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  1. Studying the stoichiometry and intracellular trafficking of the T cell antigen receptor (TCR) is pivotal in understanding its mechanisms of activation. The αβTCR includes the antigen-binding TCRαβ heterodimer ...

    Authors: Mahima Swamy, Gabrielle M Siegers, Gina J Fiala, Eszter Molnar, Elaine P Dopfer, Paul Fisch, Burkhart Schraven and Wolfgang WA Schamel

    Citation: Cell Communication and Signaling 2010 8:5

    Content type: Research

    Published on:

  2. The 13th meeting of the Signal Transduction Society was held in Weimar, from October 28 to 30, 2009. Special focus of the 2009 conference was "Aging and Senescence", which was co-organized by the SFB 728 "Envi...

    Authors: Frank Entschladen, Joachim Altschmied, Ria Baumgrass, Iris Behrmann, Klaudia Giehl, Heike Hermanns, Otmar Huber, Arnd Kieser, Lars-Oliver Klotz, Katharina F Kubatzky, Ralf Hass, Ottmar Janssen and Karlheinz Friedrich

    Citation: Cell Communication and Signaling 2010 8:2

    Content type: Review

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  3. The molecular heterogeneity of human cancer cells at the level of signaling protein activities remains poorly understood. Using a panel of 64 colorectal (CRC) cancer cell lines the activity status of the MAP k...

    Authors: Theresia R Kress, Thomas Raabe and Stephan M Feller

    Citation: Cell Communication and Signaling 2010 8:1

    Content type: Short report

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  4. ERK signaling regulates focal adhesion disassembly during cell movement, and increased ERK signaling frequently contributes to enhanced motility of human tumor cells. We previously found that the ERK scaffold ...

    Authors: Electa R Park, Ashok K Pullikuth, Evangeline M Bailey, Donald E Mercante and Andrew D Catling

    Citation: Cell Communication and Signaling 2009 7:26

    Content type: Short report

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  5. Monomeric GTPases of the Rho family control a variety of cellular functions including actin cytoskeleton organisation, cell migration and cell adhesion. Defects in these regulatory processes are involved in tu...

    Authors: Beatrix Hage, Katrin Meinel, Iris Baum, Klaudia Giehl and Andre Menke

    Citation: Cell Communication and Signaling 2009 7:23

    Content type: Research

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  6. The aim of palliative chemotherapy is to increase survival whilst maintaining maximum quality of life for the individual concerned. Although we are still continuing to explore the optimum use of traditional ch...

    Authors: Thomas Seufferlein, Johann Ahn, Denis Krndija, Ulrike Lother, Guido Adler and Götz von Wichert

    Citation: Cell Communication and Signaling 2009 7:19

    Content type: Review

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  7. microRNAs are small, non-coding RNAs that influence diverse biological functions through the repression of target genes during normal development and pathological responses. Widespread use of microRNA arrays t...

    Authors: Brandi N Davis and Akiko Hata

    Citation: Cell Communication and Signaling 2009 7:18

    Content type: Review

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  8. The investigation of biological systems highly depends on the possibilities that allow scientists to visualize and quantify biomolecules and their related activities in real-time and non-invasively. G-protein ...

    Authors: Ilka Böhme and Annette G Beck-Sickinger

    Citation: Cell Communication and Signaling 2009 7:16

    Content type: Review

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  9. After the initial discovery of activins as important regulators of reproduction, novel and diverse roles have been unraveled for them. Activins are expressed in various tissues and have a broad range of activi...

    Authors: Kunihiro Tsuchida, Masashi Nakatani, Keisuke Hitachi, Akiyoshi Uezumi, Yoshihide Sunada, Hiroshi Ageta and Kaoru Inokuchi

    Citation: Cell Communication and Signaling 2009 7:15

    Content type: Review

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  10. The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of essential signal transduction pathways in humans and other organisms that act as major convergence points in tyrosine kinase ...

    Authors: Raymond B Birge, Charalampos Kalodimos, Fuyuhiko Inagaki and Shinya Tanaka

    Citation: Cell Communication and Signaling 2009 7:13

    Content type: Review

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  11. The receptor for advanced glycation end products (RAGE) is a single transmembrane receptor of the immunoglobulin superfamily that is mainly expressed on immune cells, neurons, activated endothelial and vascula...

    Authors: Astrid Riehl, Julia Németh, Peter Angel and Jochen Hess

    Citation: Cell Communication and Signaling 2009 7:12

    Content type: Review

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  12. Cortactin activates the actin-related 2/3 (Arp2/3) complex promoting actin polymerization to remodel cell architecture in multiple processes (e.g. cell migration, membrane trafficking, invadopodia formation et...

    Authors: Elvira Nieto-Pelegrin and Narcisa Martinez-Quiles

    Citation: Cell Communication and Signaling 2009 7:11

    Content type: Research

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  13. Integrins, cell-surface receptors that mediate adhesive interactions between cells and the extracellular matrix (ECM), play an important role in cancer progression. Expression of the vitronectin receptor αvβ3 ...

    Authors: Andrew J Putnam, Veronique V Schulz, Eric M Freiter, Heather M Bill and Cindy K Miranti

    Citation: Cell Communication and Signaling 2009 7:10

    Content type: Research

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  14. Apoptosis signal-regulating kinase 1 (ASK1) is a member of the mitogen-activated protein kinase kinase kinase family, which activates c-Jun N-terminal kinase and p38 in response to a diverse array of stresses ...

    Authors: Kazuki Hattori, Isao Naguro, Christopher Runchel and Hidenori Ichijo

    Citation: Cell Communication and Signaling 2009 7:9

    Content type: Review

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  15. A variety of cell types can be identified in the adherent fraction of bone marrow mononuclear cells including more primitive and embryonic-like stem cells, mesenchymal stem cells (MSC), lineage-committed proge...

    Authors: Ingrida Majore, Pierre Moretti, Ralf Hass and Cornelia Kasper

    Citation: Cell Communication and Signaling 2009 7:6

    Content type: Short report

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  16. We have used optic nerve injury as a model to study early signaling events in neuronal tissue following axonal injury. Optic nerve injury results in the selective death of retinal ganglion cells (RGCs). The ti...

    Authors: Thomas J Lukas, Ai Ling Wang, Ming Yuan and Arthur H Neufeld

    Citation: Cell Communication and Signaling 2009 7:5

    Content type: Research

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  17. Connexins constitute a large family of trans-membrane proteins that allow intercellular communication and the transfer of ions and small signaling molecules between cells. Recent studies have revealed complex ...

    Authors: Hashem A Dbouk, Rana M Mroue, Marwan E El-Sabban and Rabih S Talhouk

    Citation: Cell Communication and Signaling 2009 7:4

    Content type: Review

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  18. Cellular signal transduction is initiated by the binding of extracellular ligands to membrane receptors. Receptors are often expressed in excess, and cells are activated when a small number of receptors bind l...

    Authors: Hiroshi Kobayashi, Ryuzo Azuma and Takuo Yasunaga

    Citation: Cell Communication and Signaling 2009 7:3

    Content type: Research

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  19. Citation: Cell Communication and Signaling 2009 7(Suppl 1):A59

    Content type: Meeting abstract

    Published on:

    This article is part of a Supplement: Volume 7 Supplement 1

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