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  1. Content type: Review

    A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordere...

    Authors: Kim Van Roey and Norman E. Davey

    Citation: Cell Communication and Signaling 2015 13:45

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  2. Content type: Review

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Authors: Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Citation: Cell Communication and Signaling 2015 13:43

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  3. Content type: Review

    It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoi...

    Authors: Toby J. Gibson, Holger Dinkel, Kim Van Roey and Francesca Diella

    Citation: Cell Communication and Signaling 2015 13:42

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  4. Content type: Research

    Abl interactor (Abi) family proteins play significant roles in actin cytoskeleton organization through participation in the WAVE complex. Mammals possess three Abi proteins: Abi-1, Abi-2, and NESH/Abi-3. Abi-1...

    Authors: Saki Sekino, Yuriko Kashiwagi, Hitoshi Kanazawa, Kazuki Takada, Takashi Baba, Seiichi Sato, Hiroki Inoue, Masaki Kojima and Katsuko Tani

    Citation: Cell Communication and Signaling 2015 13:41

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  5. Content type: Review

    Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sens...

    Authors: Claudia Lennicke, Jette Rahn, Rudolf Lichtenfels, Ludger A. Wessjohann and Barbara Seliger

    Citation: Cell Communication and Signaling 2015 13:39

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  6. Content type: Research

    Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains develop atrophic rhinitis c...

    Authors: Bianca Kloos, Sushmita Chakraborty, Sonja G. Lindner, Katrin Noack, Ulrike Harre, Georg Schett, Oliver H. Krämer and Katharina F. Kubatzky

    Citation: Cell Communication and Signaling 2015 13:40

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  7. Content type: Research

    Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP)...

    Authors: Sehyo Charley Choe, Anne Hamacher-Brady and Nathan Ryan Brady

    Citation: Cell Communication and Signaling 2015 13:37

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  8. Content type: Research Article

    The consideration of lactate as an active metabolite is a newly emerging and attractive concept. Recently, lactate has been reported to regulate gene transcription via the inhibition of histone deacetylases (H...

    Authors: Waldemar Wagner, Wojciech M. Ciszewski and Katarzyna D. Kania

    Citation: Cell Communication and Signaling 2015 13:36

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  9. Content type: Research Article

    The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocyt...

    Authors: Yoshinori Makino, Masumi Tsuda, Yusuke Ohba, Hiroshi Nishihara, Hirofumi Sawa, Kazuo Nagashima and Shinya Tanaka

    Citation: Cell Communication and Signaling 2015 13:35

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  10. Content type: Research Article

    Connexin37 (Cx37) and Cx40 are crucial for endothelial cell-cell communication and homeostasis. Both connexins interact with endothelial nitric oxide synthase (eNOS). The exact contribution of these interactio...

    Authors: Merlijn J Meens, Florian Alonso, Loïc Le Gal, Brenda R Kwak and Jacques-Antoine Haefliger

    Citation: Cell Communication and Signaling 2015 13:34

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  11. Content type: Research Article

    Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular...

    Authors: Csaba Ádám, Anna Fekete, Gábor Bőgel, Zsuzsanna Németh, Natália Tőkési, Judit Ovádi, Károly Liliom, Szabolcs Pesti, Miklós Geiszt and László Buday

    Citation: Cell Communication and Signaling 2015 13:33

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  12. Content type: Research

    Orai/CRACM1 ion channels provide the major Ca2+ influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca2+-activated K+ channel KCa3.1 modulates Ca2+ influx and the secretory respon...

    Authors: S. Mark Duffy, Ian Ashmole, Dawn T. Smallwood, Mark L. Leyland and Peter Bradding

    Citation: Cell Communication and Signaling 2015 13:32

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  13. Content type: Research

    The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details as to how TSAd regulates this process remain to be ...

    Authors: Cecilie Dahl Hem, Vibeke Sundvold-Gjerstad, Stine Granum, Lise Koll, Greger Abrahamsen, Laszlo Buday and Anne Spurkland

    Citation: Cell Communication and Signaling 2015 13:31

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  14. Content type: Review

    Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric diseases but also with several extragastric diseases. The clinical outcomes caused by H. p...

    Authors: Xin Yong, Bo Tang, Bo-Sheng Li, Rui Xie, Chang-Jiang Hu, Gang Luo, Yong Qin, Hui Dong and Shi-Ming Yang

    Citation: Cell Communication and Signaling 2015 13:30

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  15. Content type: Research Article

    In many cells, bile acids (BAs) have a multitude of effects, some of which may be mediated by specific receptors such the TGR5 or FXR receptors. In pancreas systemic BAs, as well as intra-ductal BAs from bile ...

    Authors: Justyna M. Kowal, Kristian A. Haanes, Nynne M. Christensen and Ivana Novak

    Citation: Cell Communication and Signaling 2015 13:28

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  16. Content type: Research

    Claudin-7 (cld7), a tight junction (TJ) component, is also found basolaterally and in the cytoplasm. Basolaterally located cld7 is enriched in glycolipid-enriched membrane domains (GEM), where it associates wi...

    Authors: Sarah Heiler, Wei Mu, Margot Zöller and Florian Thuma

    Citation: Cell Communication and Signaling 2015 13:29

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  17. Content type: Research article

    Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in p...

    Authors: Oddrun Elise Olsen, Karin Fahl Wader, Hanne Hella, Anne Kærsgaard Mylin, Ingemar Turesson, Ingerid Nesthus, Anders Waage, Anders Sundan and Toril Holien

    Citation: Cell Communication and Signaling 2015 13:27

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  18. Content type: Research article

    The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and in...

    Authors: Joseph Cursons, Karl-Johan Leuchowius, Mark Waltham, Eva Tomaskovic-Crook, Momeneh Foroutan, Cameron P Bracken, Andrew Redfern, Edmund J Crampin, Ian Street, Melissa J Davis and Erik W Thompson

    Citation: Cell Communication and Signaling 2015 13:26

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  19. Content type: Research

    One hallmark of cancer cells is their ability to evade physiologic signals causing regulated cell death (RCD). Correspondingly, TRAIL-based therapies to eliminate human cancer cells via enforced induction of a...

    Authors: Stephan Philipp, Justyna Sosna, Johannes Plenge, Holger Kalthoff and Dieter Adam

    Citation: Cell Communication and Signaling 2015 13:25

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  20. Content type: Review

    Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity...

    Authors: Giulio Preta, James G Cronin and I Martin Sheldon

    Citation: Cell Communication and Signaling 2015 13:24

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  21. Content type: Research

    Gastrointestinal stromal tumours (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT or platelet-derived growth factor receptor-α (PDGFR...

    Authors: Christelle Bahlawane, René Eulenfeld, Monique Y Wiesinger, Jiali Wang, Arnaud Muller, Andreas Girod, Petr V Nazarov, Kathrin Felsch, Laurent Vallar, Thomas Sauter, Venkata P Satagopam and Serge Haan

    Citation: Cell Communication and Signaling 2015 13:21

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  22. Content type: Short report

    Protein kinase C-θ (PKCθ) plays an important role in signal transduction down-stream of the T cell receptor and T cells deficient of PKCθ show impaired NF-κB as well as NFAT/AP-1 activation resulting in strongly ...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser and Gottfried Baier

    Citation: Cell Communication and Signaling 2015 13:22

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  23. Content type: Research

    Sertoli cells play key roles in regulating spermatogenesis and testis development by providing structural and nutritional supports. Recent studies demonstrate that Sertoli cells can be converted into functiona...

    Authors: Ying Guo, Yanan Hai, Chencheng Yao, Zheng Chen, Jingmei Hou, Zheng Li and Zuping He

    Citation: Cell Communication and Signaling 2015 13:20

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  24. Content type: Research

    Dendritic cells (DC) are the most potent antigen-presenting cells (APC) with the unique ability to activate naïve T cells and to initiate and maintain primary immune responses. Immunosuppressive and anti-infla...

    Authors: Michael Gutknecht, Julian Geiger, Simone Joas, Daniela Dörfel, Helmut R Salih, Martin R Müller, Frank Grünebach and Susanne M Rittig

    Citation: Cell Communication and Signaling 2015 13:19

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    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:11

  25. Content type: Research

    Chondrocytes are the main cellular component of articular cartilage. In healthy tissue, they are embedded in a strong but elastic extracelluar matrix providing resistance against mechanical forces and friction...

    Authors: Markus Wehland, Ganna Aleshcheva, Herbert Schulz, Katrin Saar, Norbert Hübner, Ruth Hemmersbach, Markus Braun, Xiao Ma, Timo Frett, Elisabeth Warnke, Stefan Riwaldt, Jessica Pietsch, Thomas Juhl Corydon, Manfred Infanger and Daniela Grimm

    Citation: Cell Communication and Signaling 2015 13:18

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  26. Content type: Research

    Diabetes mellitus is a common metabolic disorder characterized by dysfunction of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators of beta-cell activities. These non-coding RNAs have ...

    Authors: Claudiane Guay, Véronique Menoud, Sophie Rome and Romano Regazzi

    Citation: Cell Communication and Signaling 2015 13:17

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  27. Content type: Research

    Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the ...

    Authors: Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie and George S Baillie

    Citation: Cell Communication and Signaling 2015 13:16

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  28. Content type: Research

    The mechanistic target of rapamycin, (mTOR) kinase plays a pivotal role in controlling critical cellular growth and survival pathways, and its aberrant induction is implicated in cancer pathogenesis. Therefore...

    Authors: Krystyna Mazan-Mamczarz, Raymond J Peroutka, James J Steinhardt, Moriah Gidoni, Yongqing Zhang, Elin Lehrmann, Ari L Landon, Bojie Dai, Simone Houng, Parameswary A Muniandy, Sol Efroni, Kevin G Becker and Ronald B Gartenhaus

    Citation: Cell Communication and Signaling 2015 13:15

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  29. Content type: Research

    Expression of programmed cell death ligand 1 (PD-L1) is an important process by which tumor cells suppress antitumor immunity in the tumor microenvironment. Bone marrow (BM)–derived immune cells are an importa...

    Authors: Hyangsoon Noh, Jiemiao Hu, Xiaohong Wang, Xueqing Xia, Arun Satelli and Shulin Li

    Citation: Cell Communication and Signaling 2015 13:14

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  30. Content type: Review

    We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activat...

    Authors: Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yasushi Horie, Kazuhiko Hayashi, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert, Katsuyoshi Takata, Takashi Oka and Tadashi Yoshino

    Citation: Cell Communication and Signaling 2015 13:13

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  31. Content type: Research

    The RAS/MAPK signaling pathway can regulate gene expression by phosphorylating and altering the function of some, but not all, ETS transcription factors. ETS family transcription factors bind similar DNA seque...

    Authors: Nagarathinam Selvaraj, Vivekananda Kedage and Peter C Hollenhorst

    Citation: Cell Communication and Signaling 2015 13:12

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  32. Content type: Research

    Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5)...

    Authors: Dirk Fahrenkamp, Hildegard Schmitz-Van de Leur, Andrea Küster, Nicolas Chatain and Gerhard Müller-Newen

    Citation: Cell Communication and Signaling 2015 13:10

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  33. Content type: Short report

    The viral G protein-coupled receptor (vGPCR) is proposed to act as one of the predominant mediators of Kaposi’s sarcoma (KS), a human herpes virus 8 (HHV8)-elicited disease. The actions of vGPCR manifest patho...

    Authors: Julie Dwyer, Sandy Azzi, Héloïse M Leclair, Steven Georges, Agnès Carlotti, Lucas Treps, Eva M Galan-Moya, Catherine Alexia, Nicolas Dupin, Nicolas Bidère and Julie Gavard

    Citation: Cell Communication and Signaling 2015 13:11

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  34. Content type: Research

    Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL ...

    Authors: Stefania Raimondo, Laura Saieva, Chiara Corrado, Simona Fontana, Anna Flugy, Aroldo Rizzo, Giacomo De Leo and Riccardo Alessandro

    Citation: Cell Communication and Signaling 2015 13:8

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  35. Content type: Research

    Phosphatidylinositol 3-Kinases (PI3Ks) are a family of lipid kinases that phosphorylate the D3-hydroxyls of the inositol ring of phosphoinositides, and are responsible for coordinating a diverse range of cellu...

    Authors: Vivek K Gupta, Ammaji Rajala and Raju VS Rajala

    Citation: Cell Communication and Signaling 2015 13:7

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  36. Content type: Research

    Elevated levels of the inflammatory cytokine TNF-α are common in chronic diseases or inherited or degenerative muscle disorders and can lead to muscle wasting. By contrast, IGF1 has a growth promoting effect o...

    Authors: Swanhild U Meyer, Christian Thirion, Anna Polesskaya, Stefan Bauersachs, Sebastian Kaiser, Sabine Krause and Michael W Pfaffl

    Citation: Cell Communication and Signaling 2015 13:4

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  37. Content type: Research

    Homeodomain interacting protein kinases (HIPKs) function as modulators of cellular stress responses and regulate cell differentiation, proliferation and apoptosis. The HIPK family includes HIPK1, HIPK2 and HIP...

    Authors: Jan van der Laden, Ulf Soppa and Walter Becker

    Citation: Cell Communication and Signaling 2015 13:3

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  38. Content type: Research

    The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission reli...

    Authors: Annabell Bischoff, Michaela Bayerlová, Michaela Strotbek, Simone Schmid, Tim Beissbarth and Monilola A Olayioye

    Citation: Cell Communication and Signaling 2015 13:5

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  39. Content type: Research

    The Rho GTPase RhoB has been proposed to be a tumor suppressor in cancer and is downregulated in various tumors including prostate. RhoB has different effects on cell migration depending on the cell type and c...

    Authors: Francisco M Vega, Mairian Thomas, Nicolas Reymond and Anne J Ridley

    Citation: Cell Communication and Signaling 2015 13:6

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  40. Content type: Methodology

    The WNT/planar-cell-polarity (PCP) pathway is a key regulator of cell polarity and directional cell movements. Core PCP proteins such as Van Gogh-like2 (VANGL2) are evolutionarily highly conserved; however, th...

    Authors: Markéta Kaucká, Julian Petersen, Pavlína Janovská, Tomasz Radaszkiewicz, Lucie Smyčková, Avais M Daulat, Jean-Paul Borg, Gunnar Schulte and Vitezslav Bryja

    Citation: Cell Communication and Signaling 2015 13:2

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  41. Content type: Short report

    Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both ...

    Authors: Shahir S Rizk, Jean-Louis K Kouadio, Anna Szymborska, Erica M Duguid, Somnath Mukherjee, Jiamao Zheng, Charles V Clevenger and Anthony A Kossiakoff

    Citation: Cell Communication and Signaling 2015 13:1

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  42. Content type: Research

    Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in sever...

    Authors: Carla J Aguiar, João A Rocha-Franco, Pedro A Sousa, Anderson K Santos, Marina Ladeira, Cibele Rocha-Resende, Luiz O Ladeira, Rodrigo R Resende, Fernando A Botoni, Marcos Barrouin Melo, Cristiano X Lima, José M Carballido, Thiago M Cunha, Gustavo B Menezes, Silvia Guatimosim and M Fatima Leite

    Citation: Cell Communication and Signaling 2014 12:78

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  43. Content type: Research

    TGFβ1 (Transforming Growth Factor-beta1) is a versatile regulator of T cell immune responses. Depending on its context in the immunological environment, TGFβ1 guides T cells toward specific activation programs...

    Authors: Thomas Harder, Karina Guttek, Lars Philipsen, Luca Simeoni, Burkhart Schraven and Dirk Reinhold

    Citation: Cell Communication and Signaling 2014 12:74

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  44. Content type: Research

    IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocyt...

    Authors: Jiangfeng Du, Gerry AF Nicolaes, Danielle Kruijswijk, Miranda Versloot, Tom van der Poll and Cornelis van ’t Veer

    Citation: Cell Communication and Signaling 2014 12:77

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  45. Content type: Research

    B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation ...

    Authors: Narasimhulu Simma, Tanima Bose, Sascha Kahlfuß, Judith Mankiewicz, Theresa Lowinus, Fred Lühder, Thomas Schüler, Burkhart Schraven, Martin Heine and Ursula Bommhardt

    Citation: Cell Communication and Signaling 2014 12:75

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