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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Promotion or remission: a role of noncoding RNAs in colorectal cancer resistance to anti-EGFR therapy

Fig. 2

Mechanism of ceRNAs and ncRNAs involved in anti-EGFR resistance in CRC. a Mechanisms of lncRNAs and circRNAs as ceRNAs: (i) The target gene is transcribed into mRNA. (ii) The 3′-UTR of target mRNA is bound by and inhibited by miRNA, preventing protein translation. (iii) Free miRNAs in the cytoplasm are adsorbed by circRNAs and lncRNAs through miRNA response elements (MREs), resulting in a decrease in the level of miRNAs. (iv) The negative regulation of miRNA on target mRNA is weakened or eliminated, and mRNA is translated into protein, which mediates biological functions. b MREs are defined as regions on target RNAs, such as mRNAs, lncRNAs, and circRNAs, that can be bound by miRNAs through complementary base pairing. MREs are essentially short sequences, resulting in mRNAs degradation or translational inhibition. c ceRNA network associated with anti-EGFR mAbs sensitivity in CRC: UCA1/miR-495/HGF/c-MET, CRART16/miR-371a-5p/ERBB3, circHIPK3/miR-7/IGF1R/EGFR

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