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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Therapeutic potential of ADAM10 modulation in Alzheimer’s disease: a review of the current evidence

Fig. 1

ADAM10 synthesis and maturation in the cell. ADAM10 in synthesized in endoplasmic reticulum, containing pro-domain, catalytic and cysteine-rich disintegrin like domains. Golgi is involved in ADAM10 maturation, where pro-domain is dissociated by pro-protein convertases such as furin. On the other hand, other ADAMs can affect mature ADAM10 to form a soluble ectodomain

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