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  1. The past decade has seen the rise of omics data for the understanding of biological systems in health and disease. This wealth of information includes protein-protein interaction (PPI) data derived from both l...

    Authors: James E. Tomkins, Raffaele Ferrari, Nikoleta Vavouraki, John Hardy, Ruth C. Lovering, Patrick A. Lewis, Liam J. McGuffin and Claudia Manzoni

    Citation: Cell Communication and Signaling 2020 18:92

    Content type: Methodology

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  2. RNF43 and its homolog ZNRF3 are transmembrane E3 ubiquitin ligases frequently mutated in many human cancer types. Their main role relays on the inhibition of canonical Wnt signaling by the negative regulation ...

    Authors: Tomasz Radaszkiewicz and Vítězslav Bryja

    Citation: Cell Communication and Signaling 2020 18:91

    Content type: Research

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  3. Cancer displays high levels of heterogeneity and mutation potential, and curing cancer remains a challenge that clinicians and researchers are eager to overcome. In recent years, the emergence of cancer immuno...

    Authors: Zhujiang Dai, Jingqiu Zhang, Qi Wu, Huiwen Fang, Chunfeng Shi, Zhen Li, Chaobiao Lin, Dong Tang and Daorong Wang

    Citation: Cell Communication and Signaling 2020 18:90

    Content type: Review

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  4. Hyaluronan (HA) is an abundant component of the bone marrow (BM) extracellular matrix. Here, we investigated the abnormal deposition of HA in the BM microenvironment and its remodelling in mediating the malign...

    Authors: Xiaoyan Chen, Xiaoxing Shi, Yiwen Liu, Yiqing He, Yan Du, Guoliang Zhang, Cuixia Yang and Feng Gao

    Citation: Cell Communication and Signaling 2020 18:89

    Content type: Research

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  5. Autophagy has a crucial role in many cancers, including brain tumors. Several types of endogenous molecules (e.g. microRNAs, AKT, PTEN, p53, EGFR, and NF1) can modulate the process of autophagy. Recently miRNA...

    Authors: Mohammad Hossein Pourhanifeh, Maryam Mahjoubin-Tehran, Mohammad Reza Karimzadeh, Hamid Reza Mirzaei, Zahra Sadat Razavi, Amirhossein Sahebkar, Nayyerehsadat Hosseini, Hamed Mirzaei and Michael R. Hamblin

    Citation: Cell Communication and Signaling 2020 18:88

    Content type: Review

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  6. Cardiac fibrosis describes the inappropriate proliferation of cardiac fibroblasts (CFs), leading to accumulation of extracellular matrix (ECM) proteins in the cardiac muscle, which is found in many pathophysio...

    Authors: Fatemeh Yousefi, Zahra Shabaninejad, Sina Vakili, Maryam Derakhshan, Ahmad Movahedpour, Hamed Dabiri, Younes Ghasemi, Maryam Mahjoubin-Tehran, Azin Nikoozadeh, Amir Savardashtaki, Hamed Mirzaei and Michael R. Hamblin

    Citation: Cell Communication and Signaling 2020 18:87

    Content type: Review

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  7. Protease-activated receptor 4 (PAR4) is a seven transmembrane G-protein coupled receptor (GPCR) activated by endogenous proteases, such as thrombin. PAR4 is involved in various pathophysiologies including canc...

    Authors: Yukeyoung Kim and Sungho Ghil

    Citation: Cell Communication and Signaling 2020 18:86

    Content type: Research

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  8. Metastasis-associated in colon cancer 1 (MACC1) is an established marker for metastasis and tumor cell migration in a multitude of tumor entities, including glioblastoma (GBM). Nevertheless, the mechanism underly...

    Authors: Tim Hohmann, Urszula Hohmann, Marc R. Kolbe, Mathias Dahlmann, Dennis Kobelt, Ulrike Stein and Faramarz Dehghani

    Citation: Cell Communication and Signaling 2020 18:85

    Content type: Research

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  9. We previously identified PIWIL1 as an oncogene involved in endometrial carcinogenesis. However, the mechanism of Piwil1 mediated regulation of tumorigenesis remains poorly understood.

    Authors: Zheng Chen, Hua-Jing Yang, Qin Lin, Min-Jiao Zhu, Ying-Ying Yu, Xiao-Ying He and Xiao-Ping Wan

    Citation: Cell Communication and Signaling 2020 18:84

    Content type: Research

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  10. Thyroid cancer is the most common sort of endocrine-related cancer with more prevalent in women and elderly individuals which has quickly widespread expansion in worldwide over the recent decades. Common featu...

    Authors: Shabnam Heydarzadeh, Ali Asghar Moshtaghie, Maryam Daneshpoor and Mehdi Hedayati

    Citation: Cell Communication and Signaling 2020 18:83

    Content type: Review

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  11. Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of...

    Authors: Qiongyu Hao, Jaydutt V. Vadgama and Piwen Wang

    Citation: Cell Communication and Signaling 2020 18:82

    Content type: Review

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  12. Diabetes induces central nervous system damage, leading to cognitive decline. Fibroblast growth factor 1 (FGF1) has dual function of neuroprotection and normalizing hyperglycemia. To date, the precise mechanis...

    Authors: Yanqing Wu, Chengbiao Wu, Libing Ye, Beini Wang, Yuan Yuan, Yaqian Liu, Peipei Zheng, Jun Xiong, Yiyang Li, Ting Jiang, Xiaokun Li and Jian Xiao

    Citation: Cell Communication and Signaling 2020 18:81

    Content type: Research

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  13. Tubulointerstitial fibrosis represents the key underlying pathology of Chronic Kidney Disease (CKD), yet treatment options remain limited. In this study, we investigated the role of connexin43 (Cx43) hemichann...

    Authors: Gareth W. Price, Christos E. Chadjichristos, Panagiotis Kavvadas, Sydney C. W. Tang, Wai Han Yiu, Colin R. Green, Joe A. Potter, Eleftherios Siamantouras, Paul E. Squires and Claire E. Hills

    Citation: Cell Communication and Signaling 2020 18:79

    Content type: Research

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  14. Oncogenesis rewires signaling networks to confer a fitness advantage to malignant cells. For instance, the B16F0 melanoma cell model creates a cytokine sink for Interleukin-12 (IL-12) to deprive neighboring ce...

    Authors: Christina N. Byrne-Hoffman, Wentao Deng, Owen McGrath, Peng Wang, Yon Rojanasakul and David J. Klinke II

    Citation: Cell Communication and Signaling 2020 18:78

    Content type: Research

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  15. Ability to adapt to temperature changes trough the Heat Shock Response (HSR) pathways is one of the most fundamental and clinically relevant cellular response systems. Heat Shock (HS) affects the signalling an...

    Authors: Anna Paszek, Małgorzata Kardyńska, James Bagnall, Jarosław Śmieja, David G. Spiller, Piotr Widłak, Marek Kimmel, Wieslawa Widlak and Pawel Paszek

    Citation: Cell Communication and Signaling 2020 18:77

    Content type: Research

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  16. The epithelial isoform of the fibroblast growth factor receptor 2 (FGFR2b) controls the entire program of keratinocyte differentiation via the sequential involvement of protein kinase C (PKC) δ and PKCα. In co...

    Authors: Danilo Ranieri, Monica Nanni, Flavia Persechino, Maria Rosaria Torrisi and Francesca Belleudi

    Citation: Cell Communication and Signaling 2020 18:76

    Content type: Research

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  17. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Yi-Fan Shen, Jing-Huan Huang, Kai-Yang Wang, Jin Zheng, Lin Cai, Hong Gao, Xiao-Lin Li and Jing-Feng Li

    Citation: Cell Communication and Signaling 2020 18:75

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2020 18:40

  18. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv and Hua-Ping Liang

    Citation: Cell Communication and Signaling 2020 18:74

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2020 18:70

  19. The crosstalk between trophoblast cells and decidual NK cells plays an important role in the establishment and maintenance of normal pregnancy. Recent studies reported that autophagy can induce immune toleranc...

    Authors: Hai-Xia Tan, Shao-Liang Yang, Ming-Qing Li and Hai-Yan Wang

    Citation: Cell Communication and Signaling 2020 18:73

    Content type: Research

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  20. Protein neddylation plays a tumor-promoting role in esophageal cancer. Our previous study demonstrated that neddylation inhibition induced the accumulation of ATF4 to promote apoptosis in esophageal cancer cel...

    Authors: Yupei Liang, Yanyu Jiang, Xing Jin, Ping Chen, Yongqing Heng, Lili Cai, Wenjuan Zhang, Lihui Li and Lijun Jia

    Citation: Cell Communication and Signaling 2020 18:72

    Content type: Research

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  21. Efferocytosis is a physiologic phagocytic clearance of apoptotic cells, which modulates inflammatory responses and the immune environment and subsequently facilitates immune escape of cancer cells, thus promot...

    Authors: Yunxiang Zhou, Yihan Yao, Yongchuan Deng and Anwen Shao

    Citation: Cell Communication and Signaling 2020 18:71

    Content type: Review

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  22. The hydroxylase cytochrome P450 1A1 (CYP1A1) is regulated by the inflammation-limiting aryl hydrocarbon receptor (AhR), but CYP1A1 immune functions remain unclear. We observed CYP1A1 overexpression in peritone...

    Authors: Li-Xing Tian, Xin Tang, Jun-Yu Zhu, Li Luo, Xiao-Yuan Ma, Shao-Wen Cheng, Wei Zhang, Wan-Qi Tang, Wei Ma, Xue Yang, Chuan-Zhu Lv and Hua-Ping Liang

    Citation: Cell Communication and Signaling 2020 18:70

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2020 18:74

  23. Fibroblast growth factors (FGFs) via their receptors (FGFRs) transduce signals from the extracellular space to the cell interior, modulating pivotal cellular processes such as cell proliferation, motility, met...

    Authors: Martyna Sochacka, Lukasz Opalinski, Jakub Szymczyk, Marta B. Zimoch, Aleksandra Czyrek, Daniel Krowarsch, Jacek Otlewski and Malgorzata Zakrzewska

    Citation: Cell Communication and Signaling 2020 18:69

    Content type: Short report

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  24. Neurotensin, originally isolated in 1973 has both endocrine and neuromodulator activity and acts through its three main receptors. Their role in promoting tumour cell proliferation, migration, DNA synthesis ha...

    Authors: Stella Nikolaou, Shengyang Qiu, Francesca Fiorentino, Constantinos Simillis, Shahnawaz Rasheed, Paris Tekkis and Christos Kontovounisios

    Citation: Cell Communication and Signaling 2020 18:68

    Content type: Review

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  25. Increasing evidence has revealed a close correlation between cancerous inhibitor of protein phosphatase 2A (CIP2A) and cancer progression. CIP2A has been shown to participate in diverse biological processes, s...

    Authors: Wei Chen, Jing-Lin Liang, Kai Zhou, Qing-Li Zeng, Jun-Wen Ye and Mei-Jin Huang

    Citation: Cell Communication and Signaling 2020 18:67

    Content type: Research

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  26. Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not been fully elucidated, and the serious adverse events...

    Authors: Wen-Ling Dai, Bing Yan, Yi-Ni Bao, Ji-Fa Fan and Ji-Hua Liu

    Citation: Cell Communication and Signaling 2020 18:66

    Content type: Research

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  27. Neuroblastoma (NB) is a childhood neural crest tumor. There are two groups of aggressive NBs, one with MYCN amplification, and another with 11q chromosomal deletion; these chromosomal aberrations are generally mu...

    Authors: Simon Keane, Sophie Améen, Angelica Lindlöf and Katarina Ejeskär

    Citation: Cell Communication and Signaling 2020 18:65

    Content type: Research

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  28. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Nishant P. Visavadiya, Matthew P. Keasey, Vladislav Razskazovskiy, Kalpita Banerjee, Cuihong Jia, Chiharu Lovins, Gary L. Wright and Theo Hagg

    Citation: Cell Communication and Signaling 2020 18:64

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2016 14:32

  29. Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces s...

    Authors: Yunxiang Zhou, Anwen Shao, Yihan Yao, Sheng Tu, Yongchuan Deng and Jianmin Zhang

    Citation: Cell Communication and Signaling 2020 18:62

    Content type: Review

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  30. Cutaneous squamous cell carcinomas (cSCC) are the primary cause of premature deaths in patients suffering from the rare skin-fragility disorder recessive dystrophic epidermolysis bullosa (RDEB), which is in ma...

    Authors: Monika Wimmer, Roland Zauner, Michael Ablinger, Josefina Piñón-Hofbauer, Christina Guttmann-Gruber, Manuela Reisenberger, Thomas Lettner, Norbert Niklas, Johannes Proell, Mila Sajinovic, Paul De Souza, Stefan Hainzl, Thomas Kocher, Eva M. Murauer, Johann W. Bauer, Dirk Strunk…

    Citation: Cell Communication and Signaling 2020 18:61

    Content type: Research

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  31. Adiponectin, an adipokine produced and secreted by adipocytes, is involved in regulating the development and progression of insulin resistance, diabetes, and diabetic complications. Heat shock protein 60 (HSP6...

    Authors: Deling Zhang, Hua Liu, Yemin Zhang, Junfeng Li, Yalin Fu, Yuyang Zheng, Jie Wu, Mingke Ma, Zhongyuan Wen and Changhua Wang

    Citation: Cell Communication and Signaling 2020 18:60

    Content type: Short report

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  32. The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogen...

    Authors: Roghayyeh Baghban, Leila Roshangar, Rana Jahanban-Esfahlan, Khaled Seidi, Abbas Ebrahimi-Kalan, Mehdi Jaymand, Saeed Kolahian, Tahereh Javaheri and Peyman Zare

    Citation: Cell Communication and Signaling 2020 18:59

    Content type: Review

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  33. Magnolia extract (ME) is known to inhibit cancer growth and metastasis in several cell types in vitro and in animal models. However, there is no detailed study on the preventive efficacy of ME for oral cancer,...

    Authors: Qi Zhang, Gang Cheng, Jing Pan, Jacek Zielonka, Donghai Xiong, Charles R. Myers, Liang Feng, Song Seok Shin, Young Heui Kim, Dinh Bui, Ming Hu, Brian Bennett, Kathleen Schmainda, Yian Wang, Balaraman Kalyanaraman and Ming You

    Citation: Cell Communication and Signaling 2020 18:58

    Content type: Research

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  34. Chronic brain hypoperfusion (CBH) is closely related to Alzheimer’s disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, w...

    Authors: Mei-Ling Yan, Shuai Zhang, Hong-Mei Zhao, Sheng-Nan Xia, Zhuo Jin, Yi Xu, Lin Yang, Yang Qu, Si-Yu Huang, Ming-Jing Duan, Meng Mao, Xiao-Bin An, Chandan Mishra, Xin-Yu Zhang, Li-Hua Sun and Jing Ai

    Citation: Cell Communication and Signaling 2020 18:57

    Content type: Research

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  35. AKT2 is one of the key molecules that involves in the insulin-induced signaling and the development of cancer. In B cells, the function of AKT2 is unclear.

    Authors: Zuochen Du, Di Yang, Yongjie Zhang, Xingtian Xuan, Han Li, Leling Hu, Changshun Ruan, Liling Li, Anwei Chen, Liang Deng, Yan Chen, Jingwen Xie, Lisa S. Westerberg, Lu Huang and Chaohong Liu

    Citation: Cell Communication and Signaling 2020 18:56

    Content type: Research

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  36. IDH2/R140Q mutation is frequently detected in acute myeloid leukemia (AML). It contributes to leukemia via accumulation of oncometabolite D-2-HG. Therefore, mutant IDH2 is a promising target for AML. Discovery...

    Authors: Jiao Chen, Jie Yang, Qingyun Wei, Ling Weng, Fei Wu, Yun Shi, Xiaolan Cheng, Xueting Cai, Chunping Hu and Peng Cao

    Citation: Cell Communication and Signaling 2020 18:55

    Content type: Research

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  37. The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to HH activation, GLI3-FL re...

    Authors: Stephan J. Matissek and Sherine F. Elsawa

    Citation: Cell Communication and Signaling 2020 18:54

    Content type: Review

    Published on:

  38. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ting Sun, Wei Yang, Sneh M. Toprani, Wei Guo, Lile He, Albert B. DeLeo, Soldano Ferrone, Gong Zhang, Enwen Wang, Zunwen Lin, Pan Hu and Xinhui Wang

    Citation: Cell Communication and Signaling 2020 18:53

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2020 18:36

  39. Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. The current study aimed to elucidate the mechanism by which exosomes carrying KRAS mutant contribute to neutrophil recruitment...

    Authors: Anquan Shang, Chenzheng Gu, Chen Zhou, Yibao Yang, Chen Chen, Bingjie Zeng, Junlu Wu, Wenying Lu, Weiwei Wang, Zujun Sun and Dong Li

    Citation: Cell Communication and Signaling 2020 18:52

    Content type: Research

    Published on:

  40. Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a is mainly expressed in the tumor stroma, especially ...

    Authors: Qing Liu, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chen Wei, Jialin Song, Xiaobin Lin, Rongzhang Dou, Jian Bai, Zhenxian Xiang, Sihao Huang, Keshu Liu and Bin Xiong

    Citation: Cell Communication and Signaling 2020 18:51

    Content type: Research

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  41. Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and ma...

    Authors: Jie Wan, Yinqiu Wu, Xiaoyun Ji, Lan Huang, Wei Cai, Zhaoliang Su, Shengjun Wang and Huaxi Xu

    Citation: Cell Communication and Signaling 2020 18:50

    Content type: Review

    Published on:

  42. A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and i...

    Authors: Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl and Annette G. Beck-Sickinger

    Citation: Cell Communication and Signaling 2020 18:49

    Content type: Research

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  43. Recent findings suggested that premetastatic niche (PMN) is a prerequisite in mediating cancer metastasis. Previously we demonstrated that XIAOPI formula could inhibit breast cancer lung metastasis via inhibit...

    Authors: Yifeng Zheng, Neng Wang, Shengqi Wang, Bowen Yang, Honglin Situ, Lidan Zhong, Yi Lin and Zhiyu Wang

    Citation: Cell Communication and Signaling 2020 18:48

    Content type: Research

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  44. Excessive dietary fat intake induces lipid deposition and contributes to the progress of nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanisms are still unclear.

    Authors: Kun Wu, Tao Zhao, Christer Hogstrand, Yi-Chuang Xu, Shi-Cheng Ling, Guang-Hui Chen and Zhi Luo

    Citation: Cell Communication and Signaling 2020 18:47

    Content type: Research

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  45. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is a highly vascularized solid tumor. Angiopoietin-2 (ANGPT2) has been described as an attractive target for antiangiogenic therapy. E...

    Authors: Ji-yan Xie, Jin-xing Wei, Li-hong Lv, Qing-fang Han, Wei-bang Yang, Guo-lin Li, Pan-xia Wang, Shao-bin Wu, Jin-xin Duan, Wen-feng Zhuo, Pei-qing Liu and Jun Min

    Citation: Cell Communication and Signaling 2020 18:46

    Content type: Research

    Published on:

  46. Rapamycin is known to be effective in suppressing senescence and the senescence-associated secretory phenotype (SASP). Therefore, it is highly expected to represent an anti-aging drug. Its anti-aging effect ha...

    Authors: Norihiko Sasaki, Yoko Itakura and Masashi Toyoda

    Citation: Cell Communication and Signaling 2020 18:43

    Content type: Research

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  47. Na+/Ca2+ exchanger isoform 3 (NCX3) regulates mitochondrial Ca2+ handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD). Conversely, Sev...

    Authors: Maria Josè Sisalli, Gaetano Ianniello, Claudia Savoia, Ornella Cuomo, Lucio Annunziato and Antonella Scorziello

    Citation: Cell Communication and Signaling 2020 18:42

    Content type: Research

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