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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Fig. 7

Schematic model of MMP19 involvement in pathophysiological processes of E(nd)MT and pulmonary fibrosis. Overexpression of MMP19 in endothelial cells promoted E(nd)MT of endothelial cells and vascular permeability and led to more monocytes infiltration into bronchoalveolar lavage and tissue lumen through the induction of ET1 and SDF1 in endothelial cells, further facilitating fibrotic microenvironment with abundant of growth factors, cytokines, chemokines, and aggravated pulmonary fibrosis

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Cell Communication and Signaling

ISSN: 1478-811X