Table 1 Phenotypes of transgenic mice with cell-specific modified STAT3

Osteoblast linage cells

α1(I)Cre/STAT3^flox/− (10-week-old)

Disruption of STAT3 in osteoblast

Increased mineral apposition rate

[55]

Prx1 ^Cre; STAT3^fl/+ mice (8-week-old)

Deletion of STAT3 in BMSCs

Dwarfed; defects and malformation in the skeleton of new-borns

[54]

Osx^Cre; STAT3^fl/+ (8-week-old)

Deletion of STAT3 in pre-osteoblast

Dwarfed; hypo mineralization

[54]

Osteoclast linage cells

STAT3^Ctsk (20-week-old)

Knockout STAT3 in osteoclast cells

Increased bone mass

[83]

STAT3^Ctsk (8-week-old)

Knockout STAT3 in osteoclast cells

Lower BMD in female femurs

[84]

Hematopoietic cells

Hematopoietic cell-specific disruption of the STAT3

Tissue-specific STAT3 deletion in hematopoietic bone marrow cell lineages

Decreased bone mass and enhanced osteoclast function

[101]