STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Table 3 Phenotypes of osteoclastic lineage cells with modified STAT3 signaling pathway

Origin	Signaling pathway	Regulating factors	Effect on STAT3 (phosphorylation sites)	Downstream target gene	Phenotypes	Reference
RAW264.7cells and mice BMMs	STAT3/ RANKL	MSM	Decreased STAT3 phosphorylation at Ser727	NFATc1, TRAP, OSCAR, MMP9	Decreased cell viability and TRAP-positive multinucleated cells	[81]
RAW264.7cells and mice BMMs	STAT3, CD9/gp130/STAT3	WKYMVm	Decreased STAT3 phosphorylation at Ser727	NFATc1, c-Fos, MMP9, CTSK	Decreased TRAP-positive multinucleated cells	[82]
ST2 cells and mice BMMs	STAT3	HA	Decreased STAT3 phosphorylation	RANKL	Decreased TRAP-positive multinucleated cells	[97]
RAW264.7cells and mice BMMs	IL-34/STAT3/SMAD7	IL-34	Increased STAT3 phosphorylation	SMAD7	Increased TRAP-positive multinucleated cells	[86]
Mice bone marrow cells	STAT3	Heparin	Increased STAT3-DNA binding and transactivation at Ser727	gp130, RANKL	Increased TRAP-positive multinucleated cells	[93]
RAW264.7cells and BMMs	STAT3	PIAS3	Decreased DNA binding activity of STAT3	c-Fos, NFATc1, OSCAR, RANKL	Decreased TRAP-positive multinucleated cells	[90, 91]
Mice BMMs	STAT3	Niclosamide	Decreased STAT3 phosphorylation at Ser727	c-Fos, NFATc1, TRAP, OSCAR, av/b3 integrin, CTSK	Decreased TRAP-positive multinucleated cells	[95]
Mice BMMs	JAK3/STAT3	WHI-131	Increased STAT3 phosphorylation at Ser727	c-Fos, NFATc1	Decreased TRAP-positive multinucleated cells	[98]
Mice BMMs	STAT3	LIF	Increased STAT3 phosphorylation	CTSK, NFATc1, TRAP, Atp6a3, c-Fos	Increased TRAP-positive multinucleated cells	[108]

ISSN: 1478-811X