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  1. Content type: Review

    The historical town of Weimar in Thuringia, the "green heart of Germany" was the sphere of Goethe and Schiller, the two most famous representatives of German literature's classic era. Not yet entirely as influ...

    Authors: Karlheinz Friedrich, Jonathan A Lindquist, Frank Entschladen, Edgar Serfling, Gerald Thiel, Arnd Kieser, Klaudia Giehl, Christina Ehrhardt, Stephan M Feller, Oliver Ullrich, Fred Schaper, Ottmar Janssen and Ralf Hass

    Citation: Cell Communication and Signaling 2009 7:2

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  2. Content type: Review

    Nck is a ubiquitously expressed adapter protein that is almost exclusively built of one SH2 domain and three SH3 domains. The two isoproteins of Nck are functionally redundant in many aspects and differ in onl...

    Authors: Marcus Lettau, Jennifer Pieper and Ottmar Janssen

    Citation: Cell Communication and Signaling 2009 7:1

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  3. Content type: Review

    The TNF superfamily member Fas ligand acts as a prototypic death factor. Due to its ability to induce apoptosis in Fas (APO-1, CD95) expressing cells, Fas ligand participates in essential effector functions of...

    Authors: Matthias Voss, Marcus Lettau, Maren Paulsen and Ottmar Janssen

    Citation: Cell Communication and Signaling 2008 6:11

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  4. Content type: Review

    The multi-step process of the emigration of cells from the blood stream through the vascular endothelium into the tissue has been termed extravasation. The extravasation of leukocytes is fairly well characteri...

    Authors: Carina Strell and Frank Entschladen

    Citation: Cell Communication and Signaling 2008 6:10

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  5. Content type: Review

    Life on Earth developed in the presence and under the constant influence of gravity. Gravity has been present during the entire evolution, from the first organic molecule to mammals and humans. Modern research...

    Authors: Oliver Ullrich, Kathrin Huber and Kerstin Lang

    Citation: Cell Communication and Signaling 2008 6:9

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  6. Content type: Research

    Notch signalling is essential for the development and maintenance of the colonic epithelium. Its inhibition induces a differentiation phenotype in vivo and reduces adenomas in APCmin mice. Whether Notch signals a...

    Authors: Tamara Aleksic and Stephan M Feller

    Citation: Cell Communication and Signaling 2008 6:8

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  7. Content type: Research

    Src family kinases (SFK) are implicated in the development of some colorectal cancers (CRC). One SFK member, Lck, is not detectable in normal colonic epithelium, but becomes aberrantly expressed in a subset of...

    Authors: Muhammad Emaduddin, Mariola J Edelmann, Benedikt M Kessler and Stephan M Feller

    Citation: Cell Communication and Signaling 2008 6:7

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  8. Content type: Review

    Thymic stromal lymphopoietin (TSLP), a novel interleukin-7-like cytokine, triggers dendritic cell-mediated inflammatory responses ultimately executed by T helper cells of the Th2 subtype. TSLP emerged as a cen...

    Authors: Katrin Sebastian, Andreas Borowski, Michael Kuepper and Karlheinz Friedrich

    Citation: Cell Communication and Signaling 2008 6:5

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  9. Content type: Review

    The concept of a pre-emptive strike as a good means to prevent greater harm may be frequently over-stressed in daily life. However, biological systems in a homeostatic balance are prepared to withstand a certa...

    Authors: Martin Hermann, Andrey Kuznetsov, Manuel Maglione, Julija Smigelskaite, Raimund Margreiter and Jakob Troppmair

    Citation: Cell Communication and Signaling 2008 6:4

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  10. Content type: Methodology

    T cells play a central role in many inflammatory diseases, hence the identification and validation of T cell-specific target genes will increase the understanding of T cell function in pathologic inflammatory ...

    Authors: Tatjana C Gust, Luisa Neubrandt, Claudia Merz, Khusru Asadullah, Ulrich Zügel and Arne von Bonin

    Citation: Cell Communication and Signaling 2008 6:3

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  11. Content type: Review

    Secreted factors and cell surface receptors can be internalized by endocytosis and translocated to the cytoplasm. Instead of being recycled or proteolysed, they sometimes translocate to the nucleus. Nuclear im...

    Authors: Nathalie Planque

    Citation: Cell Communication and Signaling 2006 4:7

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  12. Content type: Research

    Vav proteins are guanine nucleotide exchange factors (GEF) for Rho family GTPases and are activated following engagement of membrane receptors. Overexpression of Vav proteins enhances lamellipodium and ruffle ...

    Authors: Julie L Wilsbacher, Sheri L Moores and Joan S Brugge

    Citation: Cell Communication and Signaling 2006 4:5

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  13. Content type: Review

    The principal aim of this historical review- the first in a new series- is to present the basic concepts that led to the discovery of NOV and to show how our ideas evolved regarding the role and functions of t...

    Authors: Bernard Perbal

    Citation: Cell Communication and Signaling 2006 4:3

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  14. Content type: Research

    Reversible interactions between the components of cellular signaling pathways allow for the formation and dissociation of multimolecular complexes with spatial and temporal resolution and, thus, are an importa...

    Authors: Kevin K Caldwell, Marcos Sosa and Colin T Buckley

    Citation: Cell Communication and Signaling 2006 4:2

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  15. Content type: Research

    Myeloblastosis Associated Virus type 1 (N) [MAV 1(N)] induces specifically nephroblastomas in 8–10 weeks when injected to newborn chicken. The MAV-induced nephroblastomas constitute a unique animal model of th...

    Authors: Chang Long Li, Philippe Coullin, Alain Bernheim, Véronique Joliot, Charles Auffray, Rima Zoroob and Bernard Perbal

    Citation: Cell Communication and Signaling 2006 4:1

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  16. Content type: Research

    Connective tissue growth factor (CCN2) is a matricellular protein that plays a role in hepatic stellate cell (HSC)-mediated fibrogenesis. The aim of this study was to investigate the regulation by CCN2 of cell...

    Authors: Runping Gao and David R Brigstock

    Citation: Cell Communication and Signaling 2005 3:14

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  17. Content type: Research

    It was previously shown that K+ secretion by strial marginal cell epithelium is under the control of G-protein coupled receptors of the P2Y family in the apical membrane. Receptor activation by uracil nucleotides...

    Authors: Daniel C Marcus, Jianzhong Liu, Jun Ho Lee, Elias Q Scherer, Margaret A Scofield and Philine Wangemann

    Citation: Cell Communication and Signaling 2005 3:13

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  18. Content type: Research

    S ecreted F rizzled r elated p roteins (SFRPs) are extracellular regulators of Wnt signaling. These proteins contain an N-terminal cysteine rich domain (CRD) highly similar to the CRDs of the Frizzled family of s...

    Authors: Rajeeb Kumar Swain, Masaru Katoh, Araceli Medina and Herbert Steinbeisser

    Citation: Cell Communication and Signaling 2005 3:12

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  19. Content type: Research

    CCN2/CTGF is known to be involved in tooth germ development and periodontal tissue remodeling, as well as in mesenchymal tissue development and regeneration. In this present study, we investigated the roles of...

    Authors: Masahiro Asano, Satoshi Kubota, Tohru Nakanishi, Takashi Nishida, Tomoichiro Yamaai, Gen Yosimichi, Kazumi Ohyama, Tomosada Sugimoto, Yoji Murayama and Masaharu Takigawa

    Citation: Cell Communication and Signaling 2005 3:11

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  20. Content type: Research

    Interstitial cystitis (IC) is a debilitating disease characterized by chronic inflammation of the urinary bladder, yet specific cellular mechanisms of inflammation in IC are largely unknown. Multiple lines of ...

    Authors: Erin B Harmon, Jill M Porter and James E Porter

    Citation: Cell Communication and Signaling 2005 3:10

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  21. Content type: Research

    Angiogenesis, or the remodeling of existing vasculature serves as a lifeline to nourish developing embryos and starved tissues, and to accelerate wound healing, diabetic retinopathy, and tumor progression. Rec...

    Authors: Kishore K Wary and Joseph O Humtsoe

    Citation: Cell Communication and Signaling 2005 3:9

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  22. Content type: Research

    The chondrosarcoma-derived HCS-2/8 has been known to be an excellent model of human articular chondrocytes. By mimicking the arthritic conditions through the treatment of HCS-2/8 cells with cytokines, we estim...

    Authors: Norifumi H Moritani, Satoshi Kubota, Toshio Sugahara and Masaharu Takigawa

    Citation: Cell Communication and Signaling 2005 3:6

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  23. Content type: Research

    The human cysteine rich protein 61 (CYR61, CCN1) as well as the other members of the CCN family of genes play important roles in cellular processes such as proliferation, adhesion, migration and survival. Thes...

    Authors: Norbert Schutze, Ulrich Noth, Jutta Schneidereit, Christian Hendrich and Franz Jakob

    Citation: Cell Communication and Signaling 2005 3:5

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  24. Content type: Research

    Agnogenic myeloid metaplasia (AMM) is one of the Philadelphia chromosome negative myeloproliferative disorder and is diagnosed by hyperplasia of atypical megakaryocytes, hepatosplenomegaly, extramedullary hema...

    Authors: Kirugaval C Hemavathy, Kathir Suppiah, Gazala Hashmi, Allan D Novetsky and Jen C Wang

    Citation: Cell Communication and Signaling 2005 3:4

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  25. Content type: Research

    During endochondral bone formation, the hypertrophy of chondrocytes is accompanied by selective expression of several genes including type X collagen and alkaline phosphatase. This expression is stimulated by ...

    Authors: Gwendolen C Reilly, Eleanor B Golden, Giovi Grasso-Knight and Phoebe S Leboy

    Citation: Cell Communication and Signaling 2005 3:3

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  26. Content type: Research

    A treatment to remove vascular blockages, angioplasty, can cause damage to the vessel wall and a subsequent abnormal wound healing response, known as restenosis. Vascular smooth muscle cells (VSMC) lining the ...

    Authors: Karl Kingsley and George E Plopper

    Citation: Cell Communication and Signaling 2005 3:2

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  27. Content type: Research

    The ciliary neurotrophic factor (CNTF) receptor is composed of two signalling receptor chains, gp130 and the leukaemia inhibitory factor receptor, associated with a non-signalling CNTF binding receptor α compo...

    Authors: Béatrice de Bovis, Damien Derouet, Jean-François Gauchat, Greg Elson, Hugues Gascan and Odile deLapeyrière

    Citation: Cell Communication and Signaling 2005 3:1

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  28. Content type: Research

    To study the cellular distribution of CCN3(NOV) and to determine if the carboxyterminus of CCN3 is hidden or masked due to high affinity interactions with other partners. CCN3 was detected using affinity purif...

    Authors: Stanimir Kyurkchiev, Herman Yeger, Anne-Marie Bleau and Bernard Perbal

    Citation: Cell Communication and Signaling 2004 2:9

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  29. Content type: Review

    In the early 1990's, a new cell signaling pathway was described. This new paradigm, now known as the JAK/STAT pathway, has been extensively investigated in immune-type cells in response to interferons and inte...

    Authors: Andrew C Dudley, David Thomas, James Best and Alicia Jenkins

    Citation: Cell Communication and Signaling 2004 2:8

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  30. Content type: Editorial

    In this article we briefly review the reasons and advantages that underly our publisher's decision to introduce article-processing charges (APC) for manuscripts submitted to Cell Communication and Signaling. The ...

    Authors: Bernard Perbal

    Citation: Cell Communication and Signaling 2004 2:7

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  31. Content type: Research

    The endozepine triakontatetraneuropeptide (TTN) induces intracellular calcium ([Ca++]i) changes followed by activation in human polymorphonuclear leukocytes (PMNs). The present study was undertaken to investigate...

    Authors: Franca Marino, Marco Cosentino, Marco Ferrari, Simona Cattaneo, Giuseppina Frigo, Anna M Fietta, Sergio Lecchini and Gian Mario Frigo

    Citation: Cell Communication and Signaling 2004 2:6

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  32. Content type: Research

    In human and non-human primates, migratory trophoblasts penetrate the uterine epithelium, invade uterine matrix, and enter the uterine vasculature. Invasive trophoblasts show increased expression of β1 integri...

    Authors: Twanda L Thirkill, Sonia R Hendren, Arlen Soghomonians, Natalie F Mariano, Abdul I Barakat and Gordon C Douglas

    Citation: Cell Communication and Signaling 2004 2:4

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  33. Content type: Research

    The immunosuppressive agent cyclosporin A (CsA), a calcineurin inhibitor which blocks T cell activation has provided the pharmacologic foundation for organ transplantation. CsA exerts additional effects on non...

    Authors: Parvaneh Rafiee, Jan Heidemann, Hitoshi Ogawa, Nathan A Johnson, Pamela J Fisher, Mona S Li, Mary F Otterson, Christopher P Johnson and David G Binion

    Citation: Cell Communication and Signaling 2004 2:3

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  34. Content type: Research

    Connexin43 (Cx43) is an integral membrane protein that forms intercellular channels called gap junctions. Intercellular communication in the eye lens relies on an extensive network of gap junctions essential f...

    Authors: Henrique Girão, Steve Catarino and Paulo Pereira

    Citation: Cell Communication and Signaling 2004 2:2

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  35. Content type: Research

    In the present study we have analyzed the mechanisms of calcium entry and mobilization in platelets obtained from rats chronically treated with the nitric oxide synthesis inhibitor, N-nitro L-arginine methyl e...

    Authors: David Iyú, Noemí M Atucha, Concepción Martínez-Prieto, M Clara Ortiz and Joaquín García-Estañ

    Citation: Cell Communication and Signaling 2004 2:1

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  36. Content type: Research

    Vascular smooth muscle cell (VSMC) hyperplasia plays an important role in both chronic and acute vascular pathologies including atherosclerosis and restenosis. Considerable work has focused on the mechanisms r...

    Authors: Andrew C Lake and John J Castellot Jr

    Citation: Cell Communication and Signaling 2003 1:5

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  37. Content type: Research

    Guanylyl cyclase-B (GC-B; NPR-B), the receptor for C-type natriuretic peptide (CNP) is rapidly and effectively desensitized by a factor(s) in serum. Given the potential importance of this receptor in remodelin...

    Authors: Ted D Chrisman, Dorenda T Perkins and David L Garbers

    Citation: Cell Communication and Signaling 2003 1:4

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  38. Content type: Editorial

    All forms of communication between human beings have long been recognized as a requirement for reciprocal understanding, transfer of knowledge, and productive development of societies. This also applies to liv...

    Authors: Bernard Perbal

    Citation: Cell Communication and Signaling 2003 1:3

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