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  1. Notch signalling pathway plays a key role in metazoan biology by contributing to resolution of binary decisions in the life cycle of cells during development. Outcomes such as proliferation/differentiation dic...

    Authors: Filip Vujovic, Neil Hunter and Ramin M. Farahani
    Citation: Cell Communication and Signaling 2022 20:66
  2. Ezrin/radixin/moesin (ERM) proteins are members of the protein 4.1 superfamily and function as linkers that connect the actin cytoskeleton to the plasma membrane of cells. ERM also play critical role in the Li...

    Authors: Ning Ding, Pibao Li, Huiqing Li, Yunlong Lei and Zengzhen Zhang
    Citation: Cell Communication and Signaling 2022 20:65
  3. Inflammatory bowel disease (IBD) comprises a group of chronic inflammatory disorders of the gastrointestinal tract. Accumulating evidence shows that the development of IBD is always accompanied by the dysbiosi...

    Authors: Zhilin Zhang, Huan Zhang, Tian Chen, Lin Shi, Daorong Wang and Dong Tang
    Citation: Cell Communication and Signaling 2022 20:64
  4. The tumor microenvironment consists of stromal cells, extracellular matrix, and physicochemical properties (e.g., oxygenation, acidification). An important element of the tumor niche are cancer-associated fibr...

    Authors: Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Katarzyna Pietraszek-Gremplewicz, Michał Majkowski, Magdalena Kot, Marcin Ziętek, Rafał Matkowski and Dorota Nowak
    Citation: Cell Communication and Signaling 2022 20:63
  5. Recent studies have indicated that some members of the tripartite motif (TRIM) proteins function as important regulators for non-small cell lung cancer (NSCLC), However, the regulatory mechanism underpinning a...

    Authors: Manman Liang, Lijing Wang, Zhengui Sun, Xingwu Chen, Hanli Wang, Lilong Qin, Wenying Zhao and Biao Geng
    Citation: Cell Communication and Signaling 2022 20:62
  6. Polycystic ovary syndrome (PCOS) is characterized by follicular dysplasia. An insufficient glycolysis-derived energy supply of granulosa cells (GCs) is an important cause of follicular dysplasia in PCOS. Folli...

    Authors: Jianping Cao, Peng Huo, Kuiqing Cui, Huimei Wei, Junna Cao, Jinyuan Wang, Qingyou Liu, Xiaocan Lei and Shun Zhang
    Citation: Cell Communication and Signaling 2022 20:61

    The Correction to this article has been published in Cell Communication and Signaling 2022 20:116

  7. Apolipoprotein A-I binding protein (AIBP), a secreted protein, has been shown to play a pivotal role in the development of atherosclerosis. The function of intracellular AIBP, however, is not yet well characte...

    Authors: Meng Duan, Hainan Chen, Linjie Yin, Xiao Zhu, Petr Novák, Yuncheng Lv, Guojun Zhao and Kai Yin
    Citation: Cell Communication and Signaling 2022 20:60
  8. Apoptosis signal-regulating kinase 1-interacting protein 1 (AIP1) participates in inflammatory neovascularization induction. NADPH oxidase 4 (NOX4) produces reactive oxygen species (ROS), leading to an imbalan...

    Authors: Qingyu Li, Xia Hua, Liangpin Li, Xueyan Zhou, Ye Tian, Yang Deng, Min Zhang, Xiaoyong Yuan and Wei Chi
    Citation: Cell Communication and Signaling 2022 20:59
  9. The contribution of native or modified oligodendroglia-derived extracellular vesicles (OL-EVs) in controlling chronic inflammation is poorly understood. In activated microglia, OL-EVs contribute to the removal...

    Authors: Bram Van den Broek, Charlotte Wuyts, Angela Sisto, Isabel Pintelon, Jean-Pierre Timmermans, Veerle Somers, Vincent Timmerman, Niels Hellings and Joy Irobi
    Citation: Cell Communication and Signaling 2022 20:58
  10. The epithelial-mesenchymal transition (EMT) is a vital driver of tumor progression. It is a well-known and complex trans-differentiation process in which epithelial cells undergo morphogenetic changes with los...

    Authors: Fanyun Kong, Lihong Ma, Xing Wang, Hongjuan You, Kuiyang Zheng and Renxian Tang
    Citation: Cell Communication and Signaling 2022 20:57
  11. Microglia-mediated neuroinflammatory response following traumatic brain injury (TBI) is considered as a vital secondary injury factor, which drives trauma-induced neurodegeneration and is lack of efficient tre...

    Authors: Lin Cai, Qiuyuan Gong, Lin Qi, Tongtong Xu, Qian Suo, Xiang Li, Wei Wang, Yao Jing, Dianxu Yang, Zhiming Xu, Fang Yuan, Yaohui Tang, Guoyuan Yang, Jun Ding, Hao Chen and Hengli Tian
    Citation: Cell Communication and Signaling 2022 20:56
  12. Synapses can adapt to changes in the intracerebral microenvironment by regulation of presynaptic neurotransmitter release and postsynaptic neurotransmitter receptor expression following hypoxic ischemia (HI) i...

    Authors: Kexin Li, Meng Lu, Mengxu Cui, Xiaoming Wang and Yang Zheng
    Citation: Cell Communication and Signaling 2022 20:55
  13. The Protein kinase D3 (PKD3) has been implicated in signal transduction downstream of the T cell receptor (TCR). However, its role for the activation of primary T lymphocytes has not been elucidated so far.

    Authors: Jiří Koutník, Verena Neururer, Thomas Gruber, Sebastian Peer, Natascha Hermann-Kleiter, William J. Olson, Verena Labi, Michael Leitges, Gottfried Baier and Kerstin Siegmund
    Citation: Cell Communication and Signaling 2022 20:54
  14. Peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1α (PGC-1α) downregulation in skeletal muscle contributes to insulin resistance and type 2 diabetes mellitus. Here, we examined the effects of e...

    Authors: Marta Montori-Grau, David Aguilar-Recarte, Mohammad Zarei, Javier Pizarro-Delgado, Xavier Palomer and Manuel Vázquez-Carrera
    Citation: Cell Communication and Signaling 2022 20:53
  15. Skin innervation is crucial for normal wound healing. However, the relationship between nerve receptors and wound healing and the intrinsic mechanism remains to be further identified. In this study, we investi...

    Authors: Siyuan Yin, Ru Song, Jiaxu Ma, Chunyan Liu, Zhenjie Wu, Guoqi Cao, Jian Liu, Guang Zhang, Huayu Zhang, Rui Sun, Aoyu Chen and Yibing Wang
    Citation: Cell Communication and Signaling 2022 20:52
  16. Extracellular vehicles (EVs) are a heterogeneous group of cell and membranous particles originating from different cell compartments. EVs participate in many essential physiological functions and mediate fetal...

    Authors: Mehri Ghafourian, Roya Mahdavi, Zahra Akbari Jonoush, Mahvash Sadeghi, Nooshin Ghadiri, Maryam Farzaneh and Abdolah Mousavi Salehi
    Citation: Cell Communication and Signaling 2022 20:51
  17. Myocardial infarction (MI) is one of the most common cardiac emergencies with high morbidity and is a leading cause of death worldwide. Since MI could develop into a life-threatening emergency and could also s...

    Authors: Nan Zhang, Xiahenazi Aiyasiding, Wen-jing Li, Hai-han Liao and Qi-zhu Tang
    Citation: Cell Communication and Signaling 2022 20:50
  18. Abnormal vasculature is one of the most conspicuous traits of tumor tissue, largely contributing to tumor immune evasion. The deregulation mainly arises from the potentiated pro-angiogenic factors secretion an...

    Authors: Mohammad Javed Ansari, Dmitry Bokov, Alexander Markov, Abduladheem Turki Jalil, Mohammed Nader Shalaby, Wanich Suksatan, Supat Chupradit, Hasan S. AL-Ghamdi, Navid Shomali, Amir Zamani, Ali Mohammadi and Mehdi Dadashpour
    Citation: Cell Communication and Signaling 2022 20:49
  19. Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem in view of cellular metabolism.

    Authors: Yumeng Miao, Changliu Zhang, Ling Yang, Xi Zeng, Yuxiao Hu, Xinru Xue, Yue Dai and Zhifeng Wei
    Citation: Cell Communication and Signaling 2022 20:48
  20. NOS2 expression is mostly found in bacteria-exposed or cytokine-treated tissues and is mostly connected to innate immune reactions. There are three isoforms of NOS2 (NOS2-1 to -3). In RNA-seq data sets, analyz...

    Authors: Fabian Gather, Irmgard Ihrig-Biedert, Paul Kohlhas, Tamara Krutenko, Michael Peitz, Oliver Brüstle, Andrea Pautz and Hartmut Kleinert
    Citation: Cell Communication and Signaling 2022 20:47
  21. Glioblastoma (GBM) is the most aggressive form of brain tumor and has vascular-rich features. The S100A4/non-muscle myosin IIA (NMIIA) axis contributes to aggressive phenotypes in a variety of human malignanci...

    Authors: Madoca Inukai, Ako Yokoi, Yuuki Ishizuka, Miki Hashimura, Toshihide Matsumoto, Yasuko Oguri, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Toshihiro Kumabe and Makoto Saegusa
    Citation: Cell Communication and Signaling 2022 20:46
  22. Breast cancer is the most common cancer in women worldwide. More than 70% of breast cancers are estrogen receptor (ER) alpha positive. Compared with ER alpha-negative breast cancer, which is more aggressive an...

    Authors: Ting Zhuang, Beibei Wang, Xiaojing Tan, Le Wu, Xin Li, Zhongbo Li, Yuqing Cai, Rongrong Fan, Xiao Yang, Chenmiao Zhang, Yan Xia, Zhiguo Niu, Bingtian Liu, Qi Cao, Yinlu Ding, Zhipeng Zhou…
    Citation: Cell Communication and Signaling 2022 20:45
  23. The main breakthrough in tumor immunotherapy was the discovery of immune checkpoint (IC) proteins, which act as a potent suppressor of the immune system by a myriad of mechanisms. After that, scientists focuse...

    Authors: Adel Naimi, Rebar N. Mohammed, Ahmed Raji, Supat Chupradit, Alexei Valerievich Yumashev, Wanich Suksatan, Mohammed Nader Shalaby, Lakshmi Thangavelu, Siavash Kamrava, Navid Shomali, Armin D. Sohrabi, Ali Adili, Ali Noroozi-Aghideh and Ehsan Razeghian
    Citation: Cell Communication and Signaling 2022 20:44
  24. As an important mechanism to maintain cellular homeostasis, autophagy exerts critical functions via degrading misfolded proteins and damaged organelles. Recent years, alternative autophagy, a new type of autop...

    Authors: Hong Feng, Nian Wang, Nan Zhang and Hai-han Liao
    Citation: Cell Communication and Signaling 2022 20:43
  25. Unphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression profile as compared to tyrosine-phosphorylated STAT1 (P-STAT1) homodimers. H...

    Authors: Priyanka Rajeev Menon, Julia Staab, Anke Gregus, Oliver Wirths and Thomas Meyer
    Citation: Cell Communication and Signaling 2022 20:42
  26. Tumor cells tend to utilize glycolysis rather than aerobic respiration even under aerobic conditions. OVOL2, an inhibitory C2H2 zinc finger transcription factor, is a potential tumor suppressor in cancers. How...

    Authors: Rui Zhang, Guo-Jun Geng, Jian-Guang Guo, Yan-Jun Mi, Xiao-Lei Zhu, Ning Li, Hong-Ming Liu, Jun-Feng Lin, Jian-Weng Wang, Guang Zhao, Guan-Zhi Ye, Bo-An Li, Qi-Cong Luo and Jie Jiang
    Citation: Cell Communication and Signaling 2022 20:40
  27. Hepatocellular carcinoma (HCC) is one of the most fatal cancers. Due to limited strategies for effective treatments, patients with advanced HCC have a very poor prognosis. This study aims to identify new insig...

    Authors: Miaoqin Chen, Weikai Wang, Shiman Hu, Yifan Tong, Yiling Li, Qi Wei, Lei Yu, Liyuan Zhu, Yiran Zhu, Leiming Liu, Zhenyu Ju, Xian Wang, Hongchuan Jin and Lifeng Feng
    Citation: Cell Communication and Signaling 2022 20:39
  28. The incidence of coronary heart disease (CHD) in premenopausal women is significantly lower than that of men of the same age, suggesting protective roles of estrogen for the cardiovascular system against CHD. ...

    Authors: Jingwen Chen, Yang Liu, Defeng Pan, Tongda Xu, Yuanyuan Luo, Wanling Wu, Pei Wu, Hong Zhu and Dongye Li
    Citation: Cell Communication and Signaling 2022 20:38
  29. Lung cancer remains a major cause of cancer-related mortality throughout the world at present. Repositioning of existing drugs for other diseases is a promising strategy for cancer therapies, which may rapidly...

    Authors: Junwan Lu, Yujie Li, Shiwei Gong, Jiaxin Wang, Xiaoang Lu, Qiumei Jin, Bin Lu and Qin Chen
    Citation: Cell Communication and Signaling 2022 20:37
  30. Integrin β4 (ITGB4) participates in tumorigenesis and progression of several malignancies, but its role and related mechanisms in clear cell renal cell carcinoma (ccRCC) remain unclear.

    Authors: Zhuonan Liu, Tianshui Sun, Chiyuan Piao, Zhe Zhang and Chuize Kong
    Citation: Cell Communication and Signaling 2022 20:36
  31. As a class of the opioid receptors, the kappa opioid receptor (KOR) has been verified to be a potential biomarker and therapeutic target for human malignant tumors. However, a thorough understanding of whether...

    Authors: Han-Ming Huang, Xin-Hua He, Xiao-Yu Huang, Guo-Yun Wang, Qiao-Xi Xia, Ze-Peng Du and Yong-Fa Zhang
    Citation: Cell Communication and Signaling 2022 20:35
  32. KRAS mutation is one of the dominant gene mutations in colorectal cancer (CRC). Up to present, targeting KRAS for CRC treatment remains a clinical challenge. WNT974 (LGK974) is a porcupine inhibitor that inter...

    Authors: Rui-Hong Gong, Minting Chen, Chunhua Huang, Hoi Leong Xavier Wong, Hiu Yee Kwan and Zhaoxiang Bian
    Citation: Cell Communication and Signaling 2022 20:34
  33. Store-operated channels (SOCs) are highly selective Ca2+ channels that mediate Ca2+ influx in non-excitable and excitable (i.e., skeletal and cardiac muscle) cells. These channels are triggered by Ca2+ depleti...

    Authors: Ting Lu, Yihua Zhang, Yong Su, Dayan Zhou and Qiang Xu
    Citation: Cell Communication and Signaling 2022 20:33
  34. Lung cancer is one of the most common cancers and the leading cause of cancer-related death. Glycogen synthase kinase-3 (GSK-3) α, a member of the glycogen synthase kinase-3 family, reportedly plays a role in ...

    Authors: Xiaonian Cao, Wei Wu, Dao Wang, Wei Sun and Senyan Lai
    Citation: Cell Communication and Signaling 2022 20:32
  35. Resistance to androgen deprivation therapy remains a major challenge for the clinical treatment of patients with castration-resistant prostate cancer (CRPC). CYP1B1, a critical enzyme that catalyzes the conver...

    Authors: Qimei Lin, Jiasong Cao, Xiaoling Du, Kuo Yang, Xu Yang, Zhixian Liang, Jiandang Shi and Ju Zhang
    Citation: Cell Communication and Signaling 2022 20:31
  36. Percutaneous transluminal coronary angioplasty (PTCA) represents an efficient therapeutic method for atherosclerosis but conveys a risk of causing restenosis. Endothelial colony-forming cell-derived exosomes (...

    Authors: Xiao Ke, Zhiyong Liao, Xinlin Luo, Jun-qiu Chen, Ming Deng, Yiteng Huang, Zanxin Wang and Minxin Wei
    Citation: Cell Communication and Signaling 2022 20:30
  37. CRS with nasal polyps (CRSwNP) is a multifactorial disease, and various etiological factors like bacterial superantigens are known to develop this disease. Recent studies reported that Staphylococcus aureus nasal...

    Authors: Zahra Chegini, Mojtaba Didehdar, Amin Khoshbayan, Jafar Karami, Milad Yousefimashouf and Aref shariati
    Citation: Cell Communication and Signaling 2022 20:29
  38. Mesenchymal stem cells (MSCs) and their released extracellular vesicles (Evs) have shown protective effects against kidney diseases. This study aims to study the functions of umbilical cord MSCs-released Evs (...

    Authors: Wenbiao Chen, Feng Zhang, Xianliang Hou, Huixuan Xu and Donge Tang
    Citation: Cell Communication and Signaling 2022 20:28
  39. Lung cancer is the second most common and the leading cause of cancer related deaths globally. Tyrosine Kinase Inhibitors (TKIs) are among the common therapeutic strategies in lung cancer patients, however the...

    Authors: Amirhosein Maharati, Amir Sadra Zanguei, Ghazaleh Khalili-Tanha and Meysam Moghbeli
    Citation: Cell Communication and Signaling 2022 20:27
  40. Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with high rates of recurrence and death. Surgical resection and ablation therapy have limited efficacy for patients with adv...

    Authors: Sisi Yang, Chengwei Cai, Huanqiu Wang, Xueqing Ma, Anwen Shao, Jifang Sheng and Chengbo Yu
    Citation: Cell Communication and Signaling 2022 20:26
  41. The mammary gland is responsible for milk production and secretion, which is critical for neonatal health during lactation. Lactation efficiency is largely affected by energy status with unclear mechanism.

    Authors: Zhihui Wu, Qihui Li, Siwang Yang, Tenghui Zheng, Jiayuan Shao, Wutai Guan, Fang Chen and Shihai Zhang
    Citation: Cell Communication and Signaling 2022 20:25
  42. Ras is a key cellular signaling hub that controls numerous cell fates via multiple downstream effector pathways. While pathways downstream of effectors such as Raf, PI3K and RalGDS are extensively described in...

    Authors: Simona Catozzi, Camille Ternet, Alize Gourrege, Kieran Wynne, Giorgio Oliviero and Christina Kiel
    Citation: Cell Communication and Signaling 2022 20:24
  43. The genesis and developments of solid tumors, analogous to the renewal of healthy tissues, are driven by a subpopulation of dedicated stem cells, known as cancer stem cells (CSCs), that exhibit long-term clona...

    Authors: Zhiwei Sun, Doudou Liu, Bin Zeng, Qiting Zhao, Xiaoshuang Li, Hao Chen, Jianyu Wang and H. Rosie Xing
    Citation: Cell Communication and Signaling 2022 20:22
  44. Mesenchymal stem/stromal cells (MSCs) are known as the issue in biology because of some unpredictable characteristics in the different microenvironments especially in their bone marrow niche. MSCs are used in ...

    Authors: Alireza Goodarzi, Mohsen Valikhani, Fatemeh Amiri and Armita Safari
    Citation: Cell Communication and Signaling 2022 20:21
  45. Signaling pathways allow cells to detect and respond to a wide variety of chemical (e.g. Ca2+ or chemokine proteins) and physical stimuli (e.g., sheer stress, light). Together, these pathways form an extensive co...

    Authors: Sarah E. Bondos, A. Keith Dunker and Vladimir N. Uversky
    Citation: Cell Communication and Signaling 2022 20:20
  46. The Src tyrosine kinase phosphorylates effector proteins to induce expression of the podoplanin (PDPN) receptor in order to promote tumor progression. However, nontransformed cells can normalize the growth and...

    Authors: Stephanie A. Sheehan, Edward P. Retzbach, Yongquan Shen, Harini Krishnan and Gary S. Goldberg
    Citation: Cell Communication and Signaling 2022 20:19
  47. Resistance to 5-fluorouracil (5-FU) in chemotherapy and recurrence of colorectal tumors is a serious concern that impedes improvements to clinical outcomes. In the present study, we found that conditioned medi...

    Authors: Huan Niu, Meng Zhao, Jing Huang, Jing Wang, Yang Si, Shan Cheng and Wei Ding
    Citation: Cell Communication and Signaling 2022 20:18
  48. The variable results in clinical trials of adipose tissue-derived stem cells (ASCs) for chondral defects may be due to the different ex vivo culture conditions of the ASCs which are implanted to treat the lesi...

    Authors: Christopher C. H. Mak, Kendrick To, Karim Fekir, Roger A. Brooks and Wasim S. Khan
    Citation: Cell Communication and Signaling 2022 20:17

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