Fig. 2From: Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironmentReprogramming of glutamine metabolism in tumor cells and T cells and its impact on immune response. Inhibition of the glutamine transporter inhibits the differentiation of Teff cells while simultaneously promotes the differentiation of Treg cells (①). Inhibition of the GLS promotes the differentiation and effector function of Teff cells (②). Glutamine deprivation affects the differentiation of naive T cells, and up-regulates the expression of PD-L1 in tumor cells by activating the EGFR/ERK/C-Jun signaling pathway or reducing GSH levels, inhibiting SERCA activity, and then activating the NF-κB signaling pathway (③)Back to article page