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Fig. 6 | Cell Communication and Signaling

Fig. 6

From: Notch ankyrin domain: evolutionary rise of a thermodynamic sensor

Fig. 6

Analysis of the temperature-dependent structural fluctuations of Notch-1 ankyrin domain. a The left plot shows Root mean-square fluctuation (RMSF) of alpha carbon (Cα) of Notch ANK (Met-1872: Asp-2114) at 37 °C and 39 °C. The right plot shows RMSF after substitution of ASP-1989 > ASN-1989. b Spatial organisation of acidic residues and the distance between side chain carboxyl groups of these amino acids (PDB: 2F8Y). The structural arrangement of acidic residues could give rise to coulomb repulsion and translational vibration of ANKs (particularly ANK4) along the long axis of the domain in a manner akin to multiple coupled oscillators (bottom right schematic). c Hydrogen bonds between MAML-1, Notch-1 ankyrin domain, and RBPJ in the active DNA-bound transcriptional complex (PDB: 2F8X)

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