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Review
In favor of their outgrowth, cancer cells must resist immune surveillance and edit the immune response. Cancer immunoediting is characterized by fundamental changes in the cellular composition and the inflamma...
Cell Communication and Signaling 2017 15:5
Published on: 19 January 2017
Commentary
Recent studies have demonstrated that the bacterial chaperone and serine protease high temperature requirement A (HtrA) is closely associated with the establishment and progression of several infectious diseas...
Cell Communication and Signaling 2017 15:4
Published on: 10 January 2017
Research
Uric acid (UA) is an antioxidant found in human serum. However, high UA levels may also have pro-oxidant functions. According to previous research, aldose reductase (AR) plays a vital role in the oxidative str...
Cell Communication and Signaling 2017 15:3
Published on: 5 January 2017
Review
The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...
Cell Communication and Signaling 2017 15:1
Published on: 5 January 2017
Research
Cell migration including collective cell movement and individual cell migration are crucial factors in embryogenesis. During the spreading/migration of cells, several types of adhesive structures physically in...
Cell Communication and Signaling 2017 15:2
Published on: 5 January 2017
Research
STAT3 is increasingly becoming known for its non-transcriptional regulation of mitochondrial bioenergetic function upon activation of its S727 residue (S727-STAT3). Lengthy mitochondrial dysfunction can lead t...
Cell Communication and Signaling 2016 14:32
Published on: 15 December 2016
The Erratum to this article has been published in Cell Communication and Signaling 2017 15:11
Research
Some herpesviruses like human cytomegalovirus (HCMV) encode viral G protein-coupled receptors that cause reprogramming of cell signaling to facilitate dissemination of the virus, prevent immune surveillance an...
Cell Communication and Signaling 2016 14:31
Published on: 12 December 2016
Research
The serine proteases HtrA/DegP secreted by the human gastrointestinal pathogens Helicobacter pylori (H. pylori) and Campylobacter jejuni (C. jejuni) cleave the mammalian cell adhesion protein E-cadherin to open i...
Cell Communication and Signaling 2016 14:30
Published on: 8 December 2016
Review
Mycobacterium avium subsp. paratuberculosis (MAP) is an intracellular pathogen and is the causative agent of Johne’s disease of domestic and wild ruminants. Johne’s disease is characteriz...
Cell Communication and Signaling 2016 14:29
Published on: 1 December 2016
Short report
Squamous cell carcinoma of the tongue (tongue SCC) is a major subtype of head and neck squamous cell carcinoma (HNSCC), which is an intractable cancer under current therapeutics. ARF6 and its effector AMAP1 ar...
Cell Communication and Signaling 2016 14:28
Published on: 21 November 2016
Review
The establishment, remodeling and maintenance of tissular architecture during animal development, and even across juvenile to adult life, are deeply regulated by a delicate interplay of extracellular signals, ...
Cell Communication and Signaling 2016 14:27
Published on: 4 November 2016
Research
Chemokines and their receptors play a decisive role in tumor progression and metastasis. We recently found a new signaling mechanism in malignant glioma cells mediated by transmembrane chemokines that we terme...
Cell Communication and Signaling 2016 14:26
Published on: 27 October 2016
Research
ErbB2 Receptor Tyrosine Kinase 2 (ErbB2, HER2/Neu) is amplified in breast cancer and associated with poor prognosis. Growing evidence suggests interplay between ErbB2 and insulin-like growth factor (IGF) signa...
Cell Communication and Signaling 2016 14:25
Published on: 21 October 2016
Commentary
Non-protein coding RNAs in different flavors (miRNAs, piRNAs, snoRNAs, lncRNAs, SHOT-RNAs), exosomes, large oncosomes, exoDNA and now tumor-educated platelets (TEPs) have emerged as crucial signal transmitting...
Cell Communication and Signaling 2016 14:24
Published on: 27 September 2016
Research
Reports of exocrine-to-endocrine reprogramming through expression or stabilization of the transcription factor neurogenin 3 (NGN3) have generated renewed interest in harnessing pancreatic plasticity for therap...
Cell Communication and Signaling 2016 14:23
Published on: 22 September 2016
Commentary
Under physiological conditions, endothelial cells and the endothelial nitric oxide (NO) synthase (eNOS) are the main source of NO in the cardiovascular system. However, several other cell types have also been ...
Cell Communication and Signaling 2016 14:22
Published on: 17 September 2016
Research
Vasodilator-Stimulated Phosphoprotein (VASP) is involved in the inhibition of agonist-induced platelet aggregation by cyclic nucleotides and the adhesion of platelets to the vascular wall. αIIbβ3 is the main inte...
Cell Communication and Signaling 2016 14:21
Published on: 13 September 2016
Review
Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...
Cell Communication and Signaling 2016 14:20
Published on: 8 September 2016
Research
Tyro3, Axl, and Mertk (TAMs) are a family of three conserved receptor tyrosine kinases that have pleiotropic roles in innate immunity and homeostasis and when overexpressed in cancer cells can drive tumorigene...
Cell Communication and Signaling 2016 14:19
Published on: 6 September 2016
Research
The phytoestrogen, genistein at low doses nongenomically activates mitogen-activated protein kinase p44/42 (MAPKp44/42) via estrogen receptor alpha (ERα) leading to proliferation of human uterine leiomyoma cells....
Cell Communication and Signaling 2016 14:18
Published on: 31 August 2016
Research
CASKIN2 is a homolog of CASKIN1, a scaffolding protein that participates in a signaling network with CASK (calcium/calmodulin-dependent serine kinase). Despite a high level of homology between CASKIN2 and CASK...
Cell Communication and Signaling 2016 14:17
Published on: 22 August 2016
Research
Direct interaction between Red blood cells (RBCs) and platelets is known for a long time. The bleeding time is prolonged in anemic patients independent of their platelet count and could be corrected by transfu...
Cell Communication and Signaling 2016 14:16
Published on: 11 August 2016
Research
Canonical Wnt signals, transduced by stabilized β-catenin, play similar roles across animals in maintaining stem cell pluripotency, regulating cell differentiation, and instructing normal embryonic development...
Cell Communication and Signaling 2016 14:15
Published on: 2 August 2016
Research
The serine/threonine protein kinase C (PKC) theta has been firmly implicated in T cell-mediated immunity. Because its role in macrophages has remained undefined, we employed PKCtheta-deficient (PKCtheta ...
Cell Communication and Signaling 2016 14:14
Published on: 28 July 2016
Review
Extracellular vesicles are cell-derived vesicles, which can transport various cargos out of cells. From their cell of origin, the content molecules (proteins, non-coding RNAs including miRNAs, DNA and others) ...
Cell Communication and Signaling 2016 14:13
Published on: 10 June 2016
