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  1. Research

    Aldose reductase mediates endothelial cell dysfunction induced by high uric acid concentrations

    Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative str...

    Zhiyong Huang, Quan Hong, Xueguang Zhang, Wenzhen Xiao, Liyuan Wang, Shaoyuan Cui, Zhe Feng, Yang Lv, Guangyan Cai, Xiangmei Chen and Di Wu

    Cell Communication and Signaling 2017 15:3

    Published on: 5 January 2017

  2. Review

    T cell exhaustion: from pathophysiological basics to tumor immunotherapy

    The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...

    Kemal Catakovic, Eckhard Klieser, Daniel Neureiter and Roland Geisberger

    Cell Communication and Signaling 2017 15:1

    Published on: 5 January 2017

  3. Research

    HECTD1 controls the protein level of IQGAP1 to regulate the dynamics of adhesive structures

    Cell migration including collective cell movement and individual cell migration are crucial factors in embryogenesis. During the spreading/migration of cells, several types of adhesive structures physically in...

    Xiaoli Shen, Zanhui Jia, Donato D’Alonzo, Xinggang Wang, Elisabeth Bruder, Fabienne Hélène Emch, Christian De Geyter and Hong Zhang

    Cell Communication and Signaling 2017 15:2

    Published on: 5 January 2017

  4. Research

    Integrin-FAK signaling rapidly and potently promotes mitochondrial function through STAT3

    STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead t...

    Nishant P. Visavadiya, Matthew P. Keasey, Vladislav Razskazovskiy, Kalpita Banerjee, Cuihong Jia, Chiharu Lovins, Gary L. Wright and Theo Hagg

    Cell Communication and Signaling 2016 14:32

    Published on: 15 December 2016

    The Erratum to this article has been published in Cell Communication and Signaling 2017 15:11

  5. Research

    Attenuation of chemokine receptor function and surface expression as an immunomodulatory strategy employed by human cytomegalovirus is linked to vGPCR US28

    Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance an...

    Theresa Frank, Anna Reichel, Olav Larsen, Anne-Charlotte Stilp, Mette M. Rosenkilde, Thomas Stamminger, Takeaki Ozawa and Nuska Tschammer

    Cell Communication and Signaling 2016 14:31

    Published on: 12 December 2016

  6. Research

    HtrA-mediated E-cadherin cleavage is limited to DegP and DegQ homologs expressed by gram-negative pathogens

    The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open i...

    Carmen M. Abfalter, Maria Schubert, Camilla Götz, Thomas P. Schmidt, Gernot Posselt and Silja Wessler

    Cell Communication and Signaling 2016 14:30

    Published on: 8 December 2016

  7. Review

    The role of IL-10 in Mycobacterium avium subsp. paratuberculosis infection

    Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne’s disease of domestic and wild ruminants. Johne’s disease is characteriz...

    Tariq Hussain, Syed Zahid Ali Shah, Deming Zhao, Srinand Sreevatsan and Xiangmei Zhou

    Cell Communication and Signaling 2016 14:29

    Published on: 1 December 2016

  8. Short report

    High expression of EPB41L5, an integral component of the Arf6-driven mesenchymal program, correlates with poor prognosis of squamous cell carcinoma of the tongue

    Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 ar...

    Yutaro Otsuka, Hiroki Sato, Tsukasa Oikawa, Yasuhito Onodera, Jin-Min Nam, Ari Hashimoto, Kiyoshi Fukunaga, Kanako C. Hatanaka, Yutaka Hatanaka, Yoshihiro Matsuno, Satoshi Fukuda and Hisataka Sabe

    Cell Communication and Signaling 2016 14:28

    Published on: 21 November 2016

  9. Research

    “Inverse signaling” of the transmembrane chemokine CXCL16 contributes to proliferative and anti-apoptotic effects in cultured human meningioma cells

    Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we terme...

    Kirsten Hattermann, Kareen Bartsch, Henrike H. Gebhardt, H. Maximilian Mehdorn, Michael Synowitz, Anne Dorothée Schmitt, Rolf Mentlein and Janka Held-Feindt

    Cell Communication and Signaling 2016 14:26

    Published on: 27 October 2016

  10. Commentary

    Hunting for the ultimate liquid cancer biopsy - let the TEP dance begin

    Non-protein coding RNAs in different flavors (miRNAs, piRNAs, snoRNAs, lncRNAs, SHOT-RNAs), exosomes, large oncosomes, exoDNA and now tumor-educated platelets (TEPs) have emerged as crucial signal transmitting...

    Stephan M. Feller and Marc Lewitzky

    Cell Communication and Signaling 2016 14:24

    Published on: 27 September 2016

  11. Research

    Neurogenin 3 is regulated by neurotrophic tyrosine kinase receptor type 2 (TRKB) signaling in the adult human exocrine pancreas

    Reports of exocrine-to-endocrine reprogramming through expression or stabilization of the transcription factor neurogenin 3 (NGN3) have generated renewed interest in harnessing pancreatic plasticity for therap...

    Michael J. Shamblott, Marci L. O’Driscoll, Danielle L. Gomez and Dustin L. McGuire

    Cell Communication and Signaling 2016 14:23

    Published on: 22 September 2016

  12. Commentary

    Can erythrocytes release biologically active NO?

    Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been ...

    Peter M. Benz and Ingrid Fleming

    Cell Communication and Signaling 2016 14:22

    Published on: 17 September 2016

  13. Research

    Vasodilator-Stimulated Phosphoprotein (VASP)-dependent and -independent pathways regulate thrombin-induced activation of Rap1b in platelets

    Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main inte...

    Peter M. Benz, Hebatullah Laban, Joana Zink, Lea Günther, Ulrich Walter, Stepan Gambaryan and Karim Dib

    Cell Communication and Signaling 2016 14:21

    Published on: 13 September 2016

  14. Review

    Interaction of MSC with tumor cells

    Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...

    Catharina Melzer, Yuanyuan Yang and Ralf Hass

    Cell Communication and Signaling 2016 14:20

    Published on: 8 September 2016

  15. Research

    Normalization of TAM post-receptor signaling reveals a cell invasive signature for Axl tyrosine kinase

    Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigene...

    Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Boháč, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko and Raymond B. Birge

    Cell Communication and Signaling 2016 14:19

    Published on: 6 September 2016

  16. Research

    Epigenetic regulation of transcription factor promoter regions by low-dose genistein through mitogen-activated protein kinase and mitogen-and-stress activated kinase 1 nongenomic signaling

    The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells....

    Linda Yu, Kyle Ham, Xiaohua Gao, Lysandra Castro, Yitang Yan, Grace E. Kissling, Charles J. Tucker, Norris Flagler, Ray Dong, Trevor K. Archer and Darlene Dixon

    Cell Communication and Signaling 2016 14:18

    Published on: 31 August 2016

  17. Research

    A new mode of SAM domain mediated oligomerization observed in the CASKIN2 neuronal scaffolding protein

    CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASK...

    Ekaterina Smirnova, Jamie J. Kwan, Ryan Siu, Xin Gao, Georg Zoidl, Borries Demeler, Vivian Saridakis and Logan W. Donaldson

    Cell Communication and Signaling 2016 14:17

    Published on: 22 August 2016

  18. Research

    Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis

    Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfu...

    Stepan Gambaryan, Hariharan Subramanian, Linda Kehrer, Igor Mindukshev, Julia Sudnitsyna, Cora Reiss, Natalia Rukoyatkina, Andreas Friebe, Iraida Sharina, Emil Martin and Ulrich Walter

    Cell Communication and Signaling 2016 14:16

    Published on: 11 August 2016

  19. Research

    Gtpbp2 is a positive regulator of Wnt signaling and maintains low levels of the Wnt negative regulator Axin

    Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development...

    William Q. Gillis, Arif Kirmizitas, Yasuno Iwasaki, Dong-Hyuk Ki, Jonathan M. Wyrick and Gerald H. Thomsen

    Cell Communication and Signaling 2016 14:15

    Published on: 2 August 2016

  20. Research

    Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice

    The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta ...

    Christa Pfeifhofer-Obermair, Karin Albrecht-Schgoer, Sebastian Peer, Manfred Nairz, Kerstin Siegmund, Victoria Klepsch, David Haschka, Nikolaus Thuille, Natascha Hermann-Kleiter, Thomas Gruber, Günter Weiss and Gottfried Baier

    Cell Communication and Signaling 2016 14:14

    Published on: 28 July 2016

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