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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: Transcription factor AP2 enhances malignancy of non-small cell lung cancer through upregulation of USP22 gene expression

Fig. 2

Identification of transcription factors that regulate USP22 gene expression in lung cancer cells. A Knockdown of transcription factors of TFAP2A/2B, c-Myc, NF-YA decreased the luciferase activity of USP22 promoter, while knockdown of transcription factors of SP1 and ATF3 increased the luciferase activity of USP22 promoter. B USP22 mRNA change by knockdown of TFAP2, ATF3 and SP1 in lung cancer cells; *P < 0.05, **P < 0.01, compared to the control siRNA. C Western blot analysis shows USP22 protein change upon knockdown of these transcription factors in lung cancer cells

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Cell Communication and Signaling

ISSN: 1478-811X