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  1. Content type: Research

    Orai/CRACM1 ion channels provide the major Ca2+ influx pathway for FcεRI-dependent human lung mast cell (HLMC) mediator release. The Ca2+-activated K+ channel KCa3.1 modulates Ca2+ influx and the secretory respon...

    Authors: S. Mark Duffy, Ian Ashmole, Dawn T. Smallwood, Mark L. Leyland and Peter Bradding

    Citation: Cell Communication and Signaling 2015 13:32

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  2. Content type: Research

    The Lck and Src binding adaptor protein TSAd (T cell specific adaptor) regulates actin polymerization in T cells and endothelial cells. The molecular details as to how TSAd regulates this process remain to be ...

    Authors: Cecilie Dahl Hem, Vibeke Sundvold-Gjerstad, Stine Granum, Lise Koll, Greger Abrahamsen, Laszlo Buday and Anne Spurkland

    Citation: Cell Communication and Signaling 2015 13:31

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  3. Content type: Review

    Helicobacter pylori (H. pylori) infection is strongly associated with the development of gastric diseases but also with several extragastric diseases. The clinical outcomes caused by H. p...

    Authors: Xin Yong, Bo Tang, Bo-Sheng Li, Rui Xie, Chang-Jiang Hu, Gang Luo, Yong Qin, Hui Dong and Shi-Ming Yang

    Citation: Cell Communication and Signaling 2015 13:30

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  4. Content type: Research Article

    In many cells, bile acids (BAs) have a multitude of effects, some of which may be mediated by specific receptors such the TGR5 or FXR receptors. In pancreas systemic BAs, as well as intra-ductal BAs from bile ...

    Authors: Justyna M. Kowal, Kristian A. Haanes, Nynne M. Christensen and Ivana Novak

    Citation: Cell Communication and Signaling 2015 13:28

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  5. Content type: Research

    Claudin-7 (cld7), a tight junction (TJ) component, is also found basolaterally and in the cytoplasm. Basolaterally located cld7 is enriched in glycolipid-enriched membrane domains (GEM), where it associates wi...

    Authors: Sarah Heiler, Wei Mu, Margot Zöller and Florian Thuma

    Citation: Cell Communication and Signaling 2015 13:29

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  6. Content type: Research article

    Activins are members of the TGF-β family of ligands that have multiple biological functions in embryonic stem cells as well as in differentiated tissue. Serum levels of activin A were found to be elevated in p...

    Authors: Oddrun Elise Olsen, Karin Fahl Wader, Hanne Hella, Anne Kærsgaard Mylin, Ingemar Turesson, Ingerid Nesthus, Anders Waage, Anders Sundan and Toril Holien

    Citation: Cell Communication and Signaling 2015 13:27

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  7. Content type: Research article

    The normal process of epithelial mesenchymal transition (EMT) is subverted by carcinoma cells to facilitate metastatic spread. Cancer cells rarely undergo a full conversion to the mesenchymal phenotype, and in...

    Authors: Joseph Cursons, Karl-Johan Leuchowius, Mark Waltham, Eva Tomaskovic-Crook, Momeneh Foroutan, Cameron P Bracken, Andrew Redfern, Edmund J Crampin, Ian Street, Melissa J Davis and Erik W Thompson

    Citation: Cell Communication and Signaling 2015 13:26

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  8. Content type: Research

    One hallmark of cancer cells is their ability to evade physiologic signals causing regulated cell death (RCD). Correspondingly, TRAIL-based therapies to eliminate human cancer cells via enforced induction of a...

    Authors: Stephan Philipp, Justyna Sosna, Johannes Plenge, Holger Kalthoff and Dieter Adam

    Citation: Cell Communication and Signaling 2015 13:25

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  9. Content type: Review

    Dynamin is a GTPase protein that is essential for membrane fission during clathrin-mediated endocytosis in eukaryotic cells. Dynasore is a GTPase inhibitor that rapidly and reversibly inhibits dynamin activity...

    Authors: Giulio Preta, James G Cronin and I Martin Sheldon

    Citation: Cell Communication and Signaling 2015 13:24

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  10. Content type: Research

    Gastrointestinal stromal tumours (GIST) are mainly characterised by the presence of activating mutations in either of the two receptor tyrosine kinases c-KIT or platelet-derived growth factor receptor-α (PDGFR...

    Authors: Christelle Bahlawane, René Eulenfeld, Monique Y Wiesinger, Jiali Wang, Arnaud Muller, Andreas Girod, Petr V Nazarov, Kathrin Felsch, Laurent Vallar, Thomas Sauter, Venkata P Satagopam and Serge Haan

    Citation: Cell Communication and Signaling 2015 13:21

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  11. Content type: Short report

    Protein kinase C-θ (PKCθ) plays an important role in signal transduction down-stream of the T cell receptor and T cells deficient of PKCθ show impaired NF-κB as well as NFAT/AP-1 activation resulting in strongly ...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser and Gottfried Baier

    Citation: Cell Communication and Signaling 2015 13:22

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  12. Content type: Research

    Sertoli cells play key roles in regulating spermatogenesis and testis development by providing structural and nutritional supports. Recent studies demonstrate that Sertoli cells can be converted into functiona...

    Authors: Ying Guo, Yanan Hai, Chencheng Yao, Zheng Chen, Jingmei Hou, Zheng Li and Zuping He

    Citation: Cell Communication and Signaling 2015 13:20

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  13. Content type: Research

    Dendritic cells (DC) are the most potent antigen-presenting cells (APC) with the unique ability to activate naïve T cells and to initiate and maintain primary immune responses. Immunosuppressive and anti-infla...

    Authors: Michael Gutknecht, Julian Geiger, Simone Joas, Daniela Dörfel, Helmut R Salih, Martin R Müller, Frank Grünebach and Susanne M Rittig

    Citation: Cell Communication and Signaling 2015 13:19

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    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:11

  14. Content type: Research

    Chondrocytes are the main cellular component of articular cartilage. In healthy tissue, they are embedded in a strong but elastic extracelluar matrix providing resistance against mechanical forces and friction...

    Authors: Markus Wehland, Ganna Aleshcheva, Herbert Schulz, Katrin Saar, Norbert Hübner, Ruth Hemmersbach, Markus Braun, Xiao Ma, Timo Frett, Elisabeth Warnke, Stefan Riwaldt, Jessica Pietsch, Thomas Juhl Corydon, Manfred Infanger and Daniela Grimm

    Citation: Cell Communication and Signaling 2015 13:18

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  15. Content type: Research

    Diabetes mellitus is a common metabolic disorder characterized by dysfunction of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators of beta-cell activities. These non-coding RNAs have ...

    Authors: Claudiane Guay, Véronique Menoud, Sophie Rome and Romano Regazzi

    Citation: Cell Communication and Signaling 2015 13:17

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  16. Content type: Research

    Nuclear import of protein kinase D1 (PKD1) is an important event in the transcriptional regulation of cardiac gene reprogramming leading to the hypertrophic growth response, however, little is known about the ...

    Authors: Yuan Yan Sin, Tamara P Martin, Lauren Wills, Susan Currie and George S Baillie

    Citation: Cell Communication and Signaling 2015 13:16

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  17. Content type: Research

    The mechanistic target of rapamycin, (mTOR) kinase plays a pivotal role in controlling critical cellular growth and survival pathways, and its aberrant induction is implicated in cancer pathogenesis. Therefore...

    Authors: Krystyna Mazan-Mamczarz, Raymond J Peroutka, James J Steinhardt, Moriah Gidoni, Yongqing Zhang, Elin Lehrmann, Ari L Landon, Bojie Dai, Simone Houng, Parameswary A Muniandy, Sol Efroni, Kevin G Becker and Ronald B Gartenhaus

    Citation: Cell Communication and Signaling 2015 13:15

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  18. Content type: Research

    Expression of programmed cell death ligand 1 (PD-L1) is an important process by which tumor cells suppress antitumor immunity in the tumor microenvironment. Bone marrow (BM)–derived immune cells are an importa...

    Authors: Hyangsoon Noh, Jiemiao Hu, Xiaohong Wang, Xueqing Xia, Arun Satelli and Shulin Li

    Citation: Cell Communication and Signaling 2015 13:14

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  19. Content type: Review

    We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activat...

    Authors: Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yasushi Horie, Kazuhiko Hayashi, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert, Katsuyoshi Takata, Takashi Oka and Tadashi Yoshino

    Citation: Cell Communication and Signaling 2015 13:13

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  20. Content type: Research

    The RAS/MAPK signaling pathway can regulate gene expression by phosphorylating and altering the function of some, but not all, ETS transcription factors. ETS family transcription factors bind similar DNA seque...

    Authors: Nagarathinam Selvaraj, Vivekananda Kedage and Peter C Hollenhorst

    Citation: Cell Communication and Signaling 2015 13:12

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  21. Content type: Research

    Chronic myeloid leukemia (CML) is driven by the expression of the BCR-ABL oncoprotein. STAT5 is a BCR-ABL substrate and persistently activated by tyrosine phosphorylation in CML cells. Activated STAT5 (pSTAT5)...

    Authors: Dirk Fahrenkamp, Hildegard Schmitz-Van de Leur, Andrea Küster, Nicolas Chatain and Gerhard Müller-Newen

    Citation: Cell Communication and Signaling 2015 13:10

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  22. Content type: Short report

    The viral G protein-coupled receptor (vGPCR) is proposed to act as one of the predominant mediators of Kaposi’s sarcoma (KS), a human herpes virus 8 (HHV8)-elicited disease. The actions of vGPCR manifest patho...

    Authors: Julie Dwyer, Sandy Azzi, Héloïse M Leclair, Steven Georges, Agnès Carlotti, Lucas Treps, Eva M Galan-Moya, Catherine Alexia, Nicolas Dupin, Nicolas Bidère and Julie Gavard

    Citation: Cell Communication and Signaling 2015 13:11

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  23. Content type: Research

    Chronic myeloid leukemia (CML) is a clonal hematopoietic stem cell disorder in which leukemic cells display a reciprocal t(9:22) chromosomal translocation that results in the formation of the chimeric BCR-ABL ...

    Authors: Stefania Raimondo, Laura Saieva, Chiara Corrado, Simona Fontana, Anna Flugy, Aroldo Rizzo, Giacomo De Leo and Riccardo Alessandro

    Citation: Cell Communication and Signaling 2015 13:8

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  24. Content type: Research

    Phosphatidylinositol 3-Kinases (PI3Ks) are a family of lipid kinases that phosphorylate the D3-hydroxyls of the inositol ring of phosphoinositides, and are responsible for coordinating a diverse range of cellu...

    Authors: Vivek K Gupta, Ammaji Rajala and Raju VS Rajala

    Citation: Cell Communication and Signaling 2015 13:7

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  25. Content type: Research

    Elevated levels of the inflammatory cytokine TNF-α are common in chronic diseases or inherited or degenerative muscle disorders and can lead to muscle wasting. By contrast, IGF1 has a growth promoting effect o...

    Authors: Swanhild U Meyer, Christian Thirion, Anna Polesskaya, Stefan Bauersachs, Sebastian Kaiser, Sabine Krause and Michael W Pfaffl

    Citation: Cell Communication and Signaling 2015 13:4

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  26. Content type: Research

    Homeodomain interacting protein kinases (HIPKs) function as modulators of cellular stress responses and regulate cell differentiation, proliferation and apoptosis. The HIPK family includes HIPK1, HIPK2 and HIP...

    Authors: Jan van der Laden, Ulf Soppa and Walter Becker

    Citation: Cell Communication and Signaling 2015 13:3

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  27. Content type: Research

    The growth factor heregulin (HRG) potently stimulates epithelial cell survival and proliferation through the binding of its cognate receptor ErbB3 (also known as HER3). ErbB3-dependent signal transmission reli...

    Authors: Annabell Bischoff, Michaela Bayerlová, Michaela Strotbek, Simone Schmid, Tim Beissbarth and Monilola A Olayioye

    Citation: Cell Communication and Signaling 2015 13:5

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  28. Content type: Research

    The Rho GTPase RhoB has been proposed to be a tumor suppressor in cancer and is downregulated in various tumors including prostate. RhoB has different effects on cell migration depending on the cell type and c...

    Authors: Francisco M Vega, Mairian Thomas, Nicolas Reymond and Anne J Ridley

    Citation: Cell Communication and Signaling 2015 13:6

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  29. Content type: Methodology

    The WNT/planar-cell-polarity (PCP) pathway is a key regulator of cell polarity and directional cell movements. Core PCP proteins such as Van Gogh-like2 (VANGL2) are evolutionarily highly conserved; however, th...

    Authors: Markéta Kaucká, Julian Petersen, Pavlína Janovská, Tomasz Radaszkiewicz, Lucie Smyčková, Avais M Daulat, Jean-Paul Borg, Gunnar Schulte and Vitezslav Bryja

    Citation: Cell Communication and Signaling 2015 13:2

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  30. Content type: Short report

    Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both ...

    Authors: Shahir S Rizk, Jean-Louis K Kouadio, Anna Szymborska, Erica M Duguid, Somnath Mukherjee, Jiamao Zheng, Charles V Clevenger and Anthony A Kossiakoff

    Citation: Cell Communication and Signaling 2015 13:1

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  31. Content type: Research

    Succinate is an intermediate of the citric acid cycle as well as an extracellular circulating molecule, whose receptor, G protein-coupled receptor-91 (GPR91), was recently identified and characterized in sever...

    Authors: Carla J Aguiar, João A Rocha-Franco, Pedro A Sousa, Anderson K Santos, Marina Ladeira, Cibele Rocha-Resende, Luiz O Ladeira, Rodrigo R Resende, Fernando A Botoni, Marcos Barrouin Melo, Cristiano X Lima, José M Carballido, Thiago M Cunha, Gustavo B Menezes, Silvia Guatimosim and M Fatima Leite

    Citation: Cell Communication and Signaling 2014 12:78

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  32. Content type: Research

    TGFβ1 (Transforming Growth Factor-beta1) is a versatile regulator of T cell immune responses. Depending on its context in the immunological environment, TGFβ1 guides T cells toward specific activation programs...

    Authors: Thomas Harder, Karina Guttek, Lars Philipsen, Luca Simeoni, Burkhart Schraven and Dirk Reinhold

    Citation: Cell Communication and Signaling 2014 12:74

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  33. Content type: Research

    IRAK-M is an inhibitor of Toll-like receptor signaling that acts by re-directing IRAK-4 activity to TAK1 independent NF-κB activation and by inhibition of IRAK-1/IRAK-2 activity. IRAK-M is expressed in monocyt...

    Authors: Jiangfeng Du, Gerry AF Nicolaes, Danielle Kruijswijk, Miranda Versloot, Tom van der Poll and Cornelis van ’t Veer

    Citation: Cell Communication and Signaling 2014 12:77

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  34. Content type: Research

    B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation ...

    Authors: Narasimhulu Simma, Tanima Bose, Sascha Kahlfuß, Judith Mankiewicz, Theresa Lowinus, Fred Lühder, Thomas Schüler, Burkhart Schraven, Martin Heine and Ursula Bommhardt

    Citation: Cell Communication and Signaling 2014 12:75

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  35. Content type: Research

    Epithelial-to-mesenchymal transition (EMT) induced by TGF-β1 is one of well-recognized factors contributing to renal fibrosis. However, the underlying molecular mechanisms of EMT are not fully understood. Brac...

    Authors: Shiren Sun, Wenjuan Sun, Lin Xia, Limin Liu, Rui Du, Lijie He, Rong Li, Hanmin Wang and Chen Huang

    Citation: Cell Communication and Signaling 2014 12:76

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  36. Content type: Research

    Adrenogonadal cell growth and differentiation are controlled by nuclear receptor NR5A1 (Ad4BP/SF-1) that regulates the expression of adrenal and gonadal genes. In addition, SF-1 also resides in the centrosome ...

    Authors: Chia-Yih Wang, Pao-Yen Lai, Ting-Yu Chen and Bon-chu Chung

    Citation: Cell Communication and Signaling 2014 12:55

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  37. Content type: Research

    Increased activity or expression of integrin-linked kinase (ILK), which regulates cell adhesion, migration, and proliferation, leads to oncogenesis. We identified the molecular basis for the regulation of ILK ...

    Authors: Po-Chun Tseng, Chia-Ling Chen, Yan-Shen Shan, Wen-Teng Chang, Hsiao-Sheng Liu, Tse-Ming Hong, Chia-Yuan Hsieh, Sheng-Hsiang Lin and Chiou-Feng Lin

    Citation: Cell Communication and Signaling 2014 12:69

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  38. Content type: Short report

    The nuclear factor κB (NF-κB) family members regulate several biological processes as cell proliferation and differentiation, inflammation, immunity and tumor progression. Ubiquitination plays a key role in NF...

    Authors: Naima Zemirli, Marie Pourcelot, Neslihan Dogan, Aimé Vazquez and Damien Arnoult

    Citation: Cell Communication and Signaling 2014 12:72

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  39. Content type: Methodology

    One of the most insidious characteristics of cancer is its spread to and ability to compromise distant organs via the complex process of metastasis. Communication between cancer cells and organ-resident cells ...

    Authors: Alexandra Koch, Shashank Saran, Doan Duy Hai Tran, Sabine Klebba-Färber, Hauke Thiesler, Katherina Sewald, Susann Schindler, Armin Braun, Robert Klopfleisch and Teruko Tamura

    Citation: Cell Communication and Signaling 2014 12:73

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  40. Content type: Research

    Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes and its use as a substrate for glycolysis and mitoch...

    Authors: Tomás Gutiérrez, Valentina Parra, Rodrigo Troncoso, Christian Pennanen, Ariel Contreras-Ferrat, César Vasquez-Trincado, Pablo E Morales, Camila Lopez-Crisosto, Cristian Sotomayor-Flores, Mario Chiong, Beverly A Rothermel and Sergio Lavandero

    Citation: Cell Communication and Signaling 2014 12:68

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  41. Content type: Methodology

    G protein-coupled receptors (GPCRs) represent a physiologically and pharmacologically important family of receptors that upon coupling to GαS stimulate cAMP production catalyzed by adenylyl cyclase. Thus, develop...

    Authors: Ashutosh Trehan, Emmi Rotgers, Eleanor T Coffey, Ilpo Huhtaniemi and Adolfo Rivero-Müller

    Citation: Cell Communication and Signaling 2014 12:70

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  42. Content type: Research

    The rod photoreceptor cGMP-gated cation channel, consisting of three α- and one β subunit, controls ion flow into the rod outer segment (ROS). In addition to the β-subunit, the Cngb1 locus encodes an abundant sol...

    Authors: Shanta Sarfare, Alex S McKeown, Jeffrey Messinger, Glen Rubin, Hongjun Wei, Timothy W Kraft and Steven J Pittler

    Citation: Cell Communication and Signaling 2014 12:67

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  43. Content type: Research

    Human cells release nano-sized vesicles called exosomes, containing mRNA, miRNA and specific proteins. Exosomes from one cell can be taken up by another cell, which is a recently discovered cell-to-cell commun...

    Authors: Hui Xiao, Cecilia Lässer, Ganesh Vilas Shelke, Juan Wang, Madeleine Rådinger, Taral Rameshchand Lunavat, Carina Malmhäll, Li Hui Lin, Jia Li, Li Li and Jan Lötvall

    Citation: Cell Communication and Signaling 2014 12:64

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  44. Content type: Research

    Iron transport across the blood-brain barrier (BBB) involves the cooperation of brain microvascular endothelial cells (BMVEC) and their neighboring astrocytes. Astrocytes secrete a soluble form of ceruloplasmi...

    Authors: Ryan C McCarthy and Daniel J Kosman

    Citation: Cell Communication and Signaling 2014 12:65

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  45. Content type: Research

    The TIR domain-containing proteins BtpA/Btp1/TcpB and BtpB are translocated into host cells by the facultative intracellular bacterial pathogen Brucella. Here, they interfere with Toll like receptor signalling to...

    Authors: Christine Felix, Burcu Kaplan Türköz, Sebastien Ranaldi, Thomas Koelblen, Laurent Terradot, David O’Callaghan and Annette Caroline Vergunst

    Citation: Cell Communication and Signaling 2014 12:53

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  46. Content type: Research

    Accelerated cell cycle progression is the common feature of most cancers. MiRNAs can act as oncogenes or tumor suppressors by directly modulating cell cycle machinery. It has been shown that miR-188 is upregul...

    Authors: Jiangbin Wu, Qing Lv, Jie He, Haoxiang Zhang, Xueshuang Mei, Kai Cui, Nunu Huang, Weidong Xie, Naihan Xu and Yaou Zhang

    Citation: Cell Communication and Signaling 2014 12:66

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