Fig. 5

Detection of proteinuria and nephropathy reminiscent of diabetic kidney disease in STZ-induced WT and MAP4 KI mice. A–D UACR, serum levels of CR, UN and Cys-c were determined in two mouse models at 10–14 weeks after STZ treatment. n = 8. E, F Quantitative analysis of foot processes fusion and TEM observation in WT and MAP4 KI mice at 10–14 weeks after STZ treatment. Bar, 2 µm. n = 6. G, H Representative confocal immunofluorescence images and quantitative analysis showing the epithelial and mesenchymal cell markers of frozen kidney section in two mouse models at 10–14 weeks after STZ treatment. Bar, 10 or 25 µm. n = 6. Data were shown as mean ± SEM. *P < 0.05. P values were derived from two-tailed Student's t-test