Fig. 3

ncRNAs associated with anti-EGFR therapy resistance in CRC. In terms of the number of studies, miRNAs are the most numerous, followed by lncRNAs and circRNAs. The numbers of individual ncRNAs and the strength of the evidence for their association with resistance to anti-EGFR therapy are shown in the figure: ncRNAs in the dark area have been verified by resistance experiments, and ncRNAs in the light area need further verification. ↑ represents upregulated ncRNAs in CRC, ↓ represents downregulated ncRNAs in CRC. ↑ in red represents upregulated ncRNAs is associated with poor prognosis, and ↓ in red represents downregulated ncRNAs is associated with poor prognosis