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  1. Accumulation of immunosuppressive protein programmed death-ligand 1 (PD-L1) has been documented in several cancers and contributes to the evasion of the host immune system. However, cancer cell-intrinsic signa...

    Authors: Dan Yu, Xueshibojie Liu, Guanghong Han, Yan Liu, Xue Zhao, Di Wang, Xiaomin Bian, Tingting Gu and Lianji Wen

    Citation: Cell Communication and Signaling 2019 17:173

    Content type: Research

    Published on:

  2. Uncontrolled activation of the Hedgehog/Glioma-associated oncogene (HH/GLI) pathway is a potent oncogenic driver signal promoting numerous cancer hallmarks such as proliferation, survival, angiogenesis, metast...

    Authors: Sandra Grund-Gröschke, Georg Stockmaier and Fritz Aberger

    Citation: Cell Communication and Signaling 2019 17:172

    Content type: Review

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  3. Lymphotoxin β receptor (LTβR) plays important roles in the development of the immune system and immune response. At the cellular level, ligand-bound LTβR activates the pro-inflammatory NF-κB pathway but the de...

    Authors: Magdalena Banach-Orłowska, Renata Wyszyńska, Beata Pyrzyńska, Małgorzata Maksymowicz, Jakub Gołąb and Marta Miączyńska

    Citation: Cell Communication and Signaling 2019 17:171

    Content type: Research

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  4. Dishevelled (DVL) is an essential component of the Wnt signaling cascades. Function of DVL is controlled by phosphorylation but the molecular details are missing. DVL3 contains 131 serines and threonines whose...

    Authors: Kateřina Hanáková, Ondřej Bernatík, Marek Kravec, Miroslav Micka, Jitender Kumar, Jakub Harnoš, Petra Ovesná, Petra Paclíková, Matěj Rádsetoulal, David Potěšil, Konstantinos Tripsianes, Lukáš Čajánek, Zbyněk Zdráhal and Vítězslav Bryja

    Citation: Cell Communication and Signaling 2019 17:170

    Content type: Research

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  5. Tumor endothelial cells (TECs) perform tumor angiogenesis, which is essential for tumor growth and metastasis. Tumor cells produce large amounts of lactic acid from glycolysis; however, the mechanism underlyin...

    Authors: Dorcas A. Annan, Nako Maishi, Tomoyoshi Soga, Randa Dawood, Cong Li, Hiroshi Kikuchi, Takayuki Hojo, Masahiro Morimoto, Tetsuya Kitamura, Mohammad Towfik Alam, Kazuyuki Minowa, Nobuo Shinohara, Jin-Min Nam, Yasuhiro Hida and Kyoko Hida

    Citation: Cell Communication and Signaling 2019 17:169

    Content type: Research

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  6. Our previous study has demonstrated that NAD(P)H: quinone oxidoreductase 1 (NQO1) is significantly upregulated in human liver cancer where it potentiates the apoptosis evasion of liver cancer cell. However, th...

    Authors: Hong-Zhong Zhou, Han-Qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Bo Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang and Juan Chen

    Citation: Cell Communication and Signaling 2019 17:168

    Content type: Research

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  7. Loss of monoubiquitination of histone H2B (H2Bub1) was found to be associated with poor differentiation, cancer stemness, and enhanced malignancy of non-small cell lung cancer (NSCLC). Herein, we investigated ...

    Authors: Keqiang Zhang, Lu Yang, Jinhui Wang, Ting Sun, Yuming Guo, Rebecca Nelson, Tommy R. Tong, Rajendra Pangeni, Ravi Salgia and Dan J. Raz

    Citation: Cell Communication and Signaling 2019 17:167

    Content type: Research

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  8. In vitro chondrogenesis depends on the concerted action of numerous signalling pathways, many of which are sensitive to the changes of intracellular Ca2+ concentration. N-methyl-D-aspartate (NMDA) glutamate recep...

    Authors: Csaba Matta, Tamás Juhász, János Fodor, Tibor Hajdú, Éva Katona, Csilla Szűcs-Somogyi, Roland Takács, Judit Vágó, Tamás Oláh, Ádám Bartók, Zoltan Varga, Gyorgy Panyi, László Csernoch and Róza Zákány

    Citation: Cell Communication and Signaling 2019 17:166

    Content type: Research

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  9. Non-targeting effects of radiotherapy have become as clinical concern due to secondary tumorigenesis in the patients receiving radiotherapy. Radiotherapy also affects non-tumoral cells present in the tumor mic...

    Authors: Nasrollah Jabbari, Muhammad Nawaz and Jafar Rezaie

    Citation: Cell Communication and Signaling 2019 17:165

    Content type: Research

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  10. Carcinoma cells shift between epithelial and mesenchymal phenotypes during cancer progression, as defined by surface presentation of the cell-cell cohesion molecule E-cadherin, affecting dissemination, progres...

    Authors: Bo Ma, Ahmad Khazali, Hanshuang Shao, Yuhan Jiang and Alan Wells

    Citation: Cell Communication and Signaling 2019 17:164

    Content type: Research

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  11. Recent evidence has suggested that the 1,25(OH)2D3/Vitamin D receptor (VDR) acts to suppress the immune response associated with systemic lupus erythematosus (SLE), a serious multisystem autoimmune disease. Hence...

    Authors: Dan Liu, Yu-Xuan Fang, Xia Wu, Wei Tan, Wei Zhou, Yu Zhang, Yan-Qing Liu and Guo-Qing Li

    Citation: Cell Communication and Signaling 2019 17:163

    Content type: Research

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  12. Interleukin-22 (IL-22) belongs to the IL-10 cytokine family and is mainly produced by activated Th1 cells. Although IL-22 expression is reported to be elevated in many cancers, and increased IL-22 expression c...

    Authors: Wei Li, Fen Li, Weiwei Lei and Zezhang Tao

    Citation: Cell Communication and Signaling 2019 17:162

    Content type: Research

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  13. Serine protease HtrA exhibits both proteolytic and chaperone activities, which are involved in cellular protein quality control. Moreover, HtrA is an important virulence factor in many pathogens including Helicob...

    Authors: Urszula Zarzecka, Aileen Harrer, Anna Zawilak-Pawlik, Joanna Skorko-Glonek and Steffen Backert

    Citation: Cell Communication and Signaling 2019 17:161

    Content type: Research

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  14. Decondesation of the highly compacted chromatin architecture is essential for efficient DNA repair, but how this is achieved remains largely unknown. Here, we report that microrchidia family CW-type zinc finge...

    Authors: Hong-Yan Xie, Tai-Mei Zhang, Shu-Yuan Hu, Zhi-Ming Shao and Da-Qiang Li

    Citation: Cell Communication and Signaling 2019 17:160

    Content type: Research

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  15. Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of kar...

    Authors: Elisabeth Drucker, Kerstin Holzer, Stefan Pusch, Juliane Winkler, Diego F. Calvisi, Eva Eiteneuer, Esther Herpel, Benjamin Goeppert, Stephanie Roessler, Alessandro Ori, Peter Schirmacher, Kai Breuhahn and Stephan Singer

    Citation: Cell Communication and Signaling 2019 17:159

    Content type: Research

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  16. Following publication of the original article [1], the authors reported that Figs. 3 and 6 are incorrect.

    Authors: Jinsoo Song, Dongkyun Kim, Churl-Hong Chun and Eun-Jung Jin

    Citation: Cell Communication and Signaling 2019 17:158

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2013 11:66

  17. Patients with advanced gastric cancer usually have a poor prognosis and limited therapeutic options. Overcoming this challenge requires novel targets and effective drugs. The Hedgehog (Hh) signaling pathway pl...

    Authors: Yan Xu, Shumei Song, Zhenning Wang and Jaffer A. Ajani

    Citation: Cell Communication and Signaling 2019 17:157

    Content type: Review

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  18. The numerous and diverse biological roles of Phosphatidylserine (PtdSer) are featured in this special issue. This review will focus on PtdSer as a cofactor required for stimulating TYRO3, AXL and MERTK – compr...

    Authors: Tal Burstyn-Cohen and Avi Maimon

    Citation: Cell Communication and Signaling 2019 17:156

    Content type: Review

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  19. E-cadherin has been awarded a key role in the aetiology of both sporadic and hereditary forms of gastric cancer. In this study, we aimed to identify molecular interactors that influence the expression and func...

    Authors: Patrícia Carneiro, Ana Margarida Moreira, Joana Figueiredo, Rita Barros, Patrícia Oliveira, Maria Sofia Fernandes, Anabela Ferro, Raquel Almeida, Carla Oliveira, Fátima Carneiro, Fernando Schmitt, Joana Paredes, Sérgia Velho and Raquel Seruca

    Citation: Cell Communication and Signaling 2019 17:155

    Content type: Research

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  20. Abnormal reactivation of androgen receptor (AR) signaling in castration-resistant prostate cancer (CRPC) mainly results from overexpression and down-regulation of AR. Sumoylation of AR can influence its functi...

    Authors: Nanyang Yang, Sitong Liu, Tian Qin, Xintong Liu, Nobumoto Watanabe, Kevin H. Mayo, Jiang Li and Xiaomeng Li

    Citation: Cell Communication and Signaling 2019 17:153

    Content type: Research

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  21. Overexpression of erythropoietin (EPO) and EPO receptor (EPO-R) is associated with poor prognosis in non-small-cell lung carcinoma (NSCLC). Hypoxia, a potent EPO inducer, is a major stimulating factor in the g...

    Authors: Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum and Qiuyang Zhang

    Citation: Cell Communication and Signaling 2019 17:152

    Content type: Research

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  22. Following publication of the original article [1], it was reported that Fig. 1c was not entirely readable due to overlapping Fig. 1d. The publishers apologise for this error.

    Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray

    Citation: Cell Communication and Signaling 2019 17:151

    Content type: Correction

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    The original article was published in Cell Communication and Signaling 2019 17:131

  23. Authors: Rachel NeMoyer, Arindam Mondal, Mehul Vora, Elaine Langenfeld, Danea Glover, Michael Scott, Lauren Lairson, Christopher Rongo, David J. Augeri, Youyi Peng, Salma K. Jabbour and John Langenfeld

    Citation: Cell Communication and Signaling 2019 17:150

    Content type: Research

    Published on:

  24. In recent years, copper complexes have gradually become the focus of potential anticancer drugs due to their available redox properties and low toxicity. In this study, a novel mitochondrion-targeting copper (...

    Authors: Jiangjuan Shao, Mengmeng Li, Zijian Guo, Chun Jin, Feng Zhang, Chunyan Ou, Yaochen Xie, Shanzhong Tan, Zhenyi Wang, Shizhong Zheng and Xiaoyong Wang

    Citation: Cell Communication and Signaling 2019 17:149

    Content type: Research

    Published on:

  25. Progression of prostate cancer from benign local tumors to metastatic carcinomas is a multistep process. Here we have investigated the signaling pathways that support migration and invasion of prostate cancer ...

    Authors: Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi and Päivi J. Koskinen

    Citation: Cell Communication and Signaling 2019 17:148

    Content type: Research

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  26. Neutrophils have long been considered as cells playing a crucial role in the immune defence against invading pathogens. Accumulating evidence strongly supported the direct and indirect regulatory effects of ne...

    Authors: Yang Li, Wei Wang, Fan Yang, Yanan Xu, Chang Feng and Yong Zhao

    Citation: Cell Communication and Signaling 2019 17:147

    Content type: Review

    Published on:

  27. Successful establishment of pregnancy hinges on appropriate communication between the embryo and the uterus prior to implantation, but the nature of this communication remains poorly understood. Here, we teste...

    Authors: Masoumeh Es-Haghi, Kasun Godakumara, Annika Häling, Freddy Lättekivi, Arina Lavrits, Janeli Viil, Aneta Andronowska, Tamer Nafee, Victoria James, Ülle Jaakma, Andres Salumets and Alireza Fazeli

    Citation: Cell Communication and Signaling 2019 17:146

    Content type: Research

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  28. Notch1 signalling is a stem-cell-related pathway that is essential for embryonic development, tissue regeneration and organogenesis. However, the role of Notch1 in the formation of myofibroblasts and fibrosis ...

    Authors: Weilong Hong, Ge Zhang, Hong Lu, Yangyang Guo, Shizhang Zheng, Hengyue Zhu, Yanyi Xiao, Akuetteh Percy David Papa, Cunzao Wu, Linxiao Sun, Bicheng Chen and Yongheng Bai

    Citation: Cell Communication and Signaling 2019 17:145

    Content type: Research

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  29. Excessive TGF-β signalling has been shown to underlie pulmonary hypertension (PAH). Human pulmonary artery smooth muscle cells (HPASMCs) can release extracellular vesicles (EVs) but their contents and signific...

    Authors: Fernando de la Cuesta, Ilaria Passalacqua, Julie Rodor, Raghu Bhushan, Laura Denby and Andrew H. Baker

    Citation: Cell Communication and Signaling 2019 17:143

    Content type: Research

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  30. Integrin-mediated platelet-tumor cell contacting plays an important role in promoting epithelial-mesenchymal transition (EMT) transformation of tumor cells and cancer metastasis, but whether it occurs in breas...

    Authors: Xiao-xiao Zuo, Ya Yang, Yue Zhang, Zhi-gang Zhang, Xiao-fei Wang and Yong-gang Shi

    Citation: Cell Communication and Signaling 2019 17:142

    Content type: Research

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    The Correction to this article has been published in Cell Communication and Signaling 2020 18:125

  31. Protein kinase C θ has been established as an important signaling intermediate in T-effector-cell activation and survival pathways by controlling activity of the key transcription factors NF-κB and NFAT. Previ...

    Authors: Nikolaus Thuille, Kerstin Siegmund, Victoria Klepsch, Jacqueline Schörgenhuber, Sarah Danklmaier, Michael Leitges and Gottfried Baier

    Citation: Cell Communication and Signaling 2019 17:141

    Content type: Research

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  32. In breast cancer, activation of bone morphogenetic protein (BMP) signaling and elevated levels of BMP-antagonists have been linked to tumor progression and metastasis. However, the simultaneous upregulation of...

    Authors: Ulrike Neckmann, Camilla Wolowczyk, Martina Hall, Eivind Almaas, Jiang Ren, Sen Zhao, Bjarne Johannessen, Rolf I. Skotheim, Geir Bjørkøy, Peter ten Dijke and Toril Holien

    Citation: Cell Communication and Signaling 2019 17:140

    Content type: Research

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  33. Following publication of the original article [1], it was reported that Figs. 4 and 5 were not updated during the production process.

    Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan

    Citation: Cell Communication and Signaling 2019 17:138

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2019 17:125

  34. p21-activated kinase 1 (PAK1) stimulates growth and metastasis in non-small cell lung cancer (NSCLC). Protein kinase C iota (PKCι) is an enzyme highly expressed in NSCLC, regulating PAK1 signaling. In the pres...

    Authors: Masaoki Ito, Carles Codony-Servat, Jordi Codony-Servat, David Lligé, Imane Chaib, Xiaoyan Sun, Jing Miao, Rongwei Sun, Xueting Cai, Alberto Verlicchi, Morihito Okada, Miguel Angel Molina-Vila, Niki Karachaliou, Peng Cao and Rafael Rosell

    Citation: Cell Communication and Signaling 2019 17:137

    Content type: Research

    Published on:

  35. Osteoclasts are key determinant cellular components implicated in the development and progression of disorders driven by bone damage. Herein, we studied the upshot of T007, an antagonist of peroxisome prolifer...

    Authors: Xiang Li, Lei Ning, Jianjun Ma, Ziang Xie, Xiangde Zhao, Gangliang Wang, Xinyu Wan, Pengcheng Qiu, Teng Yao, Haoming Wang, Shunwu Fan and Shuanglin Wan

    Citation: Cell Communication and Signaling 2019 17:136

    Content type: Research

    Published on:

  36. Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signa...

    Authors: Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller and Fred Schaper

    Citation: Cell Communication and Signaling 2019 17:135

    Content type: Research

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  37. Osteoarthritis (OA) is one of the most prevalent joint disease, and there are still no effective therapeutic agents or clinical methods for the cure of this disease to date. The degradation of cartilage extrac...

    Authors: Biao Duan, Yan Liu, He Hu, Fu-Guo Shi, Ya-Long Liu, Hao Xue, Xin-Yu Yun, Ming-Yu Yan, Xi-Rui Han, An-Fu Chen, Yong Wang and Zhe-Hai Li

    Citation: Cell Communication and Signaling 2019 17:134

    Content type: Research

    Published on:

  38. Notch signalling pathway is central to development of metazoans. The pathway codes a binary fate switch. Upon activation, downstream signals contribute to resolution of fate dichotomies such as proliferation/d...

    Authors: Filip Vujovic, Neil Hunter and Ramin M. Farahani

    Citation: Cell Communication and Signaling 2019 17:133

    Content type: Hypothesis

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  39. Phosphatidylserine (PtdSer) is usually present only in the inner leaf of the lipid bilayers of the cell membrane, but is exposed on the outer leaf when cells are activated and/or die. Exposure of PtdSer has ph...

    Authors: Bernadette Anne Chua, Jamie Ann Ngo, Kathy Situ and Kouki Morizono

    Citation: Cell Communication and Signaling 2019 17:132

    Content type: Review

    Published on:

  40. Metabolic reprogramming is one of the hallmarks of cancer which favours rapid energy production, biosynthetic capabilities and therapy resistance. In our previous study, we showed bitter melon extract (BME) pr...

    Authors: Subhayan Sur, Hiroshi Nakanishi, Colin Flaveny, Joseph E. Ippolito, Jane McHowat, David A. Ford and Ratna B. Ray

    Citation: Cell Communication and Signaling 2019 17:131

    Content type: Research

    Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2019 17:151

  41. Following publication of the original article [1], the authors reported that the given name of Qinhao Wang was incorrectly published as Qinghao Wang. The original article has been corrected.

    Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinhao Wang and Xia Li

    Citation: Cell Communication and Signaling 2019 17:130

    Content type: Correction

    Published on:

    The original article was published in Cell Communication and Signaling 2019 17:44

  42. While regulated WNT activity is required for normal development and stem cell maintenance, mutations that lead to constitutive activation of the WNT pathway cause cellular transformation and drive colorectal c...

    Authors: Yi-Heng Hao, M. Carmen Lafita-Navarro, Lauren Zacharias, Nofit Borenstein-Auerbach, Min Kim, Spencer Barnes, Jiwoong Kim, Jerry Shay, Ralph J. DeBerardinis and Maralice Conacci-Sorrell

    Citation: Cell Communication and Signaling 2019 17:129

    Content type: Research

    Published on:

  43. Linoleic acid is the major fatty acid moiety of cardiolipin, which is central to the assembly of components involved in mitochondrial oxidative phosphorylation (OXPHOS). Although linoleic acid is an essential ...

    Authors: Satoshi Maekawa, Shingo Takada, Hideo Nambu, Takaaki Furihata, Naoya Kakutani, Daiki Setoyama, Yasushi Ueyanagi, Dongchon Kang, Hisataka Sabe and Shintaro Kinugawa

    Citation: Cell Communication and Signaling 2019 17:128

    Content type: Research

    Published on:

  44. Hepatocellular carcinoma (HCC) is the most common primary liver malignancy. Phloretin (PH) possesses anticancer, antitumor, and hepatoprotective effects, however, the effects and potential mechanisms of phlore...

    Authors: Sarita Saraswati, Abdulqader Alhaider, Abdelgalil Mohamed Abdelgadir, Pooja Tanwer and Hesham M. Korashy

    Citation: Cell Communication and Signaling 2019 17:127

    Content type: Research

    Published on:

  45. Aberrant expression of cyclin-dependent protein kinases (CDK) is a hallmark of cancer. CDK11 plays a crucial role in cancer cell growth and proliferation. However, the molecular mechanisms of CDK11 and CDK11 t...

    Authors: Yong Feng, Yunfei Liao, Jianming Zhang, Jacson Shen, Zengwu Shao, Francis Hornicek and Zhenfeng Duan

    Citation: Cell Communication and Signaling 2019 17:125

    Content type: Research

    Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2019 17:138

  46. Cancer cells undergo global reprogramming of cellular metabolism to satisfy demands of energy and biomass during proliferation and metastasis. Computational modeling of genome-scale metabolic models is an effe...

    Authors: Ziwei Dai, Shiyu Yang, Liyan Xu, Hongrong Hu, Kun Liao, Jianghuang Wang, Qian Wang, Shuaishi Gao, Bo Li and Luhua Lai

    Citation: Cell Communication and Signaling 2019 17:124

    Content type: Research

    Published on:

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