Skip to main content

Table 2 Affinities of FKBP-binding compounds

From: FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells

FKBP-protein

FK506 (nM)

RAP (nM)

SAFit1 (nM)

19 (nM)

19(S)-Me (nM)

FKBP12

0.55

0.6

184.8

0.65

0.33

FKBP12.6

2.17

0.4

50.1

1.23*

nd

FKBP13

301.9

7.2

614.8

60.5*

nd

FKBP51

405.5

3.7

21.7

12

2.9

FKBP52

56.4

4.2

nb

11

3.2

  1. Affinities for selected FKBP compounds measured by a competitive fluorescence polarization were published earlier and are shown as inhibitory constants (Ki) in nM [36, 37, 46], *; values from [36], RAP; rapamycin, nb; not binding, nd; not determined
Back to article page

Cell Communication and Signaling

ISSN: 1478-811X