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Fig. 5 | Cell Communication and Signaling

Fig. 5

From: Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Fig. 5

AP2 binds to USP22 promoter. A Diagram for mutated AP2 binding site (-12 to -4). B Mutation of AP2 binding site resulted in decreased luciferase reporter activity of USP22 promoter (**P < 0.01 compared to the wild-type USP22 promoter driven luciferase reporter). C ChIP assay shows compared to IgG, a mixture of anti-AP2α and AP2β antibody pulled down significantly more USP22 promoter DNA in H1299 and A549 lung cancer cells (**P < 0.01 compared to the control IgG)

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Cell Communication and Signaling

ISSN: 1478-811X