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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Fig. 6

Overexpression of AP2 enhances malignancy of lung cancer cells. Overexpression of AP2A (left panel, shown by anti-Flag antibody) and AP2B (right panel, shown by anti-Flag antibody) increased A USP22 Cyclin D1 proteins and B Proliferation in the parental (USP22-WT) but not the USP22-knockout (-KO, −/−) H1299 and A549 cells. C Overexpression of AP2 increased the migration of USP22-WT but not USP22-KO H1299 and A549 cells. D Quantitative data of migration assays. E Overexpression of TFAP2 increased the invasion of USP22-WT but not USP22-KO H1299 and A549 cells. F Quantitative data of invasion assays; *P < 0.05, **P < 0.01 compared to the pcDNA empty plasmid

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Cell Communication and Signaling

ISSN: 1478-811X