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Fig. 9 | Cell Communication and Signaling

Fig. 9

From: How filopodia respond to calcium in the absence of a calcium-binding structural protein: non-channel functions of TRP

Fig. 9

Colocalization of PLC isoforms and TRPC1. a Triple localization of PLCβ2 (green), PLCγ1 (blue), and TRPC1 (red). PLCγ1 and TRPC1 coincide in interior parts of the cells (lavender). b, c Colocalization of PLCβ2 (green) and TRPC1 (red). b In an untreated cell, the labels coincide even at the cell edge (arrows). c After Ca2+ readdition, TRPC1 is concentrated at the cell edge (bracket) but the two proteins are often colocalized at the interior of the cell (yellow). d, e Colocalization of PLCβ2 (red) and PLCγ1 (green). d In an untreated cell, the proteins coincide in many sites (yellow), but PLCβ2 can also occupy a separate compartment (arrowheads). e After Ca2+ readdition, the proteins share compartments in some sites (yellow arrowheads) but not in others (green and red arrowheads). f Cumulative distribution of PLCβ2 particle sizes. The peak radius of loci in images from untreated cells is indicated. g, h Localization of PLCβ2 (g) and PLCγ1 (h) at the cell edge, showing a concentration at the pointed feature (arrowhead)

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Cell Communication and Signaling

ISSN: 1478-811X