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  1. Anti-epidermal-growth-factor-receptor (EGFR) monoclonal antibodies (mAbs) are of great significance for RAS and BRAF wild-type metastatic colorectal cancer (mCRC) patients. However, the generation of primary a...

    Authors: Shanshan Wei, Wenwei Hu, Jun Feng and Yiting Geng
    Citation: Cell Communication and Signaling 2022 20:150
    Content type: Review Published on:

  2. Tumor cells detachment from primary lesions is an early event for hepatocellular carcinoma (HCC) metastasis, in which cell adhesion molecules play an important role. The role of mechanical crowding has attract...

    Authors: Ping Han, Yu Lei, Jingmei Liu, Jiqiao Liu, Huanjun Huang, Dean Tian and Wei Yan
    Citation: Cell Communication and Signaling 2022 20:149
    Content type: Research Published on:

  3. Middle ear cholesteatoma (MEC), is a destructive, and locally invasive lesion in the middle ear driven by inflammation with an annual incidence of 10 per 100,000. Surgical extraction/excision remains the only ...

    Authors: Matthias Schürmann, Peter Goon and Holger Sudhoff
    Citation: Cell Communication and Signaling 2022 20:148
    Content type: Review Published on:

  4. Ubiquitin-specific protease 22 (USP22), a putative cancer stem cell marker, is frequently upregulated in cancers, and USP22 overexpression is associated with aggressive growth, metastasis, and therapy resistan...

    Authors: Ting Sun, Keqiang Zhang, Wendong Li, Yunze Liu, Rajendra P. Pangeni, Aimin Li, Leonidas Arvanitis and Dan J. Raz
    Citation: Cell Communication and Signaling 2022 20:147
    Content type: Research Published on:

  5. Keratinocytes constitute a major part of the melanoma microenvironment, considering their protective role towards melanocytes in physiological conditions. However, their interactions with tumor cells following...

    Authors: Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Magdalena Kot, Katarzyna Pietraszek-Gremplewicz, Dominika Wilk, Marcin Ziętek, Rafał Matkowski and Dorota Nowak
    Citation: Cell Communication and Signaling 2022 20:146
    Content type: Research Published on:

  7. Notch signaling is highly conserved and critically involved in cell differentiation, immunity, and survival. Activation of the Notch pathway modulates immune cell functions during the inflammatory response. Ho...

    Authors: Dongwei Xu, Xiaoye Qu, Yizhu Tian, Zhao Jie, Zhifeng Xi, Feng Xue, Xueyun Ma, Jianjun Zhu and Qiang Xia
    Citation: Cell Communication and Signaling 2022 20:144
    Content type: Research Published on:

  8. Spatiotemporal regulation of subcellular protein kinase A (PKA) activity for precise substrate phosphorylation is essential for cellular responses to hormonal stimulation. Ryanodine receptor 2 (RyR2) and (sarc...

    Authors: Bing Xu, Ying Wang, Sherif M. F. M. Bahriz, Meimi Zhao, Chaoqun Zhu and Yang K. Xiang
    Citation: Cell Communication and Signaling 2022 20:143
    Content type: Research Published on:

  9. Multidrug resistance (MDR) is a complex phenomenon that frequently leads to chemotherapy failure during cancer treatment. The overexpression of ATP-binding cassette (ABC) transporters represents the major mech...

    Authors: Yuchen Zhang, Cheukfai Li, Chenglai Xia, Keneth Kin Wah To, Zhixing Guo, Chongyang Ren, Lingzhu Wen, Fang Wang, Liwu Fu and Ning Liao
    Citation: Cell Communication and Signaling 2022 20:142
    Content type: Research Published on:

  10. Breast cancer is the most common cancer in females, and to date, the mortality rate of breast cancer metastasis cannot be ignored. The metastasis of breast cancer is a complex, staged process, and the pattern ...

    Authors: Xiaoxiao Chen, Jiamei Feng, Weili Chen, Shijun Shao, Li Chen and Hua Wan
    Citation: Cell Communication and Signaling 2022 20:141
    Content type: Review Published on:

  11. N6-methyl-adenosine (m6A) is the most prevalent modification on mRNAs and long noncoding RNAs (lnRNAs) in higher eukaryotes. Modulation of m6A relies on m6A writers, erasers and readers. m6A modification contribu...

    Authors: Raghda A. Elsabbagh, Mona Rady, Carsten Watzl, Khaled Abou-Aisha and Mohamed Z. Gad
    Citation: Cell Communication and Signaling 2022 20:140
    Content type: Review Published on:

  12. Authors: Rebar N. Mohammed, Rozita Tamjidifar, Heshu Sulaiman Rahman, Ali Adili, Shadi Ghoreishizadeh, Hossein Saeedi, Lakshmi Thangavelu, Navid Shomali, Ramin Aslaminabad, Faroogh Marof, Mina Tahavvori, Svetlana Danshina, Morteza Akbari and Gülinnaz Ercan
    Citation: Cell Communication and Signaling 2022 20:139
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2022 20:79

  13. Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract and are characterized by activating mutations of c-KIT or PDGFRa receptor tyrosine kinases (RTKs)....

    Authors: Jianyi Sun, Qiang Zhang, Xiangfei Sun, Anwei Xue, Xiaodong Gao and Kuntang Shen
    Citation: Cell Communication and Signaling 2022 20:138
    Content type: Research Published on:

  14. Synovitis (SI) is one of the most common and serious orthopedic diseases in horses of different age, breed and sex, which contributes to the development of osteoarthritis. The burden of SI includes economic lo...

    Authors: K. Kornicka-Garbowska, S. Groborz, B. Lynda, L. Galuppo and K. Marycz
    Citation: Cell Communication and Signaling 2022 20:137
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:128

  15. Gastric cancer is a common and lethal human malignancy worldwide and cancer cell metastasis is the leading cause of cancer-related mortality. MICAL2, a flavoprotein monooxygenase, is an important regulator of ...

    Authors: Qianwen Wang, Chenxiang Qi, Pengxiang Min, Yueyuan Wang, Fengwen Ye, Tianxiang Xia, Yujie Zhang and Jun Du
    Citation: Cell Communication and Signaling 2022 20:136
    Content type: Research Published on:

  16. The cyclin-dependent kinase 7 (CDK7) inhibitor THZ1 represses multiple cancer cells. However, its tumor-repressive efficiency in wild-type p53 breast cancer cells remains controversial.

    Authors: Yueyuan Wang, Zhihao Zhang, Xuguang Mi, Mingxi Li, Dan Huang, Tingting Song, Xiaoyan Qi and Ming Yang
    Citation: Cell Communication and Signaling 2022 20:96
    Content type: Research Published on:

  17. Nuclear hormone receptors are involved in transcriptional regulation and many important cellular processes including development and metabolism. However, its role in DNA damage-induced apoptosis remains elusive.

    Authors: Lei Sang, Rui Dong, Rui Liu, Qinggang Hao, Weiyu Bai and Jianwei Sun
    Citation: Cell Communication and Signaling 2022 20:135
    Content type: Research Published on:

  18. Apoptin, as a tumor-specific pro-apoptotic protein, plays an important anti-tumoral role, but its mechanism of autophagy activation and the interaction between autophagy and apoptosis have not been accurately ...

    Authors: Yiquan Li, Chao Shang, Zirui Liu, Jicheng Han, Wenjie Li, Pengpeng Xiao, Nan Li, Shanzhi Li, Zhiru Xiu, Gaojie Song, Yaru Li, Ningyi Jin, Jinbo Fang, Xiao Li and Yilong Zhu
    Citation: Cell Communication and Signaling 2022 20:134
    Content type: Research Published on:

  19. Glycogen-Interacting Protein 1 (GNIP1), an E3 ligase, is a member of the tripartite motif (TRIM) family proteins. Current studies on GNIP1 mainly focus on glycogen metabolism. However, the function and molecul...

    Authors: Feifei Zhou, Yufeng Liu, Wenqian Ai, Yanan Wang, Mingxi Gan, Qingkun Jiang, Tianyu Han and Jian-Bin Wang
    Citation: Cell Communication and Signaling 2022 20:133
    Content type: Research Published on:

  21. During SARS-CoV-2 infection, an effective immune response provides the first line of defense; however, excessive inflammatory innate immunity and impaired adaptive immunity may harm tissues. Soluble immune med...

    Authors: Mohammad Sadegh Soltani-Zangbar, Forough Parhizkar, Mojtaba Abdollahi, Navid Shomali, Leili Aghebati-Maleki, Sima Shahmohammadi Farid, Leila Roshangar, Ata Mahmoodpoor and Mehdi Yousefi
    Citation: Cell Communication and Signaling 2022 20:131
    Content type: Review Published on:

  22. For many cell types, directional locomotion depends on their maintaining filopodia at the leading edge. Filopodia lack any Ca2+-binding structural protein but respond to store-operated Ca2+ entry (SOCE).

    Authors: C. A. Heckman, O. M. Ademuyiwa and M. L. Cayer
    Citation: Cell Communication and Signaling 2022 20:130
    Content type: Research Published on:

  24. Retroperitoneal liposarcoma (RPLS) is a specific soft tissue sarcoma with a high recurrence rate. The short isoform of transient receptor potential cation channel subfamily M member 2 (TRPM2-S) plays an import...

    Authors: Xiangji Li, Fanqin Bu, Shixiang Ma, Ferdinando Cananzi, Yu Zhao, Mengmeng Xiao, Li Min and Chenghua Luo
    Citation: Cell Communication and Signaling 2022 20:128
    Content type: Research Published on:

  25. N-acetyltransferase 10 (NAT10), an abundant nucleolar protein with both lysine and RNA cytidine acetyltransferase activities, has been implicated in Hutchinson-Gilford progeria syndrome and human cancer. We an...

    Authors: Hong-Yi Liu, Ying-Ying Liu, Yin-Ling Zhang, Yan Ning, Fang-Lin Zhang and Da-Qiang Li
    Citation: Cell Communication and Signaling 2022 20:127
    Content type: Research Published on:

  26. During development a pool of precursors form a heart with atrial and ventricular chambers that exhibit distinct transcriptional and electrophysiological properties. Normal development of these chambers is esse...

    Authors: Rami Halabi, Paula Bernice Cechmanek, Carrie Lynn Hehr and Sarah McFarlane
    Citation: Cell Communication and Signaling 2022 20:126
    Content type: Research Published on:

  27. Pyroptosis, especially microglial pyroptosis, may play an important role in central nervous system pathologies, including traumatic brain injury (TBI). Transplantation of mesenchymal stem cells (MSCs), such as...

    Authors: Zhiming Feng, Shiting Hua, Wangan Li, Jianbang Han, Feng Li, Haijia Chen, Zhongfei Zhang, Yu Xie, Qian Ouyang, Xiaoxiong Zou, Zhizheng Liu, Cong Li, Sixian Huang, Zelin Lai, Xiaolin Cai, Yingqian Cai…
    Citation: Cell Communication and Signaling 2022 20:125
    Content type: Research Published on:

  28. Previously, a novel lamprey immune protein (LIP) was identified, which plays an important role in immunity and the regulation of growth and development in lampreys. However, the mechanism of how LIP regulates ...

    Authors: Zeyu Du, Duo Zhang, Jun Li, Qingwei Li and Yue Pang
    Citation: Cell Communication and Signaling 2022 20:124
    Content type: Research Published on:

  29. Medulloblastoma is the most common pediatric embryonal brain tumor, and may occur in cancer predisposition syndromes. We describe novel associations of medulloblastoma with atypical prolactinoma and dural high...

    Authors: Maria-Magdalena Georgescu, Stephen G. Whipple and Christina M. Notarianni
    Citation: Cell Communication and Signaling 2022 20:123
    Content type: Research Published on:

  30. B-cell acute lymphoblastic leukemia (B-ALL) comprises over 85% of all acute lymphoblastic leukemia (ALL) cases and is the most common childhood malignancy. Although the 5 year overall survival of patients with...

    Authors: Lan Huang, Xizhou An, Yao Zhu, Kainan Zhang, Li Xiao, Xinyuan Yao, Xing Zeng, Shaoyan Liang and Jie Yu
    Citation: Cell Communication and Signaling 2022 20:122
    Content type: Research Published on:

  31. Immunotherapy has proven to be an emerging treatment for non-small-cell lung cancer in recent years. Notably, smokers show higher programmed cell death ligand-1 (PD-L1) expression and better responses to PD-1/...

    Authors: Ping Zhu, Zhengxin Jin, Guiyu Kang, Yanfei Jia, Duanrui Liu, Qian Zhang, Feiyang Guo, Ying Jia, Yang Jiao, Jingtan Li, Haiji Sun and Xiaoli Ma
    Citation: Cell Communication and Signaling 2022 20:121
    Content type: Research Published on:

  32. Breast cancer, the most diagnosed cancer, remains the second leading cause of cancer death in the United States, and excessive Progesterone (PRG) or Mifepristone (MIF) exposure may be at an increased risk for ...

    Authors: Johnathan Abou-Fadel, Xiaoting Jiang, Brian Grajeda, Akhil Padarti, Cameron C. Ellis, Esmeralda Flores, Alyssa-Marie D. Cailing-De La O and Jun Zhang
    Citation: Cell Communication and Signaling 2022 20:120
    Content type: Research Published on:

  33. Bone metastatic prostate cancer does not completely respond to androgen-targeted therapy and generally evolves into lethal castration resistant prostate cancer (CRPC). Expression of AR-V7- a constitutively act...

    Authors: Rintu Thomas, John Michael Jerome, Truong D. Dang, Eric P. Souto, Joshua N. Mallam and David R. Rowley
    Citation: Cell Communication and Signaling 2022 20:119
    Content type: Research Published on:

  34. The CAAX-prenyltransferases farnesyltransferase (FTase) and geranylgeranyltransferase I (GGTase I) are heterodimers with a common α- (FTα) and unique β-subunits. Recently, α-subunits of species (e.g., human) t...

    Authors: Anna Hagemann, Sandro Tasillo, Aykut Aydin, Miriam Caroline Alice Kehrenberg and Hagen Sjard Bachmann
    Citation: Cell Communication and Signaling 2022 20:118
    Content type: Research Published on:

  35. The liver is unique in its ability to regenerate from a wide range of injuries and diseases. Liver regeneration centers around hepatocyte proliferation and requires the coordinated actions of nonparenchymal ce...

    Authors: Wenzhi Shu, Mengfan Yang, Jiayin Yang, Shengda Lin, Xuyong Wei and Xiao Xu
    Citation: Cell Communication and Signaling 2022 20:117
    Content type: Review Published on:

  36. Authors: Jianping Cao, Peng Huo, Kuiqing Cui, Huimei Wei, Junna Cao, Jinyuan Wang, Qingyou Liu, Xiaocan Lei and Shun Zhang
    Citation: Cell Communication and Signaling 2022 20:116
    Content type: Correction Published on:

    The original article was published in Cell Communication and Signaling 2022 20:61

  37. Diabetic nephropathy (DN) involves various structural and functional changes because of chronic glycemic assault and kidney failure. Proteinuria is an early clinical manifestation of DN, but the associated pat...

    Authors: Lingfei Li, Yanhai Feng, Junhui Zhang, Qiong Zhang, Jun Ren, Cheng Sun, Shujing Li, Xia Lei, Gaoxing Luo, Jiongyu Hu and Yuesheng Huang
    Citation: Cell Communication and Signaling 2022 20:115
    Content type: Research Published on:

  38. Metabolic reprogramming and immune escape play a major role in tumorigenesis. Increasing number of studies have shown that reprogramming of glutamine metabolism is a putative determinant of the anti-tumor immu...

    Authors: Guofeng Ma, Zhilei Zhang, Peng Li, Zhao Zhang, Manqin Zeng, Zhijuan Liang, Dan Li, Liping Wang, Yuanbin Chen, Ye Liang and Haitao Niu
    Citation: Cell Communication and Signaling 2022 20:114
    Content type: Review Published on:

  41. The screening biomarkers for early detection of colorectal cancer (CRC) is lacking. The aim is to identify epigenetic silenced genes and clarify its roles and underlying mechanism in CRC. We conducted integrat...

    Authors: Zixu Yuan, Xihu Yu, Wenle Chen, Daici Chen, Jian Cai, Yingming Jiang, Xiaoxia Liu, Zhijie Wu, Lei Wang, William M. Grady and Hui Wang
    Citation: Cell Communication and Signaling 2022 20:111
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2022 20:113

  42. Based on clinical observations, stroke is touted as one of the specific pathological conditions, affecting an individual’s life worldwide. So far, no effective treatment has been introduced to deal with stroke...

    Authors: Fatemehsadat Seyedaghamiri, Leila Salimi, Dara Ghaznavi, Emel Sokullu and Reza Rahbarghazi
    Citation: Cell Communication and Signaling 2022 20:110
    Content type: Review Published on:

  43. Tumorous imaginal disc 1 (hTid-1) or DnaJ homolog subfamily A member 3 (DNAJA3), is a part of the heat shock protein (Hsp) 40 family and is predominantly found to reside in the mitochondria. hTid-1 has two mRN...

    Authors: Sagarika Banerjee, Rupesh Chaturvedi, Anu Singh and Hemant R. Kushwaha
    Citation: Cell Communication and Signaling 2022 20:109
    Content type: Review Published on:

  44. Macrophage phenotypes switch from proinflammatory (M1) to anti-inflammatory (M2) following myocardial injury. Implanted stem cells (e.g., induced pluripotent stem cells (iPSCs)) for cardiomyogenesis will inevi...

    Authors: Canling Long, Rui Guo, Ruijuan Han, Kang Li, Yanbing Wan, Jiqing Xu, Xiaoyu Gong, Yanqiu Zhao, Xinhuang Yao and Jia Liu
    Citation: Cell Communication and Signaling 2022 20:108
    Content type: Research Published on:

  45. Type 2 diabetes mellitus is a global health problem. It often leads to a decline in the differentiation capacity of myoblasts and progressive loss of muscle mass, which in turn results in deterioration of skel...

    Authors: Xuan Jiang, Ninghan Feng, Yizhou Zhou, Xianlong Ye, Rong Wang, Jingwei Zhang, Siyuan Cui, Siyu Ji, Yongquan Chen and Shenglong Zhu
    Citation: Cell Communication and Signaling 2022 20:107
    Content type: Research Published on:

  46. The COVID-19 pandemic has become the world’s main life-threatening challenge in the third decade of the twenty-first century. Numerous studies have been conducted on SARS-CoV2 virus structure and pathogenesis ...

    Authors: Mohammad Sadegh Soltani-Zangbar, Forough Parhizkar, Elham Ghaedi, Ali Tarbiat, Roza Motavalli, Amin Alizadegan, Leili Aghebati-Maleki, Davoud Rostamzadeh, Yousef Yousefzadeh, Golamreza Jadideslam, Sima Shahmohammadi Farid, Leila Roshangar, Ata Mahmoodpoor, Javad Ahmadian Heris, Abolfazl Miahipour and Mehdi Yousefi
    Citation: Cell Communication and Signaling 2022 20:106
    Content type: Research Published on:

  47. Penfluridol (PF) is an FDA-approved antipsychotic drug that has recently been shown to have anticancer activity. However, the anticancer effects and underlying mechanisms of PF are not well-established in gall...

    Authors: Jiahao Hu, Jiasheng Cao, Ren’an Jin, Bin Zhang, Win Topatana, Sarun Juengpanich, Shijie Li, Tian’en Chen, Ziyi Lu, Xiujun Cai and Mingyu Chen
    Citation: Cell Communication and Signaling 2022 20:105
    Content type: Research Published on:

  48. Lung resident mesenchymal stem cells (LR-MSCs) play an important role in idiopathic pulmonary fibrosis (IPF) by transforming into myofibroblasts, thereby losing their repair ability. Evidence suggests that key...

    Authors: Wei Sun, Xiaoshu Liu, Xiaoyu Yang, Xiaoyan Jing, Chunyan Duan, Ganghao Yang, Chi Wu, Hui Huang, Qun Luo, Shu Xia, Qian Zhang, Yang Yang and Zuojun Xu
    Citation: Cell Communication and Signaling 2022 20:104
    Content type: Research Published on:

  49. Cytosolic RNA sensing can elicit immune responses against viral pathogens. However, antiviral responses must be tightly regulated to avoid the uncontrolled production of type I interferons (IFN) that might hav...

    Authors: Wei Liu, Zhenling Ma, Yaru Wu, Cui Yuan, Yanyan Zhang, Zeyang Liang, Yu Yang, Wenwen Zhang and Pengtao Jiao
    Citation: Cell Communication and Signaling 2022 20:103
    Content type: Research Published on:

  50. Circular dorsal ruffles (CDRs) are rounded membrane ruffles induced on the dorsal surfaces of cells stimulated by growth factors (GF). They can serve as signal platforms to activate AKT protein kinase. After G...

    Authors: Xiaowei Sun, Yujie Liu, Shuheng Zhou, Li Wang, Jinzi Wei, Rui Hua, Zhongyang Shen and Sei Yoshida
    Citation: Cell Communication and Signaling 2022 20:102
    Content type: Research Published on:
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