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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Exosomal AP000439.2 from clear cell renal cell carcinoma induces M2 macrophage polarization to promote tumor progression through activation of STAT3

Fig. 2

Exosomes derived from ccRCC promoted M2 macrophage polarization. A Fluorescence microscopy images proved intercellular trafficking of exosomes labelled with PKH26 dye (magnification, ×200). B qRT-PCR was used to detect the mRNA levels of TGF-β and IL-10 in macrophage treated with exosomes derived from 786-O (left) and Caki-1 (right). C The protein levels of TGF-β and IL-10 in macrophage were detected by Western Blot. The gray intensities of TGF-β and IL-10 were quantified and standardized with GAPDH. These experiments were done with three distinct biological replicates. *p < 0.05, **p < 0.01, ***p < 0.001. Two-tailed Student’s t-test

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Cell Communication and Signaling

ISSN: 1478-811X