|  | Parent cell | Biological function | Reference |
---|---|---|---|---|
EVs on tumor cells | ||||
NcRNA | miR-503 | HUVECs | Inhibits cancer proliferation and invasion | [46] |
miR-126 | HUVECs | Inhibits the growth of tumor cells | [47] | |
MALAT1 | HUVEC | Promotes invasion in HCC | [48] | |
Protein | S100A16 | HBMECs | Promotes SCLC survival in brain | [49] |
Dll4 | HMVECs | Promotes angiogenesis | [50] | |
Ang2 | Primary mouse lung endothelial cells | Promotes tumor growth | [51] | |
CEACAM1 | human endothelial cell line AS-M.5 | Modulate immune response, tumor progression, metastasis and angiogenesis | [52] | |
EVs on non-neoplastic diseases | ||||
NcRNA | miR-10b-5p | HUVEC | Reduced inflammation in cardiovascular disease | [59] |
miR-125a | Human lung microvascular | Modulate the phenotype of distant endothelial cells of large systemic | [53] | |
miR-143 | HUVEC | Control smooth muscle cell phenotype | [62] | |
miR-146a | HUVEC | Decrease in metabolic activity in peripartum cardiomyopathy | [60] | |
miR-191 | Human lung microvascular | Predicting potential function of exosomes as paracrine effectors in COPD | [53] | |
miR-210 | Endothelial progenitor cells | Protective effects on ECs against H/R injury | [54] | |
miR-375 | Endothelial progenitor cell | Rescued the cell protection activity | [55] | |
miR-214 | HMEC-1 | Blood vessel formation | [56] | |
miR-505 | HUVEC | Inducing Oxidative stress and inflammation in atherosclerosis | [64] | |
miR-155 | HUVEC | Modulate the macrophage phenotype in atherosclerosis | [65] | |
miR-19a | HUVEC | Improved vascularization and cardiac function, decreased myocardial fibrosis | [61] | |
Protein | TGF-β1 | Glomerular endothelial cells | Ameliorate renal structure and function | [66] |
Versican | HUVEC | Regulate vascular smooth muscle cells calcification/senescence in high glucose condition | [63] | |
LOXL2 | Human microvascular endothelial cells | Altered abundances after exposure of their producing cells to cellular stress | [57] | |
Cytomegalovirus | HUVEC | Stimulate allogeneic CD4 + Memory T Cells | [67] | |
HSP70 | Rat aortic endothelial cells | Induction of monocyte activation and endothelial cell adhesion | [58] |