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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: GRHL2-controlled gene expression networks in luminal breast cancer

Fig. 2

Association of GRHL2 motif with ER transcriptional complex in luminal breast cancer cells. a DNA-binding motif of GRHL2 in luminal breast cancer. From left to right, the first panel shows the identified motifs in the indicated cell lines. The second panel shows distribution of the best matches to the motif in the sequences. The third panel shows the E-value, representing the significance of the motif according to the motif discovery. The last panel shows the number of regions that match the corresponding motif. b Heatmaps showing the coverage of identified GRHL2 peaks shared between MCF7, BT474 and T47D at GRHL2 motifs (red) (n = 20,766), ER⍺ motifs (blue) (n = 76,564), FOXA1 motifs (Green) (n = 88,923) and GATA3 motifs (Orange) (n = 93,403). Note that the read coverage scale differs for the different heatmaps. c Table indicating the occurrence of ER⍺ consensus motif in a region spanning 1000 bp up- and downstream of all GRHL2 peaks either identified in the indicated cell lines (left 3 columns) or shared between the indicated cell lines (right column). d Table indicating the occurrence of published ER⍺ binding events in a region spanning 1000 bp up- and downstream of all GRHL2 peaks shared between MCF7, BT474 and T47D (upper row) or shared between 2 MCF7 datasets (bottom row)

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