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  1. Metastasis represents the leading cause of death in patients with breast cancer. Traditional Chinese medicine is particularly appreciated for metastatic diseases in Asian countries due to its benefits for surv...

    Authors: Jing Li, Shengqi Wang, Neng Wang, Yifeng Zheng, Bowen Yang, Xuan Wang, Juping Zhang, Bo Pan and Zhiyu Wang
    Citation: Cell Communication and Signaling 2021 19:89

    The Correction to this article has been published in Cell Communication and Signaling 2021 19:113

  2. For proteins, the sequence → structure → function paradigm applies primarily to enzymes, transmembrane proteins, and signaling domains. This paradigm is not universal, but rather, in addition to structured pro...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky
    Citation: Cell Communication and Signaling 2021 19:88
  3. Wnt signaling plays key roles in cellular and physiological processes, including cell proliferation, differentiation and migration during development and tissue homeostasis in adults. This pathway can be defin...

    Authors: Juan A. Godoy, Jasson Espinoza-Caicedo and Nibaldo C. Inestrosa
    Citation: Cell Communication and Signaling 2021 19:87
  4. Maspin (SERPINB5) is a potential tumor suppressor gene with pleiotropic biological activities, including regulation of cell proliferation, death, adhesion, migration and gene expression. Several studies indica...

    Authors: M. T. Longhi, L. E. Silva, M. Pereira, M. Magalhães, J. Reina, F. N. L. Vitorino, B. M. Gumbiner, J. P. C. da Cunha and N. Cella
    Citation: Cell Communication and Signaling 2021 19:86
  5. Vitamin D receptor (VDR) plays a vital protective role in oral and colonic epithelial cells. Albeit we know that VDR expression is reduced in the mucosal epithelial layers of autoimmune diseases, the mechanism...

    Authors: Xiangyu Wang, Xuejun Ge, Wang Liao, Yong Cao, Ran Li, Fang Zhang, Bin Zhao and Jie Du
    Citation: Cell Communication and Signaling 2021 19:85
  6. RNA base editing is potential for cellular function research and genetic diseases treating. There are two main RNA base editors, REPAIR and RESCUE, for in vitro use. REPAIR was developed by fusing inactivated ...

    Authors: Guo Li, Yihan Wang, Xiangyang Li, Yuzhe Wang, Xingxu Huang, Jianen Gao and Xiaoxiang Hu
    Citation: Cell Communication and Signaling 2021 19:84
  7. The positive transcription elongation factor b (P-TEFb) kinase activity is involved in the process of transcription. Cyclin-dependent kinase 9 (CDK9), a core component of P-TEFb, regulates the process of trans...

    Authors: Yingjie Qing, Xiangyuan Wang, Hongzheng Wang, Po Hu, Hui Li, Xiaoxuan Yu, Mengyuan Zhu, Zhanyu Wang, Yu Zhu, Jingyan Xu, Qinglong Guo and Hui Hui
    Citation: Cell Communication and Signaling 2021 19:83
  8. As a ubiquitous second messenger, calcium (Ca2+) can interact with numerous cellular proteins to regulate multiple physiological processes and participate in a variety of diseases, including hepatitis B virus ...

    Authors: Fanyun Kong, Fulong Zhang, Xiangye Liu, Suping Qin, Xiaoying Yang, Delong Kong, Xiucheng Pan, Hongjuan You, Kuiyang Zheng and Renxian Tang
    Citation: Cell Communication and Signaling 2021 19:82
  9. The currently available RESCUE RNA base editing system demonstrates considerable potential for the treatment of genetic diseases at the transcriptional level. However, the relatively high incidence of off-targ...

    Authors: Yihan Wang, Guo Li, Xiangyang Li, Yuzhe Wang, Xingxu Huang, Xiaoxiang Hu and Jianen Gao
    Citation: Cell Communication and Signaling 2021 19:81
  10. Hhex(human hematopoietically expressed homeobox), also known as PRH, is originally considered as a transcription factor to regulate gene expression due to its homebox domain. Increasing studies show that Hhex ...

    Authors: Xiaopeng Li, Guilin Ma, Wenjie Guo, Ning Mu, Yingying Wang, Xiangguo Liu and Ling Su
    Citation: Cell Communication and Signaling 2021 19:80
  11. The urinary tract is highly innervated by autonomic nerves which are essential in urinary tract development, the production of growth factors, and the control of homeostasis. These neural signals may become dy...

    Authors: M. Archer, N. Dogra, Z. Dovey, T. Ganta, H.-S. Jang, J. A. Khusid, A. Lantz, M. Mihalopoulos, J. A. Stockert, A. Zahalka, L. Björnebo, S. Gaglani, M. R. Noh, S. A. Kaplan, R. Mehrazin, K. K. Badani…
    Citation: Cell Communication and Signaling 2021 19:78
  12. CMTM7 is a tumor suppressor that positively regulates EGFR degradation by promoting Rab5 activation, and plays a vital role in tumor progression. Rab5 forms complexes with Beclin1 and VPS34, and acts in the ea...

    Authors: Baocai Liu, Yinliang Lu, Tingting Zhang, Xinyue Yu, Qian Wang, Yunbo Chi, Shunzi Jin and Guanghui Cheng
    Citation: Cell Communication and Signaling 2021 19:77
  13. Small extracellular vesicles (sEVs) mediate intercellular communication by transferring RNA, proteins, and lipids to recipient cells. These cargo molecules are selectively loaded into sEVs and mirror the physi...

    Authors: Xuan Luo, Renée Jean-Toussaint, Ahmet Sacan and Seena K. Ajit
    Citation: Cell Communication and Signaling 2021 19:75
  14. Our murine cancer model studies have demonstrated that Plasmodium infection activates the immune system that has been inhibited by cancer cells, counteracts tumor immunosuppressive microenvironment, inhibits tumo...

    Authors: Xiaoping Chen, Li Qin, Wen Hu and Dickson Adah
    Citation: Cell Communication and Signaling 2021 19:74
  15. The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has become an ongoing pandemic. Understanding the respiratory immune microenvironment whi...

    Authors: Lei He, Quan Zhang, Yue Zhang, Yixian Fan, Fahu Yuan and Songming Li
    Citation: Cell Communication and Signaling 2021 19:73
  16. The Jumonji domain-containing protein-3 (JMJD3) is a histone demethylase that regulates the trimethylation of histone H3 on lysine 27 (H3K27me3). H3K27me3 is an important epigenetic event associated with trans...

    Authors: Yuanjie Ding, Yuanchun Yao, Xingmu Gong, Qi Zhuo, Jinhua Chen, Miao Tian and Maryam Farzaneh
    Citation: Cell Communication and Signaling 2021 19:72
  17. The fusion oncoprotein Bcr-Abl is mostly located in the cytoplasm, which causes chronic myeloid leukemia (CML). After moving into the nucleus, the fusion protein can induce apoptosis of CML cells. The coiled-c...

    Authors: Yuhang Peng, Zhenglan Huang, Fangzhu Zhou, Teng Wang, Ke Mou and Wenli Feng
    Citation: Cell Communication and Signaling 2021 19:71
  18. Intercellular communications are important for maintaining normal physiological processes. An important intercellular communication is mediated by the exchange of membrane-enclosed extracellular vesicles. Amon...

    Authors: Yi-Wei Lin, Jennifer Nhieu, Chin-Wen Wei, Yu-Lung Lin, Hiroyuki Kagechika and Li-Na Wei
    Citation: Cell Communication and Signaling 2021 19:69
  19. The oncogenic PIM kinases and the tumor-suppressive LKB1 kinase have both been implicated in the regulation of cell growth and metabolism, albeit in opposite directions. Here we investigated whether these kina...

    Authors: Kwan Long Mung, William B. Eccleshall, Niina M. Santio, Adolfo Rivero-Müller and Päivi J. Koskinen
    Citation: Cell Communication and Signaling 2021 19:68
  20. Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progre...

    Authors: Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah and Leszek Kotula
    Citation: Cell Communication and Signaling 2021 19:67
  21. Breast cancer is a common malignancy with varying clinical behaviors and for the more aggressive subtypes, novel and more efficient therapeutic approaches are needed. Qualities of the tumor microenvironment as...

    Authors: Emma Persson, Pernilla Gregersson, Anna Gustafsson, Paul Fitzpatrick, Sara Rhost, Anders Ståhlberg and Göran Landberg
    Citation: Cell Communication and Signaling 2021 19:66
  22. Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization. Proteins that drive the f...

    Authors: Ryan J. Emenecker, Alex S. Holehouse and Lucia C. Strader
    Citation: Cell Communication and Signaling 2021 19:65
  23. Invadopodia are actin-based cell-membrane protrusions associated with the extracellular matrix degradation accompanying cancer invasion. The elucidation of the molecular mechanisms leading to invadopodia forma...

    Authors: Alessia Varone, Chiara Amoruso, Marcello Monti, Manpreet Patheja, Adelaide Greco, Luigi Auletta, Antonella Zannetti and Daniela Corda
    Citation: Cell Communication and Signaling 2021 19:64
  24. miR-1250 is localised to the second intron of AATK at chromosome 17q25. As a CpG island is present at the putative promoter region of its host gene, AATK, we postulated that the intronic miR-1250-5p is a tumor...

    Authors: Min Yue Zhang, Lu Qian Wang and Chor Sang Chim
    Citation: Cell Communication and Signaling 2021 19:62
  25. Chronic superphysiological glucose and insulin concentrations are known to trigger several tissue and organ failures, including insulin resistance, oxidative stress and chronic low-grade inflammation. Hence, t...

    Authors: Anna Kowalczuk, Nabila Bourebaba, Katarzyna Kornicka-Garbowska, Eliza Turlej, Krzysztof Marycz and Lynda Bourebaba
    Citation: Cell Communication and Signaling 2021 19:61

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:13

  26. Nuclear localization signals (NLS) are generally short peptides that act as a signal fragment that mediates the transport of proteins from the cytoplasm into the nucleus. This NLS-dependent protein recognition...

    Authors: Juane Lu, Tao Wu, Biao Zhang, Suke Liu, Wenjun Song, Jianjun Qiao and Haihua Ruan
    Citation: Cell Communication and Signaling 2021 19:60
  27. The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that A...

    Authors: Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro and Ann Marie Pendergast
    Citation: Cell Communication and Signaling 2021 19:59
  28. Mitochondrial DNA (mtDNA) is a vital driver of inflammation when it leaks from damaged mitochondria into the cytosol. mtDNA stress may contribute to cyclic GMP-AMP synthase (cGAS) stimulator of interferon gene...

    Authors: Lu Zhou, Yi-Fei Zhang, Fu-Hua Yang, Han-Qing Mao, Zhi Chen and Lu Zhang
    Citation: Cell Communication and Signaling 2021 19:58
  29. The human family of Potassium (K+) Channel Tetramerization Domain (KCTD) proteins counts 25 members, and a significant number of them are still only partially characterized. While some of the KCTDs have been link...

    Authors: Annapaola Angrisani, Annamaria Di Fiore, Enrico De Smaele and Marta Moretti
    Citation: Cell Communication and Signaling 2021 19:56
  30. The plakin family of cytoskeletal proteins play an important role in cancer progression yet are under-studied in cancer, especially ovarian cancer. These large cytoskeletal proteins have primary roles in the m...

    Authors: Tamsin Wesley, Stuart Berzins, George Kannourakis and Nuzhat Ahmed
    Citation: Cell Communication and Signaling 2021 19:55
  31. Many clinical trials are being conducted to clarify effective combinations of various drugs for immune checkpoint blockade (ICB) therapy. However, although extensive studies from multiple aspects have been con...

    Authors: Ari Hashimoto, Haruka Handa, Soichiro Hata, Akio Tsutaho, Takao Yoshida, Satoshi Hirano, Shigeru Hashimoto and Hisataka Sabe
    Citation: Cell Communication and Signaling 2021 19:54
  32. Neurodegenerative diseases like Alzheimer’s, Parkinson’s and Huntington’s disease involves abnormal aggregation and accumulation of toxic proteins aggregates. Post-translational modifications (PTMs) of the cau...

    Authors: Abhishek Ankur Balmik and Subashchandrabose Chinnathambi
    Citation: Cell Communication and Signaling 2021 19:51
  33. Recent insights into the molecular and cellular mechanisms underlying cancer development have revealed the tumor microenvironment (TME) immune cells to functionally affect the development and progression of br...

    Authors: Jing Jin, Yi Li, Qijie Zhao, Yue Chen, Shaozhi Fu and JingBo Wu
    Citation: Cell Communication and Signaling 2021 19:50
  34. Microtubule-associated protein Tau undergoes aggregation in Alzheimer`s disease (AD) and a group of other related diseases collectively known as Tauopathies. In AD, Tau forms aggregates, which are deposited in...

    Authors: Abhishek Ankur Balmik, Shweta Kishor Sonawane and Subashchandrabose Chinnathambi
    Citation: Cell Communication and Signaling 2021 19:49
  35. The G-protein-coupled receptor GPR55 has been implicated in multiple biological activities, which has fuelled interest in its functional targeting. Its controversial pharmacology and often species-dependent re...

    Authors: Maria Giovanna Mosca, Maria Mangini, Stefania Cioffi, Pasquale Barba and Stefania Mariggiò
    Citation: Cell Communication and Signaling 2021 19:48
  36. Myocardial fibrosis is caused by the adverse and powerful remodeling of the heart secondary to the death of cardiomyocytes after myocardial infarction. Regulators of G protein Signaling (RGS) 4 is involved in ...

    Authors: Jing Guo, Pengzhou Hang, Jie Yu, Wen Li, Xiuye Zhao, Yue Sun, Ziyi Fan and Zhimin Du
    Citation: Cell Communication and Signaling 2021 19:46
  37. Toll-like receptors (TLRs) are critical sensors for the detection of potentially harmful microbes. They are instrumental in initiating innate and adaptive immune responses against pathogenic organisms. However...

    Authors: Clovis H. T. Seumen, Tanja M. Grimm and Christof R. Hauck
    Citation: Cell Communication and Signaling 2021 19:45
  38. Nonalcoholic fatty liver disease (NAFLD) is increasingly prevalent and represents a growing challenge in terms of prevention and treatment. A minority of affected patients develops inflammation, subsequently f...

    Authors: Marco Raffaele, Kristina Kovacovicova, Jan Frohlich, Oriana Lo Re, Sebastiano Giallongo, Jude A. Oben, Martin Faldyna, Lenka Leva, Antonino Giulio Giannone, Daniela Cabibi and Manlio Vinciguerra
    Citation: Cell Communication and Signaling 2021 19:44
  39. Phosphotyrosine kinase (PTK)-mediated phospholipase C-γ1 (PLC-γ1) signaling plays a crucial role in the release of the universal second messenger calcium from intracellular stores, which is mandatory for sever...

    Authors: Helena M. Stricker, Nadine Rommerswinkel, Silvia Keil, Sandina A. Gnoth, Bernd Niggemann and Thomas Dittmar
    Citation: Cell Communication and Signaling 2021 19:43
  40. Progesterone receptor membrane component 1 (Pgrmc1) is a non-classical progesterone receptor associated with the development of the mammary gland and xenograft-induced breast cancer. Importantly, Pgrmc1 is ass...

    Authors: Sang R. Lee, Young Ho Lee, Seong Lae Jo, Jun H. Heo, Globinna Kim, Geun-Shik Lee, Beum-Soo An, In-Jeoung Baek and Eui-Ju Hong
    Citation: Cell Communication and Signaling 2021 19:42
  41. The family of Tribbles proteins play many critical nonenzymatic roles and regulate a wide range of key signaling pathways. Tribbles homolog 2 (Trib2) is a pseudo serine/threonine kinase that functions as a sca...

    Authors: Yu Fang, Angelina Olegovna Zekiy, Farhoodeh Ghaedrahmati, Anton Timoshin, Maryam Farzaneh, Amir Anbiyaiee and Seyed Esmaeil Khoshnam
    Citation: Cell Communication and Signaling 2021 19:41
  42. Lysosome-associated membrane protein type 2A (LAMP-2A) is the key component of chaperone-mediated autophagy (CMA), a cargo-selective lysosomal degradation pathway. Aberrant LAMP-2A expression and CMA activatio...

    Authors: Yongjie Wang, Buyi Zhang, Jianli Wang, Haijian Wu, Shenbin Xu, Jianmin Zhang and Lin Wang
    Citation: Cell Communication and Signaling 2021 19:40

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