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  1. Content type: Research

    The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role...

    Authors: Wu Fei, Daiki Kijima, Mami Hashimoto, Miki Hashimura, Yasuko Oguri, Sabine Kajita, Toshihide Matsumoto, Ako Yokoi and Makoto Saegusa

    Citation: Cell Communication and Signaling 2017 15:56

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  2. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribo...

    Authors: Minjing Li, Changzhu Jin, Maolei Xu, Ling Zhou, Defang Li and Yancun Yin

    Citation: Cell Communication and Signaling 2017 15:52

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  3. Content type: Research

    Prostate cancer (PCa), the second most common cancer affecting men worldwide, shows a broad spectrum of biological and clinical behaviour representing the epiphenomenon of an extreme heterogeneity. Androgen de...

    Authors: Nicoletta Ferrari, Ilaria Granata, Matteo Capaia, Marina Piccirillo, Mario Rosario Guarracino, Roberta Venè, Antonella Brizzolara, Andrea Petretto, Elvira Inglese, Martina Morini, Simonetta Astigiano, Adriana Agnese Amaro, Francesco Boccardo, Cecilia Balbi and Paola Barboro

    Citation: Cell Communication and Signaling 2017 15:51

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  4. Content type: Research

    The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad pro...

    Authors: Eva María García-Vizcaíno, Sergio Liarte, José Luis Alonso-Romero and Francisco José Nicolás

    Citation: Cell Communication and Signaling 2017 15:50

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  5. Content type: Correction

    Unfortunately, following publication of this article [1], it was noticed that the key in Figure 5c incorrectly showed ‘0 h’, ‘5 h’ and ‘10 h’. The corrected version, showing ‘0 h’, ‘12 h’ and ‘24 h’, can be se...

    Authors: Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li

    Citation: Cell Communication and Signaling 2017 15:49

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    The original article was published in Cell Communication and Signaling 2017 15:42

  6. Content type: Research

    Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space wher...

    Authors: Nguyet Nguyen, Awanit Kumar, Simi Chacko, Rodney J. Ouellette and Anirban Ghosh

    Citation: Cell Communication and Signaling 2017 15:48

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  7. Content type: Methodology

    Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. V...

    Authors: Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian and Emil Lou

    Citation: Cell Communication and Signaling 2017 15:46

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  8. Content type: Research

    One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not...

    Authors: Angela Lombardi, Bruno Trimarco, Guido Iaccarino and Gaetano Santulli

    Citation: Cell Communication and Signaling 2017 15:47

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  9. Content type: Research

    We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate ...

    Authors: Allal Ouhtit, Mohammed E. Abdraboh, Andrew D. Hollenbach, Hatem Zayed and Madhwa H. G. Raj

    Citation: Cell Communication and Signaling 2017 15:45

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  10. Content type: Research

    Vascular progenitor cells (VPCs) derived from embryonic stem cells (ESCs) are a valuable source for cell- and tissue-based therapeutic strategies. During the optimization of endothelial cell (EC) inductions fr...

    Authors: Simar J. Singh, William Turner, Drew E. Glaser, Kara E. McCloskey and Fabian V. Filipp

    Citation: Cell Communication and Signaling 2017 15:44

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  11. Content type: Research

    We evaluated the therapeutic effect and fate of high doses of human umbilical cord Wharton jelly cells (hUCWJCs) after IP administration to streptozotocin (STZ)-induced diabetic mice.

    Authors: Martin Maldonado, Tianhua Huang, Lujun Yang, Lan Xu and Lian Ma

    Citation: Cell Communication and Signaling 2017 15:43

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  12. Content type: Research

    In previous research, we found that cell secretion from the adult lamprey supraneural body tissues possesses cytocidal activity against tumor cells, but the protein with cytocidal activity was unidentified.

    Authors: Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li

    Citation: Cell Communication and Signaling 2017 15:42

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    The Correction to this article has been published in Cell Communication and Signaling 2017 15:49

  13. Content type: Research

    Human cancer cells often exhibit impaired IGF2 expression and the underlying mechanisms are multifaceted and complex. Besides the well-known imprinting control region IGF2/H19-ICR, the involvement of a differenti...

    Authors: Undraga Schagdarsurengin, Angela Lammert, Natalie Schunk, Diana Sheridan, Stefan Gattenloehner, Klaus Steger, Florian Wagenlehner and Temuujin Dansranjavin

    Citation: Cell Communication and Signaling 2017 15:40

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  14. Content type: Research

    Chronic inflammation is causally linked to the carcinogenesis and progression of most solid tumors. LPTS is a well-identified tumor suppressor by inhibiting telomerase activity and cancer cell growth. However,...

    Authors: Dongbo Liu, Hongping Miao, Yuanyin Zhao, Xia Kang, Shenglan Shang, Wei Xiang, Rongchen Shi, Along Hou, Rui Wang, Kun Zhao, Yingzhe Liu, Yue Ma, Huan Luo, Hongming Miao and Fengtian He

    Citation: Cell Communication and Signaling 2017 15:39

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  15. Content type: Research

    Chloride channel accessory 1 (CLCA1) belongs to the calcium-sensitive chloride conductance protein family, which is mainly expressed in the colon, small intestine and appendix. This study was conducted to inve...

    Authors: Xiaofen Li, Wangxiong Hu, Jiaojiao Zhou, Yanqin Huang, Jiaping Peng, Ying Yuan, Jiekai Yu and Shu Zheng

    Citation: Cell Communication and Signaling 2017 15:38

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  16. Content type: Research

    Glioblastoma (GBM), the most malignant primary brain tumor, leads to poor and unpredictable clinical outcomes. Recent studies showed the tumor microenvironment has a critical role in regulating tumor growth by...

    Authors: Ana Isabel Oliveira, Sandra I. Anjo, Joana Vieira de Castro, Sofia C. Serra, António J. Salgado, Bruno Manadas and Bruno M. Costa

    Citation: Cell Communication and Signaling 2017 15:37

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  17. Content type: Short report

    The small GTPase ARF1 mediates membrane trafficking mostly from the Golgi, and is essential for the G protein-coupled receptor (GPCR)-mediated chemotaxis of neutrophils. In this process, ARF1 is activated by t...

    Authors: Yuichi Mazaki, Yasuhito Onodera, Tsunehito Higashi, Takahiro Horinouchi, Tsukasa Oikawa and Hisataka Sabe

    Citation: Cell Communication and Signaling 2017 15:36

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  18. Content type: Review

    Hedgehog signaling is evolutionarily conserved and plays a pivotal role in cell fate determination, embryonic development, and tissue renewal. As aberrant Hedgehog signaling is tightly associated with a broad ...

    Authors: Long Zhao, Liguo Wang, Chunli Chi, Wenwen Lan and Ying Su

    Citation: Cell Communication and Signaling 2017 15:35

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  19. Content type: Research

    Meningiomas are the most common primary intracranial tumors in adults. While a majority of meningiomas are slow growing neoplasms that may cured by surgical resection, a subset demonstrates more aggressive beh...

    Authors: Yu Mei, Ziming Du, Changchen Hu, Noah F. Greenwald, Malak Abedalthagafi, Nathalie Y.R. Agar, Gavin P. Dunn, Wenya Linda Bi, Sandro Santagata and Ian F. Dunn

    Citation: Cell Communication and Signaling 2017 15:34

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  20. Content type: Research

    Antimicrobial peptides are important components of the host defence with a broad range of functions including direct antimicrobial activity and modulation of inflammation. Lack of cathelin-related antimicrobia...

    Authors: Eugenia Kress, Julika Merres, Lea-Jessica Albrecht, Sven Hammerschmidt, Thomas Pufe, Simone C. Tauber and Lars-Ove Brandenburg

    Citation: Cell Communication and Signaling 2017 15:32

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  21. Content type: Erratum

    Authors: Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Citation: Cell Communication and Signaling 2017 15:31

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    The original article was published in Cell Communication and Signaling 2017 15:30

  22. Content type: Research

    Magnesium (Mg2+) is an essential cation implicated in carcinogenesis, solid tumor progression and metastatic potential. The Transient Receptor Potential Melastatin Member 7 (TRPM7) is a divalent ion channel invol...

    Authors: Junhao Huang, Hideki Furuya, Malika Faouzi, Zheng Zhang, Mahealani Monteilh-Zoller, Kelly Galbraith Kawabata, F. David Horgen, Toshihiko Kawamori, Reinhold Penner and Andrea Fleig

    Citation: Cell Communication and Signaling 2017 15:30

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    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:31

  23. Content type: Research

    C-terminal Src kinase (Csk) and Csk-homologous kinase (Chk) are the major endogenous inhibitors of Src-family kinases (SFKs). They employ two mechanisms to inhibit SFKs. First, they phosphorylate the C-termina...

    Authors: Gahana Advani, Ya Chee Lim, Bruno Catimel, Daisy Sio Seng Lio, Nadia L. Y. Ng, Anderly C. Chüeh, Mai Tran, Mohd Ishtiaq Anasir, Heather Verkade, Hong-Jian Zhu, Benjamin E. Turk, Thomas E. Smithgall, Ching-Seng Ang, Michael Griffin and Heung-Chin Cheng

    Citation: Cell Communication and Signaling 2017 15:29

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  24. Content type: Research

    Phosphoinositide 3-kinase γ (PI3Kγ) and PI3Kδ are second messenger-generating enzymes with key roles in proliferation, differentiation, survival, and function of leukocytes. Deficiency of the catalytic subunit...

    Authors: Kirsten Bucher, Fee Schmitt, Benedikt Mothes, Carolin Blumendeller, Daniel Schäll, Roland Piekorz, Emilio Hirsch, Bernd Nürnberg and Sandra Beer-Hammer

    Citation: Cell Communication and Signaling 2017 15:28

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  25. Content type: Review

    Viruses exploit various cellular processes for their own benefit, including counteracting anti-viral responses and regulating viral replication and propagation. In the past 20 years, protein sumoylation has em...

    Authors: Angela J. Lowrey, Wyatt Cramblet and Gretchen L. Bentz

    Citation: Cell Communication and Signaling 2017 15:27

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  26. Content type: Research

    Estrogen receptors (ER) α and β are found in both women and men in many tissues, where they have different functions, including having roles in cell proliferation and differentiation of the reproductive tract....

    Authors: Sylvain Lecomte, Frederic Chalmel, François Ferriere, Frederic Percevault, Nicolas Plu, Christian Saligaut, Claire Surel, Marie Lelong, Theo Efstathiou and Farzad Pakdel

    Citation: Cell Communication and Signaling 2017 15:26

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  27. Content type: Research

    Hematopoietic stem cell (HSC) maintenance requires a specific microenvironment. HSC niches can be activated by tissue damaging chemotherapeutic drugs and various cell signaling molecules such as SDF-1 and FGF,...

    Authors: Kyung-Ae Yoon, YeonSung Son, Young-Jin Choi, Joo-Hyun Kim and Je-Yoel Cho

    Citation: Cell Communication and Signaling 2017 15:25

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  28. Content type: Review

    The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway plays critical roles in orchestrating of immune system, especially cytokine receptors and they can modulate the polarizati...

    Authors: Farhad Seif, Majid Khoshmirsafa, Hossein Aazami, Monireh Mohsenzadegan, Gholamreza Sedighi and Mohammadali Bahar

    Citation: Cell Communication and Signaling 2017 15:23

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  29. Content type: Research

    In mammalian intestines, Notch signaling plays a critical role in mediating cell fate decisions; it promotes the absorptive (or enterocyte) cell fate, while concomitantly inhibiting the secretory cell fate (i....

    Authors: Shaiya C. Robinson, Kristina Klobucar, Christina C. Pierre, Amna Ansari, Svetlana Zhenilo, Egor Prokhortchouk and Juliet M. Daniel

    Citation: Cell Communication and Signaling 2017 15:24

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  30. Content type: Short report

    The pathogenesis of human basal-like breast cancer (BLBC) is not well understood and patients with BLBC have a poor prognosis. Expression of the epidermal growth factor receptor (EGFR) and nuclear factor-κB (N...

    Authors: Stacey Chung, Yanli Jin, Bingchen Han, Ying Qu, Bowen Gao, Armando E. Giuliano and Xiaojiang Cui

    Citation: Cell Communication and Signaling 2017 15:22

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  31. Content type: Research

    LASP2 (LIM and SH3 Protein 2) is a small focal adhesion protein belongs to nebulin protein family. As the newest member of nebulette family, the function of LASP2 remains to be identified.

    Authors: Bin Wang, Lanzhi Zhang, Liying Zhao, Rui Zhou, Yanqing Ding, Guoxin Li and Liang Zhao

    Citation: Cell Communication and Signaling 2017 15:21

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  32. Content type: Review

    This article focusses on the role of TGF-β and its signaling crosstalk with the RHO family GTPases RAC1 and RAC1b in the progression of breast and pancreatic carcinoma. The aggressive nature of these tumor typ...

    Authors: Catharina Melzer, Ralf Hass, Juliane von der Ohe, Hendrik Lehnert and Hendrik Ungefroren

    Citation: Cell Communication and Signaling 2017 15:19

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  33. Content type: Research

    Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...

    Authors: You-Take Oh, Ping Yue and Shi-Yong Sun

    Citation: Cell Communication and Signaling 2017 15:18

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  34. Content type: Research

    There is compelling evidence associating senescent cells with the malignant progression of tumours. Of all senescence-related mechanisms, the so-called senescence-associated secretory phenotype (SASP) has attr...

    Authors: Paola Ortiz-Montero, Arturo Londoño-Vallejo and Jean-Paul Vernot

    Citation: Cell Communication and Signaling 2017 15:17

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  35. Content type: Research

    Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...

    Authors: Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher and Sebastian Heikaus

    Citation: Cell Communication and Signaling 2017 15:16

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  36. Content type: Review

    Infections with the human pathogen Helicobacter pylori (H. pylori) are closely associated with the development of inflammatory disorders and neoplastic transformation of the gastric epithelium. Drastic changes in...

    Authors: Silja Wessler, Linda M. Krisch, Dominik P. Elmer and Fritz Aberger

    Citation: Cell Communication and Signaling 2017 15:15

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  37. Content type: Research

    Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA se...

    Authors: Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz and Johannes Gebert

    Citation: Cell Communication and Signaling 2017 15:14

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  38. Content type: Review

    Hypomethylating agents (HMAs) have been widely used over the last decade, approved for use in myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia (CMML) and acute myeloid leukemia (AML). The propos...

    Authors: Florian Wolff, Michael Leisch, Richard Greil, Angela Risch and Lisa Pleyer

    Citation: Cell Communication and Signaling 2017 15:13

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  39. Content type: Review

    Cancer represents heterogeneous and aberrantly proliferative manifestations composed of (epi)genetically and phenotypically distinct cells with a common clonal origin. Cancer stem cells (CSC) make up a rare su...

    Authors: Wolfgang Gruber, Tamara Scheidt, Fritz Aberger and Christian G. Huber

    Citation: Cell Communication and Signaling 2017 15:12

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  40. Content type: Review

    C-Met is a receptor tyrosine kinase with multiple functions throughout embryonic development, organogenesis and wound healing and is expressed in various epithelia. The ligand of c-Met is Hepatocyte Growth Fac...

    Authors: Ralf Hass, Susanne Jennek, Yuanyuan Yang and Karlheinz Friedrich

    Citation: Cell Communication and Signaling 2017 15:10

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  41. Content type: Research

    Translationally controlled tumour protein TCTP is an anti-apoptotic protein frequently overexpressed in cancers, where high levels are often associated with poor patient outcome. TCTP may be involved in protec...

    Authors: Ulrich-Axel Bommer, Kara L. Vine, Prianka Puri, Martin Engel, Lisa Belfiore, Karen Fildes, Marijka Batterham, Alistair Lochhead and Morteza Aghmesheh

    Citation: Cell Communication and Signaling 2017 15:9

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  42. Content type: Review

    Treatment of acute myeloid leukemia (AML), an aggressive and heterogeneous hematological malignancy, remains a challenge. Despite advances in our understanding of the complex genetics and biology of AML pathop...

    Authors: Fritz Aberger, Evelyn Hutterer, Christina Sternberg, Pedro J. del Burgo and Tanja N. Hartmann

    Citation: Cell Communication and Signaling 2017 15:8

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  43. Content type: Research

    The mammalian target of rapamycin (mTOR) is a regulator of cell proliferation, cell growth and apoptosis working through two distinct complexes: mTORC1 and mTORC2. Although much is known about the activation a...

    Authors: Kirsten Thobe, Christine Sers and Heike Siebert

    Citation: Cell Communication and Signaling 2017 15:6

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