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  1. Content type: Research

    Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer ...

    Authors: Petr Tomek, Shanti K. Gore, Chloe L. Potts, Cristin G. Print, Michael A. Black, Ariane Hallermayr, Michael Kilian, Evelyn Sattlegger and Lai-Ming Ching

    Citation: Cell Communication and Signaling 2018 16:88

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  2. Content type: Research

    Deregulated metabolism is a hallmark of cancer and recent evidence underlines that targeting tumor energetics may improve therapy response and patient outcome. Despite the general attitude of cancer cells to e...

    Authors: Elena Andreucci, Silvia Pietrobono, Silvia Peppicelli, Jessica Ruzzolini, Francesca Bianchini, Alessio Biagioni, Barbara Stecca and Lido Calorini

    Citation: Cell Communication and Signaling 2018 16:87

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  3. Content type: Research

    MRTF-A (myocardin-related transcription factor A) is a coactivator for SRF-mediated gene expression. The activity of MRTF-A is critically dependent on the dissociation of G-actin from N-terminal RPEL motifs. M...

    Authors: Franziska Kluge, Julia Weissbach, Anja Weber, Theresia Stradal and Guido Posern

    Citation: Cell Communication and Signaling 2018 16:86

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  4. Content type: Research

    Rapamycin is a potent inhibitor of the highly conserved TOR kinase, the nutrient-sensitive controller of growth and aging. It has been utilised as a chemotherapeutic agent due to its anti-proliferative propert...

    Authors: Duygu Dikicioglu, Elif Dereli Eke, Serpil Eraslan, Stephen G. Oliver and Betul Kirdar

    Citation: Cell Communication and Signaling 2018 16:85

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  5. Content type: Research

    Impaired wound healing frequently occurs in diabetes mellitus (DM) and is implicated in impaired angiogenesis. Long non-coding RNA (lncRNA) H19 has been reported as being reduced in DM and played a critical ro...

    Authors: Jian-Rong Guo, Lei Yin, Yong-Quan Chen, Xiao-Ju Jin, Xun Zhou, Na-Na Zhu, Xiao-Qian Liu, Han-Wei Wei and Li-Shuang Duan

    Citation: Cell Communication and Signaling 2018 16:84

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  6. Content type: Research

    P2X7 is ubiquitously expressed in myeloid cells and regulates the pathophysiology of inflammatory diseases. Since mitochondrial function in microglia is highly associated with microglial functions in controlli...

    Authors: Ponarulselvam Sekar, Duen-Yi Huang, Shie-Liang Hsieh, Shwu-Fen Chang and Wan-Wan Lin

    Citation: Cell Communication and Signaling 2018 16:83

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  7. Content type: Research

    Knockdown of Akt1 promotes Epithelial-to-Mesenchymal Transition in breast cancer cells. However, the mechanisms are not completely understood.

    Authors: Wei Li, Jiu-Zhou Hou, Jie Niu, Zhuo-Qing Xi, Chang Ma, Hua Sun, Chao-Jie Wang, Dong Fang, Qin Li and Song-Qiang Xie

    Citation: Cell Communication and Signaling 2018 16:82

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  8. Content type: Research

    Four-octyl itaconate (OI), the itaconate’s cell-permeable derivative, can activate Nrf2 signaling via alkylation of Keap1 at its cysteine residues. The current study tested the potential neuroprotective functi...

    Authors: Hua Liu, Yu Feng, Min Xu, Jian Yang, Zhichun Wang and Guangfu Di

    Citation: Cell Communication and Signaling 2018 16:81

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  9. Content type: Correction

    Following publication of the original article [1], the authors reported an error in Table 3. The correct version of Table 3 is shown below:

    Authors: Julianna Kardos, László Héja, Ágnes Simon, István Jablonkai, Richard Kovács and Katalin Jemnitz

    Citation: Cell Communication and Signaling 2018 16:80

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    The original article was published in Cell Communication and Signaling 2018 16:71

  10. Content type: Research

    Insulin signaling pathway in β-cell is essential to promote β-cells proliferation and survival, while Nodal–ALK7–Smad3 signaling involves β-cells apoptosis. We attempted to address inter-relationship between N...

    Authors: Junfeng Li, Zhihong Wang, Liwei Ren, Linling Fan, Wenjuan Liu, Yaojing Jiang, Harry K. Lau, Rui Liu and Qinghua Wang

    Citation: Cell Communication and Signaling 2018 16:79

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  11. Content type: Research

    Besides its neurotransmitter and vasoconstriction functions, serotonin is an important mediator of numerous biological processes in peripheral tissues including cell proliferation, steatosis, and fibrogenesis....

    Authors: Suryakant Niture, Maxwell A. Gyamfi, Habib Kedir, Elena Arthur, Habtom Ressom, Gagan Deep and Deepak Kumar

    Citation: Cell Communication and Signaling 2018 16:78

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  12. Content type: Research

    The deubiquitinase USP17 is overexpressed in NSCLC and has been shown to be required for the growth and motility of EGFR wild-type (WT) NSCLC cells. USP17 is also required for clathrin-mediated endocytosis of EGF...

    Authors: Aidan P. McCann, Peter Smyth, Francesco Cogo, William J. McDaid, Lai Jiang, Jia Lin, Emma Evergren, Roberta E. Burden, Sandra Van Schaeybroeck, Christopher J. Scott and James F. Burrows

    Citation: Cell Communication and Signaling 2018 16:77

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  13. Content type: Review

    Tunnelling nanotubes (TNTs), also known as membrane nanochannels, are actin-based structures that facilitate cytoplasmic connections for rapid intercellular transfer of signals, organelles and membrane compone...

    Authors: Eshna Jash, Peeyush Prasad, Naveen Kumar, Taruna Sharma, Aaron Goldman and Seema Sehrawat

    Citation: Cell Communication and Signaling 2018 16:76

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  14. Content type: Research

    Basal-like breast cancer (BLBC) is a poor prognosis subgroup of triple-negative carcinomas that still lack specific target therapies and accurate biomarkers for treatment selection. P-cadherin is frequently ov...

    Authors: Ana Sofia Ribeiro, Ana Rita Nobre, Nuno Mendes, João Almeida, André Filipe Vieira, Bárbara Sousa, Filomena A. Carvalho, Joana Monteiro, António Polónia, Martina Fonseca, João Miguel Sanches, Nuno C. Santos, Raquel Seruca and Joana Paredes

    Citation: Cell Communication and Signaling 2018 16:75

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  15. Content type: Research

    We have previously evidenced apical expression of the 24p3/NGAL/lipocalin-2 receptor (Lcn2-R; SLC22A17) in inner medullary collecting duct (IMCD) cells, which are present in vivo in a hyperosmotic/-tonic environm...

    Authors: R. Betten, B. Scharner, S. Probst, B. Edemir, N. A. Wolff, C. Langelueddecke, W.-K. Lee and F. Thévenod

    Citation: Cell Communication and Signaling 2018 16:74

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  16. Content type: Research

    p130 Crk-associated substrate (p130CAS; also known as BCAR1) is a scaffold protein that modulates many essential cellular processes such as cell adhesion, proliferation, survival, cell migration, and intracell...

    Authors: Maria del Pilar Camacho Leal, Andrea Costamagna, Beatrice Tassone, Stefania Saoncella, Matilde Simoni, Dora Natalini, Aurora Dadone, Marianna Sciortino, Emilia Turco, Paola Defilippi, Enzo Calautti and Sara Cabodi

    Citation: Cell Communication and Signaling 2018 16:73

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    The Correction to this article has been published in Cell Communication and Signaling 2018 16:90

  17. Content type: Review

    The with no lysine [K] (WNK) pathway consists of the structurally unique WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK...

    Authors: Sachith Gallolu Kankanamalage, Aroon S. Karra and Melanie H. Cobb

    Citation: Cell Communication and Signaling 2018 16:72

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  18. Content type: Review

    Copper-containing enzymes perform fundamental functions by activating dioxygen (O2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O2 transport, metabolism and pr...

    Authors: Julianna Kardos, László Héja, Ágnes Simon, István Jablonkai, Richard Kovács and Katalin Jemnitz

    Citation: Cell Communication and Signaling 2018 16:71

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    The Correction to this article has been published in Cell Communication and Signaling 2018 16:80

  19. Content type: Research

    Benign Lymphoepithelial Lesion (BLEL) is a rare disease observed in the adult population. Despite the growing numbers of people suffering from BLEL, the etiology and mechanisms underlying its pathogenesis rema...

    Authors: Yao Mawulikplimi Adzavon, Pengxiang Zhao, Jianmin Ma, Xujuan Zhang, Xin Zhang, Mingzi Zhang, Mengyu Liu, Limin Wang, Danying Chen, Tarekegn Gebreyesus Abisso, Baobei Lv, Lei Wang, Fei Xie and Xuemei Ma

    Citation: Cell Communication and Signaling 2018 16:70

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  20. Content type: Research

    Transmissible gastroenteritis virus (TGEV), the etiologic agent of transmissible gastroenteritis, infects swine of all ages causing vomiting and diarrhea, in newborn piglets the mortality rate is near 100%. In...

    Authors: Shuai Zhang, Weiwei Hu, Lvfeng Yuan and Qian Yang

    Citation: Cell Communication and Signaling 2018 16:69

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  21. Content type: Research

    Myeloma bone disease (MBD) can cause bone destruction and increase the level of Ca2+ concentration in the bone marrow microenvironment by stimulating osteoclastic differentiation. Nevertheless, the relationships ...

    Authors: Hua Bai, Huayuan Zhu, Qing Yan, Xuxing Shen, Xiupan Lu, Juejin Wang, Jianyong Li and Lijuan Chen

    Citation: Cell Communication and Signaling 2018 16:68

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  22. Content type: Short report

    The tumor microenvironment enables important cellular interactions between cancer cells and recruited adjacent populations including mesenchymal stroma/stem cells (MSC). In vivo cellular interactions of primar...

    Authors: Catharina Melzer, Juliane von der Ohe and Ralf Hass

    Citation: Cell Communication and Signaling 2018 16:67

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  23. Content type: Research

    By allowing intercellular communication between cells, tunneling nanotubes (TNTs) could play critical role in cancer progression. If TNT formation is known to require cytoskeleton remodeling, key mechanism con...

    Authors: Fatéméh Dubois, Bastien Jean-Jacques, Hélène Roberge, Magalie Bénard, Ludovic Galas, Damien Schapman, Nicolas Elie, Didier Goux, Maureen Keller, Elodie Maille, Emmanuel Bergot, Gérard Zalcman and Guénaëlle Levallet

    Citation: Cell Communication and Signaling 2018 16:66

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  24. Content type: Research

    Our previous work revealed that rhomboid domain-containing protein 1 (RHBDD1) participates in the modulation of cell growth and apoptosis in colorectal cancer cells. This study aimed to investigate the functio...

    Authors: Xin Zhang, Yuechao Zhao, Changjun Wang, Hongge Ju, Wenjie Liu, Xiaohui Zhang, Shiying Miao, Linfang Wang, Qiang Sun and Wei Song

    Citation: Cell Communication and Signaling 2018 16:65

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  25. Content type: Research

    Mammalian target of rapamycin (mTOR) is a master regulator of various cellular responses by forming two functional complexes, mTORC1 and mTORC2. mTOR signaling is frequently dysregulated in pancreatic neuroend...

    Authors: Masoud Razmara, Azita Monazzam and Britt Skogseid

    Citation: Cell Communication and Signaling 2018 16:64

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  26. Content type: Research

    TEM8 is a cell membrane protein predominantly expressed in tumor endothelium, which serves as a receptor for the protective antigen (PA) of anthrax toxin. However, the physiological ligands for TEM8 remain unk...

    Authors: Lian-Cheng Zhang, Yong Shao, Li-Hua Gao, Jin Liu, Yong-Yi Xi, Yin Xu, Chutse Wu, Wei Chen, Hui-Peng Chen, You-Liang Wang, Hai-Feng Duan and Xian-Wen Hu

    Citation: Cell Communication and Signaling 2018 16:62

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  27. Content type: Research

    Glioblastomas (GBMs), the most common and most lethal of the primary brain tumors, are characterized by marked intra-tumor heterogeneity. Several studies have suggested that within these tumors a restricted po...

    Authors: Claudia R. Oliva, Brian Halloran, Anita B. Hjelmeland, Ana Vazquez, Shannon M. Bailey, Jann N. Sarkaria and Corinne E. Griguer

    Citation: Cell Communication and Signaling 2018 16:61

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  28. Content type: Short report

    Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted the...

    Authors: Keri Callegari, Shinji Maegawa, Javiera Bravo-Alegria and Vidya Gopalakrishnan

    Citation: Cell Communication and Signaling 2018 16:60

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  29. Content type: Research

    Mast cells may activate fibroblasts and contribute to remodeling processes in the lung. However, the mechanism behind these actions needs to be further investigated. Fibroblasts are major regulators of on-goin...

    Authors: Mariam Bagher, Anna-Karin Larsson-Callerfelt, Oskar Rosmark, Oskar Hallgren, Leif Bjermer and Gunilla Westergren-Thorsson

    Citation: Cell Communication and Signaling 2018 16:59

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  30. Content type: Research

    The extensive involvement of microRNA (miRNA) in the pathophysiology of psoriasis is well documented. However, in order for this information to be useful in therapeutic manipulation of miRNA levels, it is esse...

    Authors: Yan Wu, Liu Liu, Chunxiang Bian, Qingchun Diao, Muhammad Farrukh Nisar, Xuemei Jiang, Jörg W. Bartsch, Maojiao Zhong, Xiangyu Hu and Julia Li Zhong

    Citation: Cell Communication and Signaling 2018 16:58

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  31. Content type: Review

    FOXM1 (forkhead box protein M1) is a critical proliferation-associated transcription factor that is widely spatiotemporally expressed during the cell cycle. It is closely involved with the processes of cell pr...

    Authors: Guo-Bin Liao, Xin-Zhe Li, Shuo Zeng, Cheng Liu, Shi-Ming Yang, Li Yang, Chang-Jiang Hu and Jian-Ying Bai

    Citation: Cell Communication and Signaling 2018 16:57

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  32. Content type: Research

    Aberrant cell death induced by ischemic stress is implicated in the pathogenesis of ischemic diseases. Fas-associated factor 1 (FAF1) has been identified as a death-promoting protein. This study demonstrates t...

    Authors: Changsun Yu, Bok-seok Kim, Minyoung Park, Yun-Ju Do, Young-Yun Kong and Eunhee Kim

    Citation: Cell Communication and Signaling 2018 16:56

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  33. Content type: Research

    IL-6 classic signaling is linked to anti-inflammatory functions while the trans-signaling is associated with pro-inflammatory responses. Classic signaling is induced via membrane-bound IL-6 receptor (IL-6R) wh...

    Authors: Mulugeta M. Zegeye, Madelene Lindkvist, Knut Fälker, Ashok K. Kumawat, Geena Paramel, Magnus Grenegård, Allan Sirsjö and Liza U. Ljungberg

    Citation: Cell Communication and Signaling 2018 16:55

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  34. Content type: Research

    The M2 phenotype of tumor-associated macrophages (TAM) inhibits the anti-tumor inflammation, increases angiogenesis and promotes tumor progression. The transcription factor Nuclear Factor (erythroid-derived 2)...

    Authors: Rui Feng, Yuji Morine, Tetsuya Ikemoto, Satoru Imura, Shuichi Iwahashi, Yu Saito and Mitsuo Shimada

    Citation: Cell Communication and Signaling 2018 16:54

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  35. Content type: Research

    Chemotherapeutic insensitivity remains a big challenge in prostate cancer treatment. Recently, increasing evidence has indicated that KLF4 plays a key role in prostate cancer. However, the potential biological...

    Authors: Lu Zhang, Xiaojie Li, Yulin Chao, Ruiping He, Junqiang Liu, Yi Yuan, Wenzhi Zhao, Chuanchun Han and Xishuang Song

    Citation: Cell Communication and Signaling 2018 16:53

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  36. Content type: Research

    Targeting TopoisomeraseII (TopoII) and generate enzyme mediated DNA damage is an effective strategy for treatment of breast cancer. TopoII is known as a validated target for drug discovery and cancer chemother...

    Authors: Yajie Wang, Hua Sun, Zhiyan Xiao, Gang Zhang, Dan Zhang, Xiuqi Bao, Fangfang Li, Shaoyu Wu, Yuanchao Gao and Ning Wei

    Citation: Cell Communication and Signaling 2018 16:52

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  37. Content type: Research

    The outcome of cancer therapy is greatly defined by the ability of a tumor cell to evade treatment and re-establish its bulk mass after medical interventions. Consequently, there is an urgent need for the char...

    Authors: Balint Csoboz, Imre Gombos, Eniko Tatrai, Jozsef Tovari, Anna L. Kiss, Ibolya Horvath and Laszlo Vigh

    Citation: Cell Communication and Signaling 2018 16:51

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  38. Content type: Research

    Wilms’ tumor 1-associating protein (WTAP) is a nuclear protein, which is ubiquitously expressed in many tissues. Furthermore, in various types of malignancies WTAP is overexpressed and plays a role as an oncog...

    Authors: Yue Kuai, Xin Gong, Liya Ding, Fang Li, Lizhen Lei, Yuqi Gong, Qingmeng Liu, Huajiao Tan, Xinxia Zhang, Dongyu Liu, Guoping Ren, Hongyang Pan, Yaoyao Shi, Friederike Berberich-Siebelt, Zhengrong Mao and Ren Zhou

    Citation: Cell Communication and Signaling 2018 16:50

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  39. Content type: Review

    The relationship between various external agents such as pollen, food, and infectious agents and human sensitivity exists and is variable depending upon individual’s health conditions. For example, we believe ...

    Authors: Ichiro Murakami, Noriko Wada, Junko Nakashima, Mitsuko Iguchi, Makoto Toi, Yumiko Hashida, Tomonori Higuchi, Masanori Daibata, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Yasushi Horie, Keiko Nagata, Kazuhiko Hayashi, Takashi Oka, Tadashi Yoshino…

    Citation: Cell Communication and Signaling 2018 16:49

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  40. Content type: Research

    Dormant estrogen receptor positive (ER+) breast cancer micrometastases in the bone marrow survive adjuvant chemotherapy and recur stochastically for more than 20 years. We hypothesized that inflammatory cytoki...

    Authors: Samir Tivari, Haiyan Lu, Tanya Dasgupta, Mariana S. De Lorenzo and Robert Wieder

    Citation: Cell Communication and Signaling 2018 16:48

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  41. Content type: Research

    5-Fluorouracil (5-FU) has been widely applied to treat various types of cancers, including hepatocellular carcinoma (HCC). However, primary or acquired 5-FU resistance prevents the clinical application of this...

    Authors: Lili Wu, Chenwei Pan, Xin Wei, Yifen Shi, Jianjian Zheng, Xiangyang Lin and Liang Shi

    Citation: Cell Communication and Signaling 2018 16:47

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  42. Content type: Research

    Proteins of the ubiquitously expressed core proteome are quantitatively correlated across multiple eukaryotic species. In addition, it was found that many protein paralogues exhibit expression anticorrelation,...

    Authors: E. Besray Unal, Christina Kiel, Hannah Benisty, Andrew Campbell, Karen Pickering, Nils Blüthgen, Owen J. Sansom and Luis Serrano

    Citation: Cell Communication and Signaling 2018 16:46

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  43. Content type: Short report

    In T cells, the Kv1.3 and the KCa3.1 potassium channels regulate the membrane potential and calcium homeostasis. Notably, during TEM cell activation, the number of Kv1.3 channels on the cell membrane dramatically...

    Authors: José Ignacio Veytia-Bucheli, Juana María Jiménez-Vargas, Erika Isabel Melchy-Pérez, Monserrat Alba Sandoval-Hernández, Lourival Domingos Possani and Yvonne Rosenstein

    Citation: Cell Communication and Signaling 2018 16:45

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  44. Content type: Review

    The Rab27 family of small GTPases promotes the progression of breast cancer, melanoma, and other human cancers. In this review, we discuss the role of Rab27 GTPases in cancer progression and the potential appl...

    Authors: Zhihong Li, Rui Fang, Jia Fang, Shasha He and Tang Liu

    Citation: Cell Communication and Signaling 2018 16:44

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  45. Content type: Research

    The highly refractory nature of non-small cell lung cancer (NSCLC) to chemotherapeutic drugs is an important factor resulting in its poor prognosis. Recent studies have revealed that tumour necrosis factor alp...

    Authors: Ying Xing, Yuechao Liu, Tianbo Liu, Qingwei Meng, Hailing Lu, Wei Liu, Jing Hu, Chunhong Li, Mengru Cao, Shi Yan, Jian Huang, Ting Wang and Li Cai

    Citation: Cell Communication and Signaling 2018 16:43

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  46. Content type: Research

    Chronic muscle injury is characteristics of fatty infiltration and fibrosis. Recently, fibro/adipogenic progenitors (FAPs) were found to be indispensable for muscular regeneration while were also responsible f...

    Authors: Xia Kang, Ming-yu Yang, You-xing Shi, Mei-ming Xie, Min Zhu, Xiao-long Zheng, Chen-ke Zhang, Zi-lu Ge, Xu-ting Bian, Jing-tong Lv, Yun-jiao Wang, Bing-hua Zhou and Kang-lai Tang

    Citation: Cell Communication and Signaling 2018 16:42

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  47. Content type: Research

    PPFIA1 is located at the 11q13 region commonly amplified in cancer. The protein liprin-α1 encoded by PPF1A1 contributes to the adhesive and invasive structures of cytoskeletal elements and is located at the invad...

    Authors: Henna Pehkonen, Mira Lento, Pernilla von Nandelstadh, Artemis Filippou, Reidar Grénman, Kaisa Lehti and Outi Monni

    Citation: Cell Communication and Signaling 2018 16:41

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  48. Content type: Research

    The epidermal growth factor receptor (EGFR) is closely implicated in cancer, and sequencing analyses have revealed a high mutation rate of EGFR in lung cancer. Recent advances have provided novel insights into th...

    Authors: Taishu Wang, Jinrui Zhang, Shanshan Wang, Xiuna Sun, Duchuang Wang, Yurou Gao, Yang Zhang, Lu Xu, Yue Wu, Yueguang Wu, Fang Liu, Xiuxiu Liu, Shuyan Liu, Yingqiu Zhang, Yang Wang, Lijuan Zou…

    Citation: Cell Communication and Signaling 2018 16:40

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  49. Content type: Research

    CRM1 enrichment has been shown to be indicative of invasive as well as chemoresistant tumors. On the other hand, TRAIL, a powerful and specific anti-tumoral agent, has yet to be used effectively to treat gynec...

    Authors: François Fabi, Pascal Adam, Keven Vincent, Françis Demontigny, Sophie Parent, France-Hélène Joncas and Eric Asselin

    Citation: Cell Communication and Signaling 2018 16:39

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