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  1. How high-salt intake leads to the occurrence of many cardiovascular diseases such as atherosclerosis is a fundamental question in pathology. Here we postulated that high-salt-induced NFAT5 controls the inflamm...

    Authors: Pingping Ma, Shenfang Zha, Xinkun Shen, Yulan Zhao, Li Li, Li Yang, Mingxing Lei and Wanqian Liu

    Citation: Cell Communication and Signaling 2019 17:102

    Content type: Research

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  2. Previously sharpin has been identified as an endogenous inhibitor of β1-integrin activation by directly binding to a conserved region in the cytoplasmic tails (CTs) of the integrin β1-associated α subunits.

    Authors: Juan Gao, Yun Bao, Shushu Ge, Peisen Sun, Jiaojiao Sun, Jianmin Liu, Feng Chen, Li Han, Zhongyuan Cao, Jun Qin, Gilbert C. White, Zhen Xu and Yan-Qing Ma

    Citation: Cell Communication and Signaling 2019 17:101

    Content type: Research

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  3. Excessive estrogen exposure is an important pathogenic factor in uterine endometrial cancer (UEC). Recent studies have reported the metabolic propertie...

    Authors: Wen-Jie Zhou, Jie Zhang, Hui-Li Yang, Ke Wu, Feng Xie, Jiang-Nan Wu, Yan Wang, Li Yao, Yan Zhuang, Jiang-Dong Xiang, Ai-Jun Zhang, Yin-Yan He and Ming-Qing Li

    Citation: Cell Communication and Signaling 2019 17:99

    Content type: Research

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  4. Autophagy is a macromolecular degradation process playing a pivotal role in the maintenance of stem-like features and in the morpho-functional remodeling of the tissues undergoing differentiation. In this work...

    Authors: Chiara Vidoni, Alessandra Ferraresi, Eleonora Secomandi, Letizia Vallino, Chiara Gardin, Barbara Zavan, Carmen Mortellaro and Ciro Isidoro

    Citation: Cell Communication and Signaling 2019 17:98

    Content type: Research

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  5. Osteoarthritis (OA) is the most common joint disease worldwide and a leading cause of disability. Characterized by degradation of articular cartilage, synovial inflammation, and changes in periarticular and su...

    Authors: Yudan Wang, Xinhao Fan, Lei Xing and Faming Tian

    Citation: Cell Communication and Signaling 2019 17:97

    Content type: Review

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  6. Neural stem/progenitor cells (NPCs) are known to have potent therapeutic effects in neurological disorders through secreting exosomes. The limited numbers of NPCs in adult brain and the decline of NPC pool in ...

    Authors: Yizhao Ma, Chunhong Li, Yunlong Huang, Yi Wang, Xiaohuan Xia and Jialin C. Zheng

    Citation: Cell Communication and Signaling 2019 17:96

    Content type: Short report

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  7. Extracellular vesicles (EVs) play important roles in intercellular communication by delivering RNA, lipid, and proteins to neighboring or distant cells. Identification and classification of EVs secreted from d...

    Authors: Sang-Soo Lee, Jong-Hoon Won, Gippeum J. Lim, Jeongran Han, Ji Youn Lee, Kyung-Ok Cho and Young-Kyung Bae

    Citation: Cell Communication and Signaling 2019 17:95

    Content type: Research

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  8. Increased human endogenous retroviruses E clone 4–1 (HERV-E clone 4–1) mRNA expression is observed in systemic lupus erythematosus (SLE) patients and associates with the disease activity. In this study, we wan...

    Authors: Xin Wang, Chaoshuai Zhao, Chengzhong Zhang, Xingyu Mei, Jun Song, Yue Sun, Zhouwei Wu and Weimin Shi

    Citation: Cell Communication and Signaling 2019 17:94

    Content type: Research

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  9. Breast cancer is the leading cause of cancer death in women worldwide which is closely related to metastasis. But the exact molecular mechanism of ERα-36 and STAT3 on metastasis is still not fully understood.

    Authors: Yuan Xiang, Jia Peng Li, Wei Guo, Dan-Qun Wang, Ao Yao, Hui-Min Zhang, Feng Huang, Han-Han Li, Zhou-Tong Dai, Zi-Jiang Zhang, Hui Li, Yao Tan, Kun Chen, Le-Yuan Bao and Xing-Hua Liao

    Citation: Cell Communication and Signaling 2019 17:93

    Content type: Research

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  10. This study aimed to confirm that blocking RasGRP4 can effectively slow down the growth of DLBCL both in vitro and in vivo and ascertain the role of RasGRP4 in the prognosis of DLBCL clinically.

    Authors: Lin Zhu, Chunyan Xia, Lin Wu, Yuxuan Zhang, Junling Liu, Yinan Chen, Jing Liu, Yongxin Xiao, Kai Nie, Liyu Huang, Ning Qu and Hong Yu

    Citation: Cell Communication and Signaling 2019 17:92

    Content type: Research

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  11. Protein phosphorylation & dephosphorylation are ubiquitous cellular processes that allow for the nuanced and reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a multifunction phosphat...

    Authors: Xiujuan Zhu, Yuhong Ye, Chengxian Xu, Cunji Gao, Yingying Zhang, Jing Zhou, Weiqiang Lin and Jianhua Mao

    Citation: Cell Communication and Signaling 2019 17:91

    Content type: Research

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  12. Binding of tumor necrosis factor (TNF) to TNF-receptor 1 (TNF-R1) can induce either cell survival or cell death. The selection between these diametrically opposed effects depends on the subcellular location of...

    Authors: Philipp Zingler, Vinzenz Särchen, Timo Glatter, Lotta Caning, Carina Saggau, Rahul S. Kathayat, Bryan C. Dickinson, Dieter Adam, Wulf Schneider-Brachert, Stefan Schütze and Jürgen Fritsch

    Citation: Cell Communication and Signaling 2019 17:90

    Content type: Research

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  13. Escape from immune control must be important in the natural course of B-cell lymphomas, especially for those with activation of NF-κB. The pre-clinical LMP1/CD40-expressing transgenic mouse model is characteri...

    Authors: Christelle Vincent-Fabert, Lilian Roland, Ursula Zimber-Strobl, Jean Feuillard and Nathalie Faumont

    Citation: Cell Communication and Signaling 2019 17:89

    Content type: Research

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  14. Stabilization of RAS is a key event for the hyper-activation of Wnt/β-catenin signaling and activation of cancer stem cell (CSC) in colorectal cancer (CRC). WD Repeat protein 76 (WDR76) mediates the polyubiqui...

    Authors: Eun Ji Ro, Yong-Hee Cho, Woo-Jeong Jeong, Jong-Chan Park, Do Sik Min and Kang-Yell Choi

    Citation: Cell Communication and Signaling 2019 17:88

    Content type: Research

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  15. The understanding of lysosomes has been expanded in recent research way beyond their view as cellular trash can. Lysosomes are pivotal in regulating metabolism, endocytosis and autophagy and are implicated in ...

    Authors: Karin Bartel, Helmut Pein, Bastian Popper, Sabine Schmitt, Sudha Janaki-Raman, Almut Schulze, Florian Lengauer, Andreas Koeberle, Oliver Werz, Hans Zischka, Rolf Müller, Angelika M. Vollmar and Karin von Schwarzenberg

    Citation: Cell Communication and Signaling 2019 17:87

    Content type: Research

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  16. To clarify the effects of cylcin E1 expression on HCC tumor progression, we studied the expression of cyclin E1 and inhibitory efficacy of regorafenib and sorafenib in HCC cells, and investigated a potential t...

    Authors: Jianliang Xu, Fei Huang, Zhicheng Yao, Changchang Jia, Zhiyong Xiong, Hao Liang, Nan Lin and Meihai Deng

    Citation: Cell Communication and Signaling 2019 17:85

    Content type: Research

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  17. miR-449a, an intronic miRNA, is highly down-regulated in the skeletal muscle during diabetes. Its levels are epigenetically regulated by altered acetylation/deacetylation on the promoter that it shares with it...

    Authors: Shagun Poddar, Devesh Kesharwani and Malabika Datta

    Citation: Cell Communication and Signaling 2019 17:84

    Content type: Research

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  18. Growth factors, such as EGF, activate the PI3K/Akt/mTORC1 signalling pathway, which regulates a distinct program of protein synthesis leading to cell growth. This pathway relies on mTORC1 sensing sufficient le...

    Authors: Blake K. Zhang, Anne M. Moran, Charles G. Bailey, John E. J. Rasko, Jeff Holst and Qian Wang

    Citation: Cell Communication and Signaling 2019 17:83

    Content type: Research

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  19. The SUMO-activating enzyme SAE1 is indispensable for protein SUMOylation. A dysregulation of SAE1 expression involves in progression of several human cancers. However, its biological roles of SAE1 in glioma ar...

    Authors: Yanfang Yang, Ziwei Liang, Zijing Xia, Xixi Wang, Yanni Ma, Zenghua Sheng, Qingjia Gu, Guobo Shen, Liangxue Zhou, Hongxia Zhu, Ningzhi Xu and Shufang Liang

    Citation: Cell Communication and Signaling 2019 17:82

    Content type: Research

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  20. Inflammatory reaction in the dysfunction of retinal endotheliocytes has been considered to play a vital role in diabetic retinopathy (DR). Anti-inflammatory therapy so far gains poor outcome as DR treatment. T...

    Authors: Ning Wang, Cheng Zhang, Yu Xu, Sha Li, Hor-Yue Tan, Wen Xia and Yibin Feng

    Citation: Cell Communication and Signaling 2019 17:81

    Content type: Research

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  21. Expression of CD44 receptor is associated with the onset of several tumors. The intracellular domain of CD44 (CD44-ICD) has been implicated as a co-transcription factor for RUNX2 in the regulation of expressio...

    Authors: Linda T. Senbanjo, Hanan AlJohani, Sunipa Majumdar and Meenakshi A. Chellaiah

    Citation: Cell Communication and Signaling 2019 17:80

    Content type: Research

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  22. Patients with microsatellite instability-high (MSI-H) colorectal cancer (CRC) generally have a better prognosis than patients with microsatellite stable (MSS) CRC. However, some MSI-H CRC patients do not gain ...

    Authors: Wangxiong Hu, Yanmei Yang, Lina Qi, Jiani Chen, Weiting Ge and Shu Zheng

    Citation: Cell Communication and Signaling 2019 17:79

    Content type: Research

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  23. The airway epithelium is a major target tissue in respiratory infections, and its antiviral response is mainly orchestrated by the interferon regulatory factor-3 (IRF3), which subsequently induces type I (β) a...

    Authors: Engin Baturcam, Stefan Vollmer, Holger Schlüter, Rose A. Maciewicz, Nisha Kurian, Outi Vaarala, Stephan Ludwig and Danen Mootoosamy Cunoosamy

    Citation: Cell Communication and Signaling 2019 17:78

    Content type: Research

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  24. Lipogenesis is required for the optimal growth of many types of cancer cells, it is shown to control the biosynthesis of the lipid bilayer membrane during rapid proliferation and metastasis, provides cancer ce...

    Authors: Yinfang Wang, Xiaohong Wan, Yilong Hao, Yuanyuan Zhao, Lanlan Du, Yitong Huang, Zongjun Liu, Ying Wang, Nanping Wang and Peng Zhang

    Citation: Cell Communication and Signaling 2019 17:77

    Content type: Research

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  25. Tumor suppressor WWOX physically binds p53 and TIAF1 and together induces apoptosis and tumor suppression. To understand the molecular action, here we investigated the formation of WWOX/TIAF1/p53 triad and its...

    Authors: Pei-Yi Chou, Sing-Ru Lin, Ming-Hui Lee, Lori Schultz, Chun-I Sze and Nan-Shan Chang

    Citation: Cell Communication and Signaling 2019 17:76

    Content type: Research

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  26. The major limitation of organ transplantation is the shortage of available organs. Xenotransplantation is considered to be an effective way to resolve the problem. Immune rejection is a major hurdle for the su...

    Authors: Hanchao Gao, Mengtao Cao, Pengfei Chen, David K. C. Cooper, Yanli Zhao, Ling Wei, Jia Xu, Zhiming Cai, Changchun Zeng, Shaodong Luan and Lisha Mou

    Citation: Cell Communication and Signaling 2019 17:75

    Content type: Research

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  27. We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with ...

    Authors: Jody Fromm Longo, Stephanie N. Brosius, Laurel Black, Stuart H. Worley, Robert C. Wilson, Kevin A. Roth and Steven L. Carroll

    Citation: Cell Communication and Signaling 2019 17:74

    Content type: Research

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  28. Studies have recently revealed that almost every type of cells including tumor cells abundantly release small vesicles known as extracellular vesicles (EVs) into the extracellular milieu. EVs carry a repertoir...

    Authors: Reza Rahbarghazi, Nasrollah Jabbari, Neda Abbaspour Sani, Rahim Asghari, Leila Salimi, Sadegh Asghari Kalashani, Maryam Feghhi, Tahereh Etemadi, Elinaz Akbariazar, Mahmoud Mahmoudi and Jafar Rezaie

    Citation: Cell Communication and Signaling 2019 17:73

    Content type: Review

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  29. Chronic gastritis has been demonstrated to be a key cause of gastric cancer (GC), and control of gastric inflammation is regarded as an effective treatment for the clinical prevention of gastric carcinogenesis...

    Authors: Wang-Yu Cai, Ling-Yun Lin, Lin Wang, Li Yang, Guo-Dong Ye, Qiang Zeng, Jia Cheng, Yuan-Yuan Xie, Mao-Li Chen and Qi-Cong Luo

    Citation: Cell Communication and Signaling 2019 17:72

    Content type: Research

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  30. To date, several studies have confirmed that driving forces of the inflammatory tumour microenvironment trigger spontaneous cancer cell fusion. However, less is known about the underlying factors and mechanism...

    Authors: Julian Weiler and Thomas Dittmar

    Citation: Cell Communication and Signaling 2019 17:71

    Content type: Research

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  31. Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short...

    Authors: Oliver Klepsch, Lise Sarah Namer, Nadine Köhler, Raymond Kaempfer, Anna Dittrich and Fred Schaper

    Citation: Cell Communication and Signaling 2019 17:70

    Content type: Research

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  32. Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.

    Authors: Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang and Jin Tao

    Citation: Cell Communication and Signaling 2019 17:68

    Content type: Research

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  33. Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies,...

    Authors: Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe and Kenichi Nomoto

    Citation: Cell Communication and Signaling 2019 17:67

    Content type: Research

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  34. Modern quantitative mass spectrometry (MS)-based proteomics enables researchers to unravel signaling networks by monitoring proteome-wide cellular responses to different stimuli. MS-based analysis of signaling...

    Authors: Marion Janschitz, Natalie Romanov, Gina Varnavides, David Maria Hollenstein, Gabriela Gérecová, Gustav Ammerer, Markus Hartl and Wolfgang Reiter

    Citation: Cell Communication and Signaling 2019 17:66

    Content type: Short report

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  35. Fibroblast growth factor receptors (FGFRs) are integral membrane proteins that transmit signals through the plasma membrane. FGFRs signaling needs to be precisely adjusted as aberrant FGFRs function is associa...

    Authors: Marika Kucińska, Natalia Porębska, Agata Lampart, Marta Latko, Agata Knapik, Małgorzata Zakrzewska, Jacek Otlewski and Łukasz Opaliński

    Citation: Cell Communication and Signaling 2019 17:65

    Content type: Short report

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  36. The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV rem...

    Authors: Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park and Tae Kwann Park

    Citation: Cell Communication and Signaling 2019 17:64

    Content type: Research

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  37. Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer ...

    Authors: Meng-Meng Jie, Xing Chang, Shuo Zeng, Cheng Liu, Guo-Bin Liao, Ya-Ran Wu, Chun-Hua Liu, Chang-Jiang Hu, Shi-Ming Yang and Xin-Zhe Li

    Citation: Cell Communication and Signaling 2019 17:63

    Content type: Review

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  38. Oxidative stress and the resulting inflammation are essential pathological processes in acute lung injury (ALI). Nuclear factor erythroid 2-related factor 2 (Nrf2), a vital transcriptional factor, possesses an...

    Authors: Huahong Yang, Hongming Lv, Haijun Li, Xinxin Ci and Liping Peng

    Citation: Cell Communication and Signaling 2019 17:62

    Content type: Research

    Published on:

  39. The astroglial connexins Cx30 and Cx43 contribute to many important CNS functions including cognitive behaviour, motoric capacity and regulation of the sleep-wake cycle. The sleep wake cycle, is controlled by ...

    Authors: Amira A. H. Ali, Anna Stahr, Marc Ingenwerth, Martin Theis, Christian Steinhäuser and Charlotte von Gall

    Citation: Cell Communication and Signaling 2019 17:61

    Content type: Research

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  40. The accumulation of M1-polarized macrophages and excessive inflammation are important in the pathogenesis of diabetic foot ulcer (DFU). However, the underlying mechanism of DFU pathogenesis and the crucial reg...

    Authors: Juan Feng, Chang Dong, Yanlan Long, Lifang Mai, Meng Ren, Lingyi Li, Ti Zhou, Zhonghan Yang, Jianxing Ma, Li Yan, Xia Yang, Guoquan Gao and Weiwei Qi

    Citation: Cell Communication and Signaling 2019 17:60

    Content type: Research

    Published on:

  41. Overexpression of AXL receptor tyrosine kinase (AXL) in various human cancers correlates with reduced patients overall survival and resistance to first line therapies. Therefore, several AXL tyrosine kinase in...

    Authors: Markus Lauter, Anja Weber and Robert Torka

    Citation: Cell Communication and Signaling 2019 17:59

    Content type: Research

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  42. Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant stromal partners in breas...

    Authors: Xiaohui Wei, Sijing Li, Jinyong He, Hongzhi Du, Yang Liu, Wei Yu, Haolin Hu, Lifei Han, Chenfei Wang, Hongyang Li, Xin Shi, Meixiao Zhan, Ligong Lu, Shengtao Yuan and Li Sun

    Citation: Cell Communication and Signaling 2019 17:58

    Content type: Research

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  43. Androgen plays a pivotal role in spermatogenesis, accompanying a question how androgen acts on germ cells in testis since germ cells lack of androgen receptors (AR). Promyelocytic leukemia zinc-finger (PLZF) i...

    Authors: Jingjing Wang, Jinmei Li, Wei Xu, Qin Xia, Yunzhao Gu, Weixiang Song, Xiaoyu Zhang, Yang Yang, Wei Wang, Hua Li and Kang Zou

    Citation: Cell Communication and Signaling 2019 17:57

    Content type: Research

    Published on:

  44. The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser, Michael Leitges and Gottfried Baier

    Citation: Cell Communication and Signaling 2019 17:56

    Content type: Short report

    Published on:

  45. In the endothelium, the single-pass membrane protein CD93, through its interaction with the extracellular matrix protein Multimerin-2, activates signaling pathways that are critical for vascular development an...

    Authors: Stefano Barbera, Federica Nardi, Ines Elia, Giulia Realini, Roberta Lugano, Annalisa Santucci, Gian Marco Tosi, Anna Dimberg, Federico Galvagni and Maurizio Orlandini

    Citation: Cell Communication and Signaling 2019 17:55

    Content type: Research

    Published on:

  46. In previous research, we found that lamprey immune protein (LIP) possessed cytocidal activity against tumor cells, but the mechanism of the selective recognition and killing of tumor cells by LIP was not ident...

    Authors: Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang and Qingwei Li

    Citation: Cell Communication and Signaling 2019 17:54

    Content type: Research

    Published on:

  47. Tumor-associated macrophages can promote breast cancer metastasis by secreting cytokines and growth factors. Interleukin (IL)-32θ, a newly identified IL-32 isoform, was previously shown to down-regulate variou...

    Authors: Thu-Huyen Pham, Yesol Bak, Taeho Kwon, Sae-Bom Kwon, Jae-Wook Oh, Jong-Hyung Park, Yang-Kyu Choi, Jin Tae Hong and Do-Young Yoon

    Citation: Cell Communication and Signaling 2019 17:53

    Content type: Research

    Published on:

  48. Recent studies claimed the important role of cold atmospheric plasma (CAP) with nanotechnology in cancer treatments. In this study, silymarin nanoemulsion (SN) was used along with air CAP as therapeutic agent ...

    Authors: Manish Adhikari, Neha Kaushik, Bhagirath Ghimire, Bhawana Adhikari, Sanjula Baboota, Abdulaziz A. Al-Khedhairy, Rizwan Wahab, Su-Jae Lee, Nagendra Kumar Kaushik and Eun Ha Choi

    Citation: Cell Communication and Signaling 2019 17:52

    Content type: Research

    Published on:

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