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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Fig. 3

c-Myc upregulates USP22 expression in lung cancer cells. A knockdown of c-Myc by two individual gene-specific siRNA decreased USP22 mRNA; *P < 0.05, **P < 0.01 compared to the control siRNA. B Overexpression of c-Myc increased UPS22 promoter-driven luciferase activity of in both H1299 and A549 lung cancer cells; **P < 0.01 compared to the control pcDNA empty plasmid. C Overexpression of c-Myc upregulated USP22 protein in H1299 and A549 lung cancer cells and HCT116 colorectal cancer cells

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Cell Communication and Signaling

ISSN: 1478-811X