Fig. 7
From: Computational analysis of 4-1BB-induced NFκB signaling suggests improvements to CAR cell design
Dose response curves for IKKβ and NFκB in response to antigen binding to the CAR with modified expression levels. Peak concentration times and relative magnitudes were recorded for active IKKβ and nuclear NFκB for a range of antigen concentrations and with different proteins under- or overexpressed. a Relative magnitude of the peak concentration of active IKKβ; b Relative magnitude of the peak concentration of nuclear NFκB; c timing of the peak concentration of active IKKβ; d Timing of the peak concentration of nuclear NFκB. N.B. Peak timings for the case of disabled IKKβ deactivation are not shown in (c) and (d) since neither IKKβ nor NFκB show substantial local maxima