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  1. Content type: Research

    We have found that erbB receptor tyrosine kinases drive Ras hyperactivation and growth in NF1-null malignant peripheral nerve sheath tumors (MPNSTs). However, MPNSTs variably express multiple erbB receptors with ...

    Authors: Jody Fromm Longo, Stephanie N. Brosius, Laurel Black, Stuart H. Worley, Robert C. Wilson, Kevin A. Roth and Steven L. Carroll

    Citation: Cell Communication and Signaling 2019 17:74

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  2. Content type: Review

    Studies have recently revealed that almost every type of cells including tumor cells abundantly release small vesicles known as extracellular vesicles (EVs) into the extracellular milieu. EVs carry a repertoir...

    Authors: Reza Rahbarghazi, Nasrollah Jabbari, Neda Abbaspour Sani, Rahim Asghari, Leila Salimi, Sadegh Asghari Kalashani, Maryam Feghhi, Tahereh Etemadi, Elinaz Akbariazar, Mahmoud Mahmoudi and Jafar Rezaie

    Citation: Cell Communication and Signaling 2019 17:73

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  3. Content type: Research

    Chronic gastritis has been demonstrated to be a key cause of gastric cancer (GC), and control of gastric inflammation is regarded as an effective treatment for the clinical prevention of gastric carcinogenesis...

    Authors: Wang-Yu Cai, Ling-Yun Lin, Lin Wang, Li Yang, Guo-Dong Ye, Qiang Zeng, Jia Cheng, Yuan-Yuan Xie, Mao-Li Chen and Qi-Cong Luo

    Citation: Cell Communication and Signaling 2019 17:72

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  4. Content type: Research

    To date, several studies have confirmed that driving forces of the inflammatory tumour microenvironment trigger spontaneous cancer cell fusion. However, less is known about the underlying factors and mechanism...

    Authors: Julian Weiler and Thomas Dittmar

    Citation: Cell Communication and Signaling 2019 17:71

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  5. Content type: Research

    Inflammatory reactions are commonly affected by stress responses. Interleukin-6 signalling is part of the inflammatory response and is stringently regulated by the feedback inhibitor SOCS3 expressed in a short...

    Authors: Oliver Klepsch, Lise Sarah Namer, Nadine Köhler, Raymond Kaempfer, Anna Dittrich and Fred Schaper

    Citation: Cell Communication and Signaling 2019 17:70

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  6. Content type: Research

    Cholecystokinin (CCK) is implicated in the regulation of nociceptive sensitivity of primary afferent neurons. Nevertheless, the underlying cellular and molecular mechanisms remain unknown.

    Authors: Shumin Yu, Yuan Zhang, Xianyang Zhao, Zhigang Chang, Yuan Wei, Yufang Sun, Dongsheng Jiang, Xinghong Jiang and Jin Tao

    Citation: Cell Communication and Signaling 2019 17:68

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  7. Content type: Research

    Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies,...

    Authors: Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe and Kenichi Nomoto

    Citation: Cell Communication and Signaling 2019 17:67

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  8. Content type: Short report

    Modern quantitative mass spectrometry (MS)-based proteomics enables researchers to unravel signaling networks by monitoring proteome-wide cellular responses to different stimuli. MS-based analysis of signaling...

    Authors: Marion Janschitz, Natalie Romanov, Gina Varnavides, David Maria Hollenstein, Gabriela Gérecová, Gustav Ammerer, Markus Hartl and Wolfgang Reiter

    Citation: Cell Communication and Signaling 2019 17:66

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  9. Content type: Short report

    Fibroblast growth factor receptors (FGFRs) are integral membrane proteins that transmit signals through the plasma membrane. FGFRs signaling needs to be precisely adjusted as aberrant FGFRs function is associa...

    Authors: Marika Kucińska, Natalia Porębska, Agata Lampart, Marta Latko, Agata Knapik, Małgorzata Zakrzewska, Jacek Otlewski and Łukasz Opaliński

    Citation: Cell Communication and Signaling 2019 17:65

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  10. Content type: Research

    The mechanistic target of rapamycin (mTOR) pathway is a potential target to inhibit pathologic processes in choroidal neovascularization. However, the exact role of mTOR signaling in the development of CNV rem...

    Authors: Jin Young Yang, Sanjar Batirovich Madrakhimov, Dong Hyuck Ahn, Hun Soo Chang, Sang Joon Jung, Seung Kwan Nah, Ha Yan Park and Tae Kwann Park

    Citation: Cell Communication and Signaling 2019 17:64

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  11. Content type: Review

    Human telomerase reverse transcriptase (hTERT) is the core subunit of human telomerase and plays important roles in human cancers. Aberrant expression of hTERT is closely associated with tumorigenesis, cancer ...

    Authors: Meng-Meng Jie, Xing Chang, Shuo Zeng, Cheng Liu, Guo-Bin Liao, Ya-Ran Wu, Chun-Hua Liu, Chang-Jiang Hu, Shi-Ming Yang and Xin-Zhe Li

    Citation: Cell Communication and Signaling 2019 17:63

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  12. Content type: Research

    Oxidative stress and the resulting inflammation are essential pathological processes in acute lung injury (ALI). Nuclear factor erythroid 2-related factor 2 (Nrf2), a vital transcriptional factor, possesses an...

    Authors: Huahong Yang, Hongming Lv, Haijun Li, Xinxin Ci and Liping Peng

    Citation: Cell Communication and Signaling 2019 17:62

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  13. Content type: Research

    The astroglial connexins Cx30 and Cx43 contribute to many important CNS functions including cognitive behaviour, motoric capacity and regulation of the sleep-wake cycle. The sleep wake cycle, is controlled by ...

    Authors: Amira A. H. Ali, Anna Stahr, Marc Ingenwerth, Martin Theis, Christian Steinhäuser and Charlotte von Gall

    Citation: Cell Communication and Signaling 2019 17:61

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  14. Content type: Research

    The accumulation of M1-polarized macrophages and excessive inflammation are important in the pathogenesis of diabetic foot ulcer (DFU). However, the underlying mechanism of DFU pathogenesis and the crucial reg...

    Authors: Juan Feng, Chang Dong, Yanlan Long, Lifang Mai, Meng Ren, Lingyi Li, Ti Zhou, Zhonghan Yang, Jianxing Ma, Li Yan, Xia Yang, Guoquan Gao and Weiwei Qi

    Citation: Cell Communication and Signaling 2019 17:60

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  15. Content type: Research

    Overexpression of AXL receptor tyrosine kinase (AXL) in various human cancers correlates with reduced patients overall survival and resistance to first line therapies. Therefore, several AXL tyrosine kinase in...

    Authors: Markus Lauter, Anja Weber and Robert Torka

    Citation: Cell Communication and Signaling 2019 17:59

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  16. Content type: Research

    Breast cancer cells recruit surrounding stromal cells, such as cancer-associated fibroblasts (CAFs), to remodel collagen and promote tumor metastasis. Adipocytes are the most abundant stromal partners in breas...

    Authors: Xiaohui Wei, Sijing Li, Jinyong He, Hongzhi Du, Yang Liu, Wei Yu, Haolin Hu, Lifei Han, Chenfei Wang, Hongyang Li, Xin Shi, Meixiao Zhan, Ligong Lu, Shengtao Yuan and Li Sun

    Citation: Cell Communication and Signaling 2019 17:58

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  17. Content type: Research

    Androgen plays a pivotal role in spermatogenesis, accompanying a question how androgen acts on germ cells in testis since germ cells lack of androgen receptors (AR). Promyelocytic leukemia zinc-finger (PLZF) i...

    Authors: Jingjing Wang, Jinmei Li, Wei Xu, Qin Xia, Yunzhao Gu, Weixiang Song, Xiaoyu Zhang, Yang Yang, Wei Wang, Hua Li and Kang Zou

    Citation: Cell Communication and Signaling 2019 17:57

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  18. Content type: Short report

    The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser, Michael Leitges and Gottfried Baier

    Citation: Cell Communication and Signaling 2019 17:56

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  19. Content type: Research

    In the endothelium, the single-pass membrane protein CD93, through its interaction with the extracellular matrix protein Multimerin-2, activates signaling pathways that are critical for vascular development an...

    Authors: Stefano Barbera, Federica Nardi, Ines Elia, Giulia Realini, Roberta Lugano, Annalisa Santucci, Gian Marco Tosi, Anna Dimberg, Federico Galvagni and Maurizio Orlandini

    Citation: Cell Communication and Signaling 2019 17:55

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  20. Content type: Research

    In previous research, we found that lamprey immune protein (LIP) possessed cytocidal activity against tumor cells, but the mechanism of the selective recognition and killing of tumor cells by LIP was not ident...

    Authors: Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang and Qingwei Li

    Citation: Cell Communication and Signaling 2019 17:54

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  21. Content type: Research

    Tumor-associated macrophages can promote breast cancer metastasis by secreting cytokines and growth factors. Interleukin (IL)-32θ, a newly identified IL-32 isoform, was previously shown to down-regulate variou...

    Authors: Thu-Huyen Pham, Yesol Bak, Taeho Kwon, Sae-Bom Kwon, Jae-Wook Oh, Jong-Hyung Park, Yang-Kyu Choi, Jin Tae Hong and Do-Young Yoon

    Citation: Cell Communication and Signaling 2019 17:53

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  22. Content type: Research

    Recent studies claimed the important role of cold atmospheric plasma (CAP) with nanotechnology in cancer treatments. In this study, silymarin nanoemulsion (SN) was used along with air CAP as therapeutic agent ...

    Authors: Manish Adhikari, Neha Kaushik, Bhagirath Ghimire, Bhawana Adhikari, Sanjula Baboota, Abdulaziz A. Al-Khedhairy, Rizwan Wahab, Su-Jae Lee, Nagendra Kumar Kaushik and Eun Ha Choi

    Citation: Cell Communication and Signaling 2019 17:52

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  23. Content type: Research

    Prostate cancer (PCa) is the second leading cause of mortality and a leading cause of malignant tumors in males. Prostate cancer stem cells (PCSCs) are likely the responsible cell types for cancer initiation, ...

    Authors: Yongmei Shen, Jiasong Cao, Zhixian Liang, Qimei Lin, Jianxi Wang, Xu Yang, Ran Zhang, Jiaojiao Zong, Xiaoling Du, Yanfei Peng, Ju Zhang and Jiandang Shi

    Citation: Cell Communication and Signaling 2019 17:50

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  24. Content type: Methodology

    GPCRs are considered essential for various physiological processes and have been the most productive drug targets. Therefore, development of the methods of GPCR ligands screening is a high priority for pharmac...

    Authors: Fei Li, Xi Jiang, Ling-Ling Luo, Yue-Ming Xu, Xing-Xu Huang, Cheng Huang and Yu Zhang

    Citation: Cell Communication and Signaling 2019 17:49

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  25. Content type: Research

    Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults. Traditional researches mainly explored the expression profile of glioma at cell-population level, but ignored the heteroge...

    Authors: Dongsheng Yuan, Yiran Tao, Geng Chen and Tieliu Shi

    Citation: Cell Communication and Signaling 2019 17:48

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  26. Content type: Research

    Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalli...

    Authors: Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, Stefan Streif, Eric Bullinger, Monica Schliemann-Bullinger, Rolf Findeisen, Fred Schaper, Heinrich J. Huber and Anna Dittrich

    Citation: Cell Communication and Signaling 2019 17:46

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  27. Content type: Research

    Endometriosis, characterized by the presence of functional endometrial tissues outside the uterus, is one of the most common gynecological disorders. Endometrial mesenchymal stem cells (MSCs) are crucial for t...

    Authors: Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, Guiping Wan and Xiaodong Han

    Citation: Cell Communication and Signaling 2019 17:45

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  28. Content type: Research

    Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stag...

    Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinghao Wang and Xia Li

    Citation: Cell Communication and Signaling 2019 17:44

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  29. Content type: Correction

    Following publication of the original article [1], the authors reported an error in

    Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang and Xiaoping Zou

    Citation: Cell Communication and Signaling 2019 17:43

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    The original article was published in Cell Communication and Signaling 2019 17:23

  30. Content type: Research

    Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death. Autophagy is a well-defined process which governs ...

    Authors: Wei Zheng, Weiwei Xie, Danyang Yin, Rui Luo, Min Liu and Fengjin Guo

    Citation: Cell Communication and Signaling 2019 17:42

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  31. Content type: Research

    The flaviviridae family comprises single-stranded RNA viruses that enter cells via clathrin-mediated pH-dependent endocytosis. Although the initial events of the virus entry have been already identified, data reg...

    Authors: Katarzyna Owczarek, Yuliya Chykunova, Christian Jassoy, Beata Maksym, Zenon Rajfur and Krzysztof Pyrc

    Citation: Cell Communication and Signaling 2019 17:41

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  32. Content type: Research

    Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition to regulating genomic transcriptional ac...

    Authors: Thabat Khatib, Pietro Marini, Sudheer Nunna, David R. Chisholm, Andrew Whiting, Christopher Redfern, Iain R. Greig and Peter McCaffery

    Citation: Cell Communication and Signaling 2019 17:40

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  33. Content type: Research

    In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates f...

    Authors: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca and Ciro Isidoro

    Citation: Cell Communication and Signaling 2019 17:39

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  34. Content type: Research

    The NOV gene product, CCN3, has been reported in a diverse range of tumors to serve as a negative growth regulator, while acting as a tumor suppressor in Chronic Myelogenous Leukemia (CML). However, the precis...

    Authors: Mousa Vatanmakanian, Mahmood Tavallaie and Shirin Ghadami

    Citation: Cell Communication and Signaling 2019 17:38

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  35. Content type: Research

    We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is i...

    Authors: Neel Mehta, Dan Zhang, Renzhong Li, Tony Wang, Agata Gava, Pavithra Parthasarathy, Bo Gao and Joan C. Krepinsky

    Citation: Cell Communication and Signaling 2019 17:37

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  36. Content type: Research

    The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and...

    Authors: Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao and Chunmeng Shi

    Citation: Cell Communication and Signaling 2019 17:36

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  37. Content type: Review

    Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing nu...

    Authors: Yumei Li, Feng Wu, Qi Tan, Mengfei Guo, Pei Ma, Xuan Wang, Shuai Zhang, Juanjuan Xu, Ping Luo and Yang Jin

    Citation: Cell Communication and Signaling 2019 17:35

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  38. Content type: Research

    Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Ca2+channel path...

    Authors: Jeremiah Ong’achwa Machuki, Hong-Yuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Li Kexue, Zhiwei Zhao and Hong Sun

    Citation: Cell Communication and Signaling 2019 17:34

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  39. Content type: Research

    Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propa...

    Authors: Stephen R. Koch, Hyehun Choi, Eric H. Mace and Ryan J. Stark

    Citation: Cell Communication and Signaling 2019 17:33

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  40. Content type: Research

    A major challenge in the development of effective cancer immunotherapy is the ability of tumors and their microenvironment to suppress immune cells through immunosuppressive cells such as myeloid -derived supp...

    Authors: Dickson Adah, Yijun Yang, Quan Liu, Kranthi Gadidasu, Zhu Tao, Songlin Yu, Linglin Dai, Xiaofen Li, Siting Zhao, Limei Qin, Li Qin and Xiaoping Chen

    Citation: Cell Communication and Signaling 2019 17:32

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  41. Content type: Research

    p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mec...

    Authors: Liang Chen, Shuning Bi, Jiuzhou Hou, Zhijun Zhao, Chaojie Wang and Songqiang Xie

    Citation: Cell Communication and Signaling 2019 17:31

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  42. Content type: Research

    The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation...

    Authors: Yi Qin, Qiangsheng Hu, Jin Xu, Shunrong Ji, Weixing Dai, Wensheng Liu, Wenyan Xu, Qiqing Sun, Zheng Zhang, Quanxing Ni, Bo Zhang, Xianjun Yu and Xiaowu Xu

    Citation: Cell Communication and Signaling 2019 17:30

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  43. Content type: Review

    EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role durin...

    Authors: Sheng-an Su, Yao Xie, Yuhao Zhang, Yutao Xi, Jie Cheng and Meixiang Xiang

    Citation: Cell Communication and Signaling 2019 17:29

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  44. Content type: Research

    Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is neces...

    Authors: Ting Lu, Zhou Zhu, Junchao Wu, Hua She, Rong Han, Haidong Xu and Zheng-Hong Qin

    Citation: Cell Communication and Signaling 2019 17:28

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  45. Content type: Research

    Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin an...

    Authors: Taís M. Danilucci, Patty K. Santos, Bianca C. Pachane, Graziéle F. D. Pisani, Rafael L. B. Lino, Bruna C. Casali, Wanessa F. Altei and Heloisa S. Selistre-de-Araujo

    Citation: Cell Communication and Signaling 2019 17:27

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  46. Content type: Review

    Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular developm...

    Authors: Mohammad Hossein Geranmayeh, Reza Rahbarghazi and Mehdi Farhoudi

    Citation: Cell Communication and Signaling 2019 17:26

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  47. Content type: Research

    Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets o...

    Authors: Xuesen Li, Victor Pham, Matthew Tippin, Dongjun Fu, Raymond Rendon, Liankun Song, Edward Uchio, Bang H. Hoang and Xiaolin Zi

    Citation: Cell Communication and Signaling 2019 17:25

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