How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP

Table 1 Correlation coefficients for proteins paired with STIM1 and TRPC1 in untreated cells

Protein coinciding with STIM1	Orai	TRPC1	AQP4
Correlation coefficient	0.509^†	0.465^‡	0.816^†,‡
Standard error	0.043	0.033	0.012
Number of images (N)	11	17	8

Protein coinciding with TRPC1	CaV1.2	Orai	Vamp2	AQP4
Correlation coefficient	0.552^§	0.520^‖	0.546^¶	0.728^§,‖,¶
Standard error	0.029	0.039	0.030	0.039
Number of images (N)	10	7	8	8

Peripheral cytoplasm from images processed by Colocalization Finder (see Materials and Methods). Significance by one-way ANOVA of comparisons with STIM1 is P < 0.00001. ANOVA with TRPC1 is P = 0.00031
^†differ by P = 0.00000
^‡differ by P = 0.00000
^§differ by P = 0.00303
^‖differ by P = 0.00046
^¶differ by P = 0.00215

ISSN: 1478-811X