authors: Nida Haider and Louise Larose

    Citation: Cell Communication and Signaling 2020 18:26

    Content type: Research

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  16. Eukaryotic elongation factor-2 kinase (eEF2K) is a Ca 2+ /calmodulin (CaM)-dependent protein kinase that inhibits protein synthesis. However, the role of eEF2K in cancer development was reported paradoxically ...

    Authors: Min Xiao, Jianling Xie, Yu Wu, Genzhu Wang, Xin Qi, Zailiang Liu, Yuying Wang, Xuemin Wang, Ashfaqul Hoque, Jon Oakhill, Christopher G. Proud and Jing Li

    Citation: Cell Communication and Signaling 2020 18:25

    Content type: Research

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  17. Nuclear translocation of several oncogenic proteins have previously been reported, but neither the translocation of doublecortin (DCX) nor the mechanism involved has been studied. DCX is a neuronal microtubule...

    Authors: Abiola Abdulrahman Ayanlaja, Guanquan Ji, Jie Wang, Yue Gao, Bo Cheng, Kouminin Kanwore, Lin Zhang, Ye Xiong, Piniel Alphayo Kambey and Dianshuai Gao

    Citation: Cell Communication and Signaling 2020 18:24

    Content type: Research

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  18. Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome, and is associated with a number of other diseases. PCV2 is widely distributed in most developed swine indu...

    Authors: Shuai Zhang, Chunxiao Mou, Yanan Cao, En Zhang and Qian Yang

    Citation: Cell Communication and Signaling 2020 18:23

    Content type: Research

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  19. Glioblastoma and Alzheimer’s disease (AD) are the most common and devastating diseases in the central nervous system. The dysfunction of Presenilin1 is the main reason for AD pathogenesis. However, the molecul...

    Authors: Wei Yang, Peng-fei Wu, Jian-xing Ma, Mao-jun Liao, Lun-shan Xu, Min-hui Xu and Liang Yi

    Citation: Cell Communication and Signaling 2020 18:22

    Content type: Methodology

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  20. Glioblastoma multiforme is an aggressive primary brain tumor that is characterized by local invasive growth and resistance to therapy. The role of the microenvironment in glioblastoma invasiveness remains uncl...

    Authors: Nicholas W. Colangelo and Edouard I. Azzam

    Citation: Cell Communication and Signaling 2020 18:21

    Content type: Research

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  21. Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex ...

    Authors: Baoyi Zhu, Zhengfu Feng, Yan Guo, Tian Zhang, Ai Mai, Zhanfang Kang, Ting Weijen, Dai Wang, Dazhong Yin, Dongxing Zhu and Jun Gao

    Citation: Cell Communication and Signaling 2020 18:19

    Content type: Research

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  22. Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment. We have ...

    Authors: Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah, Mathew A. Vadas and Jennifer R. Gamble

    Citation: Cell Communication and Signaling 2020 18:18

    Content type: Research

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  23. Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive tumor. The inflammatory environment plays an important role in the tumorigenesis and development of ESCC. Cancer stem cells are a small ...

    Authors: Fengkai Xu, Zhonghe Liu, Ronghua Liu, Chunlai Lu, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Kunpeng Zhang, Yin Li, Yiwei Chu, Jie Gu and Di Ge

    Citation: Cell Communication and Signaling 2020 18:17

    Content type: Research

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  24. The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamid...

    Authors: Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen and Shu Zheng

    Citation: Cell Communication and Signaling 2020 18:16

    Content type: Research

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  25. We have previously shown that the zinc finger transcription repressor SNAI2 (SLUG) represses tumor suppressor BRCA2-expression in non-dividing cells by binding to the E2-box upstream of the transcription start si...

    Authors: Marshall Ellison, Mukul Mittal, Minu Chaudhuri, Gautam Chaudhuri and Smita Misra

    Citation: Cell Communication and Signaling 2020 18:15

    Content type: Research

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  26. CSDE1 (cold shock domain containing E1) plays a key role in translational reprogramming, which determines the fate of a number of RNAs during biological processes. Interestingly, the role of CSDE1 is bidirecti...

    Authors: Ao-Xiang Guo, Jia-Jia Cui, Lei-Yun Wang and Ji-Ye Yin

    Citation: Cell Communication and Signaling 2020 18:14

    Content type: Review

    Published on:

  27. Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this study, mass spectrometry (MS)-based tyrosine phosph...

    Authors: Nicole J. Chew, Elizabeth V. Nguyen, Shih-Ping Su, Karel Novy, Howard C. Chan, Lan K. Nguyen, Jennii Luu, Kaylene J. Simpson, Rachel S. Lee and Roger J. Daly

    Citation: Cell Communication and Signaling 2020 18:13

    Content type: Research

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  28. Cell death triggered by unmitigated endoplasmic reticulum (ER) stress plays an important role in physiology and disease, but the death-inducing signaling mechanisms are incompletely understood. To gain more in...

    Authors: Paula Lindner, Søren Brøgger Christensen, Poul Nissen, Jesper Vuust Møller and Nikolai Engedal

    Citation: Cell Communication and Signaling 2020 18:12

    Content type: Research

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  29. Androgen receptor targeted therapies have emerged as an effective tool to manage advanced prostate cancer (PCa). Nevertheless, frequent occurrence of therapy resistance represents a major challenge in the clin...

    Authors: Hannes Neuwirt, Jan Bouchal, Gvantsa Kharaishvili, Christian Ploner, Karin Jöhrer, Florian Pitterl, Anja Weber, Helmut Klocker and Iris E. Eder

    Citation: Cell Communication and Signaling 2020 18:11

    Content type: Research

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  30. The establishment of parasitic infection is dependent on the development of efficient strategies to evade the host defense mechanisms. Phosphatidylserine (PS) molecules are pivotal for apoptotic cell recogniti...

    Authors: João Luiz Mendes Wanderley, Renato Augusto DaMatta and Marcello André Barcinski

    Citation: Cell Communication and Signaling 2020 18:10

    Content type: Review

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  31. Dysfunction in survival and differentiation of osteoblasts commonly occurs in patients with osteoporosis. Cannabinoid receptor type 2 (CNR2) is a major receptor of endocannabinoid system that is crucial for bo...

    Authors: Aihua Xu, Yang Yang, Yang Shao, Meng Wu and Yongxin Sun

    Citation: Cell Communication and Signaling 2020 18:9

    Content type: Research

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  32. NR2F6 has been proposed as an alternative cancer immune checkpoint in the effector T cell compartment. However, a realistic assessment of the in vivo therapeutic potential of NR2F6 requires acute depletion.

    Authors: Victoria Klepsch, Maria Pommermayr, Dominik Humer, Natascha Brigo, Natascha Hermann-Kleiter and Gottfried Baier

    Citation: Cell Communication and Signaling 2020 18:8

    Content type: Research

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  33. Low expression of FOXE1, a member of Forkhead box (FOX) transcription factor family that plays vital roles in cancers, contributes to poor prognosis of colorectal cancer (CRC) patients. However, the underlying...

    Authors: Weixing Dai, Xianke Meng, Shaobo Mo, Wenqiang Xiang, Ye Xu, Long Zhang, Renjie Wang, Qingguo Li and Guoxiang Cai

    Citation: Cell Communication and Signaling 2020 18:7

    Content type: Research

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  34. Following publication of the original article [1], the authors reported that they would like to correct the second last sentence of “Authors’ information” section as PW is an undergraduate, but was incorrectly...

    Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li

    Citation: Cell Communication and Signaling 2020 18:4

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2019 17:16

  35. Ras are small cellular GTPases which regulate diverse cellular processes. It has three isoforms: H-Ras, K-Ras, and N-Ras. Owing to the N-terminus (1–165 residues) sequence homology these isoforms were thought ...

    Authors: Arathi Nair, Sushmita Chakraborty, Late Anirban Banerji, Ankita Srivastava, Charudutta Navare and Bhaskar Saha

    Citation: Cell Communication and Signaling 2020 18:3

    Content type: Research

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  36. Gliomas are the most common and malignant brain tumors. The standard therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive methods. However, the emergence of chemoresistance i...

    Authors: Fan Zeng, Kuanyu Wang, Xiu Liu and Zheng Zhao

    Citation: Cell Communication and Signaling 2020 18:2

    Content type: Research

    Published on:

  37. The calcium/calcineurin signaling pathway is mediated by the transcription factors NFAT (nuclear factor of activated T cells) in mammals and Crz1 (calcineurin-responsive zinc finger 1) in yeasts and other lowe...

    Authors: Huihui Xu, Tianshu Fang, Raha Parvizi Omran, Malcolm Whiteway and Linghuo Jiang

    Citation: Cell Communication and Signaling 2020 18:1

    Content type: Research

    Published on:

  38. LRP5/6 are co-receptors in Wnt/β-catenin pathway. Recently, we discovered multiple β-catenin independent functions of LRP5/6 in tumor cells and in the diseased heart. Nucleoporin 37 (NUP37) is an important com...

    Authors: Jinxiao Chen, Da Wo, En Ma, Hongwei Yan, Jun Peng, Weidong Zhu, Yong Fang and Dan-ni Ren

    Citation: Cell Communication and Signaling 2019 17:174

    Content type: Research

    Published on:

  39. Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-L1) has been documented in several cancers and contributes to the evasion of the host immune system. However, cancer cell-intrinsic signa...

    Authors: Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang, Xiaomin Bian, Tingting Gu and Lianji Wen

    Citation: Cell Communication and Signaling 2019 17:173

    Content type: Research

    Published on:

  40. Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metast...

    Authors: Sandra Grund-Gröschke, Georg Stockmaier and Fritz Aberger

    Citation: Cell Communication and Signaling 2019 17:172

    Content type: Review

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  41. Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the de...

    Authors: Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb and Marta Miączyńska

    Citation: Cell Communication and Signaling 2019 17:171

    Content type: Research

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  42. Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose...

    Authors: Kateřina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal and Vítězslav Bryja

    Citation: Cell Communication and Signaling 2019 17:170

    Content type: Research

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  43. Tumor endothelial cells (TECs) perform tumor angiogenesis, which is essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid from glycolysis; however, the mechanism underlyin...

    Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida and Kyoko Hida

    Citation: Cell Communication and Signaling 2019 17:169

    Content type: Research

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  44. Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell. However, th...

    Authors: Hong-Zhong Zhou, Han-Qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Bo Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang and Juan Chen

    Citation: Cell Communication and Signaling 2019 17:168

    Content type: Research

    Published on:

  45. Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC). Herein, we investigated ...

    Authors: Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia and Dan J. Raz

    Citation: Cell Communication and Signaling 2019 17:167

    Content type: Research

    Published on:

  46. In vitro chondrogenesis depends on the concerted action of numerous signalling pathways, many of which are sensitive to the changes of intracellular Ca2+ concentration. N-methyl-D-aspartate (NMDA) glutamate recep...

    Authors: Csaba Matta, Tamás Juhász, János Fodor, Tibor Hajdú, Éva Katona, Csilla Szűcs-Somogyi, Roland Takács, Judit Vágó, Tamás Oláh, Ádám Bartók, Zoltan Varga, Gyorgy Panyi, László Csernoch and Róza Zákány

    Citation: Cell Communication and Signaling 2019 17:166

    Content type: Research

    Published on:

  47. Non-targeting effects of radiotherapy have become as clinical concern due to secondary tumorigenesis in the patients receiving radiotherapy. Radiotherapy also affects non-tumoral cells present in the tumor mic...

    Authors: Nasrollah Jabbari, Muhammad Nawaz and Jafar Rezaie

    Citation: Cell Communication and Signaling 2019 17:165

    Content type: Research

    Published on:

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