NcRNAs | Upregulated/downregulated | Target | References |
---|---|---|---|
miRNAs | |||
miR-100 | Upregulated | DKK1, ZNRF3/Wnt/β-catenin pathway | [41] |
miR-125b | Upregulated | ZNRF3, RNF43, DKK3, APC2/Wnt/β-catenin pathway p53 HER2 | [41] [46] [47] |
miR-7 | Downregulated | YY1 TYRO3, PI3K/AKT/mTOR pathway EGFR RAF-1 IGF1R | [49] [50] [51] [52] |
miR-143 | Downregulated | Sos1, AKT, ERK KRAS, RREB1 MAPK pathway c-MYC ADCC | [58] [60] [60] [61] [62] |
miR-145 | Downregulated | RHBDD1, EGFR/RAF/MEK/ERK pathway KRAS, RREB1 MAPK pathway c-MYC ADCC | [59] [60] [60] [61] [62] |
miR-302a | Downregulated | CD44 | [65] |
miR-378 | Downregulated | RAS/RAF/MAPK pathway ERK pathway BRAF, RAS/RAF/MEK/ERK pathway | [68] |
miR-193a-3p | Downregulated | KRAS, RAS/RAF pathway MAPK pathway Mcl1 | [69] [70] [70] |
miR-141-3p | Downregulated | EGFR, RAS/RAF1/ERK pathway EGFR, AKT pathway | [71] [71] |
Let-7 | Downregulated | KRAS, MYC, IGF1, HMGA2 | [72] |
miR-375 | Downregulated | CTGF/EGFR/PIK3CA/AKT pathway EGFR/KRAS/BRAF/ERK pathway PHLPP1 | [76] [76] [42] |
miR-181d | Downregulated | PEAK1 KLK6 | [81] [80] |
Upregulated | FBXL3, CRY2 KRAS | [82] [85] | |
miR-545 | Downregulated | EGFR CDK4 MYO6 | [86] [87] [88] |
Upregulated | RIG-I, PI3K/AKT pathway | [90] | |
Other miRNAs that may be involved in anti-EGFR resistance | |||
miR-181a | Upregulated | PTEN WIF-1 | [94] [93] |
miR-31-3p | Upregulated | E2F2, c-MYC pathway RAS/MAPK pathway | [61] |
miR-31-5p | Upregulated | BRAF Wnt/β-catenin pathway | [97] [98] |
miR-425-5p | Upregulated | BRAF/RAS/MAPK pathway PI3K/AKT pathway p53 CTNND1, Wnt/β-catenin pathway | [98] [98] [98] [99] |
miR-21 | Upregulated | 15-PGDH, EGFR pathway PTEN, PI3K/AKT pathway Wnt/β-catenin pathway c-MYC | [105] [105] |
miR-133b | Downregulated | EGFR | [106] |
miR-320d | Downregulated | PI3K/AKT/mTOR pathway TUSC3 | [111] [111] |
miR-192 | Downregulated | TRIP13, EGFR/AKT pathway TRIP13, Wnt/β-catenin pathway APC, c-Fos | [113] [113] [114] |
miR-802 | Downregulated | EGFR, ERK pathway EGFR, AKT pathway | [116] [116] |
miR-497 | Downregulated | IRS1, PI3K/AKT pathway IRS1, MAPK pathway IGF1R, PI3K/AKT pathway PI3K/AKT/mTOR pathway | [117] [117] [118] [119] |
miR-4689 | Downregulated | KRAS, RAF/MEK/MAPK pathway KRAS, RAF/MEK/ERK pathway PI3K/AKT1 pathway | [120] [120] [120] |
miR-130a-3p | Downregulated | WNT1 | [121] |
miR-708-5p | Downregulated | CD44, EGFR pathway CTNNB1, Wnt/β-catenin pathway PI3K/AKT pathway | [122] [123] [124] |
miR-520a-3p | Downregulated | EGFR | [125] |
miR-342-3p | Downregulated | EGFR, BCL2 | [127] |
miR-215-5p | Downregulated | EREG, HOXB9 | [128] |
miR-99a | Downregulated | mTOR | [130] |
miR-200a | Downregulated | EphA2/EGFR/MAPK pathway | [131] |
miR-26b | Downregulated | EphA2/EGFR/MAPK pathway | [131] |
miR-875-5p | Downregulated | EGFR | [134] |
lncRNAs | |||
MIR100HG | Upregulated | Wnt/β-catenin pathway | |
UCA1 | Upregulated | HGF/c-MET pathway | [32] |
CRART16 | Upregulated | ERBB3, ERBB3/MAPK pathway | [33] |
LINC00973 | Upregulated | / | [152] |
SLCO4A1-AS1 | Upregulated | EGFR/MAPK pathway Wnt/β-catenin pathway c-MYC pathway | [153] [154] [155] |
TTN-AS1 | Upregulated | PI3K/AKT/mTOR pathway | [119] |
POU5F1P4 | Downregulated | PI3K/AKT pathway | [157] |
Other lncRNAs that may be involved in anti-EGFR resistance | |||
HOTAIR | Upregulated | EGFR FUT6, PI3K/AKT/mTOR pathway | [86] [158] |
ZEB1-AS1 | Upregulated | β-catenin, Wnt/β-catenin pathway | [160] |
TCF4, MYC, MMP-7, cyclin D1 | [160] | ||
CRNDE | Upregulated | β-catenin, TCF4, Wnt/β-catenin pathway | [161] |
DNAJC3-AS1 | Upregulated | EGFR/PI3K/AKT pathway | [162] |
LINC00265 | Upregulated | Wnt/β-catenin pathway EGFR | [163] [163] |
LOXL1-AS1 | Upregulated | CD44, EGFR pathway | [122] |
MINCR | Upregulated | CTNNB1, Wnt/β-catenin pathway | [123] |
SCARNA2 | Upregulated | EGFR, BCL-2 | [127] |
circRNAs | |||
circHIPK3 | Upregulated | EGFR, MEK/ERK pathway IGF1R, PI3K/AKT pathway YY1, β-catenin pathway | [184] [184] |
CDR1as | Upregulated | EGFR, IGF1R | [52] |
circRNA_0000392 | Upregulated | PIK3R3, AKT/mTOR pathway | [188] |