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  1. Content type: Research

    Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we terme...

    Authors: Kirsten Hattermann, Kareen Bartsch, Henrike H. Gebhardt, H. Maximilian Mehdorn, Michael Synowitz, Anne Dorothée Schmitt, Rolf Mentlein and Janka Held-Feindt

    Citation: Cell Communication and Signaling 2016 14:26

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  2. Content type: Research

    ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signa...

    Authors: Susan M. Farabaugh, Bonita T. Chan, Xiaojiang Cui, Robert K. Dearth and Adrian V. Lee

    Citation: Cell Communication and Signaling 2016 14:25

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  3. Content type: Research

    Reports of exocrine-to-endocrine reprogramming through expression or stabilization of the transcription factor neurogenin 3 (NGN3) have generated renewed interest in harnessing pancreatic plasticity for therap...

    Authors: Michael J. Shamblott, Marci L. O’Driscoll, Danielle L. Gomez and Dustin L. McGuire

    Citation: Cell Communication and Signaling 2016 14:23

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  4. Content type: Commentary

    Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been ...

    Authors: Peter M. Benz and Ingrid Fleming

    Citation: Cell Communication and Signaling 2016 14:22

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  5. Content type: Research

    Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main inte...

    Authors: Peter M. Benz, Hebatullah Laban, Joana Zink, Lea Günther, Ulrich Walter, Stepan Gambaryan and Karim Dib

    Citation: Cell Communication and Signaling 2016 14:21

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  6. Content type: Review

    Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...

    Authors: Catharina Melzer, Yuanyuan Yang and Ralf Hass

    Citation: Cell Communication and Signaling 2016 14:20

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  7. Content type: Research

    Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigene...

    Authors: Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Boháč, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko and Raymond B. Birge

    Citation: Cell Communication and Signaling 2016 14:19

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  8. Content type: Research

    The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells....

    Authors: Linda Yu, Kyle Ham, Xiaohua Gao, Lysandra Castro, Yitang Yan, Grace E. Kissling, Charles J. Tucker, Norris Flagler, Ray Dong, Trevor K. Archer and Darlene Dixon

    Citation: Cell Communication and Signaling 2016 14:18

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  9. Content type: Research

    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASK...

    Authors: Ekaterina Smirnova, Jamie J. Kwan, Ryan Siu, Xin Gao, Georg Zoidl, Borries Demeler, Vivian Saridakis and Logan W. Donaldson

    Citation: Cell Communication and Signaling 2016 14:17

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  10. Content type: Research

    Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfu...

    Authors: Stepan Gambaryan, Hariharan Subramanian, Linda Kehrer, Igor Mindukshev, Julia Sudnitsyna, Cora Reiss, Natalia Rukoyatkina, Andreas Friebe, Iraida Sharina, Emil Martin and Ulrich Walter

    Citation: Cell Communication and Signaling 2016 14:16

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  11. Content type: Research

    Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development...

    Authors: William Q. Gillis, Arif Kirmizitas, Yasuno Iwasaki, Dong-Hyuk Ki, Jonathan M. Wyrick and Gerald H. Thomsen

    Citation: Cell Communication and Signaling 2016 14:15

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  12. Content type: Research

    The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta ...

    Authors: Christa Pfeifhofer-Obermair, Karin Albrecht-Schgoer, Sebastian Peer, Manfred Nairz, Kerstin Siegmund, Victoria Klepsch, David Haschka, Nikolaus Thuille, Natascha Hermann-Kleiter, Thomas Gruber, Günter Weiss and Gottfried Baier

    Citation: Cell Communication and Signaling 2016 14:14

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  13. Content type: Review

    Extracellular vesicles are cell-derived vesicles, which can transport various cargos out of cells. From their cell of origin, the content molecules (proteins, non-coding RNAs including miRNAs, DNA and others) ...

    Authors: Giulia Cesi, Geoffroy Walbrecq, Christiane Margue and Stephanie Kreis

    Citation: Cell Communication and Signaling 2016 14:13

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  14. Content type: Research

    Antigen (Ag)/IgE-mediated mast cell (MC) responses play detrimental roles in allergic diseases. MC activation via the high-affinity receptor for IgE (FcεRI) is controlled by the Src family kinase Lyn. Lyn-defi...

    Authors: Susana M. Nunes de Miranda, Thomas Wilhelm, Michael Huber and Carolin N. Zorn

    Citation: Cell Communication and Signaling 2016 14:12

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  15. Content type: Research

    Cyclic nucleotides have been shown to play important signaling roles in many physiological processes in plants including photosynthesis and defence. Despite this, little is known about cyclic nucleotide-depend...

    Authors: Lara Donaldson, Stuart Meier and Christoph Gehring

    Citation: Cell Communication and Signaling 2016 14:10

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  16. Content type: Review

    RNA-binding proteins play a key role in the regulation of all aspects of RNA metabolism, from the synthesis of RNA to its decay. Protein-RNA interactions have been thought to be mostly mediated by canonical RN...

    Authors: Aino I. Järvelin, Marko Noerenberg, Ilan Davis and Alfredo Castello

    Citation: Cell Communication and Signaling 2016 14:9

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  17. Content type: Review

    Protein-protein interactions (PPI) are involved in virtually every cellular process and thus represent an attractive target for therapeutic interventions. A significant number of protein interactions are frequ...

    Authors: Carles Corbi-Verge and Philip M. Kim

    Citation: Cell Communication and Signaling 2016 14:8

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  18. Content type: Erratum

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Citation: Cell Communication and Signaling 2016 14:7

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    The original article was published in Cell Communication and Signaling 2016 14:4

  19. Content type: Short report

    Chronic myeloid leukemia (CML) is driven by the fusion kinase Bcr-Abl. Bcr-Abl tyrosine kinase inhibitors (TKIs), such as imatinib mesylate (IM), revolutionized CML therapy. Nevertheless, about 20 % of CMLs di...

    Authors: Sebastian Halbach, Zehan Hu, Christine Gretzmeier, Julia Ellermann, Franziska U. Wöhrle, Jörn Dengjel and Tilman Brummer

    Citation: Cell Communication and Signaling 2016 14:6

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  20. Content type: Research

    Growth factors induce a characteristically short-lived Ras activation in cells emerging from quiescence. Extensive work has shown that transient as opposed to sustained Ras activation is critical for the induc...

    Authors: Anne Hennig, Robby Markwart, Katharina Wolff, Katja Schubert, Yan Cui, Ian A. Prior, Manuel A. Esparza-Franco, Graham Ladds and Ignacio Rubio

    Citation: Cell Communication and Signaling 2016 14:5

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  21. Content type: Research

    Cells of the tumor microenvironment are recognized as important determinants of the tumor biology. The adjacent non-malignant cells can regulate drug responses of the cancer cells by secreted paracrine factors...

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova

    Citation: Cell Communication and Signaling 2016 14:4

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    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:7

  22. Content type: Review

    Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are...

    Authors: Matheus de Castro Fonseca, Carla J. Aguiar, Joao Antônio da Rocha Franco, Rafael N. Gingold and M. Fatima Leite

    Citation: Cell Communication and Signaling 2016 14:3

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  23. Content type: Methodology

    Human mesenchymal stromal cells (hMSC) are multipotent cells with both regenerative and immunomodulatory activities making them an attractive tool for cellular therapy. In the last few years it has been shown ...

    Authors: Teresa L. Ramos, Luis Ignacio Sánchez-Abarca, Sandra Muntión, Silvia Preciado, Noemí Puig, Guillermo López-Ruano, Ángel Hernández-Hernández, Alba Redondo, Rebeca Ortega, Concepción Rodríguez, Fermín Sánchez-Guijo and Consuelo del Cañizo

    Citation: Cell Communication and Signaling 2016 14:2

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  24. Content type: Review

    A substantial portion of the regulatory interactions in the higher eukaryotic cell are mediated by simple sequence motifs in the regulatory segments of genes and (pre-)mRNAs, and in the intrinsically disordere...

    Authors: Kim Van Roey and Norman E. Davey

    Citation: Cell Communication and Signaling 2015 13:45

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  25. Content type: Review

    Short sequence motifs are ubiquitous across the three major types of biomolecules: hundreds of classes and thousands of instances of DNA regulatory elements, RNA motifs and protein short linear motifs (SLiMs) ...

    Authors: Norman E. Davey, Martha S. Cyert and Alan M. Moses

    Citation: Cell Communication and Signaling 2015 13:43

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  26. Content type: Review

    It has become clear in outline though not yet in detail how cellular regulatory and signalling systems are constructed. The essential machines are protein complexes that effect regulatory decisions by undergoi...

    Authors: Toby J. Gibson, Holger Dinkel, Kim Van Roey and Francesca Diella

    Citation: Cell Communication and Signaling 2015 13:42

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  27. Content type: Research

    Abl interactor (Abi) family proteins play significant roles in actin cytoskeleton organization through participation in the WAVE complex. Mammals possess three Abi proteins: Abi-1, Abi-2, and NESH/Abi-3. Abi-1...

    Authors: Saki Sekino, Yuriko Kashiwagi, Hitoshi Kanazawa, Kazuki Takada, Takashi Baba, Seiichi Sato, Hiroki Inoue, Masaki Kojima and Katsuko Tani

    Citation: Cell Communication and Signaling 2015 13:41

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  28. Content type: Research

    Pasteurella multocida toxin (PMT) is a potent inducer of osteoclast formation. Pigs suffering from an infection with toxigenic Pasteurella multocida strains develop atrophic rhinitis c...

    Authors: Bianca Kloos, Sushmita Chakraborty, Sonja G. Lindner, Katrin Noack, Ulrike Harre, Georg Schett, Oliver H. Krämer and Katharina F. Kubatzky

    Citation: Cell Communication and Signaling 2015 13:40

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  29. Content type: Review

    Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sens...

    Authors: Claudia Lennicke, Jette Rahn, Rudolf Lichtenfels, Ludger A. Wessjohann and Barbara Seliger

    Citation: Cell Communication and Signaling 2015 13:39

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  30. Content type: Research

    Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP)...

    Authors: Sehyo Charley Choe, Anne Hamacher-Brady and Nathan Ryan Brady

    Citation: Cell Communication and Signaling 2015 13:37

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  31. Content type: Research Article

    The consideration of lactate as an active metabolite is a newly emerging and attractive concept. Recently, lactate has been reported to regulate gene transcription via the inhibition of histone deacetylases (H...

    Authors: Waldemar Wagner, Wojciech M. Ciszewski and Katarzyna D. Kania

    Citation: Cell Communication and Signaling 2015 13:36

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  32. Content type: Research Article

    The complex of Dock180/ELMO1 that functions as a bipartite guanine nucleotide exchange factor for Rac is essential for diverse physiological and pathological processes of cells such as cell migration, phagocyt...

    Authors: Yoshinori Makino, Masumi Tsuda, Yusuke Ohba, Hiroshi Nishihara, Hirofumi Sawa, Kazuo Nagashima and Shinya Tanaka

    Citation: Cell Communication and Signaling 2015 13:35

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  33. Content type: Research Article

    Connexin37 (Cx37) and Cx40 are crucial for endothelial cell-cell communication and homeostasis. Both connexins interact with endothelial nitric oxide synthase (eNOS). The exact contribution of these interactio...

    Authors: Merlijn J Meens, Florian Alonso, Loïc Le Gal, Brenda R Kwak and Jacques-Antoine Haefliger

    Citation: Cell Communication and Signaling 2015 13:34

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  34. Content type: Research Article

    Cells deploy quality control mechanisms to remove damaged or misfolded proteins. Recently, we have reported that a mutation (R43W) in the Frank-ter Haar syndrome protein Tks4 resulted in aberrant intracellular...

    Authors: Csaba Ádám, Anna Fekete, Gábor Bőgel, Zsuzsanna Németh, Natália Tőkési, Judit Ovádi, Károly Liliom, Szabolcs Pesti, Miklós Geiszt and László Buday

    Citation: Cell Communication and Signaling 2015 13:33

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  35. Content type: Research

    Orai/CRACM1 ion channels provide the major Ca2+ influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca2+-activated K+ channel KCa3.1 modulates Ca2+ influx and the secretory respon...

    Authors: S. Mark Duffy, Ian Ashmole, Dawn T. Smallwood, Mark L. Leyland and Peter Bradding

    Citation: Cell Communication and Signaling 2015 13:32

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  36. Content type: Research

    The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details as to how TSAd regulates this process remain to be ...

    Authors: Cecilie Dahl Hem, Vibeke Sundvold-Gjerstad, Stine Granum, Lise Koll, Greger Abrahamsen, Laszlo Buday and Anne Spurkland

    Citation: Cell Communication and Signaling 2015 13:31

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  37. Content type: Review

    Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric diseases but also with several extragastric diseases. The clinical outcomes caused by H. p...

    Authors: Xin Yong, Bo Tang, Bo-Sheng Li, Rui Xie, Chang-Jiang Hu, Gang Luo, Yong Qin, Hui Dong and Shi-Ming Yang

    Citation: Cell Communication and Signaling 2015 13:30

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  38. Content type: Research

    Claudin-7 (cld7), a tight junction (TJ) component, is also found basolaterally and in the cytoplasm. Basolaterally located cld7 is enriched in glycolipid-enriched membrane domains (GEM), where it associates wi...

    Authors: Sarah Heiler, Wei Mu, Margot Zöller and Florian Thuma

    Citation: Cell Communication and Signaling 2015 13:29

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  39. Content type: Research Article

    In many cells, bile acids (BAs) have a multitude of effects, some of which may be mediated by specific receptors such the TGR5 or FXR receptors. In pancreas systemic BAs, as well as intra-ductal BAs from bile ...

    Authors: Justyna M. Kowal, Kristian A. Haanes, Nynne M. Christensen and Ivana Novak

    Citation: Cell Communication and Signaling 2015 13:28

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  40. Content type: Research article

    Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in p...

    Authors: Oddrun Elise Olsen, Karin Fahl Wader, Hanne Hella, Anne Kærsgaard Mylin, Ingemar Turesson, Ingerid Nesthus, Anders Waage, Anders Sundan and Toril Holien

    Citation: Cell Communication and Signaling 2015 13:27

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  41. Content type: Research article

    The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and in...

    Authors: Joseph Cursons, Karl-Johan Leuchowius, Mark Waltham, Eva Tomaskovic-Crook, Momeneh Foroutan, Cameron P Bracken, Andrew Redfern, Edmund J Crampin, Ian Street, Melissa J Davis and Erik W Thompson

    Citation: Cell Communication and Signaling 2015 13:26

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  42. Content type: Research

    One hallmark of cancer cells is their ability to evade physiologic signals causing regulated cell death (RCD). Correspondingly, TRAIL-based therapies to eliminate human cancer cells via enforced induction of a...

    Authors: Stephan Philipp, Justyna Sosna, Johannes Plenge, Holger Kalthoff and Dieter Adam

    Citation: Cell Communication and Signaling 2015 13:25

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  43. Content type: Review

    Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity...

    Authors: Giulio Preta, James G Cronin and I Martin Sheldon

    Citation: Cell Communication and Signaling 2015 13:24

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  44. Content type: Short report

    Protein kinase C-θ (PKCθ) plays an important role in signal transduction down-stream of the T cell receptor and T cells deficient of PKCθ show impaired NF-κB as well as NFAT/AP-1 activation resulting in strongly ...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser and Gottfried Baier

    Citation: Cell Communication and Signaling 2015 13:22

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