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Fig. 4 | Cell Communication and Signaling

Fig. 4

From: Microtubule associated protein 4 phosphorylation-induced epithelial-to-mesenchymal transition of podocyte leads to proteinuria in diabetic nephropathy

Fig. 4

MAP4 hyperphosphorylation mutation leads to EMT and diabetic retinopathy in MAP4 KI mice. A, B Representative confocal immunofluorescence images (A) and quantitative analysis (B) showing the epithelial and mesenchymal cell markers of frozen kidney section at different ages. Bar, 10 or 25 µm. n = 6. C Fluorescein angiogram showing retinal vasculature of (a) normal control mouse (c) STZ-induced diabetic mouse (e) MAP4 KI mouse (g) STZ treated MAP4 KI mouse. The (b), (d), (f) and (h) are the represented enlarged area of the (a), (c), (e) and (g). Arrow points to the microaneurysms. *P < 0.05, ***P < 0.001. P values were derived from one-way ANOVA with Bonferroni’s post-test

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