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Fig. 3 | Cell Communication and Signaling

Fig. 3

From: MST4 negatively regulates type I interferons production via targeting MAVS-mediated pathway

Fig. 3

MST4 inhibits the production of type I IFN by targeting MAVS. A–F 293 T cells transfected with IFN-β-Luc and β-gal, along with the plasmid expressing Flag-tagged RIG-I-N (A), MDA5-N (B), MAVS (C), TBK1 (D), IKKε (E), or IRF3–5D (F), as well as increasing amounts of the plasmid encoding MST4. The expression levels of indicated proteins were analyzed by Western blot. Data information: The data are represented as mean ± SD (A–F: n = 3). **P < 0.01 and ***P < 0.001 (unpaired two-tailed Student’s t-test). The data are representative of at least three independent experiments

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