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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: Reprogramming of glutamine metabolism and its impact on immune response in the tumor microenvironment

Fig. 1

Association of glutamine metabolism with tumor cells and immune cells. The competition for glutamine between tumor cells and immune cells in the TME causes glutamine deficiency, which affects the function of immune cells, including macrophages, DCs, Treg cells, neutrophils, B cells and so on (A). Cell-programmed glutamine partitioning results in the highest consumption of glutamine by tumor cells in the TME. CAFs can up-regulate their glutamine synthesis, and complement glutamine depletion in the TME by secreting glutamine into the TME (B)

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Cell Communication and Signaling

ISSN: 1478-811X