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  1. Anti-nerve growth factor (NGF) monoclonal antibodies (anti-NGF mAbs) have been reported to significantly attenuate pain, but the mechanism involved has not been fully elucidated, and the serious adverse events...

    Authors: Wen-Ling Dai, Bing Yan, Yi-Ni Bao, Ji-Fa Fan and Ji-Hua Liu
    Citation: Cell Communication and Signaling 2020 18:66
    Content type: Research Published on:

  3. Traumatic brain injury (TBI) is one of the leading causes of fatality and disability worldwide. Despite its high prevalence, effective treatment strategies for TBI are limited. Traumatic brain injury induces s...

    Authors: Yunxiang Zhou, Anwen Shao, Yihan Yao, Sheng Tu, Yongchuan Deng and Jianmin Zhang
    Citation: Cell Communication and Signaling 2020 18:62
    Content type: Review Published on:

  4. Cutaneous squamous cell carcinomas (cSCC) are the primary cause of premature deaths in patients suffering from the rare skin-fragility disorder recessive dystrophic epidermolysis bullosa (RDEB), which is in ma...

    Authors: Monika Wimmer, Roland Zauner, Michael Ablinger, Josefina Piñón-Hofbauer, Christina Guttmann-Gruber, Manuela Reisenberger, Thomas Lettner, Norbert Niklas, Johannes Proell, Mila Sajinovic, Paul De Souza, Stefan Hainzl, Thomas Kocher, Eva M. Murauer, Johann W. Bauer, Dirk Strunk…
    Citation: Cell Communication and Signaling 2020 18:61
    Content type: Research Published on:

  5. Adiponectin, an adipokine produced and secreted by adipocytes, is involved in regulating the development and progression of insulin resistance, diabetes, and diabetic complications. Heat shock protein 60 (HSP6...

    Authors: Deling Zhang, Hua Liu, Yemin Zhang, Junfeng Li, Yalin Fu, Yuyang Zheng, Jie Wu, Mingke Ma, Zhongyuan Wen and Changhua Wang
    Citation: Cell Communication and Signaling 2020 18:60
    Content type: Short report Published on:

  6. The dynamic interactions of cancer cells with their microenvironment consisting of stromal cells (cellular part) and extracellular matrix (ECM) components (non-cellular) is essential to stimulate the heterogen...

    Authors: Roghayyeh Baghban, Leila Roshangar, Rana Jahanban-Esfahlan, Khaled Seidi, Abbas Ebrahimi-Kalan, Mehdi Jaymand, Saeed Kolahian, Tahereh Javaheri and Peyman Zare
    Citation: Cell Communication and Signaling 2020 18:59
    Content type: Review Published on:

  7. Magnolia extract (ME) is known to inhibit cancer growth and metastasis in several cell types in vitro and in animal models. However, there is no detailed study on the preventive efficacy of ME for oral cancer,...

    Authors: Qi Zhang, Gang Cheng, Jing Pan, Jacek Zielonka, Donghai Xiong, Charles R. Myers, Liang Feng, Song Seok Shin, Young Heui Kim, Dinh Bui, Ming Hu, Brian Bennett, Kathleen Schmainda, Yian Wang, Balaraman Kalyanaraman and Ming You
    Citation: Cell Communication and Signaling 2020 18:58
    Content type: Research Published on:

  8. Chronic brain hypoperfusion (CBH) is closely related to Alzheimer’s disease (AD) and vascular dementia (VaD). Meanwhile, synaptic pathology plays a prominent role in the initial stage of AD and VaD. However, w...

    Authors: Mei-Ling Yan, Shuai Zhang, Hong-Mei Zhao, Sheng-Nan Xia, Zhuo Jin, Yi Xu, Lin Yang, Yang Qu, Si-Yu Huang, Ming-Jing Duan, Meng Mao, Xiao-Bin An, Chandan Mishra, Xin-Yu Zhang, Li-Hua Sun and Jing Ai
    Citation: Cell Communication and Signaling 2020 18:57
    Content type: Research Published on:

  9. AKT2 is one of the key molecules that involves in the insulin-induced signaling and the development of cancer. In B cells, the function of AKT2 is unclear.

    Authors: Zuochen Du, Di Yang, Yongjie Zhang, Xingtian Xuan, Han Li, Leling Hu, Changshun Ruan, Liling Li, Anwei Chen, Liang Deng, Yan Chen, Jingwen Xie, Lisa S. Westerberg, Lu Huang and Chaohong Liu
    Citation: Cell Communication and Signaling 2020 18:56
    Content type: Research Published on:

  10. IDH2/R140Q mutation is frequently detected in acute myeloid leukemia (AML). It contributes to leukemia via accumulation of oncometabolite D-2-HG. Therefore, mutant IDH2 is a promising target for AML. Discovery...

    Authors: Jiao Chen, Jie Yang, Qingyun Wei, Ling Weng, Fei Wu, Yun Shi, Xiaolan Cheng, Xueting Cai, Chunping Hu and Peng Cao
    Citation: Cell Communication and Signaling 2020 18:55
    Content type: Research Published on:

  11. The transcription factor GLI3 is a member of the Hedgehog (Hh/HH) signaling pathway that can exist as a full length (Gli3-FL/GLI3-FL) or repressor (Gli3-R/GLI3-R) form. In response to HH activation, GLI3-FL re...

    Authors: Stephan J. Matissek and Sherine F. Elsawa
    Citation: Cell Communication and Signaling 2020 18:54
    Content type: Review Published on:

  12. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Ting Sun, Wei Yang, Sneh M. Toprani, Wei Guo, Lile He, Albert B. DeLeo, Soldano Ferrone, Gong Zhang, Enwen Wang, Zunwen Lin, Pan Hu and Xinhui Wang
    Citation: Cell Communication and Signaling 2020 18:53
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2020 18:36

  13. Colorectal cancer (CRC) remains one of the leading causes of cancer-related death. The current study aimed to elucidate the mechanism by which exosomes carrying KRAS mutant contribute to neutrophil recruitment...

    Authors: Anquan Shang, Chenzheng Gu, Chen Zhou, Yibao Yang, Chen Chen, Bingjie Zeng, Junlu Wu, Wenying Lu, Weiwei Wang, Zujun Sun and Dong Li
    Citation: Cell Communication and Signaling 2020 18:52
    Content type: Research Published on:

  14. Tumor-associated macrophages (TAMs) in the tumor microenvironment influence tumor initiation, invasion and metastasis. Several studies have shown that Wnt5a is mainly expressed in the tumor stroma, especially ...

    Authors: Qing Liu, Chaogang Yang, Shuyi Wang, Dongdong Shi, Chen Wei, Jialin Song, Xiaobin Lin, Rongzhang Dou, Jian Bai, Zhenxian Xiang, Sihao Huang, Keshu Liu and Bin Xiong
    Citation: Cell Communication and Signaling 2020 18:51
    Content type: Research Published on:

  15. Interleukin (IL)-9 belongs to the IL-2Rγc chain family and is a multifunctional cytokine that can regulate the function of many kinds of cells. It was originally identified as a growth factor of T cells and ma...

    Authors: Jie Wan, Yinqiu Wu, Xiaoyun Ji, Lan Huang, Wei Cai, Zhaoliang Su, Shengjun Wang and Huaxi Xu
    Citation: Cell Communication and Signaling 2020 18:50
    Content type: Review Published on:

  16. A sensitive balance between receptor activation and desensitization is crucial for cellular homeostasis. Like many other GPCR, the human neuropeptide Y2 receptor (hY2R) undergoes ligand dependent activation and i...

    Authors: Isabelle Ziffert, Anette Kaiser, Stefanie Babilon, Karin Mörl and Annette G. Beck-Sickinger
    Citation: Cell Communication and Signaling 2020 18:49
    Content type: Research Published on:

  17. Recent findings suggested that premetastatic niche (PMN) is a prerequisite in mediating cancer metastasis. Previously we demonstrated that XIAOPI formula could inhibit breast cancer lung metastasis via inhibit...

    Authors: Yifeng Zheng, Neng Wang, Shengqi Wang, Bowen Yang, Honglin Situ, Lidan Zhong, Yi Lin and Zhiyu Wang
    Citation: Cell Communication and Signaling 2020 18:48
    Content type: Research Published on:

  18. Excessive dietary fat intake induces lipid deposition and contributes to the progress of nonalcoholic fatty liver disease (NAFLD). However, the underlying mechanisms are still unclear.

    Authors: Kun Wu, Tao Zhao, Christer Hogstrand, Yi-Chuang Xu, Shi-Cheng Ling, Guang-Hui Chen and Zhi Luo
    Citation: Cell Communication and Signaling 2020 18:47
    Content type: Research Published on:

  19. Hepatocellular carcinoma (HCC) is the most common primary liver cancer and is a highly vascularized solid tumor. Angiopoietin-2 (ANGPT2) has been described as an attractive target for antiangiogenic therapy. E...

    Authors: Ji-yan Xie, Jin-xing Wei, Li-hong Lv, Qing-fang Han, Wei-bang Yang, Guo-lin Li, Pan-xia Wang, Shao-bin Wu, Jin-xin Duan, Wen-feng Zhuo, Pei-qing Liu and Jun Min
    Citation: Cell Communication and Signaling 2020 18:46
    Content type: Research Published on:

  21. Sialic acids are widely distributed in animal tissues, and aberrantly expressed in a variety of cancer types. High expression of sialic acid contributes to tumor aggressiveness by promoting cell proliferation,...

    Authors: Xiaoman Zhou, Yanhong Zhai, Changmei Liu, Ganglong Yang, Jia Guo, Guang Li, Chengwen Sun, Xiaowei Qi, Xiang Li and Feng Guan
    Citation: Cell Communication and Signaling 2020 18:44
    Content type: Research Published on:

  22. Rapamycin is known to be effective in suppressing senescence and the senescence-associated secretory phenotype (SASP). Therefore, it is highly expected to represent an anti-aging drug. Its anti-aging effect ha...

    Authors: Norihiko Sasaki, Yoko Itakura and Masashi Toyoda
    Citation: Cell Communication and Signaling 2020 18:43
    Content type: Research Published on:

  23. Na+/Ca2+ exchanger isoform 3 (NCX3) regulates mitochondrial Ca2+ handling through the outer mitochondrial membrane (OMM) and promotes neuronal survival during oxygen and glucose deprivation (OGD). Conversely, Sev...

    Authors: Maria Josè Sisalli, Gaetano Ianniello, Claudia Savoia, Ornella Cuomo, Lucio Annunziato and Antonella Scorziello
    Citation: Cell Communication and Signaling 2020 18:42
    Content type: Research Published on:

  24. Phosphatidylserine (PS) is an anionic phospholipid found on the membranes of a variety of organelles throughout the cell, most notably the plasma membrane. Under homeostatic conditions, PS is typically restric...

    Authors: David C. Calianese and Raymond B. Birge
    Citation: Cell Communication and Signaling 2020 18:41
    Content type: Editorial Published on:

  25. Diabetic wounds are a disturbing and rapidly growing clinical problem. A novel peptide, parathyroid hormone related peptide (PTHrP-2), is assumed as multifunctional factor in angiogenesis, fibrogenesis and re-...

    Authors: Yi-Fan Shen, Jing-Huan Huang, Kai-Yang Wang, Jin Zheng, Lin Cai, Hong Gao, Xiao-Lin Li and Jing-Feng Li
    Citation: Cell Communication and Signaling 2020 18:40
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2020 18:75

  26. The (pro) renin receptor ((P)RR) plays important roles in various pathways, such as the Wnt/β-catenin, renin-angiotensin system (RAS), MAPK/ERK and PI3K/AKT/mTOR pathways, that are involved in a wide range of ...

    Authors: Juan Wang, Akira Nishiyama, Makoto Matsuyama, Zhiyu Wang and Ying Yuan
    Citation: Cell Communication and Signaling 2020 18:39
    Content type: Review Published on:

  27. Cancer stem cells (CSCs), the major driver of tumorigenesis, is a sub-population of tumor cells responsible for poor clinical outcomes. However, molecular mechanism to identify targets for controlling CSCs is ...

    Authors: Yong-Hee Cho, Eun Ji Ro, Jeong-Su Yoon, Dong-Kyu Kwak, Jaebeom Cho, Dong Woo Kang, Ho-Young Lee and Kang-Yell Choi
    Citation: Cell Communication and Signaling 2020 18:38
    Content type: Research Published on:

  28. This investigation was arranged to elucidate whether single nucleotide polymorphisms (SNPs) of lncRNA UCA1 was implicated in elevating colorectal cancer (CRC) risk by interacting with environmental exposures.

    Authors: Yang Fu, Yizheng Zhang, Jinyuan Cui, Ge Yang, Sanfei Peng, Wunan Mi, Xiangya Yin, Yang Yu, Jianwu Jiang, Qi Liu, Yiyu Qin and Wen Xu
    Citation: Cell Communication and Signaling 2020 18:37
    Content type: Research Published on:

  29. The current successful clinical use of agents promoting robust anti-tumor immunity in cancer patients warrants noting that radiation therapy (RT) induces immunogenic cell death (ICD) of tumor cells, which can ...

    Authors: Ting Sun, Wei Yang, Sneh M. Toprani, Wei Guo, Lile He, Albert B. DeLeo, Soldano Ferrone, Gong Zhang, Enwen Wang, Zunwen Lin, Pan Hu and Xinhui Wang
    Citation: Cell Communication and Signaling 2020 18:36
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2020 18:53

  30. Chitinase 3 like 1 protein (Chi3L1) is expressed in several cancers, and a few evidences suggest that the secreted Chi3L1 contributes to tumor development. However, the molecular mechanisms of intracellular Ch...

    Authors: Kyung-Ran Park, Hyung-Mun Yun, Kyeongwon Yoo, Young Wan Ham, Sang Bae Han and Jin Tae Hong
    Citation: Cell Communication and Signaling 2020 18:5
    Content type: Research Published on:

  31. Inflammation and oxidative stress induced by oxidized low density lipoprotein are the main causes of vascular endothelial injury and atherosclerosis. Endothelial cells are important for the formation and repai...

    Authors: Jianming Guo, Qiuling Xiang, Yaojie Xin, Yongyi Huang, Gang Zou and Te Liu
    Citation: Cell Communication and Signaling 2020 18:35
    Content type: Research Published on:

  32. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy and its mortality continues to rise globally. Because of its high heterogeneity and complex molecular landscapes, published gene signatures...

    Authors: Ping Wang, Chunlong Zhang, Weidong Li, Bo Zhai, Xian Jiang, Shiva Reddy, Hongchi Jiang and Xueying Sun
    Citation: Cell Communication and Signaling 2020 18:34
    Content type: Research Published on:

  33. Breast cancer has grown to be the second leading cause of cancer-related deaths in women. Only a few treatment options are available for breast cancer due to the widespread occurrence of chemoresistance, which...

    Authors: Jia-hui Ma, Li Qin and Xia Li
    Citation: Cell Communication and Signaling 2020 18:33
    Content type: Review Published on:

  34. Mimicking ischemia-reperfusion injury, oxygen and glucose deprivation (OGD)-re-oxygenation (OGDR) applied to endometrial cells produces significant oxidative stress and programmed necrosis, which can be inhibi...

    Authors: Shu-ping Li, Wei-nan Cheng, Ya Li, Hong-bin Xu, Hui Han, Ping Li and Deng-Xia Zhang
    Citation: Cell Communication and Signaling 2020 18:32
    Content type: Research Published on:

  35. Medium-chain fatty acids and their 3-hydroxy derivatives are metabolites endogenously produced in humans, food-derived or originating from bacteria. They activate G protein-coupled receptors, including GPR84 a...

    Authors: Anna Peters, Philipp Rabe, Petra Krumbholz, Hermann Kalwa, Robert Kraft, Torsten Schöneberg and Claudia Stäubert
    Citation: Cell Communication and Signaling 2020 18:31
    Content type: Research Published on:

  36. Candida albicans is the most common opportunistic human fungal pathogen. The chemokine ligand CXCL1 plays a protective role in fungal infection through the recruitment of neutrophils. TRAF1 (tumor necrosis factor...

    Authors: Wenjuan Bai, Qingqing Wang, Zihou Deng, Tiantian Li, Hui Xiao and Zhiyuan Wu
    Citation: Cell Communication and Signaling 2020 18:30
    Content type: Research Published on:

  38. Excessive light exposure is a detrimental environmental factor that plays a critical role in the pathogenesis of retinal degeneration. However, the mechanism of light-induced death of retina/photoreceptor cell...

    Authors: Yi-Ran Pan, Jing-Yao Song, Bin Fan, Ying Wang, Lin Che, Si-Ming Zhang, Yu-Xin Chang, Chang He and Guang-Yu Li
    Citation: Cell Communication and Signaling 2020 18:27
    Content type: Research Published on:

  39. The limited options to treat obesity and its complications result from an incomplete understanding of the underlying molecular mechanisms regulating white adipose tissue development, including adipocyte hypert...

    Authors: Nida Haider and Louise Larose
    Citation: Cell Communication and Signaling 2020 18:26
    Content type: Research Published on:

  40. Eukaryotic elongation factor-2 kinase (eEF2K) is a Ca 2+ /calmodulin (CaM)-dependent protein kinase that inhibits protein synthesis. However, the role of eEF2K in cancer development was reported paradoxically ...

    Authors: Min Xiao, Jianling Xie, Yu Wu, Genzhu Wang, Xin Qi, Zailiang Liu, Yuying Wang, Xuemin Wang, Ashfaqul Hoque, Jon Oakhill, Christopher G. Proud and Jing Li
    Citation: Cell Communication and Signaling 2020 18:25
    Content type: Research Published on:

  41. Nuclear translocation of several oncogenic proteins have previously been reported, but neither the translocation of doublecortin (DCX) nor the mechanism involved has been studied. DCX is a neuronal microtubule...

    Authors: Abiola Abdulrahman Ayanlaja, Guanquan Ji, Jie Wang, Yue Gao, Bo Cheng, Kouminin Kanwore, Lin Zhang, Ye Xiong, Piniel Alphayo Kambey and Dianshuai Gao
    Citation: Cell Communication and Signaling 2020 18:24
    Content type: Research Published on:

  42. Porcine circovirus type 2 (PCV2) is the causative agent of postweaning multisystemic wasting syndrome, and is associated with a number of other diseases. PCV2 is widely distributed in most developed swine indu...

    Authors: Shuai Zhang, Chunxiao Mou, Yanan Cao, En Zhang and Qian Yang
    Citation: Cell Communication and Signaling 2020 18:23
    Content type: Research Published on:

  43. Glioblastoma and Alzheimer’s disease (AD) are the most common and devastating diseases in the central nervous system. The dysfunction of Presenilin1 is the main reason for AD pathogenesis. However, the molecul...

    Authors: Wei Yang, Peng-fei Wu, Jian-xing Ma, Mao-jun Liao, Lun-shan Xu, Min-hui Xu and Liang Yi
    Citation: Cell Communication and Signaling 2020 18:22
    Content type: Methodology Published on:

  44. Glioblastoma multiforme is an aggressive primary brain tumor that is characterized by local invasive growth and resistance to therapy. The role of the microenvironment in glioblastoma invasiveness remains uncl...

    Authors: Nicholas W. Colangelo and Edouard I. Azzam
    Citation: Cell Communication and Signaling 2020 18:21
    Content type: Research Published on:

  46. Neutrophils form the first line of innate host defense against invading microorganisms. We previously showed that F0F1 ATP synthase (F-ATPase), which is widely known as mitochondrial respiratory chain complex ...

    Authors: Baoyi Zhu, Zhengfu Feng, Yan Guo, Tian Zhang, Ai Mai, Zhanfang Kang, Ting Weijen, Dai Wang, Dazhong Yin, Dongxing Zhu and Jun Gao
    Citation: Cell Communication and Signaling 2020 18:19
    Content type: Research Published on:

  47. Vascular endothelial cell alignment in the direction of flow is an adaptive response that protects against aortic diseases such as atherosclerosis. The RhoGTPases are known to regulate this alignment. We have ...

    Authors: Paul R. Coleman, Angelina J. Lay, Ka Ka Ting, Yang Zhao, Jia Li, Sorour Jarrah, Mathew A. Vadas and Jennifer R. Gamble
    Citation: Cell Communication and Signaling 2020 18:18
    Content type: Research Published on:

  48. Esophageal squamous cell cancer (ESCC) is one kind of frequent digestive tumor. The inflammatory environment plays an important role in the tumorigenesis and development of ESCC. Cancer stem cells are a small ...

    Authors: Fengkai Xu, Zhonghe Liu, Ronghua Liu, Chunlai Lu, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Kunpeng Zhang, Yin Li, Yiwei Chu, Jie Gu and Di Ge
    Citation: Cell Communication and Signaling 2020 18:17
    Content type: Research Published on:

  49. The role and mechanism of the nicotinamide adenine dinucleotide (NAD+) salvage pathway in cancer cell proliferation is poorly understood. Nicotinamide phosphoribosyltransferase (NAMPT), which converts nicotinamid...

    Authors: Chenyang Ye, Lina Qi, Xiaofen Li, Ji Wang, Jiekai Yu, Biting Zhou, Cheng Guo, Jiani Chen and Shu Zheng
    Citation: Cell Communication and Signaling 2020 18:16
    Content type: Research Published on:

  50. Triple negative breast cancer (TNBC) accounts for 16% of breast cancers and represents an aggressive subtype that lacks targeted therapeutic options. In this study, mass spectrometry (MS)-based tyrosine phosph...

    Authors: Nicole J. Chew, Elizabeth V. Nguyen, Shih-Ping Su, Karel Novy, Howard C. Chan, Lan K. Nguyen, Jennii Luu, Kaylene J. Simpson, Rachel S. Lee and Roger J. Daly
    Citation: Cell Communication and Signaling 2020 18:13
    Content type: Research Published on:
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