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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Autophagy modulators influence the content of important signalling molecules in PS-positive extracellular vesicles

Fig. 2

Expression of proteins involved in the autophagy machinery. (a) Protein expression of p-ULK1 (Ser 757), p-ULK1 (Ser 556), ULK1, ATG5, ATG7, SQSTM1, GABARAP, LC3, and LAMP2; p- indicates phosphorylation. Uncropped western blots for this figure are shown in Additional file 3. (b) Densitometric analyses: the ratio of ULK1 phosphorylation on Ser 757 to ULK1 expression; the ratio of ULK1 phosphorylation on Ser 556 to ULK1 expression; the ratio of ULK1 phosphorylation on Ser 556/ Ser 757; the ratio of GABARAP II/I; the ratio of LC3 II/I. (c) Pearson correlation. The ratio of ULK1 phosphorylation on Ser-556 to Ser-757 was in positive correlation with LC3II/I ratio (p = 0.046). GABARAPII/I ratio and LC3II/I ratio were in positive correlation (p = 0.044). LAMP2 expression was in negative correlation with γ-4EBP1 (p ≤ 0.0001)

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Cell Communication and Signaling

ISSN: 1478-811X