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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Fig. 4

Knockdown of TFAP2 downregulated USP22, suppressed cell proliferation of NSCLC cells. Knockdown TFAP2A (left panel) and TFAP2B (right panel) by siRNA decreased A USP22 mRNA (*P < 0.05, **P < 0.01 compared to the control siRNA) and B USP22 protein in H1299 and A549 cells. C Knockdown of TFAP2A (left panel) and TFAP2B (right panel) decreased the proliferation of A549 and H1299 lung cancer cells; *P < 0.05, **P < 0.01 compared to the control siRNA. D The ggscatterstats diagram shows the positive association of the USP22 mRNA to TFAP2A mRNA (left panel) and TFAP2B mRNA (right panel) in human lung cancer tissues

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