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  1. Human cancer cells often exhibit impaired IGF2 expression and the underlying mechanisms are multifaceted and complex. Besides the well-known imprinting control region IGF2/H19-ICR, the involvement of a differenti...

    Authors: Undraga Schagdarsurengin, Angela Lammert, Natalie Schunk, Diana Sheridan, Stefan Gattenloehner, Klaus Steger, Florian Wagenlehner and Temuujin Dansranjavin

    Citation: Cell Communication and Signaling 2017 15:40

    Content type: Research

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  2. Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix. This study was conducted to inve...

    Authors: Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu and Shu Zheng

    Citation: Cell Communication and Signaling 2017 15:38

    Content type: Research

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  3. Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed the tumor microenvironment has a critical role in regulating tumor growth by...

    Authors: Ana Isabel Oliveira, Sandra I. Anjo, Joana Vieira de Castro, Sofia C. Serra, António J. Salgado, Bruno Manadas and Bruno M. Costa

    Citation: Cell Communication and Signaling 2017 15:37

    Content type: Research

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  4. The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils. In this process, ARF1 is activated by t...

    Authors: Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa and Hisataka Sabe

    Citation: Cell Communication and Signaling 2017 15:36

    Content type: Short report

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  5. Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad ...

    Authors: Long Zhao, Liguo Wang, Chunli Chi, Wenwen Lan and Ying Su

    Citation: Cell Communication and Signaling 2017 15:35

    Content type: Review

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  6. Meningiomas are the most common primary intracranial tumors in adults. While a majority of meningiomas are slow growing neoplasms that may cured by surgical resection, a subset demonstrates more aggressive beh...

    Authors: Yu Mei, Ziming Du, Changchen Hu, Noah F. Greenwald, Malak Abedalthagafi, Nathalie Y.R. Agar, Gavin P. Dunn, Wenya Linda Bi, Sandro Santagata and Ian F. Dunn

    Citation: Cell Communication and Signaling 2017 15:34

    Content type: Research

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  7. Antimicrobial peptides are important components of the host defence with a broad range of functions including direct antimicrobial activity and modulation of inflammation. Lack of cathelin-related antimicrobia...

    Authors: Eugenia Kress, Julika Merres, Lea-Jessica Albrecht, Sven Hammerschmidt, Thomas Pufe, Simone C. Tauber and Lars-Ove Brandenburg

    Citation: Cell Communication and Signaling 2017 15:32

    Content type: Research

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  8. Authors: Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Citation: Cell Communication and Signaling 2017 15:31

    Content type: Erratum

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    The original article was published in Cell Communication and Signaling 2017 15:30

  9. Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel invol...

    Authors: Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Citation: Cell Communication and Signaling 2017 15:30

    Content type: Research

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    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:31

  10. C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-termina...

    Authors: Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin and Heung-Chin Cheng

    Citation: Cell Communication and Signaling 2017 15:29

    Content type: Research

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  11. Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunit...

    Authors: Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg and Sandra Beer-Hammer

    Citation: Cell Communication and Signaling 2017 15:28

    Content type: Research

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  12. Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has em...

    Authors: Angela J. Lowrey, Wyatt Cramblet and Gretchen L. Bentz

    Citation: Cell Communication and Signaling 2017 15:27

    Content type: Review

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  13. Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract....

    Authors: Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou and Farzad Pakdel

    Citation: Cell Communication and Signaling 2017 15:26

    Content type: Research

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  14. Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...

    Authors: Kyung-Ae Yoon, YeonSung Son, Young-Jin Choi, Joo-Hyun Kim and Je-Yoel Cho

    Citation: Cell Communication and Signaling 2017 15:25

    Content type: Research

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  15. In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while concomitantly inhibiting the secretory cell fate (i....

    Authors: Shaiya C. Robinson, Kristina Klobucar, Christina C. Pierre, Amna Ansari, Svetlana Zhenilo, Egor Prokhortchouk and Juliet M. Daniel

    Citation: Cell Communication and Signaling 2017 15:24

    Content type: Research

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  16. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarizati...

    Authors: Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi and Mohammadali Bahar

    Citation: Cell Communication and Signaling 2017 15:23

    Content type: Review

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  17. The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...

    Authors: Stacey Chung, Yanli Jin, Bingchen Han, Ying Qu, Bowen Gao, Armando E. Giuliano and Xiaojiang Cui

    Citation: Cell Communication and Signaling 2017 15:22

    Content type: Short report

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  18. LASP2 (LIM and SH3 Protein 2) is a small focal adhesion protein belongs to nebulin protein family. As the newest member of nebulette family, the function of LASP2 remains to be identified.

    Authors: Bin Wang, Lanzhi Zhang, Liying Zhao, Rui Zhou, Yanqing Ding, Guoxin Li and Liang Zhao

    Citation: Cell Communication and Signaling 2017 15:21

    Content type: Research

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  19. This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor typ...

    Authors: Catharina Melzer, Ralf Hass, Juliane von der Ohe, Hendrik Lehnert and Hendrik Ungefroren

    Citation: Cell Communication and Signaling 2017 15:19

    Content type: Review

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  20. Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...

    Authors: You-Take Oh, Ping Yue and Shi-Yong Sun

    Citation: Cell Communication and Signaling 2017 15:18

    Content type: Research

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  21. There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attr...

    Authors: Paola Ortiz-Montero, Arturo Londoño-Vallejo and Jean-Paul Vernot

    Citation: Cell Communication and Signaling 2017 15:17

    Content type: Research

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  22. Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...

    Authors: Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher and Sebastian Heikaus

    Citation: Cell Communication and Signaling 2017 15:16

    Content type: Research

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  23. Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...

    Authors: Silja Wessler, Linda M. Krisch, Dominik P. Elmer and Fritz Aberger

    Citation: Cell Communication and Signaling 2017 15:15

    Content type: Review

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  24. Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA se...

    Authors: Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz and Johannes Gebert

    Citation: Cell Communication and Signaling 2017 15:14

    Content type: Research

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  25. Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...

    Authors: Florian Wolff, Michael Leisch, Richard Greil, Angela Risch and Lisa Pleyer

    Citation: Cell Communication and Signaling 2017 15:13

    Content type: Review

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  26. Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...

    Authors: Wolfgang Gruber, Tamara Scheidt, Fritz Aberger and Christian G. Huber

    Citation: Cell Communication and Signaling 2017 15:12

    Content type: Review

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  27. C-Met is a receptor tyrosine kinase with multiple functions throughout embryonic development, organogenesis and wound healing and is expressed in various epithelia. The ligand of c-Met is Hepatocyte Growth Fac...

    Authors: Ralf Hass, Susanne Jennek, Yuanyuan Yang and Karlheinz Friedrich

    Citation: Cell Communication and Signaling 2017 15:10

    Content type: Review

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  28. Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protec...

    Authors: Ulrich-Axel Bommer, Kara L. Vine, Prianka Puri, Martin Engel, Lisa Belfiore, Karen Fildes, Marijka Batterham, Alistair Lochhead and Morteza Aghmesheh

    Citation: Cell Communication and Signaling 2017 15:9

    Content type: Research

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  29. Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...

    Authors: Fritz Aberger, Evelyn Hutterer, Christina Sternberg, Pedro J. del Burgo and Tanja N. Hartmann

    Citation: Cell Communication and Signaling 2017 15:8

    Content type: Review

    Published on:

  30. The mammalian target of rapamycin (mTOR) is a regulator of cell proliferation, cell growth and apoptosis working through two distinct complexes: mTORC1 and mTORC2. Although much is known about the activation a...

    Authors: Kirsten Thobe, Christine Sers and Heike Siebert

    Citation: Cell Communication and Signaling 2017 15:6

    Content type: Research

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  31. In favor of their outgrowth, cancer cells must resist immune surveillance and edit the immune response. Cancer immunoediting is characterized by fundamental changes in the cellular composition and the inflamma...

    Authors: Richard Greil, Evelyn Hutterer, Tanja Nicole Hartmann and Lisa Pleyer

    Citation: Cell Communication and Signaling 2017 15:5

    Content type: Review

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  32. Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative str...

    Authors: Zhiyong Huang, Quan Hong, Xueguang Zhang, Wenzhen Xiao, Liyuan Wang, Shaoyuan Cui, Zhe Feng, Yang Lv, Guangyan Cai, Xiangmei Chen and Di Wu

    Citation: Cell Communication and Signaling 2017 15:3

    Content type: Research

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  33. Cell migration including collective cell movement and individual cell migration are crucial factors in embryogenesis. During the spreading/migration of cells, several types of adhesive structures physically in...

    Authors: Xiaoli Shen, Zanhui Jia, Donato D’Alonzo, Xinggang Wang, Elisabeth Bruder, Fabienne Hélène Emch, Christian De Geyter and Hong Zhang

    Citation: Cell Communication and Signaling 2017 15:2

    Content type: Research

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  34. The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...

    Authors: Kemal Catakovic, Eckhard Klieser, Daniel Neureiter and Roland Geisberger

    Citation: Cell Communication and Signaling 2017 15:1

    Content type: Review

    Published on:

  35. STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead t...

    Authors: Nishant P. Visavadiya, Matthew P. Keasey, Vladislav Razskazovskiy, Kalpita Banerjee, Cuihong Jia, Chiharu Lovins, Gary L. Wright and Theo Hagg

    Citation: Cell Communication and Signaling 2016 14:32

    Content type: Research

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    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:11

  36. Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance an...

    Authors: Theresa Frank, Anna Reichel, Olav Larsen, Anne-Charlotte Stilp, Mette M. Rosenkilde, Thomas Stamminger, Takeaki Ozawa and Nuska Tschammer

    Citation: Cell Communication and Signaling 2016 14:31

    Content type: Research

    Published on:

  37. The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open i...

    Authors: Carmen M. Abfalter, Maria Schubert, Camilla Götz, Thomas P. Schmidt, Gernot Posselt and Silja Wessler

    Citation: Cell Communication and Signaling 2016 14:30

    Content type: Research

    Published on:

  38. Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 ar...

    Authors: Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Kiyoshi Fukunaga, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Satoshi Fukuda and Hisataka Sabe

    Citation: Cell Communication and Signaling 2016 14:28

    Content type: Short report

    Published on:

  39. Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we terme...

    Authors: Kirsten Hattermann, Kareen Bartsch, Henrike H. Gebhardt, H. Maximilian Mehdorn, Michael Synowitz, Anne Dorothée Schmitt, Rolf Mentlein and Janka Held-Feindt

    Citation: Cell Communication and Signaling 2016 14:26

    Content type: Research

    Published on:

  40. ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signa...

    Authors: Susan M. Farabaugh, Bonita T. Chan, Xiaojiang Cui, Robert K. Dearth and Adrian V. Lee

    Citation: Cell Communication and Signaling 2016 14:25

    Content type: Research

    Published on:

  41. Reports of exocrine-to-endocrine reprogramming through expression or stabilization of the transcription factor neurogenin 3 (NGN3) have generated renewed interest in harnessing pancreatic plasticity for therap...

    Authors: Michael J. Shamblott, Marci L. O’Driscoll, Danielle L. Gomez and Dustin L. McGuire

    Citation: Cell Communication and Signaling 2016 14:23

    Content type: Research

    Published on:

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