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  1. Content type: Research

    Integrins are essential regulators of angiogenesis. However, the antiangiogenic potential of peptides derived from the integrin cytoplasmic tails (CT) remains mostly undetermined.

    Authors: Zhongyuan Cao, Xinfeng Suo, Yudan Chu, Zhou Xu, Yun Bao, Chunxiao Miao, Wenfeng Deng, Kaijun Mao, Juan Gao, Zhen Xu and Yan-Qing Ma

    Citation: Cell Communication and Signaling 2018 16:38

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  2. Content type: Research

    Fascin is a F-actin bundling protein and its overexpression is correlated with poor prognosis and increases metastatic potential in a number of cancers. But underlying function and mechanism of fascin on tumor...

    Authors: Jiaxin Kang, Jian Wang, Zhuang Yao, Yuanzhao Hu, Shijie Ma, Qin Fan, Feng Gao, Yan Sun and Jianwei Sun

    Citation: Cell Communication and Signaling 2018 16:37

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  3. Content type: Research

    Chemotherapeutic efficacy can be improved by targeting the structure and function of the extracellular matrix (ECM) in the carcinomal stroma. This can be accomplished by e.g. inhibiting TGF-β1 and -β3 or treat...

    Authors: P. Olof Olsson, Renata Gustafsson, Alexei V. Salnikov, Maria Göthe, Kathrin S. Zeller, Tomas Friman, Bo Baldetorp, Louise A. Koopman, Paul H. Weinreb, Shelia M. Violette, Sebastian Kalamajski, Nils-Erik Heldin and Kristofer Rubin

    Citation: Cell Communication and Signaling 2018 16:36

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  4. Content type: Research

    Loss of PTEN is involved in tumor progression of several tumor entities including renal cell carcinoma (RCC). During the translation process PTEN generates a number of splice variants, including PTEN-Δ. We ana...

    Authors: Ines Breuksch, Jonas Welter, Heide-Katharina Bauer, Thorsten Enklaar, Sebastian Frees, Joachim W. Thüroff, Annette Hasenburg, Dirk Prawitt and Walburgis Brenner

    Citation: Cell Communication and Signaling 2018 16:35

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  5. Content type: Short report

    The International Conference on Cell Death in Cancer and Toxicology 2018 (February 20–22, 2018) provided an international forum for scientific collaborations across multiple disciplines in cancer, cell death, ...

    Authors: Kausar M. Ansari, Praveen R. Arany, Eli Arama, Sarit Larisch, Raymond B. Birge and Dhyan Chandra

    Citation: Cell Communication and Signaling 2018 16:34

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  6. Content type: Research

    Saccharomyces cerevisiae ScGdt1 and mammalian TMEM165 are two members of the UPF0016 membrane protein family that is likely to form a new group of Ca2+/H+ antiporter and/or a Mn2+ transporter in the Golgi apparat...

    Authors: Linghuo Jiang, Junjun Wang, Faiza Asghar, Nathan Snyder and Kyle W. Cunningham

    Citation: Cell Communication and Signaling 2018 16:33

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  7. Content type: Research

    To determine whether adipocyte-derived lipids could be transferred into breast cancer cells and investigate the underlying mechanisms of subsequent lipolysis and fatty acid trafficking in breast cancer cells.

    Authors: Dejuan Yang, Yunhai Li, Lei Xing, Yiqing Tan, Jiazheng Sun, Beilei Zeng, Tingxiu Xiang, Jinxiang Tan, Guosheng Ren and Yuanyuan Wang

    Citation: Cell Communication and Signaling 2018 16:32

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  8. Content type: Review

    The MiT/TFE transcription factors play a pivotal role in the regulation of autophagy and lysosomal biogenesis. The subcellular localization and activity of MiT/TFE proteins are primarily regulated through phos...

    Authors: Min Yang, En Liu, Li Tang, Yuanyuan Lei, Xuemei Sun, Jiaxi Hu, Hui Dong, Shi-Ming Yang, Mingfa Gao and Bo Tang

    Citation: Cell Communication and Signaling 2018 16:31

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  9. Content type: Research

    In this study, we investigated the role of microRNA-644a (miR-644a) in the growth and survival of hepatocellular carcinoma (HCC) cells. MiR-644a levels were lower in HCC tissues than in adjacent peri-cancerous...

    Authors: Wenjin Liang, Yong Liao, Zeming Li, Yan Wang, Siqi Zheng, Xiaochen Xu, Fulin Ran, Bo Tang and Zhenran Wang

    Citation: Cell Communication and Signaling 2018 16:30

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  10. Content type: Review

    TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TRIOBP va...

    Authors: Sungjin Park, Hyunji Lee, Minhee Kim, Jisoo Park, Seon-Hwan Kim and Jongsun Park

    Citation: Cell Communication and Signaling 2018 16:29

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  11. Content type: Research

    SOD1 is an abundant enzyme that has been studied as a regulator of the antioxidant defence system, and this enzyme is well known for catalyzing the dismutation of superoxide into hydrogen peroxide. However the...

    Authors: Shuai Li, Lanyan Fu, Tian Tian, Liwen Deng, Huangbin Li, Weixiong Xia and Qing Gong

    Citation: Cell Communication and Signaling 2018 16:28

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  12. Content type: Research

    Altered expression of Solute Carrier Family 12 Member 7 (SLC12A7) is implicated to promote malignant behavior in multiple cancer types through an incompletely understood mechanism. Recent studies have shown re...

    Authors: Taylor C. Brown, Timothy D. Murtha, Jill C. Rubinstein, Reju Korah and Tobias Carling

    Citation: Cell Communication and Signaling 2018 16:27

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  13. Content type: Research

    Klotho (KL) was originally characterized as an aging suppressor gene, and has been identified as a tumor suppressor gene in a variety of cancers, including colorectal cancer. Recent years have witnessed the im...

    Authors: Qingguo Li, Yaqi Li, Lei Liang, Jing Li, Dakui Luo, Qi Liu, Sanjun Cai and Xinxiang Li

    Citation: Cell Communication and Signaling 2018 16:26

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  14. Content type: Research

    Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fract...

    Authors: Jiangfeng Du, Yaping Qin, Yahong Wu, Wenshan Zhao, Wenjie Zhai, Yuanming Qi, Chuchu Wang and Yanfeng Gao

    Citation: Cell Communication and Signaling 2018 16:25

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  15. Content type: Research

    The release of neutrophil extracellular traps (NETs), a mesh of DNA, histones and neutrophil proteases from neutrophils, was first demonstrated as a host defence against pathogens. Recently it became clear tha...

    Authors: Omar Elaskalani, Norbaini Binti Abdol Razak and Pat Metharom

    Citation: Cell Communication and Signaling 2018 16:24

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  16. Content type: Review

    Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, c...

    Authors: Shaojie Jiang, Miaofeng Zhang, Jihong Sun and Xiaoming Yang

    Citation: Cell Communication and Signaling 2018 16:23

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  17. Content type: Research

    SDF1/CXCR4 and AnnexinA7 play important roles in many physiological and pathological conditions, but the molecular association between them in cancer cells has not been studied thus far.

    Authors: Jingwen Wang, Yuhong Huang, Jun Zhang, Boyi Xing, Wei Xuan, Honghai Wang, He Huang, Jiayu Yang and Jianwu Tang

    Citation: Cell Communication and Signaling 2018 16:22

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  18. Content type: Research

    The CXCR4 receptor antagonist plerixafor (AMD3100) is raising interest as an anti-cancer agent that disrupts the CXCL12-CXCR4 chemokine – receptor interaction between neoplastic cells and their microenvironmen...

    Authors: Philipp Berning, Christiane Schaefer, Dagmar Clemens, Eberhard Korsching, Uta Dirksen and Jenny Potratz

    Citation: Cell Communication and Signaling 2018 16:21

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  19. Content type: Research

    Histone deacetylases (HDACs) are involved in epigenetic gene regulation via deacetylation of acetylated lysine residues of both histone and non-histone proteins. Among the 18 HDACs identified in humans, HDAC8,...

    Authors: G. R. Vanaja, Hemalatha Golaconda Ramulu and Arunasree M. Kalle

    Citation: Cell Communication and Signaling 2018 16:20

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  20. Content type: Research

    Golgin-97 is a tethering factor in the trans-Golgi network (TGN) and is crucial for vesicular trafficking and maintaining cell polarity. However, the significance of golgin-97 in human diseases such as cancer rem...

    Authors: Rae-Mann Hsu, Cai-Yan Zhong, Chih-Liang Wang, Wei-Chao Liao, Chi Yang, Shih-Yu Lin, Jia-Wei Lin, Hsiao-Yun Cheng, Po-Yu Li and Chia-Jung Yu

    Citation: Cell Communication and Signaling 2018 16:19

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  21. Content type: Research

    Transcription factors YAP and TAZ function as the primary mediators of the Hippo pathway. Yet, crosstalk of YAP and TAZ with other signaling pathways remains relatively unexplored. We have explored the impact ...

    Authors: Zhaoping Qin, Wei Xia, Gary J. Fisher, John J. Voorhees and Taihao Quan

    Citation: Cell Communication and Signaling 2018 16:18

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  22. Content type: Short report

    Macrophages are one of the most important players in the tumor microenvironment. The polarization status of tumor associated macrophages into a pro-inflammatory type M1 or anti-inflammatory type M2 may influen...

    Authors: Ineta Popēna, Artūrs Ābols, Līga Saulīte, Kārlis Pleiko, Elīna Zandberga, Kaspars Jēkabsons, Edgars Endzeliņš, Alicia Llorente, Aija Linē and Una Riekstiņa

    Citation: Cell Communication and Signaling 2018 16:17

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  23. Content type: Research

    Gain-of-function mutations and overexpression of KIT are characteristic features of gastrointestinal stromal tumor (GIST). Dysregulation in miRNA expression may lead to KIT overexpression and tumorigenesis.

    Authors: Yu Wang, Jun Li, Dong Kuang, Xiaoyan Wang, Yuanli Zhu, Sanpeng Xu, Yaobing Chen, Henghui Cheng, Qiu Zhao, Yaqi Duan and Guoping Wang

    Citation: Cell Communication and Signaling 2018 16:16

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  24. Content type: Research

    In the adult central nervous system (CNS), Wnt signaling regulates dendritic structure and synaptic plasticity. The Wnt signaling pathway can be divided into the canonical (β-catenin-dependent) and non-canonic...

    Authors: Juvenal A. Ríos, Juan A. Godoy and Nibaldo C. Inestrosa

    Citation: Cell Communication and Signaling 2018 16:15

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  25. Content type: Research

    In addition to physiological events such as fertilisation, placentation, osteoclastogenesis, or tissue regeneration/wound healing, cell fusion is involved in pathophysiological conditions such as cancer. Cell ...

    Authors: Julian Weiler, Marieke Mohr, Kurt S. Zänker and Thomas Dittmar

    Citation: Cell Communication and Signaling 2018 16:14

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  26. Content type: Research

    Osteosarcoma (OS) is the representative primary malignant bone tumor with the highest incidence. It is known that malignant phenotypes of OS, such as proliferation, invasion, and metastasis, are significantly ...

    Authors: Masanori Kawano, Kazuhiro Tanaka, Ichiro Itonaga, Tatsuya Iwasaki and Hiroshi Tsumura

    Citation: Cell Communication and Signaling 2018 16:13

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  27. Content type: Review

    Hedgehog (Hh) signaling pathway plays an essential role during vertebrate embryonic development and tumorigenesis. It is already known that Sonic hedgehog (Shh) pathway is important for the evolution of radio ...

    Authors: Gabriela Basile Carballo, Jéssica Ribeiro Honorato, Giselle Pinto Farias de Lopes and Tania Cristina Leite de Sampaio e Spohr

    Citation: Cell Communication and Signaling 2018 16:11

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  28. Content type: Research

    Transformation by oncogene Ras overcomes TGF-β mediated growth inhibition in epithelial cells. However, it cooperates with each other to mediate epithelial to mesenchymal transition (EMT). The mechanism of how...

    Authors: Sheng Liu, Josephine Iaria, Richard J. Simpson and Hong-Jian Zhu

    Citation: Cell Communication and Signaling 2018 16:10

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  29. Content type: Research

    The WNT-beta-catenin pathway is known to regulate cellular homeostasis during development and tissue regeneration. Activation of WNT signaling increases the stability of cytoplasmic beta-catenin and enhances i...

    Authors: Yuanyuan Tang, Joshua Berlind and Nirmala Mavila

    Citation: Cell Communication and Signaling 2018 16:9

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  30. Content type: Research

    High-mobility group box 2 (HMGB2) is implicated in tumorigenesis in various cancers. However, the clinical significance of HMGB2 signaling in human breast cancer progression remains unknown.

    Authors: Deyuan Fu, Jing Li, Jinli Wei, Zhengquan Zhang, Yulin Luo, Haosheng Tan and Chuanli Ren

    Citation: Cell Communication and Signaling 2018 16:8

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  31. Content type: Research

    5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal ...

    Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu and John C. Schmitz

    Citation: Cell Communication and Signaling 2018 16:7

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  32. Content type: Research

    Despite the implications for tumor growth and cancer drug resistance, the mechanisms underlying differences in energy metabolism among cells remain unclear.

    Authors: Li Wu, Jiayu Zhao, Kexin Cao, Xiao Liu, Hao Cai, Jiaqi Wang, Weidong Li and Zhipeng Chen

    Citation: Cell Communication and Signaling 2018 16:6

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  33. Content type: Research

    Long non-coding RNAs (lncRNAs) have emerged as a new and crucial layer of gene regulation in recent years and regulate various biological processes such as carcinogenesis and metastasis. LncRNA HOTAIR, an onco...

    Authors: Peng Zheng, Ze Yin, Ying Wu, Yao Xu, Ying Luo and Tong-Cun Zhang

    Citation: Cell Communication and Signaling 2018 16:5

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  34. Content type: Research

    Notch signaling controls many cellular processes, including cell fate determination, cell differentiation, proliferation and apoptosis. In mammals, four Notch receptors (Notch 1–4) can interact with five disti...

    Authors: Sylvain Pagie, Nathalie Gérard and Béatrice Charreau

    Citation: Cell Communication and Signaling 2018 16:4

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  35. Content type: Research

    Dysregulation of hedgehog pathway is observed in numerous cancers. Relevance of hedgehog pathway genes in cancer cohort and inhibition of its downstream effector (GLI1) towards metastasis in cell lines are exp...

    Authors: Syeda Kiran Riaz, Jahangir Sarwar Khan, Syed Tahir Abbas Shah, Fen Wang, Lin Ye, Wen G. Jiang and Muhammad Faraz Arshad Malik

    Citation: Cell Communication and Signaling 2018 16:3

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  36. Content type: Research

    Fusion of breast cancer cells with tumor-associated populations of the microenvironment including mesenchymal stroma/stem-like cells (MSC) represents a rare event in cell communication whereby the metastatic c...

    Authors: Catharina Melzer, Juliane von der Ohe and Ralf Hass

    Citation: Cell Communication and Signaling 2018 16:2

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  37. Content type: Short report

    The small GTPase Arf6 and its downstream effector AMAP1 (also called ASAP1/DDEF1) constitute a signaling pathway promoting cell invasion, in which AMAP1 interacts with several different proteins, including PRK...

    Authors: Yutaro Otsuka, Tsukasa Oikawa, Hinako Yoshino, Shigeru Hashimoto, Haruka Handa, Hiroki Yamamoto, Ari Hashimoto and Hisataka Sabe

    Citation: Cell Communication and Signaling 2018 16:1

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  38. Content type: Research

    The left-right determination factor (LEFTY) is a novel member of the TGF-β/Smad2 pathway and belongs to the premenstrual/menstrual repertoire in human endometrium, but little is known about its functional role...

    Authors: Wu Fei, Daiki Kijima, Mami Hashimoto, Miki Hashimura, Yasuko Oguri, Sabine Kajita, Toshihide Matsumoto, Ako Yokoi and Makoto Saegusa

    Citation: Cell Communication and Signaling 2017 15:56

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  39. Content type: Research

    Glioblastoma multiformae (GBM) is the most aggressive type of malignant brain tumor with complex molecular profile. Overexpression of Na+/H+ Exchanger isoform 9 (NHE9) promotes tumor progression and correlates po...

    Authors: Daniela M. Gomez Zubieta, Mohamed A. Hamood, Rami Beydoun, Ashley E. Pall and Kalyan C. Kondapalli

    Citation: Cell Communication and Signaling 2017 15:55

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  40. Content type: Research

    Hepatocellular carcinoma (HCC) is one of the cancer types with poor prognosis. To effectively treat HCC, new molecular targets and therapeutic approaches must be identified. 5-aminoimidazole-4-carboxamide ribo...

    Authors: Minjing Li, Changzhu Jin, Maolei Xu, Ling Zhou, Defang Li and Yancun Yin

    Citation: Cell Communication and Signaling 2017 15:52

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  41. Content type: Research

    Prostate cancer (PCa), the second most common cancer affecting men worldwide, shows a broad spectrum of biological and clinical behaviour representing the epiphenomenon of an extreme heterogeneity. Androgen de...

    Authors: Nicoletta Ferrari, Ilaria Granata, Matteo Capaia, Marina Piccirillo, Mario Rosario Guarracino, Roberta Venè, Antonella Brizzolara, Andrea Petretto, Elvira Inglese, Martina Morini, Simonetta Astigiano, Adriana Agnese Amaro, Francesco Boccardo, Cecilia Balbi and Paola Barboro

    Citation: Cell Communication and Signaling 2017 15:51

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  42. Content type: Research

    The simplicity of Transforming Growth Factor ß (TGFβ) signaling pathway, linear and non-amplified, hardly sustains its variety of responses. This is often justified by the complex regulation showed by Smad pro...

    Authors: Eva María García-Vizcaíno, Sergio Liarte, José Luis Alonso-Romero and Francisco José Nicolás

    Citation: Cell Communication and Signaling 2017 15:50

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  43. Content type: Correction

    Unfortunately, following publication of this article [1], it was noticed that the key in Figure 5c incorrectly showed ‘0 h’, ‘5 h’ and ‘10 h’. The corrected version, showing ‘0 h’, ‘12 h’ and ‘24 h’, can be se...

    Authors: Yue Pang, Changzhi Li, Shiyue Wang, Wei Ba, Tao Yu, Guangying Pei, Dan Bi, Hongfang Liang, Xiong Pan, Ting Zhu, Meng Gou, Yinglun Han and Qingwei Li

    Citation: Cell Communication and Signaling 2017 15:49

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    The original article was published in Cell Communication and Signaling 2017 15:42

  44. Content type: Research

    Human hyaluronic acid (HA) molecules are synthesized by three membrane spanning Hyaluronic Acid Synthases (HAS1, HAS2 and HAS3). Of the three, HAS1 is found to be localized more into the cytoplasmic space wher...

    Authors: Nguyet Nguyen, Awanit Kumar, Simi Chacko, Rodney J. Ouellette and Anirban Ghosh

    Citation: Cell Communication and Signaling 2017 15:48

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  45. Content type: Research

    One of the most common side effects of the immunosuppressive drug tacrolimus (FK506) is the increased risk of new-onset diabetes mellitus. However, the molecular mechanisms underlying this association have not...

    Authors: Angela Lombardi, Bruno Trimarco, Guido Iaccarino and Gaetano Santulli

    Citation: Cell Communication and Signaling 2017 15:47

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  46. Content type: Methodology

    Tunneling nanotubes (TNTs) are naturally-occurring filamentous actin-based membranous extensions that form across a wide spectrum of mammalian cell types to facilitate long-range intercellular communication. V...

    Authors: Venugopal Thayanithy, Patrick O’Hare, Phillip Wong, Xianda Zhao, Clifford J. Steer, Subbaya Subramanian and Emil Lou

    Citation: Cell Communication and Signaling 2017 15:46

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  47. Content type: Research

    We have previously validated three novel CD44-downstream positively regulated transcriptional targets, including Cortactin, Survivin and TGF-β2, and further characterized the players underlying their separate ...

    Authors: Allal Ouhtit, Mohammed E. Abdraboh, Andrew D. Hollenbach, Hatem Zayed and Madhwa H. G. Raj

    Citation: Cell Communication and Signaling 2017 15:45

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