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  1. Content type: Short report

    The protein kinase C theta (PKCθ) has an important and non-redundant function downstream of the antigen receptor and co-receptor complex in T lymphocytes. PKCθ is not only essential for activation of NF-κB, AP...

    Authors: Kerstin Siegmund, Nikolaus Thuille, Nina Posch, Friedrich Fresser, Michael Leitges and Gottfried Baier

    Citation: Cell Communication and Signaling 2019 17:56

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  2. Content type: Research

    In the endothelium, the single-pass membrane protein CD93, through its interaction with the extracellular matrix protein Multimerin-2, activates signaling pathways that are critical for vascular development an...

    Authors: Stefano Barbera, Federica Nardi, Ines Elia, Giulia Realini, Roberta Lugano, Annalisa Santucci, Gian Marco Tosi, Anna Dimberg, Federico Galvagni and Maurizio Orlandini

    Citation: Cell Communication and Signaling 2019 17:55

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  3. Content type: Research

    In previous research, we found that lamprey immune protein (LIP) possessed cytocidal activity against tumor cells, but the mechanism of the selective recognition and killing of tumor cells by LIP was not ident...

    Authors: Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang and Qingwei Li

    Citation: Cell Communication and Signaling 2019 17:54

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  4. Content type: Research

    Tumor-associated macrophages can promote breast cancer metastasis by secreting cytokines and growth factors. Interleukin (IL)-32θ, a newly identified IL-32 isoform, was previously shown to down-regulate variou...

    Authors: Thu-Huyen Pham, Yesol Bak, Taeho Kwon, Sae-Bom Kwon, Jae-Wook Oh, Jong-Hyung Park, Yang-Kyu Choi, Jin Tae Hong and Do-Young Yoon

    Citation: Cell Communication and Signaling 2019 17:53

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  5. Content type: Research

    Recent studies claimed the important role of cold atmospheric plasma (CAP) with nanotechnology in cancer treatments. In this study, silymarin nanoemulsion (SN) was used along with air CAP as therapeutic agent ...

    Authors: Manish Adhikari, Neha Kaushik, Bhagirath Ghimire, Bhawana Adhikari, Sanjula Baboota, Abdulaziz A. Al-Khedhairy, Rizwan Wahab, Su-Jae Lee, Nagendra Kumar Kaushik and Eun Ha Choi

    Citation: Cell Communication and Signaling 2019 17:52

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  6. Content type: Research

    Prostate cancer (PCa) is the second leading cause of mortality and a leading cause of malignant tumors in males. Prostate cancer stem cells (PCSCs) are likely the responsible cell types for cancer initiation, ...

    Authors: Yongmei Shen, Jiasong Cao, Zhixian Liang, Qimei Lin, Jianxi Wang, Xu Yang, Ran Zhang, Jiaojiao Zong, Xiaoling Du, Yanfei Peng, Ju Zhang and Jiandang Shi

    Citation: Cell Communication and Signaling 2019 17:50

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  7. Content type: Methodology

    GPCRs are considered essential for various physiological processes and have been the most productive drug targets. Therefore, development of the methods of GPCR ligands screening is a high priority for pharmac...

    Authors: Fei Li, Xi Jiang, Ling-Ling Luo, Yue-Ming Xu, Xing-Xu Huang, Cheng Huang and Yu Zhang

    Citation: Cell Communication and Signaling 2019 17:49

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  8. Content type: Research

    Glioma is the most commonly diagnosed malignant and aggressive brain cancer in adults. Traditional researches mainly explored the expression profile of glioma at cell-population level, but ignored the heteroge...

    Authors: Dongsheng Yuan, Yiran Tao, Geng Chen and Tieliu Shi

    Citation: Cell Communication and Signaling 2019 17:48

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  9. Content type: Research

    Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalli...

    Authors: Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, Stefan Streif, Eric Bullinger, Monica Schliemann-Bullinger, Rolf Findeisen, Fred Schaper, Heinrich J. Huber and Anna Dittrich

    Citation: Cell Communication and Signaling 2019 17:46

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  10. Content type: Research

    Endometriosis, characterized by the presence of functional endometrial tissues outside the uterus, is one of the most common gynecological disorders. Endometrial mesenchymal stem cells (MSCs) are crucial for t...

    Authors: Zhenzhen Zhang, Jing Wang, Yabing Chen, Luxuan Suo, Huixian Chen, Li Zhu, Guiping Wan and Xiaodong Han

    Citation: Cell Communication and Signaling 2019 17:45

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  11. Content type: Research

    Over-activation of phosphatidylinositol 3-kinase (PI3K)-AKT-mammalian target of rapamycin (mTOR) signaling pathway is one of important mechanisms to promote castration resistant prostate cancer, the final stag...

    Authors: Guang Yan, Yi Ru, Fengqi Yan, Xin Xiong, Wei Hu, Tao Pan, Jianming Sun, Chi Zhang, Qinghao Wang and Xia Li

    Citation: Cell Communication and Signaling 2019 17:44

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  12. Content type: Correction

    Following publication of the original article [1], the authors reported an error in

    Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang and Xiaoping Zou

    Citation: Cell Communication and Signaling 2019 17:43

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    The original article was published in Cell Communication and Signaling 2019 17:23

  13. Content type: Research

    Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death. Autophagy is a well-defined process which governs ...

    Authors: Wei Zheng, Weiwei Xie, Danyang Yin, Rui Luo, Min Liu and Fengjin Guo

    Citation: Cell Communication and Signaling 2019 17:42

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  14. Content type: Research

    The flaviviridae family comprises single-stranded RNA viruses that enter cells via clathrin-mediated pH-dependent endocytosis. Although the initial events of the virus entry have been already identified, data reg...

    Authors: Katarzyna Owczarek, Yuliya Chykunova, Christian Jassoy, Beata Maksym, Zenon Rajfur and Krzysztof Pyrc

    Citation: Cell Communication and Signaling 2019 17:41

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  15. Content type: Research

    Retinoic acid (RA) is the active metabolite of vitamin A and essential for many physiological processes, particularly the induction of cell differentiation. In addition to regulating genomic transcriptional ac...

    Authors: Thabat Khatib, Pietro Marini, Sudheer Nunna, David R. Chisholm, Andrew Whiting, Christopher Redfern, Iain R. Greig and Peter McCaffery

    Citation: Cell Communication and Signaling 2019 17:40

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  16. Content type: Research

    In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates f...

    Authors: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca and Ciro Isidoro

    Citation: Cell Communication and Signaling 2019 17:39

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  17. Content type: Research

    The NOV gene product, CCN3, has been reported in a diverse range of tumors to serve as a negative growth regulator, while acting as a tumor suppressor in Chronic Myelogenous Leukemia (CML). However, the precis...

    Authors: Mousa Vatanmakanian, Mahmood Tavallaie and Shirin Ghadami

    Citation: Cell Communication and Signaling 2019 17:38

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  18. Content type: Research

    We previously showed that caveolin-1 (cav-1), an integral membrane protein, is required for the synthesis of matrix proteins by glomerular mesangial cells (MC). In a previous study to understand how cav-1 is i...

    Authors: Neel Mehta, Dan Zhang, Renzhong Li, Tony Wang, Agata Gava, Pavithra Parthasarathy, Bo Gao and Joan C. Krepinsky

    Citation: Cell Communication and Signaling 2019 17:37

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  19. Content type: Research

    The human positive cofactor 4 (PC4) is initially identified as a transcriptional cofactor and has an important role in embryonic development and malignant transformation. However, the clinical significance and...

    Authors: Peng Luo, Chi Zhang, Fengying Liao, Long Chen, Zhenyu Liu, Lei Long, Zhongyong Jiang, Yawei Wang, Ziwen Wang, Zujuan Liu, Hongming Miao and Chunmeng Shi

    Citation: Cell Communication and Signaling 2019 17:36

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  20. Content type: Review

    Forkhead box M1 (FOXM1), a transcriptional regulator of G1/S and G2/M transition and M phase progression in the cell cycle, plays a principal role in many physiological and pathological processes. A growing nu...

    Authors: Yumei Li, Feng Wu, Qi Tan, Mengfei Guo, Pei Ma, Xuan Wang, Shuai Zhang, Juanjuan Xu, Ping Luo and Yang Jin

    Citation: Cell Communication and Signaling 2019 17:35

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  21. Content type: Research

    Male and female hearts have many structural and functional differences. Here, we investigated the role of estrogen (E2) in the mechanisms of sex differences in contraction through the cAMP-L-type Ca2+channel path...

    Authors: Jeremiah Ong’achwa Machuki, Hong-Yuan Zhang, Juan Geng, Lu Fu, Gabriel Komla Adzika, Lijuan Wu, Wenkang Shang, Jinxia Wu, Li Kexue, Zhiwei Zhao and Hong Sun

    Citation: Cell Communication and Signaling 2019 17:34

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  22. Content type: Research

    Vascular dysfunction is commonly seen during severe viral infections. Endothelial nitric oxide synthase (eNOS), has been postulated to play an important role in regulating vascular homeostasis as well as propa...

    Authors: Stephen R. Koch, Hyehun Choi, Eric H. Mace and Ryan J. Stark

    Citation: Cell Communication and Signaling 2019 17:33

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  23. Content type: Research

    A major challenge in the development of effective cancer immunotherapy is the ability of tumors and their microenvironment to suppress immune cells through immunosuppressive cells such as myeloid -derived supp...

    Authors: Dickson Adah, Yijun Yang, Quan Liu, Kranthi Gadidasu, Zhu Tao, Songlin Yu, Linglin Dai, Xiaofen Li, Siting Zhao, Limei Qin, Li Qin and Xiaoping Chen

    Citation: Cell Communication and Signaling 2019 17:32

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  24. Content type: Research

    p21-activated kinase 1 (PAK1) plays a fundamental role in promoting the development and progression of several cancers and is a potential therapeutic target. However, the biological function and underlying mec...

    Authors: Liang Chen, Shuning Bi, Jiuzhou Hou, Zhijun Zhao, Chaojie Wang and Songqiang Xie

    Citation: Cell Communication and Signaling 2019 17:31

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  25. Content type: Research

    The epigenetic factor protein arginine methyltransferase 5 (PRMT5) has been reported to play vital roles in a wide range of cellular processes, such as gene transcription, genomic organization, differentiation...

    Authors: Yi Qin, Qiangsheng Hu, Jin Xu, Shunrong Ji, Weixing Dai, Wensheng Liu, Wenyan Xu, Qiqing Sun, Zheng Zhang, Quanxing Ni, Bo Zhang, Xianjun Yu and Xiaowu Xu

    Citation: Cell Communication and Signaling 2019 17:30

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  26. Content type: Review

    EphrinB2, a membrane-tethered ligand preferentially binding to its receptor EphB4, is ubiquitously expressed in all mammals. Through the particular bidirectional signaling, EphrinB2 plays a critical role durin...

    Authors: Sheng-an Su, Yao Xie, Yuhao Zhang, Yutao Xi, Jie Cheng and Meixiang Xiang

    Citation: Cell Communication and Signaling 2019 17:29

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  27. Content type: Research

    Macroautophagy (hereafter autophagy) is a tightly regulated process that delivers cellular components to lysosomes for degradation. Damage-regulated autophagy modulator 1 (DRAM1) induces autophagy and is neces...

    Authors: Ting Lu, Zhou Zhu, Junchao Wu, Hua She, Rong Han, Haidong Xu and Zheng-Hong Qin

    Citation: Cell Communication and Signaling 2019 17:28

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  28. Content type: Research

    Integrins mediate cell adhesion, migration, and survival by connecting the intracellular machinery with the surrounding extracellular matrix. Previous studies demonstrated the interaction between αvβ3 integrin an...

    Authors: Taís M. Danilucci, Patty K. Santos, Bianca C. Pachane, Graziéle F. D. Pisani, Rafael L. B. Lino, Bruna C. Casali, Wanessa F. Altei and Heloisa S. Selistre-de-Araujo

    Citation: Cell Communication and Signaling 2019 17:27

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  29. Content type: Review

    Pericytes, as a key cellular part of the blood-brain barrier, play an important role in the maintenance of brain neurovascular unit. These cells participate in brain homeostasis by regulating vascular developm...

    Authors: Mohammad Hossein Geranmayeh, Reza Rahbarghazi and Mehdi Farhoudi

    Citation: Cell Communication and Signaling 2019 17:26

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  30. Content type: Research

    Flavokawain B (FKB) has been identified from kava root extracts as a potent apoptosis inducer for inhibiting the growth of various cancer cell lines, including prostate cancer. However, the molecular targets o...

    Authors: Xuesen Li, Victor Pham, Matthew Tippin, Dongjun Fu, Raymond Rendon, Liankun Song, Edward Uchio, Bang H. Hoang and Xiaolin Zi

    Citation: Cell Communication and Signaling 2019 17:25

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  31. Content type: Research

    Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered en...

    Authors: Szymon J. Szymura, Jacob P. Zaemes, David F. Allison, Sheena H. Clift, Jaclyn M. D’Innocenzi, Lisa G. Gray, Brian D. McKenna, Benjamin B. Morris, Stefan Bekiranov, Robin D. LeGallo, David R. Jones and Marty W. Mayo

    Citation: Cell Communication and Signaling 2019 17:24

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  32. Content type: Research

    Cancer cells avidly consume glucose and convert it to lactate, resulting in a low pyruvate level. This phenomenon is known as the Warburg effect, and is important for cell proliferation. Although cMyc has ofte...

    Authors: Mingming Zhang, Yida Pan, Dehua Tang, Robert Gregory Dorfman, Lei Xu, Qian Zhou, Lixing Zhou, Yuming Wang, Yang Li, Yuyao Yin, Bo Kong, Helmut Friess, Shimin Zhao, Jian-lin Wu, Lei Wang and Xiaoping Zou

    Citation: Cell Communication and Signaling 2019 17:23

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    The Correction to this article has been published in Cell Communication and Signaling 2019 17:43

  33. Content type: Research

    Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) sig...

    Authors: Yiran Li, Yuanhui Jia, Yiding Bian, Huan Tong, Junjie Qu, Kai Wang and Xiao-Ping Wan

    Citation: Cell Communication and Signaling 2019 17:22

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  34. Content type: Research

    Platelet-activating factor (PAF) is a potent lipid mediator whose involvement in the onset and progression of atherosclerosis is mediated by, among others, the modulation of cytokine expression patterns. The p...

    Authors: Geneviève Hamel-Côté, Fanny Lapointe, Daniel Gendron, Marek Rola-Pleszczynski and Jana Stankova

    Citation: Cell Communication and Signaling 2019 17:21

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  35. Content type: Research

    Shp1, a tyrosine-phosphatase-1 containing the Src-homology 2 (SH2) domain, is involved in inflammatory and immune reactions, where it regulates diverse signalling pathways, usually by limiting cell responses t...

    Authors: Alessia Varone, Stefania Mariggiò, Manpreet Patheja, Vincenzo Maione, Antonio Varriale, Mariangela Vessichelli, Daniela Spano, Fabio Formiggini, Matteo Lo Monte, Nadia Brancati, Maria Frucci, Pompea Del Vecchio, Sabato D’Auria, Angela Flagiello, Clara Iannuzzi, Alberto Luini…

    Citation: Cell Communication and Signaling 2019 17:20

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  36. Content type: Short report

    Oncogenic KRAS plays a vital role in controlling tumor metabolism by enhancing aerobic glycolysis. Obesity driven by chronic consumption of high-fat diet (HFD) is a major risk factor for oncogenic KRAS-mediate...

    Authors: Dan Wang, Yawei Bi, Lianghao Hu, Yongde Luo, Juntao Ji, Albert Z. Mao, Craig D. Logsdon, Ellen Li, James L. Abbruzzese, Zhaoshen Li, Vincent W. Yang and Weiqin Lu

    Citation: Cell Communication and Signaling 2019 17:19

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  37. Content type: Research

    Oral lichen planus (OLP) is known as a chronic inflammatory disease. Our recent studies have suggested that vitamin D/vitamin D receptor (VDR) signaling exerts its protective effects on oral keratinocyte apopt...

    Authors: Xuejun Ge, Lixiang Wang, Mengdi Li, Na Xu, Feiyan Yu, Fang Yang, Ran Li, Fang Zhang, Bin Zhao and Jie Du

    Citation: Cell Communication and Signaling 2019 17:18

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  38. Content type: Research

    Chondrosarcoma is a malignant cartilaginous neoplasm of the bone which resistant to radiation therapy and chemotherapy. Cyclin-dependent kinase 4 (CKD4) is highly expressed in human cancer, and palbociclib, th...

    Authors: Zhengxiao Ouyang, Sisi Wang, Ming Zeng, Zhihong Li, Qing Zhang, Wanchun Wang and Tang Liu

    Citation: Cell Communication and Signaling 2019 17:17

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  39. Content type: Research

    The periodic growth of hair follicles is regulated by the balance of activators and inhibitors. The BMP signaling pathway plays an important role during hair follicle regeneration, but the exact BMP protein th...

    Authors: Pan Wu, Yiming Zhang, Yizhan Xing, Wei Xu, Haiying Guo, Fang Deng, Xiaogen Ma and Yuhong Li

    Citation: Cell Communication and Signaling 2019 17:16

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  40. Content type: Research

    ErbB2 overexpression identifies a subset of breast cancer as ErbB2-positive and is frequently associated with poor clinical outcomes. As a membrane-embedded receptor tyrosine kinase, cell surface levels of Erb...

    Authors: Jinrui Zhang, Qiong Li, Yueguang Wu, Duchuang Wang, Lu Xu, Yang Zhang, Shanshan Wang, Taishu Wang, Fang Liu, Mohamed Y. Zaky, Shuai Hou, Shuyan Liu, Kun Zou, Haixin Lei, Lijuan Zou, Yingqiu Zhang…

    Citation: Cell Communication and Signaling 2019 17:15

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  41. Content type: Research

    Glucose is the main secretagogue of pancreatic beta-cells. Uptake and metabolism of the nutrient stimulates the beta-cell to release the blood glucose lowering hormone insulin. This metabolic activation is ass...

    Authors: Jaime Santo-Domingo, Antonio Núñez Galindo, Ornella Cominetti, Umberto De Marchi, Pedro Cutillas, Loïc Dayon and Andreas Wiederkehr

    Citation: Cell Communication and Signaling 2019 17:14

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  42. Content type: Research

    Exosomes are small membrane-bound vesicles that contribute to tumor progression and metastasis by mediating cell-to-cell communication and modifying the tumor microenvironment at both local and distant sites. ...

    Authors: Bethany N. Hannafon, Amy L. Gin, Yi-Fan Xu, Matthew Bruns, Cameron L. Calloway and Wei-Qun Ding

    Citation: Cell Communication and Signaling 2019 17:13

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  43. Content type: Research

    The existence of differentiated thyroid cells is critical to respond radioactive iodide treatment strategy in thyroid cancer, and loss of the differentiated phenotype is a trademark of iodide-refractive thyroi...

    Authors: Neha Kaushik, Min-Jung Kim, Nagendra Kumar Kaushik, Jae Kyung Myung, Mi-Young Choi, Jae-Hyeok Kang, Hyuk-Jin Cha, Cha-Soon Kim, Seon-Young Nam and Su-Jae Lee

    Citation: Cell Communication and Signaling 2019 17:12

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  44. Content type: Research

    Contraction of hepatic stellate cells (HSCs) plays an important role in the pathogenesis of liver fibrosis by regulating sinusoidal blood flow and extracellular matrix remodeling. Here, we investigated how HSC...

    Authors: Feixia Wang, Yan Jia, Mengmeng Li, Ling Wang, Jiangjuan Shao, Qinglong Guo, Shanzhong Tan, Hai Ding, Anping Chen, Feng Zhang and Shizhong Zheng

    Citation: Cell Communication and Signaling 2019 17:11

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  45. Content type: Research

    Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate...

    Authors: Gernot Posselt, Maria Wiesauer, Bianca E. Chichirau, Daniela Engler, Linda M. Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F. Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller and Silja Wessler

    Citation: Cell Communication and Signaling 2019 17:10

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  46. Content type: Research

    To examine the influence of HOXD10 on the metabolism and growth of colon carcinoma cells by suppressing the RHOC/AKT/MAPK pathway.

    Authors: Yu-hong Yuan, Han-yu Wang, Yu Lai, Wa Zhong, Wei-ling Liang, Fu-de Yan, Zhong Yu, Jun-kai Chen and Ying Lin

    Citation: Cell Communication and Signaling 2019 17:9

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  47. Content type: Research

    Ghrelin modulates many physiological processes. However, the effects of intestinal ghrelin on hepatic glucose production (HGP) are still unclear. The current study was to explore the roles of intestinal ghreli...

    Authors: Yao Lin, Zerong Liang, Liping He, Mengliu Yang, Dongfang Liu, Harvest F. Gu, Hua Liu, Zhiming Zhu, Hongting Zheng, Ling Li and Gangyi Yang

    Citation: Cell Communication and Signaling 2019 17:8

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  48. Content type: Short report

    Through a genome-wide screen we have identified calcium-tolerant deletion mutants for five genes in the budding yeast Saccharomyces cerevisiae. In addition to CNB1 and RCN1 that are known to play a role in the ca...

    Authors: Huihui Xu, Tianshu Fang, Hongbo Yan and Linghuo Jiang

    Citation: Cell Communication and Signaling 2019 17:7

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