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Fig. 2 | Cell Communication and Signaling

Fig. 2

From: STAT3-mediated osteogenesis and osteoclastogenesis in osteoporosis

Fig. 2

Jak2/STAT3 signal network positively regulates osteogenic differentiation. Proposed model of the role of JAK/STAT3 mediated network that positively regulating osteogenic differentiation of osteoblast precursors. A series of cytokines, molecules including some miRNAs interacted with JAK/STAT3 axis to regulate downstream effectors take account for osteogenic differentiation, all marked with event-specific colored line or arrows. Those delineated in a rectangle with dotted line indicate functional similarity. Ending with red bars indicate inhibition or downregulation, arrows indicate positive stimulation or upregulation

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