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Fig. 1 | Cell Communication and Signaling

Fig. 1

From: NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143

Fig. 1

NEK2 was highly expressed in ESCC and indicated worse overall survival in patients. A The mRNA expression of NEK2 in ESCC tissues was varied from 2.475 to 5.205 folds of those in normal esophageal epithelia in TCGA-ESCA, GSE23400, GSE20347. B NEK2 presented as a reliable cancerous biomarker with distinguished AUC at 93.8% in the TCGA cohort. C NEK2 was expressed abundantly throughout the ESCC and its level was higher than normal epithelia in tissue revealed by TMA, most of which were confined to the basal layer in the latter (P < 0.001, Mann–Whitney U test). D Higher expression of NEK2 was more frequently found in invading ESCC than non-invading ones in GSE21293(P < 0.001, Wilcoxon test). E Higher expression of NEK2 led to worse overall survival in ESCC patients. F Higher expression of NEK2, as well as lymph node invasion, were two independent predictors of ESCC mortality. TCGA The Cancer Genome Atlas; ESCA esophageal carcinoma; AUC area under the curve; TMA tissue microarray

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