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Page 7 of 17

  1. Content type: Research

    Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-depend...

    Authors: Lara Donaldson, Stuart Meier and Christoph Gehring

    Citation: Cell Communication and Signaling 2016 14:10

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  2. Content type: Review

    RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...

    Authors: Aino I. Järvelin, Marko Noerenberg, Ilan Davis and Alfredo Castello

    Citation: Cell Communication and Signaling 2016 14:9

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  3. Content type: Review

    Protein-protein interactions (PPI) are involved in virtually every cellular process and thus represent an attractive target for therapeutic interventions. A significant number of protein interactions are frequ...

    Authors: Carles Corbi-Verge and Philip M. Kim

    Citation: Cell Communication and Signaling 2016 14:8

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  4. Content type: Erratum

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Citation: Cell Communication and Signaling 2016 14:7

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    The original article was published in Cell Communication and Signaling 2016 14:4

  5. Content type: Short report

    Chronic myeloid leukemia (CML) is driven by the fusion kinase Bcr-Abl. Bcr-Abl tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), revolutionized CML therapy. Nevertheless, about 20 % of CMLs di...

    Authors: Sebastian Halbach, Zehan Hu, Christine Gretzmeier, Julia Ellermann, Franziska U. Wöhrle, Jörn Dengjel and Tilman Brummer

    Citation: Cell Communication and Signaling 2016 14:6

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  6. Content type: Research

    Growth factors induce a characteristically short-lived Ras activation in cells emerging from quiescence. Extensive work has shown that transient as opposed to sustained Ras activation is critical for the induc...

    Authors: Anne Hennig, Robby Markwart, Katharina Wolff, Katja Schubert, Yan Cui, Ian A. Prior, Manuel A. Esparza-Franco, Graham Ladds and Ignacio Rubio

    Citation: Cell Communication and Signaling 2016 14:5

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  7. Content type: Research

    Cells of the tumor microenvironment are recognized as important determinants of the tumor biology. The adjacent non-malignant cells can regulate drug responses of the cancer cells by secreted paracrine factors...

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Citation: Cell Communication and Signaling 2016 14:4

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    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:7

  8. Content type: Review

    Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are...

    Authors: Matheus de Castro Fonseca, Carla J. Aguiar, Joao Antônio da Rocha Franco, Rafael N. Gingold and M. Fatima Leite

    Citation: Cell Communication and Signaling 2016 14:3

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  9. Content type: Methodology

    Human mesenchymal stromal cells (hMSC) are multipotent cells with both regenerative and immunomodulatory activities making them an attractive tool for cellular therapy. In the last few years it has been shown ...

    Authors: Teresa L. Ramos, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Silvia Preciado, Noemí Puig, Guillermo López-Ruano, Ángel Hernández-Hernández, Alba Redondo, Rebeca Ortega, Concepción Rodríguez, Fermín Sánchez-Guijo and Consuelo del Cañizo

    Citation: Cell Communication and Signaling 2016 14:2

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  10. Content type: Review

    A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordere...

    Authors: Kim Van Roey and Norman E. Davey

    Citation: Cell Communication and Signaling 2015 13:45

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  11. Content type: Review

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Authors: Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Citation: Cell Communication and Signaling 2015 13:43

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  12. Content type: Review

    It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoi...

    Authors: Toby J. Gibson, Holger Dinkel, Kim Van Roey and Francesca Diella

    Citation: Cell Communication and Signaling 2015 13:42

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  13. Content type: Research

    Abl interactor (Abi) family proteins play significant roles in actin cytoskeleton organization through participation in the WAVE complex. Mammals possess three Abi proteins: Abi-1, Abi-2, and NESH/Abi-3. Abi-1...

    Authors: Saki Sekino, Yuriko Kashiwagi, Hitoshi Kanazawa, Kazuki Takada, Takashi Baba, Seiichi Sato, Hiroki Inoue, Masaki Kojima and Katsuko Tani

    Citation: Cell Communication and Signaling 2015 13:41

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  14. Content type: Research

    Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains develop atrophic rhinitis c...

    Authors: Bianca Kloos, Sushmita Chakraborty, Sonja G. Lindner, Katrin Noack, Ulrike Harre, Georg Schett, Oliver H. Krämer and Katharina F. Kubatzky

    Citation: Cell Communication and Signaling 2015 13:40

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  15. Content type: Review

    Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sens...

    Authors: Claudia Lennicke, Jette Rahn, Rudolf Lichtenfels, Ludger A. Wessjohann and Barbara Seliger

    Citation: Cell Communication and Signaling 2015 13:39

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  16. Content type: Research

    Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP)...

    Authors: Sehyo Charley Choe, Anne Hamacher-Brady and Nathan Ryan Brady

    Citation: Cell Communication and Signaling 2015 13:37

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  17. Content type: Research Article

    The consideration of lactate as an active metabolite is a newly emerging and attractive concept. Recently, lactate has been reported to regulate gene transcription via the inhibition of histone deacetylases (H...

    Authors: Waldemar Wagner, Wojciech M. Ciszewski and Katarzyna D. Kania

    Citation: Cell Communication and Signaling 2015 13:36

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  18. Content type: Research Article

    The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocyt...

    Authors: Yoshinori Makino, Masumi Tsuda, Yusuke Ohba, Hiroshi Nishihara, Hirofumi Sawa, Kazuo Nagashima and Shinya Tanaka

    Citation: Cell Communication and Signaling 2015 13:35

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  19. Content type: Research Article

    Connexin37 (Cx37) and Cx40 are crucial for endothelial cell-cell communication and homeostasis. Both connexins interact with endothelial nitric oxide synthase (eNOS). The exact contribution of these interactio...

    Authors: Merlijn J Meens, Florian Alonso, Loïc Le Gal, Brenda R Kwak and Jacques-Antoine Haefliger

    Citation: Cell Communication and Signaling 2015 13:34

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  20. Content type: Research Article

    Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular...

    Authors: Csaba Ádám, Anna Fekete, Gábor Bőgel, Zsuzsanna Németh, Natália Tőkési, Judit Ovádi, Károly Liliom, Szabolcs Pesti, Miklós Geiszt and László Buday

    Citation: Cell Communication and Signaling 2015 13:33

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  21. Content type: Research

    Orai/CRACM1 ion channels provide the major Ca2+ influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca2+-activated K+ channel KCa3.1 modulates Ca2+ influx and the secretory respon...

    Authors: S. Mark Duffy, Ian Ashmole, Dawn T. Smallwood, Mark L. Leyland and Peter Bradding

    Citation: Cell Communication and Signaling 2015 13:32

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  22. Content type: Research

    The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details as to how TSAd regulates this process remain to be ...

    Authors: Cecilie Dahl Hem, Vibeke Sundvold-Gjerstad, Stine Granum, Lise Koll, Greger Abrahamsen, Laszlo Buday and Anne Spurkland

    Citation: Cell Communication and Signaling 2015 13:31

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  23. Content type: Review

    Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric diseases but also with several extragastric diseases. The clinical outcomes caused by H. p...

    Authors: Xin Yong, Bo Tang, Bo-Sheng Li, Rui Xie, Chang-Jiang Hu, Gang Luo, Yong Qin, Hui Dong and Shi-Ming Yang

    Citation: Cell Communication and Signaling 2015 13:30

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  24. Content type: Research

    Claudin-7 (cld7), a tight junction (TJ) component, is also found basolaterally and in the cytoplasm. Basolaterally located cld7 is enriched in glycolipid-enriched membrane domains (GEM), where it associates wi...

    Authors: Sarah Heiler, Wei Mu, Margot Zöller and Florian Thuma

    Citation: Cell Communication and Signaling 2015 13:29

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  25. Content type: Research Article

    In many cells, bile acids (BAs) have a multitude of effects, some of which may be mediated by specific receptors such the TGR5 or FXR receptors. In pancreas systemic BAs, as well as intra-ductal BAs from bile ...

    Authors: Justyna M. Kowal, Kristian A. Haanes, Nynne M. Christensen and Ivana Novak

    Citation: Cell Communication and Signaling 2015 13:28

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  26. Content type: Research article

    Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in p...

    Authors: Oddrun Elise Olsen, Karin Fahl Wader, Hanne Hella, Anne Kærsgaard Mylin, Ingemar Turesson, Ingerid Nesthus, Anders Waage, Anders Sundan and Toril Holien

    Citation: Cell Communication and Signaling 2015 13:27

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  27. Content type: Research article

    The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and in...

    Authors: Joseph Cursons, Karl-Johan Leuchowius, Mark Waltham, Eva Tomaskovic-Crook, Momeneh Foroutan, Cameron P Bracken, Andrew Redfern, Edmund J Crampin, Ian Street, Melissa J Davis and Erik W Thompson

    Citation: Cell Communication and Signaling 2015 13:26

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  28. Content type: Research

    One hallmark of cancer cells is their ability to evade physiologic signals causing regulated cell death (RCD). Correspondingly, TRAIL-based therapies to eliminate human cancer cells via enforced induction of a...

    Authors: Stephan Philipp, Justyna Sosna, Johannes Plenge, Holger Kalthoff and Dieter Adam

    Citation: Cell Communication and Signaling 2015 13:25

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  29. Content type: Review

    Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity...

    Authors: Giulio Preta, James G Cronin and I Martin Sheldon

    Citation: Cell Communication and Signaling 2015 13:24

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  30. Content type: Short report

    Protein kinase C-θ (PKCθ) plays an important role in signal transduction down-stream of the T cell receptor and T cells deficient of PKCθ show impaired NF-κB as well as NFAT/AP-1 activation resulting in strongly ...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser and Gottfried Baier

    Citation: Cell Communication and Signaling 2015 13:22

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  31. Content type: Research

    Gastrointestinal stromal tumours (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT or platelet-derived growth factor receptor-α (PDGFR...

    Authors: Christelle Bahlawane, René Eulenfeld, Monique Y Wiesinger, Jiali Wang, Arnaud Muller, Andreas Girod, Petr V Nazarov, Kathrin Felsch, Laurent Vallar, Thomas Sauter, Venkata P Satagopam and Serge Haan

    Citation: Cell Communication and Signaling 2015 13:21

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  32. Content type: Research

    Sertoli cells play key roles in regulating spermatogenesis and testis development by providing structural and nutritional supports. Recent studies demonstrate that Sertoli cells can be converted into functiona...

    Authors: Ying Guo, Yanan Hai, Chencheng Yao, Zheng Chen, Jingmei Hou, Zheng Li and Zuping He

    Citation: Cell Communication and Signaling 2015 13:20

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  33. Content type: Research

    Dendritic cells (DC) are the most potent antigen-presenting cells (APC) with the unique ability to activate naïve T cells and to initiate and maintain primary immune responses. Immunosuppressive and anti-infla...

    Authors: Michael Gutknecht, Julian Geiger, Simone Joas, Daniela Dörfel, Helmut R Salih, Martin R Müller, Frank Grünebach and Susanne M Rittig

    Citation: Cell Communication and Signaling 2015 13:19

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    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:11

  34. Content type: Research

    Chondrocytes are the main cellular component of articular cartilage. In healthy tissue, they are embedded in a strong but elastic extracelluar matrix providing resistance against mechanical forces and friction...

    Authors: Markus Wehland, Ganna Aleshcheva, Herbert Schulz, Katrin Saar, Norbert Hübner, Ruth Hemmersbach, Markus Braun, Xiao Ma, Timo Frett, Elisabeth Warnke, Stefan Riwaldt, Jessica Pietsch, Thomas Juhl Corydon, Manfred Infanger and Daniela Grimm

    Citation: Cell Communication and Signaling 2015 13:18

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  35. Content type: Research

    Diabetes mellitus is a common metabolic disorder characterized by dysfunction of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators of beta-cell activities. These non-coding RNAs have ...

    Authors: Claudiane Guay, Véronique Menoud, Sophie Rome and Romano Regazzi

    Citation: Cell Communication and Signaling 2015 13:17

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  36. Content type: Research

    Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the ...

    Authors: Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie and George S Baillie

    Citation: Cell Communication and Signaling 2015 13:16

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  37. Content type: Research

    The mechanistic target of rapamycin, (mTOR) kinase plays a pivotal role in controlling critical cellular growth and survival pathways, and its aberrant induction is implicated in cancer pathogenesis. Therefore...

    Authors: Krystyna Mazan-Mamczarz, Raymond J Peroutka, James J Steinhardt, Moriah Gidoni, Yongqing Zhang, Elin Lehrmann, Ari L Landon, Bojie Dai, Simone Houng, Parameswary A Muniandy, Sol Efroni, Kevin G Becker and Ronald B Gartenhaus

    Citation: Cell Communication and Signaling 2015 13:15

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  38. Content type: Research

    Expression of programmed cell death ligand 1 (PD-L1) is an important process by which tumor cells suppress antitumor immunity in the tumor microenvironment. Bone marrow (BM)–derived immune cells are an importa...

    Authors: Hyangsoon Noh, Jiemiao Hu, Xiaohong Wang, Xueqing Xia, Arun Satelli and Shulin Li

    Citation: Cell Communication and Signaling 2015 13:14

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  39. Content type: Review

    We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activat...

    Authors: Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yasushi Horie, Kazuhiko Hayashi, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert, Katsuyoshi Takata, Takashi Oka and Tadashi Yoshino

    Citation: Cell Communication and Signaling 2015 13:13

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  40. Content type: Research

    The RAS/MAPK signaling pathway can regulate gene expression by phosphorylating and altering the function of some, but not all, ETS transcription factors. ETS family transcription factors bind similar DNA seque...

    Authors: Nagarathinam Selvaraj, Vivekananda Kedage and Peter C Hollenhorst

    Citation: Cell Communication and Signaling 2015 13:12

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  41. Content type: Short report

    The viral G protein-coupled receptor (vGPCR) is proposed to act as one of the predominant mediators of Kaposi’s sarcoma (KS), a human herpes virus 8 (HHV8)-elicited disease. The actions of vGPCR manifest patho...

    Authors: Julie Dwyer, Sandy Azzi, Héloïse M Leclair, Steven Georges, Agnès Carlotti, Lucas Treps, Eva M Galan-Moya, Catherine Alexia, Nicolas Dupin, Nicolas Bidère and Julie Gavard

    Citation: Cell Communication and Signaling 2015 13:11

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  42. Content type: Research

    Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5)...

    Authors: Dirk Fahrenkamp, Hildegard Schmitz-Van de Leur, Andrea Küster, Nicolas Chatain and Gerhard Müller-Newen

    Citation: Cell Communication and Signaling 2015 13:10

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  43. Content type: Research

    Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL ...

    Authors: Stefania Raimondo, Laura Saieva, Chiara Corrado, Simona Fontana, Anna Flugy, Aroldo Rizzo, Giacomo De Leo and Riccardo Alessandro

    Citation: Cell Communication and Signaling 2015 13:8

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  44. Content type: Research

    Phosphatidylinositol 3-Kinases (PI3Ks) are a family of lipid kinases that phosphorylate the D3-hydroxyls of the inositol ring of phosphoinositides, and are responsible for coordinating a diverse range of cellu...

    Authors: Vivek K Gupta, Ammaji Rajala and Raju VS Rajala

    Citation: Cell Communication and Signaling 2015 13:7

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  45. Content type: Research

    The Rho GTPase RhoB has been proposed to be a tumor suppressor in cancer and is downregulated in various tumors including prostate. RhoB has different effects on cell migration depending on the cell type and c...

    Authors: Francisco M Vega, Mairian Thomas, Nicolas Reymond and Anne J Ridley

    Citation: Cell Communication and Signaling 2015 13:6

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