Table 2 Natural compounds-induced ADAM10 modulation in AD

Curcumin

Curcuma longa

HEK293 cells overexpressing ADAM10

Increase ADAM10 expression

Increase sAPPα production and exert neuroprotective effects

[107]

Icariin

Epimedium brevicornum

Rat model of permanent occlusion of bilateral common carotid arteries

Reduce BACE1 and increase ADAM10 expression

Decrease in the level of insoluble Aβ fragments

[108]

Astaxanthin

Euphausia pacifica

3xTg AD mice

Induce ADAM10 expression

Up-regulation of non-Amyloidogenesis pathway

[109]

Epigallocatechin-3-gallate

Green tea

SweAPP N2a cells

Increase active form of ADAM10 (∼ 60 kDa mature form)

Increase sAPPα production and exert neuroprotective effects

[110]

SweAPP N2a cells

Activation of ADAM10 through the PI3K/AKT pathway activation

Increase sAPPα production and exert neuroprotective effects

[111]

Resveratrol

Polygonum cuspidatum

CHO-APPswe cells

Augment altered expression and subcellular localization of ADAM10 induced by high cholestrol

Up-regulation of non-Amyloidogenesis pathway

[112]

Bilobalide

Ginkgo biloba

Differentiated SH-SY5Y cell

Induction of ADAM10 through the PI3K/AKT pathway activation

Increase sAPPα production and exert neuroprotective effects

[113]

Quercetin

Hypericum perforatum

Aluminum chloride -induced AD rat model

Up-regulation of ADAM10

Inhibit Aβ aggregation

[114]

Ligustilide

Angelica sinesis

APP/PS1 mice

Up-regulation of ADAM10

Inhibit Aβ aggregation

[115]

Cryptotanshinone

Salvia miltiorrhiza

N2a-SwedAβPP cells

Activation and translocation of ADAM10 and PKC-alpha

Up-regulation of non-Amyloidogenesis pathway

[116]

Berberine

Berberis vulgaris

APP/PS1 transgenic mice

Increase ADAM10 expression

Reduce Aβ deposition and improve memory function

[117]