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Fig. 7 | Cell Communication and Signaling

Fig. 7

From: Exosomal AP000439.2 from clear cell renal cell carcinoma induces M2 macrophage polarization to promote tumor progression through activation of STAT3

Fig. 7

AP000439.2 interacts with STAT3 and regulates the NF-κB pathway in macrophage. A Heat map of differentially expressed genes in macrophage pretreated with AP000439.2-overexpressed exosome or NC-exo. OE1, OE2 and OE3 represent AP000439.2-overexpressed exosome group. C1, C2, and C3 represent the control group. B Top 20 KEGG enrichment pathways of differentially expressed genes. C The expression of 5 differentially expressed genes in NF-κB signaling pathway was verified by qRT-PCR. D The phosphorylation level of p65 (a representative gene for activation of NF-κB signaling pathway) in macrophages after overexpression of AP000439.2 and knockdown of STAT3. E Statistical analysis results of western blot. F A graphical summary of lncRNA AP000439.2 regulation. Exosomal lncRNA AP000439.2 derived from ccRCC promote the M2 macrophage polarization though phosphorylated STAT3 and activated NF-κB signaling pathway, thus facilitate the progression of ccRCC. ns p > 0.05, *p < 0.05, **p < 0.01, ***p < 0.001, Two-tailed Student’s t-test for two groups, one-way ANOVA following Tukey’s test for three groups

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