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  1. Autophagy is a multi-step catabolic process that delivers cellular components to lysosomes for degradation and recycling. The dysregulation of this precisely controlled process disrupts cellular homeostasis an...

    Authors: Yanan Sun, Huihui Wang, Taiqi Qu, Junjie Luo, Peng An, Fazheng Ren, Yongting Luo and Yixuan Li
    Citation: Cell Communication and Signaling 2023 21:4
    Content type: Review Published on:

  2. SCARB1 belongs to class B of Scavenger receptors (SRs) that are known to be involved in binding and endocytosis of various pathogens. SRs have emerging role in regulating innate immunity and host–pathogen inte...

    Authors: Qamar Taban, Syed Mudasir Ahmad, Peerzada Tajamul Mumtaz, Basharat Bhat, Ehtishamul Haq, Suhail Magray, Sahar Saleem, Nadeem Shabir, Amatul Muhee, Zahid Amin Kashoo, Mahrukh Hameed Zargar, Abrar A. Malik, Nazir A. Ganai and Riaz A. Shah
    Citation: Cell Communication and Signaling 2023 21:3
    Content type: Research Published on:

  3. We previously found that (pro)renin receptor ((P)RR) augments Wnt3 protein without affecting Wnt3 gene transcription in colorectal cancer (CRC) cells, thus contributes to CRC initiation. The present study aims to...

    Authors: Juan Wang, Yuwei Ding, Dan Li, Ning Zhu, Akira Nishiyama and Ying Yuan
    Citation: Cell Communication and Signaling 2023 21:2
    Content type: Research Published on:

  4. The NLRP3 inflammasome activation is the molecular basis of Helicobacter pylori (Hp)-associated gastritis. Tripartite motif (TRIM) 31 is involved in diverse pathological events. However, whether TRIM31 plays a ro...

    Authors: Qiao Yu, Huiying Shi, Zhen Ding, Zhe Wang, Hailing Yao and Rong Lin
    Citation: Cell Communication and Signaling 2023 21:1
    Content type: Research Published on:

  5. Severe acute respiratory syndrome coronavirus 2 causes coronavirus disease 19 (COVID-19). The number of confirmed cases of COVID-19 is also rapidly increasing worldwide, posing a significant challenge to human...

    Authors: Yue Li, Ye Liu, Mengjie Duo, Ruhao Wu, Tianci Jiang, Pengfei Li, Yu Wang and Zhe Cheng
    Citation: Cell Communication and Signaling 2022 20:201
    Content type: Research Published on:

  6. Despite advances in treatment, patients with refractory colorectal cancer (CRC) still have poor long-term survival, so there is a need for more effective therapeutic options.

    Authors: Huey-Jiun Ko, Shean-Jaw Chiou, Cheng-Yu Tsai, Joon-Khim Loh, Xin-Yi Lin, Thu-Ha Tran, Chia-Chung Hou, Tai-Shan Cheng, Jin-Mei Lai, Peter Mu-Hsin Chang, Feng-Sheng Wang, Chun-Li Su, Chi-Ying F. Huang and Yi-Ren Hong
    Citation: Cell Communication and Signaling 2022 20:200
    Content type: Research Published on:

  7. The treatment of chronic myeloid leukemia (CML) is facing the dilemma of tyrosine kinase inhibitors (TKIs) resistance and disease recurrence. The dysfunctional DNA damage repair mechanism plays an essential ro...

    Authors: Fanting Zeng, Yuhang Peng, Yuefeng Qin, Jianming Wang, Guoyun Jiang, Wenli Feng and Ying Yuan
    Citation: Cell Communication and Signaling 2022 20:199
    Content type: Research Published on:

  8. Premature ovarian failure is a to some extent unknown and intricate problem with diverse causes and clinical manifestations. The lack of ovarian sex hormones presumably is effective in the occurrence of ovaria...

    Authors: Narjes Nouri, Olduz Shareghi-Oskoue, Leili Aghebati-Maleki, Shahla Danaii, Javad Ahmadian Heris, Mohammad Sadegh Soltani-Zangbar, Amin Kamrani and Mehdi Yousefi
    Citation: Cell Communication and Signaling 2022 20:198
    Content type: Review Published on:

  9. Specific members of the Nima-Related Kinase (NEK) family have been linked to cancer development and progression, and a role for NEK5, one of the least studied members, in breast cancer has recently been propos...

    Authors: Camila de Castro Ferezin, Terry C. C. Lim Kam Sian, Yunjian Wu, Xiuquan Ma, Anderly C. Chüeh, Cheng Huang, Ralf B. Schittenhelm, Jörg Kobarg and Roger J. Daly
    Citation: Cell Communication and Signaling 2022 20:197
    Content type: Research Published on:

  10. Z-DNA binding protein 1 (ZBP1) is a vital innate immune sensor that regulates inflammation during pathogen invasion. ZBP1 may contribute to pyroptosis, apoptosis and necroptosis in infectious diseases. In this...

    Authors: Hui Liu, Yuxuan Liu, Wei Fan and Bing Fan
    Citation: Cell Communication and Signaling 2022 20:196
    Content type: Research Published on:

  12. Tumor glycolysis is a critical event for tumor progression. Docetaxel is widely used as a first-line drug for chemotherapy and shown to have a survival advantage. However, the role of docetaxel in tumor glycol...

    Authors: Junming Peng, Zhijun He, Yeqing Yuan, Jing Xie, Yu Zhou, Baochun Guo and Jinan Guo
    Citation: Cell Communication and Signaling 2022 20:194
    Content type: Research Published on:

  13. Neuromedin U (NMU) was identified as one of the hub genes closely related to colorectal cancer (CRC) progression and was recently shown to be a motility inducer in CRC cells. Its autocrine signalling through s...

    Authors: Patrycja Przygodzka, Kamila Soboska, Ewelina Sochacka, Marcin Pacholczyk, Marcin Braun, Hassan Kassassir, Izabela Papiewska-Pająk, Michal Kielbik and Joanna Boncela
    Citation: Cell Communication and Signaling 2022 20:193
    Content type: Research Published on:

  14. Lysosomes are a central hub for cellular metabolism and are involved in the regulation of cell homeostasis through the degradation or recycling of unwanted or dysfunctional organelles through the autophagy pat...

    Authors: Raghbendra Kumar Dutta, Joon No Lee, Yunash Maharjan, Channy Park, Seong-Kyu Choe, Ye-Shih Ho, Hyug Moo Kwon and Raekil Park
    Citation: Cell Communication and Signaling 2022 20:192
    Content type: Research Published on:

  15. Exosomes are small vesicles released by cells, which have crucial functions in intercellular communication. Exosomes originated from cell membrane invagination and are released followed by multivesicular bodie...

    Authors: Xiaotong Cen, Qing Chen, Bin Wang, Hongjie Xu, Xu Wang, Yixia Ling, Xiaofei Zhang and Dajiang Qin
    Citation: Cell Communication and Signaling 2022 20:191
    Content type: Research Published on:

  16. TGF-β superfamily signaling is indispensable for bone homeostasis. However, the global expression profiles of all the genes that make up this signaling module in bone and bone-related diseases have not yet bee...

    Authors: Ying-Wen Wang, Wen-Yu Lin, Fang-Ju Wu and Ching-Wei Luo
    Citation: Cell Communication and Signaling 2022 20:190
    Content type: Research Published on:

  17. Autophagy is an intracellular degradation process crucial for homeostasis. During autophagy, a double-membrane autophagosome fuses with lysosome through SNARE machinery STX17 to form autolysosome for degradati...

    Authors: Yunash Maharjan, Raghbendra Kumar Dutta, Jinbae Son, Xiaofan Wei, Channy Park, Hyug Moo Kwon and Raekil Park
    Citation: Cell Communication and Signaling 2022 20:189
    Content type: Research Published on:

  18. Pancreatic cancer (PC) is a highly lethal malignancy regarding digestive system, which is the fourth leading factor of cancer-related mortalities in the globe. Prognosis is poor due to diagnosis at advanced di...

    Authors: Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin and Dachuan Qi
    Citation: Cell Communication and Signaling 2022 20:188
    Content type: Research Published on:

  19. Current therapeutic management of advanced melanoma patients largely depends on their BRAF mutation status. However, the vast heterogeneity of the tumors hampers the success of therapies targeting the MAPK/ERK...

    Authors: Eyleen Corrales, Ella Levit-Zerdoun, Patrick Metzger, Ralf Mertes, Ariane Lehmann, Julia Münch, Steffen Lemke, Silke Kowar and Melanie Boerries
    Citation: Cell Communication and Signaling 2022 20:187
    Content type: Research Published on:

  20. Innate and adaptive immune cells patrol and survey throughout the human body and sometimes reside in the tumor microenvironment (TME) with a variety of cell types and nutrients that may differ from those in wh...

    Authors: Hamidreza Zalpoor, Fatemeh Aziziyan, Mahsa Liaghat, Maryam Bakhtiyari, Abdullatif Akbari, Mohsen Nabi-Afjadi, Razieh Forghaniesfidvajani and Nima Rezaei
    Citation: Cell Communication and Signaling 2022 20:186
    Content type: Review Published on:

  21. The Isoleucyl-tRNA synthetase (IARS) catalyzes isoleucine to the corresponding tRNA, maintaining the accuracy of gene translation. Its role in psoriasis has been not investigated so far. In this study, we aime...

    Authors: Bing-Xi Yan, Xue-Yan Chen, Zhao-Yuan Wang, Ying-Zhe Cui, Lilla Landeck, Ni-Chang Fu, Xing-Yu Yang, Fan Xu, Yuan Zhou, Jia-Qi Chen and Xiao-Yong Man
    Citation: Cell Communication and Signaling 2022 20:185
    Content type: Research Published on:

  22. CD6 is one of many cell surface receptors known to regulate signal transduction upon T cell activation. However, whether CD6 mediates costimulatory or inhibitory signals is controversial. When T cells engage w...

    Authors: Sónia N. Henriques, Liliana Oliveira, Rita F. Santos and Alexandre M. Carmo
    Citation: Cell Communication and Signaling 2022 20:184
    Content type: Research Published on:

  23. Hyperoxia-induced acute lung injury (HALI) is a critical life-threatening disorder characterized by severe infiltration immune cells and death of type II alveolar epithelial cells (AECII). However, little is k...

    Authors: Baoyue Guo, Zhongfu Zuo, Xingwei Di, Ying Huang, Gu Gong, Bo Xu, Lulu Wang, Xiaoyu Zhang, Zhuang Liang, Yang Hou, Xuezheng Liu and Zhansheng Hu
    Citation: Cell Communication and Signaling 2022 20:183
    Content type: Research Published on:

  24. Among the FGF proteins, the least characterized superfamily is the group of fibroblast growth factor homologous factors (FHFs). To date, the main role of FHFs has been primarily seen in the modulation of volta...

    Authors: Martyna Sochacka, Radoslaw Karelus, Lukasz Opalinski, Daniel Krowarsch, Martyna Biadun, Jacek Otlewski and Malgorzata Zakrzewska
    Citation: Cell Communication and Signaling 2022 20:182
    Content type: Brief Report Published on:

  25. Although a lack of functional PTEN contributes to tumorigenesis in a wide spectrum of human malignancies, little is known about the functional role of its overexpression in the tumors. The current study focuse...

    Authors: Ako Yokoi, Marina Minami, Miki Hashimura, Yasuko Oguri, Toshihide Matsumoto, Yoshinori Hasegawa, Mayu Nakagawa, Yu Ishibashi, Takashi Ito, Kensuke Ohhigata, Youhei Harada, Naomi Fukagawa and Makoto Saegusa
    Citation: Cell Communication and Signaling 2022 20:181
    Content type: Research Published on:

  26. Vascular smooth muscle cells (VSMCs) are the most abundant cell in vessels. Earlier experiments have found that VSMCs possess high plasticity. Vascular injury stimulates VSMCs to switch into a dedifferentiated...

    Authors: Genmao Cao, Xuezhen Xuan, Jie Hu, Ruijing Zhang, Haijiang Jin and Honglin Dong
    Citation: Cell Communication and Signaling 2022 20:180
    Content type: Review Published on:

  28. Bicalutamide is a nonsteroidal antiandrogen widely used as a first-line clinical treatment for advanced prostate cancer (PCa). Although patients initially show effective responses to bicalutamide treatment, re...

    Authors: Lei Tian, Yanfei Peng, Kuo Yang, Jiasong Cao, Xiaoling Du, Zhixian Liang, Jiandang Shi and Ju Zhang
    Citation: Cell Communication and Signaling 2022 20:178
    Content type: Methodology Published on:

  29. Loss-of-function (LOF) mutations of JAK1, a member of the JAK kinase family, were frequently observed in EC, indicating that JAK1 may act as a tumor suppressor, at least in EC. However, the mechanism of JAK1 m...

    Authors: Qin Lin, Zheng Chen, Wei Shi, Zeheng Lv, Xiaoping Wan and Kun Gao
    Citation: Cell Communication and Signaling 2022 20:177
    Content type: Research Published on:

  30. Serous ovarian carcinoma is the most frequent histological subgroup of ovarian cancer and the leading cause of death among gynecologic tumors. The tumor microenvironment and cancer-associated fibroblasts (CAFs...

    Authors: Robson Francisco Carvalho, Luisa Matos do Canto, Cecilie Abildgaard, Mads Malik Aagaard, Monica Søgaard Tronhjem, Marianne Waldstrøm, Lars Henrik Jensen, Karina Dahl Steffensen and Silvia Regina Rogatto
    Citation: Cell Communication and Signaling 2022 20:176
    Content type: Research Published on:

  31. Spermine is frequently elevated in tumor tissues and body fluids of cancer patients and is critical for cancer cell proliferation, migration and invasion. However, the immune functions of spermine in hepatocel...

    Authors: Hong-Xiang Shi, Chao Liang, Chao-Yan Yao, Zi-Xuan Gao, Jia Qin, Jin-Lan Cao, Ming-Zhu Zhang, Ying-Ying Li, Meng-Qing Wang, Hua Sun, Song-Qiang Xie and Dong Fang
    Citation: Cell Communication and Signaling 2022 20:175
    Content type: Research Published on:

  32. Recurrence, metastasis, and drug resistance are still big challenges in breast cancer therapy. Internal and external stresses have been proven to substantially facilitate breast cancer progression through mole...

    Authors: Di Xu, Zhen Liu, Ming-Xing Liang, Yin-Jiao Fei, Wei Zhang, Yang Wu and Jin-Hai Tang
    Citation: Cell Communication and Signaling 2022 20:174
    Content type: Review Published on:

  33. Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been growing swiftly worldwide. Patients with background chronic pulmonary inflammations such as asthma or chronic obstructive pu...

    Authors: Hadi Rajabi, Deniz Mortazavi, Nur Konyalilar, Gizem Tuse Aksoy, Sinem Erkan, Seval Kubra Korkunc, Ozgecan Kayalar, Hasan Bayram and Reza Rahbarghazi
    Citation: Cell Communication and Signaling 2022 20:173
    Content type: Review Published on:

  34. Acute myeloid leukemia (AML) is a type of leukemia with a poor prognosis and survival characterized by abnormal cell proliferation and differentiation. Despite advances in treatment, AML still has a low comple...

    Authors: Hamidreza Zalpoor, Maryam Bakhtiyari, Abdullatif Akbari, Fatemeh Aziziyan, Hooriyeh Shapourian, Mahsa Liaghat, Zahra Zare-Badie, Sheida Yahyazadeh, Vahideh Tarhriz and Mazdak Ganjalikhani-Hakemi
    Citation: Cell Communication and Signaling 2022 20:172
    Content type: Review Published on:

  35. Presently, more than half of cancer patients receive radiotherapy to cure localized cancer, palliate symptoms, or control the progression of cancer. However, radioresistance and radiation-induced bystander eff...

    Authors: Zhenyi Yang, Wen Zhong, Liang Yang, Ping Wen, Yixuan Luo and Chunli Wu
    Citation: Cell Communication and Signaling 2022 20:171
    Content type: Review Published on:

  36. Molecule interacting with CasL-like protein 2 (MICALL2) is believed to regulate cytoskeleton dynamics, tight junction formation, and neurite outgrowth. However, its biological role and the underlying mechanism...

    Authors: Pushuai Wen, Huade Wang, Yi Li, Xinyao Sui, Zhijuan Hou, Xiaoyan Guo, Wanying Xue, Dahua Liu, Yu Wang and Jing Gao
    Citation: Cell Communication and Signaling 2022 20:170
    Content type: Research Published on:

  37. Myelodysplastic syndrome (MDS) is a clonal disease of hematopoietic cells, characterized by hematopoietic cell hematopoiesis and a high risk of transformation into acute myeloid leukemia (AML). Although the un...

    Authors: Zhaoyun Liu, Yixuan Guo, Lei Huang, Yue Jia, Hui Liu, Fengping Peng, Lixiang Duan, Hongkai Zhang and Rong Fu
    Citation: Cell Communication and Signaling 2022 20:169
    Content type: Research Published on:

  38. DNA methyltransferase 3A (DNMT3A) often mutate on arginine 882 (DNMT3AR882) in acute myeloid leukemia (AML). AML patients with DNMT3A R882 mutation are usually resistant to daunorubicin treatment; however, the as...

    Authors: Xuan Chu, Liang Zhong, Wenran Dan, Xiao Wang, Zhonghui Zhang, Zhenyan Liu, Yang Lu, Xin Shao, Ziwei Zhou, Shuyu Chen and Beizhong Liu
    Citation: Cell Communication and Signaling 2022 20:168
    Content type: Research Published on:

  39. Concanavalin A (ConA), the most studied plant lectin, has been known as a potent anti-neoplastic agent for a long time. Since initial reports on its capacity to kill cancer cells, much attention has been devot...

    Authors: Huldani Huldani, Ahmed Ibraheem Rashid, Khikmatulla Negmatovich Turaev, Maria Jade Catalan Opulencia, Walid Kamal Abdelbasset, Dmitry Olegovich Bokov, Yasser Fakri Mustafa, Moaed E. Al-Gazally, Ali Thaeer Hammid, Mustafa M. Kadhim and Seyed Hossein Ahmadi
    Citation: Cell Communication and Signaling 2022 20:167
    Content type: Review Published on:

  40. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) belongs to the epidermal growth factor (EGF) family of growth factors. HB-EGF and its receptors, epidermal growth factor receptor (EGFR) and ...

    Authors: Jung-Chien Cheng, Xiaoyu Han, Qingxue Meng, Yanjie Guo, Boqun Liu, Tinglin Song, Yuanyuan Jia, Lanlan Fang and Ying-Pu Sun
    Citation: Cell Communication and Signaling 2022 20:166
    Content type: Research Published on:

  41. Postmenopausal bone loss, mainly caused by excessive bone resorption mediated by osteoclasts, has become a global public health burden. Metformin, a hypoglycemic drug, has been reported to have beneficial effe...

    Authors: Xudong Xie, Liangcong Hu, Bobin Mi, Hang Xue, Yiqiang Hu, Adriana C. Panayi, Yori Endo, Lang Chen, Chenchen Yan, Ze Lin, Hui Li, Wu Zhou and Guohui Liu
    Citation: Cell Communication and Signaling 2022 20:165
    Content type: Research Published on:

  42. Triple negative breast cancer (TNBC) is one of the most lethal breast cancer subtypes. Due to a lack of effective therapeutic targets, chemotherapy is still the main medical treatment for TNBC patients. Thus, ...

    Authors: Zhongbo Li, Peng Su, Yinlu Ding, Honglei Gao, Huijie Yang, Xin Li, Xiao Yang, Yan Xia, Chenmiao Zhang, Mingxi Fu, Dehai Wang, Ye Zhang, Shu Zhuo, Jian Zhu and Ting Zhuang
    Citation: Cell Communication and Signaling 2022 20:164
    Content type: Research Published on:

  43. Nesfatin-1 and -2 are produced from a reaction in which the N-terminus of human Nucleobindin-2 undergoes proteolytical processing. To date, Nucleobindin-2 and/or nesfatin-1 have only been shown to act as pepti...

    Authors: Rafał Lenda, Michał Padjasek, Artur Krężel, Andrzej Ożyhar and Dominika Bystranowska
    Citation: Cell Communication and Signaling 2022 20:163
    Content type: Research Published on:

  44. Frameshift mutations in LRPAP1 are responsible for autosomal recessive high myopia in human beings but its underlying mechanism remains elusive. This study aims to investigate the effect of LRPAP1 defect on ocula...

    Authors: Shanshan Liu, Ting Chen, Binghao Chen, Yijun Liu, Xiaohe Lu and Jiali Li
    Citation: Cell Communication and Signaling 2022 20:162
    Content type: Research Published on:

  46. High-altitude cerebral edema (HACE) is a serious and potentially fatal brain injury that is caused by acute hypobaric hypoxia (HH) exposure. Vasogenic edema is the main pathological factor of this condition. H...

    Authors: Yan Xue, Xueting Wang, Baolan Wan, Dongzhi Wang, Meiqi Li, Kang Cheng, Qianqian Luo, Dan Wang, Yapeng Lu and Li Zhu
    Citation: Cell Communication and Signaling 2022 20:160
    Content type: Research Published on:

  47. We mourn, and briefly describe the life and contributions of, Andrew H. Wyllie, who was a co-author of the first paper to describe apoptosis, and a primary proponent of the concept.

    Authors: Zahra Zakeri and Richard A. Lockshin
    Citation: Cell Communication and Signaling 2022 20:159
    Content type: Obituary Published on:

  48. Ongoing differentiation processes characterize the mammary gland during sexual development and reproduction. In contrast, defective remodelling is assumed to be causal for breast tumorigenesis. We have shown r...

    Authors: Marie-Luise Melcher, Ines Block, Karolin Kropf, Anurag Kumar Singh and Guido Posern
    Citation: Cell Communication and Signaling 2022 20:158
    Content type: Research Published on:

  49. EGFR mutations in non-small cell lung cancer (NSCLC) are associated with a poor response to immune checkpoint inhibitors (ICIs), and only 20% of NSCLC patients harboring EGFR mutations benefit from immunotherapy....

    Authors: Dantong Sun, Haili Qian, Jinsong Wang, Tongji Xie, Fei Teng, Junling Li and Puyuan Xing
    Citation: Cell Communication and Signaling 2022 20:156
    Content type: Research Published on:

  50. Age-related macular degeneration (AMD), a progressive chronic disease of the central retina, is a leading cause of blindness worldwide. Activated macrophages recruited to the injured eyes greatly contribute to...

    Authors: Pengfei Zhan, Yuqing Cui, Yujuan Cao, Xun Bao, Meili Wu, Qian Yang, Jiahui Yang, Haohan Zheng, Jian Zou, Tianhua Xie, Jiping Cai, Yong Yao and Xiaolu Wang
    Citation: Cell Communication and Signaling 2022 20:155
    Content type: Research Published on:
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ISSN: 1478-811X