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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Cell adhesion molecule BVES functions as a suppressor of tumor cells extrusion in hepatocellular carcinoma metastasis

Fig. 2

Extrusion in HCC cells and tissues. A The representative images of extrusion in Huh7, SMMC-7721, and SK-Hep-1 cells (× 200). Certain cells were surrounded and suffered “collective attack” by neighboring cells. B Golgi matrix protein GM130 (the arrows) reflected the direction of force and migration of cells (× 200). Red, GM130; blue, nuclei; green, GFP labeled HCC cells. C Confocal projections analysis of HCC cells extrusion by overlaying the XY plane of the actin-extruding ring with the XY plane of the DNA of the extruded cells. Red, F-actin; blue, nuclei; green, GFP labeled HCC cells. D 3D cell culture model for detecting HCC cells extrusion (× 200). Red, F-actin; blue, nuclei. Arrows pointed to extruded cells. The pictures below were the corresponding images of the cells under microscope. E Confocal projections analysis of Huh7 cells extrusion in 3D cell culture model. F The representative images of extrusion in HCC tissues (× 200). Red, GM130; blue, nuclei; green, F-actin. Arrows pointed to extruded cells

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Cell Communication and Signaling

ISSN: 1478-811X