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Fig. 8 | Cell Communication and Signaling

Fig. 8

From: METTL3 and STAT3 form a positive feedback loop to promote cell metastasis in hepatocellular carcinoma

Fig. 8

METTL3-STAT3 positive feedback loop promotes cell metastasis in vivo. A, B Imaging (A) and weights (B) of the xenograft tumors harvested from 5 mice per group. Error bars represent mean ± SD, *P < 0.05, **P < 0.01, ***P < 0.001 by one-way ANOVA. C IHC staining of Ki67, METTL3 and STAT3 in the tissues of xenograft tumors. Scale bar, 20 μm. The right panel shows the quantification of average optical density of Ki67, METTL3 and STAT3 in the tissues of xenograft tumors. *P < 0.05, **P < 0.01, ***P < 0.001 by 2-tailed Student’s t-test. D Western blotting analysis of the protein levels of METTL3, STAT3 and Ki67 in the indicated groups of tumor samples. The right panel shows the quantification of the intensity relative to tubulin. *P < 0.05, **P < 0.01, ***P < 0.001 by 2-tailed Student’s t-test. E The representative bioluminescence images were captured in the indicated time after transplantation. The lower panel shows the bioluminescence intensity (photons/s/cm2/sr) in the lungs was quantitatively analyzed. The significance of differences was assessed by one-way ANOVA, *P < 0.05, **P < 0.01, ***P < 0.001. F Representative images of hematoxylin–eosin (H&E) staining in lung tissue after transplantation

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