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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Fig. 4

MMP19 promotes E(nd)MT and vascular permeability. A Western blot was performed for markers of E(nd)MT in lung homogenates of MMP19WT- and MMP19E213A-AAV-infected mice treated with saline control or BLM. B Immunohistochemical staining of lung sections for Collagen I and Collagen IV. C Immunostaining was performed to localize CD31 (red) and α-SMA (green) in endothelial cells in mice. n = 3 in vector and MMP19-AAV-infected mice treated with bleomycin, and n = 4 in other groups. D Assay of permeability of vascular permeability to EB. E Total cells in bronchoalveolar lavage (BAL) fluid. n = 3 in all groups

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