Fig. 3
From: Computational analysis of 4-1BB-induced NFκB signaling suggests improvements to CAR cell design
Dose response curves for IKKβ and NFκB in response to antigen binding the CAR. Relative magnitude and timing of the peak concentration of active IKKβ and nuclear NFκB were recorded for a range of antigen concentrations. a Relative magnitude of the peak concentration of enzymatically active IKKβ; b relative magnitude of the peak concentration of nuclear NFκB; c timing of the peak concentration of enzymatically active IKKβ; d timing of the peak concentration of nuclear NFκB